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INTRODUCTION

CLOSAL CREAM is a combination of Clobetasol propionate and Salicylic acid which belongs to a group of medicines called Topical Corticosteroids and Keratolytic agents, respectively. CLOSAL CREAM is used to treat and provide relief from inflammatory manifestations of skin conditions such as psoriasis (skin condition marked by rash and itchiness) and eczema (skin inflammation) in affected individuals.

CLOSAL CREAM is also used to provide relief from skin redness, itching and/or swelling due to various skin conditions. It is also indicated for use to treat other skin conditions such as dermatoses (skin lesion), seborrheic dermatitis of scalp (skin condition marked by scaly patches and red skin on the scalp) and/or ichthyosis vulgaris (inherited skin condition marked by dry & scaly skin) in affected individuals.

CLOSAL CREAM is generally not recommended for use in patients allergic to clobetasol and/or salicylic acid. CLOSAL CREAM is advised to be used in pregnant and breastfeeding women only if it is clearly necessary.

CLOSAL CREAM is not recommended for use in children and adolescents (aged below 12 years). The medicine is advised to be used with caution in elderly patients (aged above 65 years) after consulting the doctor.

The most common side-effects associated with the use of CLOSAL CREAM are irritation, burning, redness and/or stinging sensation (at the site of application), skin rash, itching and/or peeling/ thinning of skin. Consult your doctor if any of these symptoms worsens.

USES OF CLOSAL CREAM

  • Treats and provide relief from inflammatory manifestations of skin conditions such as psoriasis and eczema
  • Provides relief from skin redness, itching and/or swelling due to various skin conditions
  • Treats other skin conditions such as dermatoses, seborrheic dermatitis of scalp and/or ichthyosis vulgaris in affected individuals

DIRECTIONS FOR USE

CLOSAL CREAM provides relief from psoriasis and eczema, where Clobetasol propionate prevents inflammation by blocking the production of certain chemical messengers (prostaglandins) that make the skin red, swollen and/or itchy and Salicylic acid softens the skin by removing dead skin cells and breaking down keratin clumps which results in reducing itchiness and redness of skin, thus providing relief from psoriasis and eczema in affected individuals.

SIDE EFFECTS OF CLOSAL CREAM

COMMON

  • irritation, burning, redness and/or stinging sensation at the site of application
  • skin rash, itching
  • peeling/thinning of skin

UNCOMMON

  • erythema (skin redness)
  • telangiectasia (condition marked by small, widened blood vessels on the skin)

RARE

Stop applying CLOSAL CREAM and contact your doctor immediately if you experience any of the following side effects:

  • blurred vision, dizziness, fainting and/or irregular heartbeat
  • irritation and/or sensitization

HOW TO MANAGE SIDE EFFECTS

Itchy Skin:

Try to pat/tap your skin instead of scratching it. Hold a damp towel to cool your skin. Wear loose clothing and avoid tight clothes or clothes made from wool or synthetic fabrics. Avoid using perfumed soaps, deodorants and/or moisturizers and use a skin softener regularly. Consult your doctor if the symptom does not improve or gets worse.

WARNING & PRECAUTIONS

PREGNANCY

CLOSAL CREAM should be used with caution in pregnant women only if it is clearly necessary. Consult your doctor before applying it.

BREASTFEEDING

CLOSAL CREAM should be used with caution in breastfeeding women only if it is clearly necessary. Consult your doctor before applying the medicine.

ALCOHOL

Inform your doctor if you are planning to consume alcohol while on treatment with CLOSAL CREAM.

ALLERGY

Do not apply CLOSAL CREAM if you are allergic to Clobetasol, salicylic acid and/or any other ingredients of this medicine.

OTHERS

Use in Paediatrics:

CLOSAL CREAM is not recommended for use in children and adolescents (aged below 12 years). Consult your doctor before using the medicine.

Use in Geriatrics:

CLOSAL CREAM should be used with caution in elderly patients (over 65 years of age) Consult your doctor before applying it.

INTERACTIONS

A. Drug - Drug interactions:

Inform your doctor if you are taking any ayurvedic, homeopathic and/or any other medicines before applying CLOSAL CREAM.

Overdosage:

If you or anyone else applies too much of CLOSAL CREAM or accidentally swallows it, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.

SYNOPSIS

Drug :   Clobetasol propionate, Salicylic acid
Pharmacological Category :   Topical Corticosteroids, Keratolytic agent
Therapeutic Indication :   Psoriasis, Eczema, Other skin conditions (such as dermatoses, seborrheic dermatitis of scalp and/or ichthyosis vulgaris
Dosage Forms :   Cream, Lotion, Ointment

MORE INFORMATION

  • Keep CLOSAL CREAM out of reach of children
  • Store CLOSAL CREAM below 30°C

FAQs ABOUT CLOSAL CREAM

What is CLOSAL CREAM used for?

CLOSAL CREAM is used to treat and provide relief from inflammatory manifestations of skin conditions such as psoriasis (skin condition marked by rash and itchiness) and eczema (skin inflammation). It is also used to provide relief from skin redness, itching and/or swelling (due to various skin conditions) which is also indicated for use to treat other skin conditions such as dermatoses (skin lesion), seborrheic dermatitis of scalp (skin condition marked by scaly patches and red skin on the scalp) and/or ichthyosis vulgaris (inherited skin condition marked by dry & scaly skin) in affected individuals.

What are the side effects of CLOSAL CREAM?

The most common side-effects associated with the use of CLOSAL CREAM are irritation, burning, redness and/or stinging sensation (at the site of application), skin rash, itching and/or peeling/ thinning of skin. Consult your doctor if any of these symptoms worsens.

How CLOSAL CREAM works?

CLOSAL CREAM provides relief from psoriasis and eczema, where Clobetasol propionate prevents inflammation by blocking the production of certain chemical messengers (prostaglandins) that make the skin red, swollen and/or itchy and Salicylic acid softens the skin by removing dead skin cells and breaking down keratin clumps which results in reducing itchiness and redness of skin, thus providing relief from psoriasis and eczema in affected individuals.

How CLOSAL CREAM is applied?

Always apply CLOSAL CREAM as directed by your physician. It is for external use only. Wash your hands and apply a thin layer of medicine on the affected area. Avoid covering the affected area with airtight dressings unless recommended. Avoid applying the medicine on face, groin or axillae. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Can CLOSAL CREAM be used in pregnant and breastfeeding women?

Yes, CLOSAL CREAM can be used but with caution in pregnant and breastfeeding women only if it is clearly necessary. Consult your doctor before applying CLOSAL CREAM.

REFERENCES

1. KD. Tripathi. Drugs Acting on Skin and Mucous Membranes. Essentials of medical pharmacology. Seventh edition. 2013. Page – 889, 889.

2. Jana Petersen, Claudia Garbe, Sandra Wolf, Brigitte Stephan, Matthias Augustin, Kristina Hagenström. Medicinal Treatment of Elderly Psoriasis Patients before and after Entering a Nursing Home.  NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in September 2022] [Accessed on 16th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498407/

3. Lilit Garibyan, Albert S. Chiou, Sarina B. Elmariah. Advanced Aging Skin and Itch: Addressing an Unmet Need. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in June 2014] [Accessed on 16th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051285/

4. Ziska Pharmaceuticals Ltd. Closalic Ointment. [Accessed on 16th November 2022] http://ziskapharma.com/uploads/products/Closalic_Insert_Size.pdf

5. Sangrose Laboratories Pvt. Ltd. Closal. [Accessed on 16th November 2022] https://sangroselaboratories.com/products/

6. Swisschem Dermacare. CLOBSOL-S. [Accessed on 16th November 2022] https://www.swisscosmed.in/product/clobetasol-salicylic-acid-3

7. Care Formulation Labs Pvt. Ltd. MYSELIC. [Accessed on 16th November 2022] https://careformulationlabs.com/product/myselic/

8. Velite. CLOBISOL-S LOTION.  [Accessed on 16th November 2022] https://velite.in/index.php?route=product/product&product_id=183

9. Ederma Pharma India Pvt Ltd. ECZIVATE-S 6% LOTION. [Accessed on 16th November 2022] https://edermapharma.com/product/eczivate-s-6-lotion/

10. QndQ Derma. Comply-S. [Accessed on 16th November 2022] https://www.qndqdermacare.com/product/comply-s

11. Hanuchem Laboratories. Comply-S. [Accessed on 16th November 2022] https://www.hanuchemlabs.com/ointemnts

12. Innovative Pharmaceuticals Pvt Ltd. Clotrol-S Ointment. [Accessed on 16th November 2022] https://www.innovativepharma.in/product/clotrol-s-ointment/

USEFUL DIAGNOSTIC TESTS

  • Patch test
  • Skin biopsy

PRODUCT DETAILS

    Country Of Origin
    India
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