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Introduction About BUCELON 60MG INJECTION
BUCELON 60MG INJECTION contains Busulphan, which belongs to the group of medicines called Anti-cancer agents. It is used as a preparative medicine prior to bone marrow or stem cell transplantation to suppress immune functions and manage graft rejection among patients with chronic myelogenous leukemia (cancer of white blood cells in the blood).
It is generally used in combination with other anticancer medicines (such as cyclophosphamide, fludarabine, or melphalan) and can be used in both adults and in children (including newborns).
Before receiving BUCELON 60MG INJECTION, inform your doctor if you have a history of seizures or any lung, liver, or kidney problems. BUCELON 60MG INJECTION should not be used in pregnant or breastfeeding women, as it may cause serious harm to the growing fetus or nursing infant.
Men receiving BUCELON 60MG INJECTION must not father a child during management with BUCELON 60MG INJECTION and up to six months after stopping the therapy. Both men and women receiving BUCELON 60MG INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with BUCELON 60MG INJECTION.
The use of BUCELON 60MG INJECTION may cause an abnormal decrease in white blood cells (WBC) and platelet count in the blood. To avoid this, your doctor will closely monitor your blood count periodically before and during management with BUCELON 60MG INJECTION. It may also precipitate fits and/or nausea, and so your doctor will pre-manage you with a few anticonvulsants and anti-emetic medicines to manage them.
Other common side effects of receiving BUCELON 60MG INJECTION are mouth sores, diarrhea, hair loss, infections, problems sleeping, confusion, weight gain, and difficulty urinating. Consult your doctor if any of these side effects worsen.
Uses Of BUCELON 60MG INJECTION
It is used among patients (adults and children) with chronic myelogenous leukemia as a pre-management prior to bone marrow or stem cell transplantation to:
- To manage transplant (bone marrow or stem cell) rejection
How BUCELON 60MG INJECTION Works
BUCELON 60MG INJECTION is an anticancer medicine with immune-suppressing properties. When used prior to stem cell or bone marrow transplantation, BUCELON 60MG INJECTION can suppress the functions of immune cells (white blood cells) and manage the risk of transplant rejection among patients with a high WBC count or leukemia.
How to use BUCELON 60MG INJECTION
BUCELON 60MG INJECTION will be given to you only by a doctor or a nurse into the vein as an intravenous infusion. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
Side Effects Of BUCELON 60MG INJECTION
Common
- low blood counts (WBC, RBC, and platelets)
- signs of infections such as sore throat, cough
- difficulty sleeping, anxiety, dizziness, confusion, and depression
- loss of appetite, low magnesium, sodium, and potassium levels in the blood
- fast heart rate, changes in blood pressure, blood clots
- difficulty breathing, nasal secretion (rhinitis), hiccups, nasal bleeds, abnormal breath sounds
- increased blood sugar levels
- nausea, vomiting, stomach pain, diarrhea, constipation, and heartburn
- mouth ulcers (oral sores)
- jaundice (yellowing of the skin or whites of the eye)
- inflammation at the injected site
- hair loss
- skin rash, itching or redness, skin discoloration
- back pain, joint pain, and muscle pain
- bloody urine or difficulty in urination
- fever, chills, pain
- headache
- feeling weak, edema
- weight gain
Uncommon
- problems in thinking, nervousness, hallucinations
- fits (seizure)
- bleeding in the brain or in the gut
Stop receiving BUCELON 60MG INJECTION and contact your doctor immediately if you experience any of the following side effects:
- any signs of fever or infection (chills, sore throat, mouth sores, cough, urinary problems) caused by a sudden decrease in WBC counts
- abnormal bleeding and bruising caused by a sudden decrease in platelet counts
- pale skin and tiredness caused by low RBC counts
- sudden feeling of unwellness
- blockade of the liver vein
- graft versus host disease (reaction between the transplanted graft and the host)
- lung problems causing shortness of breath and chest pain
How To Manage Side Effects
Diarrhea
Drink plenty of fluids, such as water, fruit juices, or electrolytes, to avoid dehydration in your body. Consult your doctor if your symptoms worsen.
Dizziness Or Drowsiness
Lie down until the dizziness passes away, and then move slowly and carefully. Take plenty of rest and drink plenty of fluids. If your symptom does not improve, consult your doctor.
Headache
Try to take a rest. Apply a pain-relieving balm to your forehead. If the symptom does not improve, consult with your doctor.
Mouth Ulcers
Use a soft toothbrush to brush your teeth. Avoid eating spicy and acidic foods such as beverages, sodas, and processed foods. Also, you may use over-the-counter pain-relieving oral gel to get some relief.
Warning & Precautions
Pregnancy
ContraindicatedBUCELON 60MG INJECTION is not recommended for use by pregnant women. Women of childbearing age must use a suitable contraceptive before and during management with BUCELON 60MG INJECTION to avoid pregnancy and up to 6 months after discontinuation. If you became pregnant while undergoing therapy with BUCELON 60MG INJECTION, stop taking the medicine and contact your doctor immediately.
Breastfeeding
ContraindicatedBUCELON 60MG INJECTION is not recommended for use by breastfeeding women. However, consult your doctor before receiving it.
Driving and Using Machines
Use with CautionBUCELON 60MG INJECTION does not cause any side effects that affect your ability to drive or operate any machines. If you experience any side effects that impair your ability to concentrate, avoid driving and operating machines.
Alcohol
ContraindicatedConsumption of alcohol is not recommended during management with BUCELON 60MG INJECTION.
Kidney
Use with CautionBUCELON 60MG INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
Liver
Use with CautionBUCELON 60MG INJECTION should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.
Allergy
ContraindicatedDo not receive BUCELON 60MG INJECTION if you are allergic to Busulphan.
Lungs
Use with CautionBUCELON 60MG INJECTION should be used with caution in patients with lung problems. Therefore, consult your doctor before receiving it.
Use In Pediatrics
Monitoring requiredBUCELON 60MG INJECTION should be used in infants, children, and adolescents (aged between 0-18 years) only if prescribed by a physician. Therefore, consult your doctor before administration.
Use In Geriatrics
Use with CautionBUCELON 60MG INJECTION should be used with caution with elderly patients. Therefore, consult your doctor before receiving it.
Others
Before receiving BUCELON 60MG INJECTION, inform your doctor if you:
- have a history of seizures
- are you a man wishing to father a child
Interactions
A. Drug-Drug interactions:
Before receiving BUCELON 60MG INJECTION, inform your doctor if you are receiving any of the following medicines, such as:
- other chemotherapy medicines (used to manage cancer) such as cyclophosphamide, cisplatin, carboplatin, methotrexate, etc.
- itraconazole (a medicine used to manage fungal infections)
- metronidazole (a medicine used to manage bacterial and protozoal infections)
- ketobemidone (a medicine used for pain relief)
- deferasirox (a medicine used to remove excess iron from the body)
- paracetamol (used to manage fever and pain)
Overdosage:
BUCELON 60MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Busulphan |
| Pharmacological Category | : | Alkylating agents |
| Therapeutic Indication | : | To manage transplant rejection |
| Dosage Forms | : | Tablet, Injection |
More Information
- Keep BUCELON 60MG INJECTION out of reach of children
- Store in a refrigerator between 2-8°C
FAQs About BUCELON 60MG INJECTION
Q: What is the use of BUCELON 60MG INJECTION?
A: BUCELON 60MG INJECTION is an anticancer medicine with immune-suppressing properties. It is used as a preparative medicine prior to bone marrow or stem cell transplantation to suppress immune functions and manage graft rejection among patients with chronic myelogenous leukemia (cancer of white blood cells in the blood).
Q: Is BUCELON 60MG INJECTION chemotherapy?
A: Yes. BUCELON 60MG INJECTION is a chemotherapeutic agent with immune-suppressing properties. When used prior to stem cell or bone marrow transplantation, BUCELON 60MG INJECTION can suppress the functions of immune cells (white blood cells) and manage the risk of transplant rejection among patients with a high WBC count or leukemia.
Q: Is the use of BUCELON 60MG INJECTION safe?
A: BUCELON 60MG INJECTION is safe when used under proper medical supervision and at the prescribed doses.
Q: What are the side effects of BUCELON 60MG INJECTION?
A: BUCELON 60MG INJECTION may cause an abnormal decrease in WBC and platelet counts. It may also cause nausea, vomiting, seizures, diarrhea, mouth sores, and difficulty urinating. Therefore, consult your doctor for advice if they trouble you.
Q: How does BUCELON 60MG INJECTION work?
A: BUCELON 60MG INJECTION works by suppressing your immune system. When used prior to stem cell or bone marrow transplantation, BUCELON 60MG INJECTION can suppress the functions of immune cells (white blood cells) and manage the risk of transplant rejection among patients with a high WBC count or leukemia.
Q: Can the use of BUCELON 60MG INJECTION cause hair loss?
A: Yes. Hair loss is one of the common side effects of receiving BUCELON 60MG INJECTION. Consult your doctor if it bothers you.
Q: Will the use of BUCELON 60MG INJECTION affect fertility?
A: Yes. The use of BUCELON 60MG INJECTION may affect fertility in both men and women. It may cause a lack of periods, delayed puberty, early menopause in women, and decreased sperm production in men. Consult your doctor if they trouble you.
Q: Can I stop therapy with BUCELON 60MG INJECTION without consulting your doctor?
A: No, you should not stop therapy with BUCELON 60MG INJECTION without consulting your doctor because it may lead to a reversal of symptoms. If you feel better after using BUCELON 60MG INJECTION, consult your doctor for advice. Your doctor might reduce the dose gradually before discontinuation of therapy.
Q: Can the use of BUCELON 60MG INJECTION cause seizures?
A: Yes. BUCELON 60MG INJECTION may cause seizures in some individuals. To avoid this, your doctor will manage you with a few anticonvulsant medicines such as phenytoin or benzodiazepines (Ex. diazepam, clonazepam, lorazepam, alprazolam, and midazolam) prior to the management with BUCELON 60MG INJECTION. However, if you still experience any unpleasant reactions, contact your doctor for advice.
Q: Can the use of BUCELON 60MG INJECTION cause vomiting?
A: Yes. BUCELON 60MG INJECTION may cause vomiting in some individuals. To avoid this, your doctor will manage you with a few medicines that can help manage vomiting. However, if you still experience any unpleasant reactions, contact your doctor for advice.
References
1. KD. Tripathi. Chemotherapy of Neoplastic Diseases. Essentials of medical pharmacology. Seventh edition. 2013. Page – 861.
2. Partow Kebriaei, Claudio Anasetti, Mei-Jie Zhang, Hai-Lin Wang, Ibrahim Aldoss, Marcos de Lima, H Jean Khoury, Brenda M. Sandmaier, Mary M. Horowitz, Andrew Artz, Nelli Bejanyan, Stefan Ciurea, Hillard M. Lazarus, Robert Peter Gale, Mark Litzow, Christopher Bredeson, Matthew D. Seftel, Michael A. Pulsipher, Jaap-Jan Boelens, Joseph Alvarnas, Richard Champlin, Stephen Forman, Vinod Pullarkat, Daniel Weisdorf, David I. Marks. Intravenous busulfan compared to total body irradiation pre-transplant conditioning for adults with acute lymphoblastic leukaemia. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. April 2019. [Accessed on 3rd September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902420/
3. MD ANDERSON. Q&A: Intravenous busulfan before stem cell transplant. MD Anderson Cancer Center. The University of Texas. May 2010. [Accessed on 3rd September 2022] https://www.mdanderson.org/cancerwise/qa-intravenous-busulfan-before-stem-cell-transplant.h00-158592945.html#:~:text=Busulfan%20acts%20directly%20on%20the,before%20a%20stem%20cell%20transplant.
4. Donna A. Wall MD, Ka Wah Chan MD, Michael L. Nieder MD, Robert J. Hayashi MD, Andrew M. Yeager MD, Richard Kadota MD, Donna Przepiorka MD, Khaled Mezzi MD, Morris Kletzel MD. Safety, efficacy, and pharmacokinetics of intravenous busulfan in children undergoing allogeneic hematopoietic stem cell transplantation. Paediatric Blood and Cancer. Wiley Online Library. September 2009. [Accessed on 3rd September 2022] https://onlinelibrary.wiley.com/doi/10.1002/pbc.22227
5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in July 2020] [Accessed on 3rd September 2022] https://www.medicines.org.uk/emc/files/pil.2160.pdf
6. Gland Pharma Limited. Pfizer Ltd. [Revised in August 2020]. [Accessed on 3rd September 2022] https://labeling.pfizer.com/ShowLabeling.aspx?format=PDF&id=11523
Useful Diagnostic Tests
- Bcr-Abl Gene Translocation
- Complete Blood Count
- Kidney Function Test
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