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INTRODUCTION
BESICOR 5 TABLET contains Bisoprolol which belongs to a group of medicines called Beta- blockers. It is used to treat stable heart failure in combination with other medicines. Stable heart failure is a condition in which patients of heart failure are receiving medication and show no physical symptoms suggestive of worsening of the condition.
BESICOR 5 TABLET is used to treat high blood pressure (Hypertension) and angina pectoris (Chest pain). Hypertension is defined as persistently elevated arterial blood pressure and Angina is a type of chest pain which is caused by reduced blood flow to the heart as a result of coronary artery disease. Symptoms are feeling pressure, squeezing, heaviness, tightness or pain in the chest or a heavy weight is lying on the chest.
BESICOR 5 TABLET is not recommended for use in patients having heart and severe lung diseases, impaired blood supply of the arms and legs (peripheral arterial occlusive disease), severe blood circulation problem in limbs (Raynaud’s syndrome), untreated pheochromocytoma, metabolic acidosis, low blood pressure (Hypotension).
Before taking BESICOR 5 TABLET, inform your doctor, if you have severe kidney or liver diseases, diabetes, are on strict fasting, ongoing desensitisation therapy, history of a scaly skin rash (Ex. psoriasis), pheochromocytoma, thyroid disorder, to receive general anaesthesia.
BESICOR 5 TABLET is not recommended for use in pregnant and breast-feeding women unless considered clearly necessary. Consult your doctor before taking it. BESICOR 5 TABLET is not recommended for use in children. Consult your doctor before taking it.
The most common side effects of taking BESICOR 5 TABLET are tiredness, feeling weak, dizziness, headache, feeling of coldness or numbness in hands or feet, low blood pressure, nausea, vomiting, diarrhoea or constipation. Ask for your doctor’s advice if any of these worsen or doesn’t improve.
USES OF BESICOR 5 TABLET
Treats:
- high blood pressure (Hypertension)
- angina pectoris (Chest pain)
- stable heart failure (in combination with other medicines)
HOW BESICOR 5 TABLET WORKS
BESICOR 5 TABLET works by blocking certain receptors (beta-1 receptors) present mainly in the heart and prevents the binding of nerve chemicals such as epinephrine. Therefore, leading to decrease in heart rate, blood pressure and makes the heart more efficient at pumping blood around the body and it also reduces the amount of blood required by the heart, reducing oxygen demand. BESICOR 5 TABLET also decrease the release of a substance called renin in the kidneys (which normally increases blood pressure), decreasing blood pressure and heart rate.
DIRECTIONS FOR USE
Take BESICOR 5 TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your body weight, age and severity of disease condition.
SIDE EFFECTS OF BESICOR 5 TABLET
COMMON
- tiredness, feeling weak
- dizziness
- headache
- low pulse rate or slow heartbeat
- worsening of the pre-existing heart-failure
- coldness, numbness in your hands or feet
- low blood pressure
- gastrointestinal symptoms (nausea, vomiting, diarrhoea or constipation)
UNCOMMON
- sleep disturbances
- depression
- feeling weak
- dizziness when standing up
- breathing problems in asthma or chronic lung disease patients
- muscle weakness, muscle cramps
- exacerbation of existing heart rhythm disorders such as AV-block
RARE
- hearing problems
- blocked or runny nose
- reduced tear flow (dry eyes)
- inflammation of the liver (hepatitis), causing abdominal pain, loss of appetite and jaundice (yellowing of the whites of the eyes and skin and dark urine)
- increased levels of blood triglycerides and liver enzymes
- allergic reactions such as itching, flush, rash and severe allergic reactions, which may involve face, neck, tongue, mouth or throat swelling or difficulty breathing
- impaired erection
- nightmares, hallucinations
- fainting
Stop taking BESICOR 5 TABLET and contact your doctor immediately if you experience any of the following side effects:
- slowing of heart rate
- worsening of heart failure (increased breathlessness and swelling of legs)
- slow or irregular heartbeat
- worsening of symptoms of blockage of the main blood vessel to the legs
- dizziness or weakness or have breathing difficulty
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.
Nausea:
Take this medicine with or after meals. Stick to simple meals while taking this medicine. Avoid eating rich or spicy food. Do not take any medication on your own. Ask for your doctor’s advice if nausea doesn’t improve.
Vomiting:
Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, oily or sweet foods. Avoid carbonated drinks. Ask for your doctor’s advice if vomiting doesn’t improve.
Runny nose or sneezing:
Take rest and have plenty of fluids to stay hydrates. Blow your nose using a soft tissue. Take steam. You can have warm fluids such as tea. If the symptom doesn’t improve, ask for your doctor’s advice.
Muscle pain:
Give your body a rest. Do not overexert or over stretch yourself. Do stress relieving activities such as yoga or meditation. If the symptom doesn’t improve, ask for your doctor’s advice.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for treating diarrhea. Contact your doctor if the symptom did not improve.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
BESICOR 5 TABLET is not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking BESICOR 5 TABLET.
BREASTFEEDING
BESICOR 5 TABLET is not recommended for use in breastfeeding women as it is not known if this medicine passes into breast milk. Consult your doctor before taking BESICOR 5 TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines until you know the effect of BESICOR 5 TABLET on your ability to drive.
KIDNEY
BESICOR 5 TABLET should be taken with caution in patients with severely impaired kidney diseases. Consult your doctor before taking BESICOR 5 TABLET.
LIVER
BESICOR 5 TABLET should be used with caution in patients with severely impaired liver function. Consult your doctor before taking BESICOR 5 TABLET.
ALLERGY
Do not take BESICOR 5 TABLET if you are allergic to Bisoprolol or any of the other ingredients of this medicine.
LUNGS
BESICOR 5 TABLET is not recommended for use in patients with breathing problems such as Asthma and COPD. Consult your doctor before taking BESICOR 5 TABLET.
HEART DISEASE
BESICOR 5 TABLET is not recommended for use in patients with heart diseases such as acute heart failure, heart conduction disorders such as 2 or 3rd degree AV-block, sick sinus syndrome, sinoatrial block, slow heart rate (bradycardia), low blood pressure (hypotension) and cardiogenic shock. BESICOR 5 TABLET should be used with caution in patients having other heart diseases such as congenital heart disease, restrictive cardiomyopathy, hemodynamically significant organic valvular disease, myocardial infarction (withing 3 months), 1st degree AV block or Prinzmetal’s angina. Consult your doctor before taking BESICOR 5 TABLET.
OTHERS
BESICOR 5 TABLET is not recommended for use if you have:
- Raynaud’s syndrome (severe blood circulation problem in the limbs)
- untreated pheochromocytoma
- metabolic acidosis
- low blood pressure
- peripheral arterial occlusive disease (late-stage vascular condition causing impaired perfusion of the arms and legs)
Before taking BESICOR 5 TABLET, inform your doctor if you have:
- diabetes type 1
- strict fasting
- ongoing desensitisation therapy
- less severe blood circulation problem in the limbs
- history of a scaly skin rash (Ex. psoriasis)
- thyroid disorder
- to undergo general anaesthesia
Use in paediatrics:
BESICOR 5 TABLET is generally not recommended for use in children. Consult with your child’s doctor before giving BESICOR 5 TABLET to your child.
Use in geriatrics:
BESICOR 5 TABLET can be used elderly patients without dose adjustment. Your doctor might suggest the lowest dose to you. Consult your doctor before taking BESICOR 5 TABLET.
INTERACTIONS
A) Drug - Drug interactions:
Before taking BESICOR 5 TABLET, inform your doctor if you are taking any of the following medicine:
- medicines used to treat heart diseases such as irregular or abnormal heartbeat, high blood pressure or angina pectoris (Ex. quinidine, lidocaine, flecainide, disopyramide, phenytoin, propafenone, verapamil, diltiazem, digoxin, isoprenaline, dobutamine, clonidine, methyldopa, adrenaline, nor-adrenaline, moxonodine, rilmenidine, amiodarone, felodipine and amlodipine)
- medicines used for glaucoma (Ex. timolol, pilocarpine)
- medicines used to treat diabetes (Ex. insulin, metformin, tolbutamide)
- medicines used in anaesthesia (Ex. propofol, lidocaine)
- medicines used to treat pain or inflammation (Ex. Ibuprofen, diclofenac, acetyl salicylic acid)
- mefloquine (used for treatment, prevention of malaria)
- medicines used for depression (Ex. imipramine, isocarboxazid, amitriptyline, clomipramine, moclobemide)
B) Drug - Food interaction:
NA
Overdosage:
If you or anyone else accidentally take too much of BESICOR 5 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are decreased heart rate, severe difficulty in breathing, feeling dizzy or trembling due to decreased blood sugar.
SYNOPSIS
| Drug | : | Bisoprolol |
| Pharmacological Category | : | Beta-blockers |
| Therapeutic Indication | : | Hypertension, Angina, Stable heart failure |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep BESICOR 5 TABLET out of the sight and reach of children
- Store BESICOR 5 TABLET below 30°C
FAQs ABOUT BESICOR 5 TABLET
Does BESICOR 5 TABLET lower blood pressure?
Yes. BESICOR 5 TABLET causes low blood pressure. If you experience any unusual symptoms like dizziness, headache, sweating etc. Stop taking BESICOR 5 TABLET and Contact your doctor.
Does BESICOR 5 TABLET increase blood sugar levels?
Yes. BESICOR 5 TABLET may increase blood sugar levels. Contact your doctor if you experience any symptoms like increased thirst and hunger or increased urination.
Can I drink coffee while being treated with BESICOR 5 TABLET?
It is better to avoid tea or coffee while taking BESICOR 5 TABLET. This is because, caffeine-containing food items and beverages along with beta blockers like BESICOR 5 TABLET may decrease the effectiveness of the medicine.
Is BESICOR 5 TABLET safe for use in pregnant?
BESICOR 5 TABLET is generally not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking it.
Does BESICOR 5 TABLET cause slow heartbeat?
Yes. BESICOR 5 TABLET cause slow heartbeat. If you feel any unusual symptoms like pounding, fluttering or skipped heart beats. Immediately, contact your doctor.
Do I need to stop taking BESICOR 5 TABLET before having a surgery that requires general anaesthesia?
Do not stop taking BESICOR 5 TABLET on your own. Inform your anaesthetist if you are taking BESICOR 5 TABLET. This is important to avoid any harmful interactions with other medications. If at all it is required for you to stop taking BESICOR 5 TABLET, your doctor will guide you.
REFERENCES
- Barbara G. wells, Terry L. schwinghammer, Joseph T. dipiro, Cecily V. dipiro. Heart failure. Pharmacotherapy handbook. Tenth edition. 2017. Page – 120
- Pascal de Groote, Pierre-Vladimir Ennezat, Fréderic Mouquet. Bisoprolol in the treatment of chronic heart failure. NIH National Library ofmedicine National Centre for Biotechnology Information. Pubmed Central. August 2007. [Accessed on 3rd May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291328/
- Linda Wagner, Charlotte Kenreigh. Bisoprolol. Science Direct. [Accessed on 3rd May 2022] https://www.sciencedirect.com/topics/medicine-and-dentistry/bisoprolol
- Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 3rd May 2022] https://www.medicines.org.uk/emc/files/pil.6126.pdf
- McDermott Laboratories Ltd. Bisoprolol. [Revised in July 2022] [Accessed on 3rd May 2022] https://www.medicines.ie/medicines/bisoprolol-mylan-31447/spc#tabs
- Papaloizou Ltd. Concor (Bisoprolol). [Revised in August 2022] [Accessed on 3rd May 2022] https://www.papaloizou.com/PublicDocsPDF/SPCs/Concor_SPC.pdf
- Drug Bank. Bisoprolol. [Accessed on 3rd May 2022] https://go.drugbank.com/drugs/DB00612
USEFUL DIAGNOSTIC TESTS
- ECG (Echocardiograph)
- Echocardiogram
- Kidney function test
- Liver Function Test
AUTHOR DETAILS
Written By Dr. Priyanka Goel, BDS
Last updated on 20 Oct 2022 | 09:55 AM(IST)
PRODUCT DETAILS
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