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Drug Information

What is Promethazine used for?

Promethazine tablet/syrup is used for the treatment of allergic symptoms, such as itching, runny nose, sneezing and rash. It is also recommended for the prevention of nausea, vomiting and motion sickness after surgery.

Promethazine injection is used to improve allergic reactions and treat motion sickness. It is also used as a sedative in certain surgeries.

Promethazine may also be prescribed for other conditions as determined by the doctor.

How does Promethazine work?

Promethazine belongs to the class of drugs called anti-histamines. This drug acts by blocking the histamine receptors in the gastrointestinal tract, uterus and bronchial muscle. Thus, it blocks the release of histamine and reduces the intensity of allergic reactions.

How to use Promethazine?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Use Promethazine as prescribed by your doctor.

  • Swallow the tablet whole. Do not crush or chew the tablet. Take the drug with or without food. However, taking the drug with food prevents stomach upset.
  • For syrup dosage form, shake the syrup well before taking each dose to ensure the uniform mixing of the drug. Use a measuring cup to measure each dose.
  • Promethazine injection should be administered only under the medical supervision.

If you miss a dose of Promethazine, please consult the doctor immediately.

The overdose symptoms of Promethazine may include:

  • Severe dizziness
  • Shallow breathing
  • Seizures
  • Muscle stiffness
  • Widened pupils
  • Mood swings

You must seek immediate medical care if you experience any of the above symptoms.

What are the drugs that interact with Promethazine?

Drugs that interact with Promethazine include the following:

  • Acetaminophen
  • Artemether
  • Bupropion
  • Cisapride
  • Citalopram
  • Dolasetron
  • Naltrexone
  • Propoxyphene
  • Sotalol
  • Topiramate

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Promethazine?

The following are the most common side effects of Promethazine:

  • Drowsiness
  • Dizziness
  • Constipation
  • Blurred vision
  • Dry mouth

The following are the severe side effects, and you may require immediate medical attention:

  • Convulsions
  • Irregular heartbeat
  • Muscle stiffness
  • Unusual tiredness
  • Pale skin
  • Stomach pain
  • High fever

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while using Promethazine?

  • Avoid using the medicine if you are allergic to Promethazine or similar drugs.
  • Be cautious while using Promethazine if you have any kidney or liver impairment.
  • Do not drive or operate heavy machinery if Promethazine causes dizziness or blurred vision.
  • Avoid Promethazine during pregnancy or breastfeeding because the safe use of the drug is not yet established.
  • Do not stop using the medication abruptly unless instructed by the doctor. Stopping the medication suddenly may cause the illness to return.

You are advised not to use Promethazine if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering, or there is discolouration.

What should you tell your doctor before using Promethazine?

  • Tell your doctor if you have any history of heart, kidney, liver or respiratory diseases.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • Inform your doctor if you are pregnant or breastfeeding.

Frequently asked questions about Promethazine

  1. Is it safe to use Promethazine in asthma patients?
  2. No. It is not safe to use Promethazine in asthma patients. Promethazine is contraindicated in patients with asthma or other respiratory diseases.

  3. Is Promethazine recommended for relieving surgical pain?
  4. Yes. Promethazine is recommended to reduce surgical pain. However, please consult your doctor. Don’t self-medicate.

  5. When should I take Promethazine for treating motion sickness?
  6. It is advised to take Promethazine at least 30 to 60 minutes before travelling.

  7. What are the other formulations of Promethazine available?
  8. Promethazine is also available as rectal suppositories and oral solutions.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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