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INTRODUCTION
AMITRYN 25MG contain Amitriptyline which belongs to a group of medicine called tricyclic antidepressants. Tricyclic antidepressants are used to treat depression as well as manage a variety of other conditions, ranging from obsessive-compulsive disorder to bedwetting. This medicine is used to treat depression in adults (major depressive episodes), neuropathic pain in adults, chronic tension type headache prophylaxis in adults, migraine prophylaxis in adults, bed-wetting at night in children aged 6 years and above, only when organic causes such as spina bifida and related disorders
Depression is a mood disorder that will causes a persistent feeling of sadness and loss of interest. Neuropathic pain is a pain condition that is usually chronic. It is usually caused by chronic, progressive nerve disease. It can occur as the result of injury or infection. This medicine is strictly not recommended for use in children and adolescents under 18 years. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF AMITRYN 25MG
- Depression in adults (major depressive episodes)
- Neuropathic pain in adults
- Chronic tension type headache prophylaxis in adults
- Migraine prophylaxis in adults
- Bed-wetting at night in children aged 6 years and above, only when organic causes such as spina bifida and related disorders
HOW AMITRYN 25MG WORKS
AMITRYN 25MG works by increasing the levels of chemical messengers in the brain that help in regulating mood and treat depression. It also stops the transmission of pain signals from nerves to the brain thereby relieving neuropathic pain (pain from damaged nerves).
DIRECTIONS FOR USE
Always take AMITRYN 25MG exactly as your doctor has told you. This medicine must be taken with or without food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.
SIDE EFFECTS OF AMITRYN 25MG
COMMON
- heart problem, irregular, hard or rapid heartbeat
- sleepiness/drowsiness
- shakiness of hands or other body parts
- dizziness, headache
- dry mouth
- constipation
- nausea
- excessive sweating
- weight gain
- slurred or slow speech
- aggression
- congested nose
- confusion
- sexual disturbances (decreased sex-drive, problems with erection)
- disturbance in attention
- changes in taste
- numbness in the arms or legs
- disturbed coordination
- dilated pupils
- fatigue
- low sodium concentration in the blood
- agitation
- urination disorders
- feeling thirsty
RARE
- swollen stomach, fever, and vomiting
- jaundice (yellowing of the skin and the white in the eyes)
- bruising, bleeding, pallor, or persistent sore throat (symptoms can be the first signs that your blood or bone marrow may be affected, decrease in the number of red cells, white cells, and platelets)
- suicidal thoughts or behavior
- decreased appetite
- delirium (especially in elderly patients), hallucinations
- swelling of the salivary glands
- hair loss
- increased sensitivity to sunlight
- breast enlargement in men
- weight loss
- abnormal liver function
HOW TO MANAGE SIDE EFFECTS
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Constipation:
Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.
Nausea:
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
WARNING & PRECAUTIONS
PREGNANCY
AMITRYN 25MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
AMITRYN 25MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate any machine while taking this medicine since it may cause drowsiness and dizziness.
ALCOHOL
Consumption of alcohol is not recommended during treatment with AMITRYN 25MG.
KIDNEY
AMITRYN 25MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
AMITRYN 25MG is not recommended in patients with active liver diseases. Before taking, discuss the risks and benefits with your doctor.
ALLERGY
Do not take AMITRYN 25MG if you are allergic (hypersensitive) to Amitriptyline or any other ingredients in this medicine.
HEART DISEASE
AMITRYN 25MG is not recommended in patients with active heart diseases. Before taking, discuss the risks and benefits with your doctor.
OTHERS
Tell your doctor if you have or had a condition such as,
- have a problem that gives you a low level of potassium or magnesium, or a high level of potassium in your blood
- have a surgery planned
- have an overactive thyroid gland or receive thyroid medication
- thoughts of suicide and worsening of your depression
- have thoughts of harming or killing yourself at any time
- narrow angle glaucoma (loss of vision due to abnormally high pressure in the eye)
- epilepsy, a history of convulsions or fits
- pylorus stenosis (narrowing of the gastric outlet) and paralytic ileus (blocked intestine)
- diabetes
- suffer from certain side effects, such as dizziness when you stand up due to low blood pressure
INTERACTIONS
Talk to your doctor if you are taking,
- monoamine oxidase inhibitors (MAOIs) such as phenelzine, iproniazid, isocarboxazid, nialamide, ortranylcypromine (used to treat depression) or selegiline (used to treat Parkinson's disease)
- medicine such as adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine, and phenylpropanolamine (these may be present in cough or cold medicine, and in some anaesthetics)
- medicine to treat high blood pressure for example calcium-channel blockers (such as diltiazem and verapamil), guanethidine, betanidine, clonidine reserpine and methyldopa
- thioridazine (used to treat schizophrenia)
- tramadol (painkiller)
- medicines to treat fungal infections (e.g. fluconazole, terbinafine, ketoconazole, and itraconazole)
- sedatives (e.g. barbiturates)
- medicines for certain heart conditions (e.g. beta blockers and antiarrhythmics such as amiodarone, disopyramide, propafenone)
- valproic acid (used to treat mania)
- quinidine and sotalol (used to treat irregular heartbeats)
- astemizole and terfenadine (used to treat allergies and hay fever)
- pimozide and sertindole (used to treat some mental illnesses)
- cisapride (used to treat certain types of indigestion)
- halofantrine (used to treat malaria)
- methadone (used to treat pain and for detoxification)
- diuretics (“water tablets” e.g. furosemide)
SYNOPSIS
| Drug | : | Amitriptyline |
| Pharmacological Category | : | Tricyclic Anti-depressant |
| Therapeutic Indication | : | Depression |
| Dosage Forms | : | Tablet, Injection |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
REFERENCES
1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 192 – 196.
2. R Andrew Moore 1, Sheena Derry, Dominic Aldington, Peter Cole, Philip J Wiffen. Amitriptyline for neuropathic pain in adults. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. 6 Jul 2015. [Accessed 26 Nov 2020] https://pubmed.ncbi.nlm.nih.gov/26146793/
3. Accord Healthcare Limited, Sep 2019; Electronic Medicines Compendium (EMC); [Accessed 26 Nov 2020] https://www.medicines.org.uk/emc/files/pil.6017.pdf
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