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What is AMITRYN 25MG?
- AMITRYN 25MG contain Amitriptyline belongs to a group of medicines known as tricyclic antidepressants
What AMITRYN 25MG is used for?
It is used to treat:
- Depression in adults (major depressive episodes)
- Neuropathic pain in adults
- Chronic tension type headache prophylaxis in adults
- Migraine prophylaxis in adults
- Bed-wetting at night in children aged 6 years and above, only when organic causes, such as spina bifida and related disorders
Talk to Doctor
Pregnancy & Breast Feeding
Children & Adolescents
Driving & Using Machines
Talk to your Doctor if you
- are allergic to AMITRYN 25MG or any of the other ingredients of this medicine
- have had a heart attack (myocardial infarction)
- have heart problems such as disturbances in heart rhythm which are seen on an electrocardiogram (ECG), heart block, or coronary artery disease
- have slow heart rate, heart failure
- have a low level of potassium or magnesium, or a high level of potassium in your blood
- have an over active thyroid gland or receive thyroid medication.
- have thoughts of suicide and worsening of your depression, mania, bipolar disorder schizophrenia
- have thoughts about killing or harming yourself
- have narrow angle glaucoma (loss of vision due to abnormally high pressure in the eye)
- have epilepsy, a history of convulsions or fits
- have difficulty in passing urine
- have enlarged prostate
- severe liver, heart disease, diabetes
- have pylorus stenosis (narrowing of the gastric outlet) and paralytic ileus (blocked intestine)
- If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine
- If you have taken AMITRYN 25MG during the last part of the pregnancy, the newborn may have withdrawal symptoms such as irritability, increased muscle tension, tremor, irregular breathing, poor drinking, loud crying, urinary retention, and constipation
- AMITRYN 25MG is recommended in children and adolescents before 6 years of age only in the treatment of Bed-wetting at night
- If you feel dizzy or tired when taking this medicine, do not drive or use any tools or machines
Tell your doctor about any other medicine you are taking:
- monoamine oxidase inhibitors (MAOIs) e.g. phenelzine, iproniazid, isocarboxazid, nialamide or tranylcypromine (used to treat depression) or selegiline (used to treat Parkinson's disease)
- adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine (these may be present in cough or cold medicine, and in some anaesthetics)
- medicine to treat high blood pressure for example calcium-channel blockers (e.g. diltiazem and verapamil), guanethidine, betanidine, clonidine reserpine and methyldopa
- anticholinergic drugs such as certain medicines to treat Parkinson’s disease and gastrointestinal disorders (e.g. atropine, hyoscyamine)
- thioridazine (used to treat schizophrenia)
- tramadol (painkiller)
- medicines to treat fungal infections (e.g. fluconazole, terbinafine, ketoconazole, and itraconazole)
- sedatives (e.g. barbiturates)
- antidepressants (e.g. SSRIs (fluoxetine, paroxetine, fluvoxamine), and bupropion)
- medicines for certain heart conditions (e.g. beta blockers and antiarrhythmics)
- cimetidine (used to treat stomach ulcers)
- methylphenidate (used to treat ADHD)
- ritonavir (used to treat HIV)
- oral contraceptives
- rifampicin (to treat infections)
- phenytoin and carbamazepine (used to treat epilepsy)
- John´s Wort (hypericum perforatum) – a herbal remedy used for depression
- thyroid medication
- medicines to treat irregular heartbeats (e.g. quinidine and sotalol)
- astemizole and terfenadine (used to treat allergies and hay fever)
- medicines used to treat some mental illnesses (e.g. pimozide and sertindole)
- cisapride (used to treat certain types of indigestion)
- halofantrine (used to treat malaria)
- methadone (used to treat pain and for detoxification)
- diuretics (“water tablets” e.g. furosemide)
- Always take this medicine exactly as your doctor has told you
- AMITRYN 25MG can be taken with or without food
- Swallow the tablets with a drink of water. Do not chew or crush them
For Depression
Adults
- The recommended initial dose is 25 mg two times daily
- Depending on your response to the medicine, your doctor may gradually increase the dose to 150 mg per day divided in two doses
Elderly (above 65 years of age) and patients with cardiovascular disease
- The recommended initial dose is 10 mg – 25 mg daily
- Depending on your response to the medicine, your doctor may gradually increase the dose to a total daily dose of 100 mg divided in two doses
For Neuropathic pain, chronic tension type headache and migraine prophylaxis
Adults
- The recommended initial dose is 10 mg - 25 mg in the evening
- The recommended daily dose is 25 mg - 75 mg
- If you receive doses above 100 mg daily, your doctor may need to do more frequent follow-up with you
Elderly (above 65 years of age) and patients with cardiovascular disease
- The recommended initial dose is 10 mg – 25 mg in the evening
- If you receive doses above 75 mg daily, your doctor may need to do more frequent follow-up with you
Bed-wetting at night:
The recommended doses for children:
- aged 6 to 10 years: 10 mg – 20 mg daily. A suitable dosage form should be used for this age group
- aged 11 years and above: 25 mg – 50 mg
If you take more AMITRYN 25MG
- If you take more AMITRYN 25MG or if someone else has taken your medicine, talk to your doctor immediately and you may need Medical attention
If you forget to take AMITRYN 25MG
- If you forget to take a dose, take it as soon as you remember, unless it is time for your next dose
- Do not take a double dose to make up for a forgotten dose
If you stop taking AMITRYN 25MG
- Do not stop taking AMITRYN 25MG without talking to your doctor
Like all medicine, this medicine can cause side effcts, although not everybody gets them.
- heart problem
- sleepiness/drowsiness
- shakiness of hands or other body parts
- headache, dizziness when you stand up due to low blood pressure (orthostatic hypotension)
- irregular, hard, or rapid heartbeat
- dry mouth, constipation, nausea, excessive sweating, weight gain, slurred or slow speech, aggression, congested nose, confusion, disturbance in attention, disturbed coordination, agitation, sexual disturbances (decreased sex-drive, problems with erection),changes in taste, feeling thirsty, numbness or tingling in the arms or legs, dilated pupils, heart block, fatigue, low sodium concentration in the blood, urination disorders
- excitement, anxiety, difficulties sleeping, nightmares
- convulsions
- tinnitus
- increased blood pressure
- diarrhoea, vomiting
- skin rash, nettle rash (urticarial), swelling of the face and tongue
- difficulties passing urine
- increased production of breast milk
- increased pressure in the eye ball
- collapse conditions
- worsening of cardiac failure
- liver function impairment (e.g. cholestatic liver disease)
- decreased appetite
- delirium (especially in elderly patients)
- abnormality in the heart’s rhythm, or heartbeat pattern
- swelling of the salivary glands
- hair loss
- increased sensitivity to sunlight
- breast enlargement in men
- fever
- weight loss
- abnormal results of liver function tests.
- constipation, a swollen stomach, fever and vomiting.
- yellowing of the skin and the white in the eyes (jaundice)
- bruising, bleeding, pallor or persistent sore throat
- suicidal thoughts or behavior
- feeling of inner restlessness and a compelling need to be in constant motion
- disorder of the peripheral nerves
- abnormal heart rhythm (so called torsades de pointes)
- allergic inflammation of the lung alveoli and of the lung tissue
- acute glaucoma
- heart muscle disease
- feeling of inner restlessness and a compelling need to be in constant motion
- disorder of the peripheral nerves
- acute increase of pressure in the eye
- allergic inflammation of the lung alveoli and of the lung tissue
- Protect from excess heat and light
- Keep out of reach of children
- Store at room temperature (15-25°C)
- Do not use this medicine after the expiry date
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