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INTRODUCTION
AGGRIFIB INJECTION contains Tirofiban which belongs to the group of medicines called Platelet Aggregation Inhibitors. It is used to assist the blood flow to the heart and prevent chest pain and heart attacks. It may also be used in patients whose heart vessels are dilated with a balloon (a procedure known as percutaneous coronary intervention where a small tube or stent is implanted to improve the blood flow to the heart). It is a possibly with implantation of a small tube (stent), to improve the blood flow to the heart. AGGRIFIB INJECTION is not recommended for use in patients who have a history of bleeding, stroke with bleeding within last 30 days, history of bleeding in the brain, brain tumour or abnormal blood vessels in the brain, severe uncontrolled high blood pressure (malignant hypertension), severe liver disease, low platelet count (thrombocytopenia) either in current situation or as a previous encounter to usage of Tirofiban.
Before receiving AGGRIFIB INJECTION inform your doctor if you have or had any medical problems, allergies, cardiopulmonary resuscitation (CPR), biopsy, serious injury or major surgery, ulcer in the stomach or intestine within the last 3 months, bleeding disorder within 1 year, recent spinal procedure, history or symptoms of splitting of the aorta, uncontrolled high blood pressure, inflammation of the heart lining or blood vessels, disorder of the blood vessels in the back of the eye, kidney problems, heart failure, unusually low blood pressure due to heart failure, liver disorder, or low blood count.
AGGRIFIB INJECTION is not recommended during pregnancy. Contact your doctor before receiving. The most common side effects of AGGRIFIB INJECTION are bleeding post-surgery under the skin at the site of the injection causing swelling, small red bruises on the skin, invisible blood in urine or stool, nausea, or headache. Contact your doctor if you experience any of the above side effects or persists for a longer duration.
USES OF AGGRIFIB INJECTION
It is used:
- to assist the blood flow to the heart and prevent chest pain and heart attack
- in patients whose heart vessels are dilated with a balloon (a procedure known as percutaneous coronary intervention where a small tube or stent is implanted to improve the blood flow to the heart)
HOW AGGRIFIB INJECTION WORKS
AGGRIFIB INJECTION is a reversible antagonist of fibrinogen that binds to the glycoprotein (GP) IIb/IIIa receptor, the major platelet surface receptor involved in platelet aggregation. It works by preventing platelets, cells found in the blood, from forming blood clots.
DIRECTIONS FOR USE
AGGRIFIB INJECTION will be administered intravenously by your doctor or nurse only. Dose and duration will be decided by your physician depending upon your age, body weight and disease condition.
SIDE EFFECTS OF AGGRIFIB INJECTION
COMMON
- bleeding post surgery
- bleeding under the skin at the site of an injection, or into a muscle, causing swelling
- small red bruises on the skin
- invisible blood in urine or stool
- nausea
- headache
- blood in urine or while coughing
- bleeding in the nose, gums, and mouth or from the puncture site
- reduction in red blood cells
- decreases in platelet count
- fever
UNCOMMON
- bleeding in the stomach or intestines
- vomiting of blood
Stop receiving AGGRIFIB INJECTION and contact your doctor immediately if you experience any of the following side effects:
- signs of bleeding in the skull such as headache, sensory impairments (visual or hearing), speech difficulties, numbness or difficulty in movement or balance
- signs of internal bleeding such as coughing up blood or blood in urine or stool
- signs of serious allergic reactions such as breathing difficulty and dizziness
HOW TO MANAGE SIDE EFFECTS
Nausea And Vomiting
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating rich or spicy food.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedAGGRIFIB INJECTION is not recommended for use in pregnancy. Contact your doctor before receiving.
BREASTFEEDING
Consult your doctorIt is not known whether AGGRIFIB INJECTION is excreted in human milk. Your doctor will decide whether to discontinue breastfeeding or to discontinue the medicine. Contact your doctor before receiving.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate machines while receiving AGGRIFIB INJECTION. Contact your doctor before receiving.
KIDNEY
Use with CautionAGGRIFIB INJECTION should be used with caution in patients with severe kidney disease. Contact your doctor before receiving.
LIVER
Consult your doctorAGGRIFIB INJECTION is not recommended for use in patients with severe liver disease. Contact your doctor before receiving. It should be used with caution in patients with liver disorder. Contact your doctor before receiving.
ALLERGY
ContraindicatedDo not receive AGGRIFIB INJECTION if you are allergic to Tirofiban or any of the other ingredients of this medicine.
HEART DISEASE
Consult your doctorAGGRIFIB INJECTION is not recommended for use in patients with severe uncontrolled high blood pressure (malignant hypertension). AGGRIFIB INJECTION should be used with caution in patients with history or symptoms of splitting of the aorta, uncontrolled high blood pressure, inflammation of the heart lining or blood vessels, heart failure, unusually low blood pressure due to heart failure. Contact your doctor before receiving.
USE IN PEDIATRICS
Consult your doctorAGGRIFIB INJECTION is not recommended for use in children and adolescents under 18 years of age as safety and effectiveness in children have not established. Contact your doctor before receiving.
OTHERS
AGGRIFIB INJECTION is not recommended for use if you have:
- history of bleeding in the brain, abnormal blood vessels in the brain
- low platelet count (thrombocytopenia) either in current situation or as a previous encounter to usage of Tirofiban
Before receiving AGGRIFIB INJECTION tell your doctor if you have or had:
- any other medical problems
- cardiopulmonary resuscitation (CPR)
- biopsy, serious injury or major surgery
- ulcer in the stomach or intestine within the last 3 months
- recent spinal procedure
- disorder of the blood vessels in the back of the eye
- low blood count
INTERACTIONS
A. Drug-Drug Interactions:
Before receiving AGGRIFIB INJECTION, inform your doctor if you are taking any of the following medicine:
- warfarin (medicine used to prevent blood clot)
Overdosage:
It is unlikely to cause overdose, AGGRIFIB INJECTION will be administered into your vein only by a doctor or nurse.
SYNOPSIS
| Drug | : | Tirofiban |
| Pharmacological Category | : | Platelet Aggregation Inhibitors |
| Therapeutic Indication | : | Assist the blood flow to the heart and prevent chest pain and heart attacks |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Keep AGGRIFIB INJECTION out of the sight and reach of children
- Store AGGRIFIB INJECTION at room temperature
FAQs ABOUT AGGRIFIB INJECTION
Q: How should I use AGGRIFIB INJECTION?
A: AGGRIFIB INJECTION will be administered into a vein by your doctor or nurse only. Dose and duration will be decided by your physician depending upon your age, body weight and disease condition.
Q: How does AGGRIFIB INJECTION work?
A: AGGRIFIB INJECTION is a reversible antagonist of fibrinogen that binds to the glycoprotein (GP) IIb/IIIa receptor, the major platelet surface receptor involved in platelet aggregation. It works by preventing platelets, cells found in the blood, from forming blood clots.
Q: What is the use of AGGRIFIB INJECTION?
A: It is used to assist the blood flow to the heart and prevent chest pain and heart attacks. It may also be used in patients whose heart vessels are dilated with a balloon (a procedure known as percutaneous coronary intervention where a small tube or stent is implanted to improve the blood flow to the heart).
Q: What are the contraindications of AGGRIFIB INJECTION?
A: AGGRIFIB INJECTION is not recommended for use in patients who have a history of bleeding (internal or external), stroke, history of bleeding in the brain, brain tumour or abnormal blood vessels in the brain, severe uncontrolled high blood pressure (malignant hypertension), severe liver disease, low platelet count (thrombocytopenia) either in current situation or as a previous encounter to usage of Tirofiban.
Q: What will happen if I receive extra dose of AGGRIFIB INJECTION?
A: AGGRIFIB INJECTION will be administered into your vein only by a doctor or nurse in a proper healthcare setup so chances of overdose are minimal. If you are accidentally given extra dose of AGGRIFIB INJECTION the most common symptom may be bleeding. Contact your doctor immediately.
Q: What are the common side effects of AGGRIFIB INJECTION?
A: The most common side effects of AGGRIFIB INJECTION are bleeding post-surgery under the skin at the site of the injection causing swelling, small red bruises on the skin, invisible blood in urine or stool, nausea, or headache. Contact your doctor if you experience any of the side effects.
REFERENCES
1. K.D. Tripathi. Essentials of Medical Pharmacology. 7th edition. 2013. Drugs Affecting Blood and Blood Formation. Page 631.
2. Cuihua Zhao. Guanchang Cheng. Ruili He. Hongyu Guo. Yanming Li. Xueli Lu. Yuan Zhang. Chunguang Qiu. Effects of different routes of tirofiban injection on the left ventricular function and prognosis of patients with myocardial infarction treated with percutaneous coronary intervention. [Published in April 2015] [Accessed on 11th March 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473353/
3. Lili Sun. Jinping Zhang. Yun Song. Wei Zhao. Meimei Zheng. Jun Zhang. Hao Yin. Wei Wang. Yao Meng. Jiyou Tang. Ju Han. Safety and Efficacy of Tirofiban in Rescue Treatment for Acute Intracranial Intraprocedural Stent Thrombosis [Accessed on 11th March 2023] https://www.frontiersin.org/articles/10.3389/fneur.2020.00492/full
4. Arvato Distribution GmbH. Tirofiban. European Medicines Agency (EMA). [Revised in Aug 2022] [Accessed on 11th March 2023] https://www.medicines.org.uk/emc/files/pil.566.pdf
5. Emergent Biosolutions. U.S. Food and Drugs Association (FDA). [Revised in December 2020] [Accessed on 11th March 2023] https://www.aggrastathdb.com/wp-content/uploads/2022/05/aggrastat-pharmacy-prescribing-information.pdf
6. Altan Pharmaceuticals. Tirofiban. Electronic Medicines Compendium (EMC). [Revised in Feb 2020] [Accessed on 11th March 2023] https://www.medicines.org.uk/emc/files/pil.8842.pdf
7. Biocon Limited. Tirofiban. [Accessed on 11th March 2023] https://biocon.com/docs/prescribing_information/cardiology/tirozest_pi.pdf
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count (CBC)
- Electrocardiogram (ECG)
AUTHOR DETAILS
Written By Dr. Janet.C, Pharm.D
Last updated on 16 Mar 2023 | 05:56 PM(IST)
PRODUCT DETAILS
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