Uses of Duloxetine+Pregabalin

The combination of Duloxetine and Pregabalin is used to treat severe nerve pain (such as diabetic neuropathy, postherpetic neuralgia) and fibromyalgia (severe muscle pain with tiredness, mood swings, sleepiness and memory loss).

Therapeutic Category

Duloxetine: Antidepressants

Pregabalin:  Anticonvulsants

How Duloxetine+Pregabalin works

Duloxetine + Pregabalin reduces pain sensation by altering the activity of certain brain chemicals (dopamine, serotonin and adrenaline) within the nervous system. As a result, it reduces the transmission of pain signals from the damaged nerves to the brain and vice versa.

Common side effects of Duloxetine+Pregabalin

• dizziness, drowsiness, headache
• increased appetite
• increased mood, confusion, disorientation, irritability
• lack of attention, clumsiness, memory impairment
• tremor, difficulty in speaking
• tingling or numbness, sedation, lethargy
• difficulty in sleeping, tiredness
• blurred vision, double vision
• spinning sensation, problems with balance
• dry mouth, constipation, diarrhea, vomiting, flatulence, diarrhoea, nausea, swelling in abdomen
• swelling of the extremities (such as hands, legs, or fingers)
• weight gain, increased sweating
• muscle cramps, joint or back pain, pain in limbs
• difficulties with erection, decreased sexual drive

When to consult your doctor

Consult your doctor:

• In case of accidental overdosage
• If you experience severe allergic reaction, suicidal thoughts and behaviour, severe skin reactions, feeling restless, urge to move, increased irritation
• signs of serotonin syndrome (feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles, or muscle twitching, loss of coordination, nausea, vomiting, diarrhea or seizures)

Health Tips for Duloxetine+Pregabalin

• Follow the prescribed dosage and schedule provided by your doctor. Do not exceed the recommended dose or duration of treatment without medical supervision
• Duloxetine + Pregabalin can be taken with or without food. However, if you experience stomach upset, your doctor may recommend taking them with meals. Follow your doctor's guidance on whether to take them with or without food
• Stay adequately hydrated by drinking plenty of water throughout the day. This can help maintain overall health and support the effectiveness of the medications
• It is generally advised to avoid or limit alcohol consumption while taking Duloxetine + Pregabalin. Alcohol can increase the risk of side effects such as drowsiness, dizziness, and impaired coordination
• Do not take Duloxetine + Pregabalin without consulting your doctor if you are pregnant or breastfeeding. Women of childbearing age must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with this medicine