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Introduction About CIDMUS 50MG TABLET

Cidmus 50 mg Tablet is a fixed-dose combination of Sacubitril (24 mg) and Valsartan (26 mg), belonging to a class of medicines called ARNIs (Angiotensin Receptor–Neprilysin Inhibitors). It is commonly included in personalized care plans for individuals whose heart does not pump blood efficiently. This condition may lead to symptoms like fatigue, breathlessness, or fluid retention, especially in individuals undergoing long-term cardiovascular monitoring. Cidmus is designed to support both heart efficiency and blood pressure stability through dual-action mechanisms—sacubitril enhances protective peptides that relax blood vessels, while valsartan blocks the effects of substances that tighten them.

Cidmus is generally recommended for patients with chronic heart-related conditions who require support in maintaining circulatory balance and reducing strain on the heart. Clinical studies have shown that ARNI combinations can contribute to improved cardiovascular outcomes when used consistently under specialist supervision. It may be considered in individuals who have previously used ACE inhibitors or ARBs and require a more advanced approach to managing heart efficiency and blood pressure regulation.

The tablet is usually taken once or twice daily, as directed by a physician. It can be taken with or without food, but should be consumed at the same time each day to maintain steady levels in the bloodstream. Patients must avoid using this medicine within 36 hours of taking an ACE inhibitor, and regular monitoring of blood pressure, kidney function, and potassium levels is essential. Those with a history of angioedema or severe liver or kidney conditions should inform their healthcare provider before starting this medication. Avoid sudden posture changes, stay hydrated, and follow dietary recommendations to enhance safety during use.

Cidmus is not recommended during pregnancy as it may affect fetal development, and its use during breastfeeding is generally avoided unless advised otherwise by a healthcare provider. Women of childbearing potential should consult their doctor regarding appropriate contraceptive measures while on this medicine. Common side effects may include dizziness, low blood pressure, changes in kidney function, or elevated potassium levels. Most side effects are manageable under medical guidance, but any persistent symptoms should be promptly reported.

Uses Of CIDMUS 50MG TABLET

Support heart function in long-term heart failure in adults
Help improve symptoms of reduced heart efficiency.

Benefits of CIDMUS 50MG TABLET

Supports heart function with specific cardiac conditions

Cidmus 50 mg Tablet contains a combination of sacubitril and valsartan, which is often prescribed to individuals diagnosed with certain heart-related conditions. When used as part of a structured health plan, it can assist in supporting the heart’s pumping capacity and overall function. This is particularly relevant for individuals with conditions that may affect how effectively the heart supplies blood to the body.

Aids in managing symptoms associated with reduced heart efficiency

Individuals with decreased heart efficiency may experience fatigue, shortness of breath or fluid retention. Under proper supervision, Cidmus 50 mg is used to help in the management of these symptoms by promoting better blood circulation and reducing the workload on the heart. This support may contribute to improved day-to-day comfort and energy levels.

Contributes to improved heart rhythm regulation

Cidmus 50 mg Tablet are part of a group of medicines that assist in maintaining cardiovascular balance. By supporting stable blood pressure and fluid management, it can play a role in helping regulate heart rhythm as advised by healthcare professionals. Consistent use under guidance may support a more regular heart pattern.

Promotes Blood Pressure Stability in Cardiac Health Monitoring

Cidmus 50 mg Tablet is often used under clinical guidance to support balanced blood pressure levels in individuals with specific heart-related conditions. Stable blood pressure is a key factor in reducing strain on the heart and maintaining consistent cardiovascular performance. As part of a broader cardiac health plan, Cidmus 50 mg may assist in minimizing blood pressure fluctuations, thereby contributing to more effective heart function monitoring over time.

How CIDMUS 50MG TABLET Works

How does Cidmus improve cardiac efficiency?

Cidmus 50 mg Tablet works to support the heart’s ability to pump blood more effectively. Sacubitril helps increase levels of natural substances in the body that promote blood vessel relaxation and fluid balance, easing the heart’s workload. Meanwhile, valsartan supports this effect by helping to manage the tension in blood vessels. This combined action helps the heart work more efficiently, supporting better circulation and contributing to overall cardiovascular wellness when used as part of a doctor-guided care plan.

How does the dual action of Cidmus benefit heart function?

Cidmus act through different but complementary pathways. Sacubitril inhibits neprilysin, an enzyme responsible for breaking down beneficial peptides that help relax blood vessels and reduce fluid buildup. Valsartan blocks specific receptors involved in narrowing blood vessels and raising blood pressure. This dual mechanism supports balanced blood pressure and reduces strain on the heart, making it easier for the heart to function optimally. Together, these actions offer a comprehensive approach to supporting heart health under medical supervision.

How Cidmus Helps Manage Blood Pressure

Cidmus 50 mg Tablet work to support blood pressure management in individuals with specific heart-related conditions. Sacubitril enhances the effect of natural substances that relax blood vessels and support fluid balance, while valsartan helps reduce the action of hormones that cause blood vessel narrowing. This dual action supports smoother blood flow and helps reduce pressure within the circulatory system. When included in a medically guided care plan, Cidmus contributes to maintaining more stable blood pressure, easing the effort required by the heart to pump blood efficiently.

How to use CIDMUS 50MG TABLET

Cidmus: Recommended Dosage and Frequency

Usually prescribed once or twice daily, depending on individual clinical needs.
Dosage may be adjusted by a doctor based on response and tolerability.
Must be taken exactly as prescribed—do not skip, increase, or reduce the dose without consulting a healthcare provider.
Consistent timing each day improves the effectiveness of the medicine.

Cidmus 50 mg before or after meals

Can be taken with or without food.
Taking with meals may reduce the chance of stomach upset for some individuals.
It is important to take it at the same time every day for steady absorption.
If a preferred timing fits your schedule better, discuss it with your doctor.

Can I split the Cidmus tablet?

Cidmus 50 mg Tablet is not meant to be split, crushed, or chewed.
Splitting may interfere with the way the medicine is absorbed in the body.
If swallowing is difficult, consult your doctor for possible alternative strengths or formulations.
Always follow guidance provided by your healthcare professional.

How long should Cidmus 50 mg be taken?

Cidmus 50 mg Tablet is not meant to be split, crushed, or chewed.
Splitting may interfere with the way the medicine is absorbed in the body.
If swallowing is difficult, consult your doctor for possible alternative strengths or formulations.
Always follow guidance provided by your healthcare professional.

What if I forgot to take CIDMUS 50MG TABLET

If you forget to take a dose of Cidmus 50 mg Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects like low blood pressure or dizziness. It is important to take the tablet consistently each day to maintain its effectiveness. If you frequently miss doses, consider setting a daily reminder or alarm, and consult your doctor for support strategies.

Overdose

Taking more than the prescribed dose of Cidmus 50 mg Tablet may lead to a significant drop in blood pressure (hypotension), dizziness, or complications related to kidney function or electrolyte imbalance. In case of an accidental or intentional overdose, seek immediate medical attention. Do not attempt to manage symptoms on your own. Keep the medication out of reach of children and store it as per the instructions on the label. Prompt medical guidance is essential to manage overdosage safely and effectively.

Side Effects Of CIDMUS 50MG TABLET

Common side effects of Cidmus 50 mg Tablet

Dizziness, light-headedness (low blood pressure)
Signs of high levels of potassium in the blood (irregular heartbeat, muscle weakness)
Decrease in renal function
Cough
Diarrhoea
Signs of low red blood cells (anemia)
Tiredness, weakness
Headache
Fainting or spinning sensation
Nausea
Inflammation of lining of the stomach (stomach pain, nausea)
Signs of low sugar levels in the blood (fast heartbeat, sweating, nervousness or anxiety)

When to Seek Medical Attention?

Stop taking CIDMUS 50MG TABLET and contact your doctor immediately if you experience any of the following side effects:

Severe allergic reactions (swelling of the face, lips, tongue or throat, which may cause difficulties in breathing or swallowing (angioedema))

Warning & Precautions

Pregnancy

Contraindicated

CIDMUS 50MG TABLET is not recommended for use in early pregnancy and must not be used in pregnant women when more than 3 months pregnant, as it may cause serious harm to the baby. Consult your doctor before taking CIDMUS 50MG TABLET if you think you may be pregnant.

Breastfeeding

Contraindicated

CIDMUS 50MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking CIDMUS 50MG TABLET if you are breast-feeding or about to start breast-feeding.

Driving and Using Machines

Use with Caution

Avoid driving or handling any machines while taking CIDMUS 50MG TABLET because it may cause dizziness or tiredness.

Kidney

Use with Caution

CIDMUS 50MG TABLET should be used with caution in patients with severe kidney disease and with narrowed kidney artery. Consult your doctor before taking CIDMUS 50MG TABLET.

Liver

Consult your doctor

CIDMUS 50MG TABLET is not recommended for use in patients with severe liver disease and it should be used with caution in patients with liver disease. Consult your doctor before taking CIDMUS 50MG TABLET.

Allergy

Contraindicated

Do not take CIDMUS 50MG TABLET if you are allergic (hypersensitive) to Sacubitril and Valsartan.

Use In Pediatrics

Contraindicated

CIDMUS 50MG TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

CIDMUS 50MG TABLET should be used with caution in elderly patients (above 65 years of age). Consult your doctor before taking CIDMUS 50MG TABLET.

Other Warnings for CIDMUS 50MG TABLET

Before taking CIDMUS 50MG TABLET inform your doctor if you have:

History of angioedema
Low blood pressure
Vomiting or diarrhea
Dehydration
Hallucinations, paranoia or changes in sleeping pattern

Who should not take [GBNKEYWORD

CIDMUS 50MG TABLET is not recommended for use, if you have:

Diabetes or impaired kidney function (and being managed with aliskiren (blood pressure lowering medicine))
Personal or family history of angioedema (when taking angiotensin receptor blockers (ARB) such as valsartan, telmisartan)

Safety Advice

Patient safety tips for Cidmus

Always take Cidmus exactly as prescribed by your healthcare provider to ensure safe and effective use.
Inform your doctor about all other medications, supplements, or herbal products you are taking to avoid potential interactions.
Regularly monitor your blood pressure and kidney function through scheduled medical check-ups.
Stay hydrated but avoid excessive fluid intake unless advised by your healthcare provider.
Report any unusual symptoms such as dizziness, swelling, persistent cough, or difficulty breathing promptly to your doctor.
Avoid abrupt discontinuation of Cidmus without consulting your healthcare professional, as this may impact heart function.

Cidmus and electrolyte imbalance risks

Cidmus may influence electrolyte levels in the body, particularly potassium, which is vital for normal heart and muscle function.
An increase in potassium levels (hyperkalemia) can lead to symptoms such as muscle weakness, irregular heartbeat, or fatigue.
Patients with kidney problems or those taking potassium supplements, salt substitutes, or certain diuretics are at higher risk for electrolyte imbalances.
Regular blood tests are essential to monitor electrolyte levels during treatment with Cidmus, allowing timely adjustments if needed.
Inform your healthcare provider immediately if you experience muscle cramps, palpitations, or unusual tiredness, as these may signal electrolyte changes requiring medical attention.

Are there special precautions for patients with low blood pressure?

Patients with low blood pressure (hypotension) should exercise caution when using Cidmus 50 mg Tablet, as this medication can further lower blood pressure. It is important to monitor blood pressure regularly to avoid symptoms such as dizziness, light-headedness, or fainting, especially when standing up quickly. To help manage these risks, healthcare providers may start treatment at a lower dose and adjust gradually based on individual response.

Patients should avoid activities that require full alertness, like driving or operating machinery, until they understand how Cidmus affects their blood pressure. Staying hydrated and rising slowly from sitting or lying positions can also help minimize symptoms. If signs of very low blood pressure occur-such as severe dizziness, confusion, or weakness-it is important to seek medical advice promptly.

Always communicate any history of low blood pressure with your doctor before starting Cidmus, and never adjust the medication dose without professional guidance.

Diet and Lifestyle Advice

Maintain a Heart-Healthy Diet: Focus on balanced meals rich in fruits, vegetables, whole grains, and lean proteins. Limit intake of saturated fats, trans fats, and excessive salt to support heart and blood pressure health.
Monitor Potassium Intake: Since Cidmus can affect potassium levels, avoid excessive consumption of high-potassium foods like bananas, oranges, spinach, and salt substitutes containing potassium unless advised otherwise by your healthcare provider.
Stay Hydrated: Drink adequate amounts of water daily, but avoid excessive fluid intake unless specifically recommended by your doctor, especially if you have heart or kidney conditions.
Limit Alcohol Consumption: Alcohol can enhance the blood pressure-lowering effect of Cidmus and increase the risk of dizziness or fainting. It is best to limit or avoid alcohol while on this medication.
Regular Physical Activity: Engage in moderate exercise like walking, swimming, or cycling as recommended by your healthcare provider. Exercise helps improve heart function and overall wellbeing but always check with your doctor before starting new activities.
Avoid Smoking: Smoking can worsen heart conditions and reduce the effectiveness of medications like Cidmus. Quitting smoking supports better heart health and treatment outcomes.
Monitor Blood Pressure and Symptoms: Regularly check your blood pressure and report any unusual symptoms such as persistent dizziness, swelling, or fatigue to your healthcare professional promptly.

Light activity suggestions to support cardiovascular function:

Incorporating gentle movement into your daily routine can play a valuable role in maintaining heart efficiency, especially for individuals using medicines like Cidmus 50 mg Tablet. Light activities help encourage circulation, maintain muscle tone, and support overall cardiovascular well-being—without putting excess strain on the heart.

Here are some safe and commonly recommended light activities:

Walking at a Comfortable Pace
A short walk (10–20 minutes) once or twice a day—whether indoors or in a shaded outdoor space—can help maintain stamina and boost circulation.
Stretching and Flexibility Movements
Gentle morning or evening stretches promote joint mobility and reduce stiffness. Consider slow neck rolls, shoulder stretches, or ankle circles.
Chair-Based Exercises
Ideal for individuals with limited mobility. Seated leg lifts, arm raises, or gentle twists can help activate muscles while staying safe.
Breathing Exercises and Relaxation Techniques
Deep breathing practices (like diaphragmatic breathing) support oxygen intake and help regulate heart rhythm. Pair with short mindfulness sessions for added benefit.
Light Household Activities
Tasks like folding laundry, watering plants, or light dusting keep the body moving without overexertion.

Comparison Cidmus Vs. ACE inhibitors (Enalapril, Ramipril)

Parameter	Cidmus (Sacubitril + Valsartan)	ACE Inhibitors (e.g., Enalapril, Ramipril)
Drug Class	ARNI (Angiotensin Receptor-Neprilysin Inhibitor)	ACEI (Angiotensin-Converting Enzyme Inhibitor)
Mechanism of Action	Blocks neprilysin (via sacubitril) + angiotensin II receptor (via valsartan)	Inhibits ACE enzyme, reducing angiotensin II formation
Clinical Benefit in Heart Health	Shown to support better cardiac outcomes and reduce hospitalizations in certain heart failure types (PARADIGM-HF trial)	Effective in improving symptoms of heart inefficiency; standard therapy
Commonly Used For	Heart function support in patients with reduced ejection fraction	Management of heart function and blood pressure
Effect on Blood Pressure	Strong blood pressure-lowering effect; may require monitoring	Moderate blood pressure control; well-established use
Risk of Cough	Lower risk of dry cough	Higher incidence of persistent dry cough
Angioedema Risk	Possible, but slightly lower than ACEIs	Notable risk of angioedema, especially in certain ethnic groups
Use After ACE Inhibitors	Requires a 36-hour washout period after stopping ACEI	Can be started directly as a first-line medicine
Kidney Monitoring	Required – may affect renal function and potassium levels	Also requires regular kidney and electrolyte monitoring
Pregnancy Use	Not recommended during pregnancy	Not recommended during pregnancy
Dosing Convenience	Fixed-dose combination – convenient once/twice daily	Available in multiple dosing options
Guideline Preference	Preferred in updated heart failure guidelines for specific patients	Still used but gradually being replaced in some patients

Drug - Drug interaction

Cidmus 50 mg Tablet may interact with other medicines that affect blood pressure, kidney function and electrolyte balance. Understanding these interactions is important to ensure safe and effective use of this medicine, especially for individuals who are on multiple medications as part of their chronic care management.

Below are some commonly recognized drug interactions associated with Cidmus 50 mg, along with general precautions and management advice:

1. Other Blood Pressure–Lowering Medicines

Examples: ACE inhibitors (e.g., enalapril), ARBs (e.g., losartan), beta-blockers, diuretics.
Risk: Enhanced risk of low blood pressure (hypotension).
Management: Do not use ACE inhibitors within 36 hours before or after taking Cidmus. Monitor blood pressure regularly and adjust dose under medical guidance.

2. Potassium Supplements and Potassium-Sparing Diuretics

Examples: Spironolactone, amiloride, potassium chloride.
Risk: May increase the risk of high potassium levels (hyperkalemia).
Management: Avoid combining unless specifically directed. Regular blood tests may be needed to monitor potassium levels.

3. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Examples: Ibuprofen, diclofenac, naproxen.
Risk: May reduce kidney function, especially in older adults or dehydrated individuals.
Management: Use NSAIDs cautiously or avoid prolonged use. Stay well-hydrated and monitor kidney function when used together.

4. Lithium

Risk: Risk of increased lithium levels, which may lead to toxicity.
Management: Avoid concurrent use or monitor lithium levels closely if used together.

5. Certain Antibiotics or Antifungals

Examples: Rifampicin, ketoconazole.
Risk: May alter how the body processes sacubitril/valsartan.
Management: Inform your doctor about all prescription and over-the-counter medicines.

Drug - Food interaction

Cidmus 50 mg Tablet is typically well tolerated with or without food. However, certain dietary factors may influence the effectiveness and safety of the medication, especially in individuals managing chronic heart conditions. Being mindful of what you eat and drink while taking Cidmus can help maintain stable blood pressure and avoid unwanted effects.

Below are the key food-related interactions and how to manage them effectively:

1. High-Potassium Foods

Examples: Bananas, oranges, potatoes, spinach, coconut water.
Risk: These foods may increase potassium levels in the body, which could lead to hyperkalemia (high blood potassium), especially when taken alongside Cidmus.
Management: Limit the intake of high-potassium foods if advised by your doctor. Regular blood tests may be done to monitor potassium balance.

2. Salt Substitutes Containing Potassium

Examples: Low-sodium salts labeled as "potassium salt" or "potassium chloride".
Risk: May significantly raise potassium levels, affecting heart rhythm and kidney function.
Management: Avoid salt substitutes unless specifically recommended by a healthcare provider. Read food labels carefully.

3. Alcohol Consumption

Risk: Alcohol may amplify the blood pressXure-lowering effect of Cidmus, causing dizziness or light-headedness, especially when standing up suddenly.
Management: Limit alcohol intake and be cautious with activities that require alertness until you understand how your body reacts.

Synopsis

Drug	:	Sacubitril and Valsartan
Pharmacological Category	:	Neprilysin Inhibitor, Angiotensin II Receptor Blocker
Therapeutic Indication	:	Heart failure
Dosage Forms	:	Tablet

More Information

Storage

Keep Cidmus 50 mg Tablet out of the sight and reach of children
Store Cidmus 50 mg Tablet below 30°C

FAQs About CIDMUS 50MG TABLET

Q: What is Cidmus 50 mg used for?

A: Cidmus 50 mg is commonly prescribed for adults with certain types of chronic heart failure. It helps improve the efficiency of the heart by lowering strain, improving blood flow, and managing symptoms like fatigue or shortness of breath. The combination of sacubitril and valsartan supports long-term heart health under clinical supervision.

Q: Is Cidmus 50 mg safe for long-term use?

A: Yes, Cidmus is generally considered safe for long-term use when monitored regularly by a healthcare provider. Long-term usage helps support stable cardiac function and reduce hospitalizations related to heart failure. Periodic evaluations are necessary to assess kidney function, blood pressure, and electrolyte balance.

Q: Can Cidmus affect kidney function?

A: Yes, Cidmus may affect kidney function, especially in people with existing kidney issues or when taken with other medicines like NSAIDs. Doctors usually monitor kidney function through blood tests during ongoing use. Staying well-hydrated and avoiding nephrotoxic drugs helps manage this risk.

Q: Does Cidmus cause low blood pressure?

A: Yes, low blood pressure (hypotension) is a known effect of Cidmus, particularly when starting therapy or after a dosage change. Patients may experience dizziness or lightheadedness. It is important to rise slowly from sitting or lying positions and avoid activities that require alertness if symptoms occur.

Q: Are side effects more severe in older adults?

A: Older adults may be more sensitive to the blood pressure-lowering and kidney-related effects of Cidmus. Close monitoring and slower dose adjustments are often recommended for elderly patients. Physicians may also monitor electrolyte levels more frequently in this group.

Q: How often should I get my blood checked on Cidmus?

A: Blood tests are typically recommended at regular intervals, particularly during the first few months of therapy. Tests often include serum potassium, sodium, kidney function (creatinine, BUN), and sometimes liver function. Your doctor will adjust the frequency based on your individual health profile.

Q: Who should avoid taking Cidmus?

A: Cidmus should be avoided by individuals who are allergic to sacubitril or valsartan, those with a history of angioedema, severe liver impairment, or pregnant women. It is also not recommended for people currently on ACE inhibitors or those with severely low blood pressure unless advised otherwise by a doctor.

Q: Can I eat salty foods while on Cidmus?

A: It is advisable to limit salty foods while on Cidmus, as high sodium intake can worsen fluid retention and strain the heart. Following a low-sodium diet helps enhance the effectiveness of the medicine and supports better cardiac function.

Q: Is it safe during pregnancy?

A: No, Cidmus is not safe during pregnancy. It may harm fetal development and is contraindicated in all trimesters. Women of reproductive age should use effective contraception while on the medication and consult their doctor immediately if pregnancy is suspected.

Q: Can I take potassium supplements with Cidmus?

A: Potassium supplements are generally not recommended with Cidmus unless specifically advised by your doctor. The medication can raise potassium levels, and combining it with supplements or potassium-rich foods can lead to hyperkalemia, a potentially serious condition.

Q: What tests are needed during Cidmus therapy?

A: Routine tests include serum potassium, sodium, kidney function tests (like serum creatinine and BUN), and sometimes blood pressure monitoring. These help assess how well the medicine is working and ensure it is not causing side effects.

Q: How often should I see my doctor?

A: Initially, follow-up visits may be more frequent—every 2 to 4 weeks—especially after starting therapy or adjusting the dose. Once your condition stabilizes, visits may become less frequent, usually every 3 to 6 months, depending on individual health status.

Q: Is regular blood pressure monitoring at home recommended?

A: Yes, home monitoring of blood pressure is encouraged while taking Cidmus. It helps track your response to therapy and alerts you to potential hypotension. Keep a record of your readings and share them with your healthcare provider during appointments.

Q: Can I exercise while taking Cidmus?

A: Yes, engage in moderate activities like walking, but avoid strenuous exercises unless cleared by your doctor. Monitor for any unusual symptoms during physical activity.

References

1. KD Tripathi MD. Cardiovascular drugs. Essentials of Medical Pharmacology. Seventh Edition. New Delhi, May 2013. Page-508.

2. Loretta Fala. Entresto (Sacubitril/Valsartan): First-in-Class Angiotensin Receptor Neprilysin Inhibitor FDA Approved for Patients with Heart Failure. NCBI; PMC. Pubmed Central. National Library of Medicine, National Institute of Health. September 2018. [Accessed on 3rd June 2025]

3. Peter Khalil, Ghazal Kabbach, Sarmad Said and Debabrata Mukherje. Entresto, a New Panacea for Heart Failure. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2018. [Accessed on 3rd June 2025]

4. Novartis Pharmaceuticals UK Ltd. Electronic Medicines Compendium (EMC) [Revised in May 2021] [Accessed on 3rd June 2025]

5. Cipla Ltd. Azmarda Tablets (Sacubitril/Valsartan). Ciplamed. [Revised in March 2017] [Accessed on 3rd June 2025]

Useful Diagnostic Tests

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Venkatesh Poludasu - MBBS

Last updated on 04 Jun 2025 | 02:46 PM(IST)

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