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Introduction About TIDILAN INJECTION
TIDILAN INJECTION contains Isoxsuprine which belongs to the group of medicines called Vasodilators. It is used in the management of premature labor (when the uterus contraction starts for birth too early than usual) or threatened abortion, cerebral vascular insufficiency (poor blood flow to the brain) and arteriosclerosis obliterans (hardening of the arteries).
TIDILAN INJECTION is also used to manage Buerger's disease (blood vessels become inflamed, swell and can become blocked with blood clots) and Raynaud’s phenomenon (decreased blood flow to the nose, ears, fingers, toes, nipples or knees). You should avoid participating in any stressful or heavy activities in order to manage premature labor.
Avoid smoking tobacco during TIDILAN INJECTION management as it can further constrict your blood vessels. TIDILAN INJECTION should not be used immediately postpartum (after delivering a baby) or if you have a bleeding disorder, heart disease, severe anemia, premature detachment of the placenta and premature labor if there is infection.
TIDILAN INJECTION should be used in pregnant women only if the potential benefits outweigh the potential risks to mother and her baby. There are no reports of problems with TIDILAN INJECTION use in breastfeeding babies but consult your doctor before receiving it.
TIDILAN INJECTION is not recommended for use in children. The most common side effects of receiving TIDILAN INJECTION are fast heartbeat and vomiting. Contact your physician if any of the symptoms deteriorate.
Uses Of TIDILAN INJECTION
Manage:
- premature labor, threatened abortion
- cerebral vascular insufficiency
- arteriosclerosis obliterans
- Buerger's disease
- Raynaud’s phenomenon
How TIDILAN INJECTION Works
TIDILAN INJECTION manages premature labor by managing the contractions of the smooth muscles in the uterus. In peripheral vascular disease, it helps in widening of blood vessels to increase blood flow, thereby improving blood circulation to certain parts of the body (such as the hands, feet and brain).
How to use TIDILAN INJECTION
TIDILAN INJECTION will be given to you only by a physician or a nurse into a vein as an intravenous infusion or into a muscle (intramuscular). The correct dose and duration will be decided by your physician for you according to your age, body weight and disease condition.
Side Effects Of TIDILAN INJECTION
Common
- fast heartbeat
- vomiting
Rare
Stop receiving TIDILAN INJECTION and contact your doctor immediately if you experience any of the following side effects:
- rash
- excessive fluid in the lungs (difficulty breathing, cough, throbbing sensation)
How To Manage Side Effects
Vomiting:
Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy foods. If symptom persists, contact your doctor.
Skin rash:
Avoid hot showers as it can irritate your skin more. Do not scratch the affected area. Use protective clothing when going outdoors and moisturize your skin regularly. If symptom persists, contact your doctor.
Warning & Precautions
Pregnancy
TIDILAN INJECTION should be used in pregnant women only if the potential benefits outweigh the potential risks to the mother and her baby. Consult your doctor before receiving it.
Breastfeeding
There are no reports of problems with TIDILAN INJECTION use in breastfeeding babies, however, consult your doctor before receiving it.
Allergy
Do not receive TIDILAN INJECTION if you are allergic to Isoxsuprine or to any of the other ingredients of this medicine.
Heart Disease
TIDILAN INJECTION is not recommended for use in patients having known heart disease, low blood pressure or fast heartbeat. Consult your physician before receiving it.
Others
TIDILAN INJECTION is not recommended for use if you:
- recently had any arterial bleeding
- have severe anemia (low red blood cells)
- have prematurely detached placenta
- have premature labor along with an infection
Use in pediatrics:
TIDILAN INJECTION is not recommended for use in children. Consult your child’s doctor for advice.
Use in geriatrics:
No specific information is available on the use of TIDILAN INJECTION in elderly patients. It may reduce tolerance to cold temperatures in these patients. Consult your doctor before receiving it.
Interactions
A. Drug-Drug interactions:
Before receiving TIDILAN INJECTION, inform your doctor if you are taking any of the following medicines:
- medicines used to manage low blood pressure (Ex. cilnidipine, phenylephrine)
- other medicines used to relax blood vessels (Ex. hydralazine, minoxidil)
Overdosage:
TIDILAN INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Isoxsuprine |
| Pharmacological Category | : | Vasodilators |
| Therapeutic Indication | : | Premature labor, threatened abortion, to improve blood flow |
| Dosage Forms | : | Tablet, Capsule, Injection |
More Information
- Keep TIDILAN INJECTION out of reach of children
- Store below 30°C
FAQs About TIDILAN INJECTION
Can I smoke during TIDILAN INJECTION management?
Avoid smoking during management with TIDILAN INJECTION as its concurrent heavy use may interfere with the therapeutic effects of this medicine. This is because cigarettes contain nicotine that constricts blood vessels. Consult your doctor for further doubts.
Is it safe to take TIDILAN INJECTION in patients with heart problems?
TIDILAN INJECTION is not recommended for use in patients having known heart disease, low blood pressure or fast heartbeat. Consult your physician before taking it. The doctor will determine a proper dose of TIDILAN INJECTION or select a suitable alternative management for you.
Can TIDILAN INJECTION be used in pregnant women?
TIDILAN INJECTION should be used in pregnant women only if the potential benefits outweigh the potential risks to the mother and her baby. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before receiving it.
Can I receive TIDILAN INJECTION if I am already taking medicine for high blood pressure?
TIDILAN INJECTION may cause severely low blood pressure when taken with other medicines used to manage high blood pressure. Tell your doctor if you are taking, have taken or might take any other medicines, including prescription, over the counter or any herbal medicine, as these might cause serious side effects due to drug interactions.
Can TIDILAN INJECTION cause fast heartbeat?
Yes. TIDILAN INJECTION might cause fast heartbeat, but it can be controlled by dose reduction or by lying in a supine position. Consult your doctor if this symptom becomes bothersome for you.
References
1. K.D. Tripathi. Adrenergic system and drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 136.
2. Jaju PB. Effectiveness and Safety of Isoxsuprine Hydrochloride as Tocolytic Agent in Arresting Active/Threatened Preterm Labor and Its Role in Maintenance Tocolysis: A Prospective, Open-Label Study. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. February 2021. [Accessed on 9th July 2022]. https://pubmed.ncbi.nlm.nih.gov/31550735/
3. Prerna Jain, Supriya Suman, Manju Gita Mishra. Comparative study of nifepidine and isoxsuprine in suppression of preterm labour. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. October 2016. [Accessed on 9th July 2022]. https://www.ijrcog.org/index.php/ijrcog/article/viewFile/325/317
4. Unilab. Isoxilan (Isoxsuprine hydrochloride). [Revised in June 2006] [Accessed on 9th July 2022]. https://www.unilab.com.ph/products/isoxilan
5. Critical care companies. Isoxsuprine injection 5mg/mL. [Accessed on 9th July 2022]. https://criticalcarecompanies.in/product/isoxsuprine-injection-5-mg-ml/
6. Taj Lifesciences. Isoxsuprine for Injection 5mg. [Accessed on 9th July 2022]. https://tajlifesciences.com/portfolio/isoxsuprine-for-injection-5mg/
7. MIMS. Isoxsuprine hydrochloride. [Accessed on 9th July 2022]. https://www.mims.com/philippines/drug/info/isoxilan?type=full
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