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Introduction About SOL U PRED 1GM INJECTION

SOL U PRED 1GM INJECTION contains Methylprednisolone which belongs to the group of medicines called Corticosteroids. It is used to manage problematic conditions of the adrenal glands (such as adrenal insufficiency, congenital adrenal hyperplasia and nonsuppurative thyroiditis).

It can also be used to manage various inflammatory auto-immune disease conditions affecting the bones and joints (Ex. rheumatoid arthritis, ankylosing spondylitis), skin and collagen (Ex. severe erythema multiforme), eyes (Ex. optic neuritis, uveitis or iritis), respiratory tract (Ex. asthma, tuberculosis), blood or blood vessels (Ex. leukemia), bowel and gut (Ex. Crohn’s disease and ulcerative colitis) and brain (Ex. tuberculous meningitis).

It is also indicated in the management of drug induced hypersensitivity reactions and in other allergic conditions (such as atopic dermatitis, allergic conjunctivitis and allergic rhinitis). It also helps in the management of graft rejection following organ transplantation, reduce flare-ups of multiple sclerosis and reduces protein loss in urine among patients having kidney problems (such as nephrotic syndrome).

Before receiving SOL U PRED 1GM INJECTION inform your doctor if you any viral infections, or any liver, kidney or heart problems. You must also inform your doctor if you have hypertension, diabetes, thyroid deficiency, glaucoma, skin problem, gut inflammation, muscle problems, osteoporosis, any types of tumors or cancer in the body, depression or any other forms of mental illness.

SOL U PRED 1GM INJECTION is not recommended for use in patients with severe fungal infections, brain swelling due to malaria, or brain injury or stroke. It should be used in pregnant or breastfeeding women only if it is considered necessary by the physician. Avoid drinking grapefruit juice or eating grapefruit while receiving SOL U PRED 1GM INJECTION as it may lead to unwanted side effects.

The most common side effects of receiving SOL U PRED 1GM INJECTION are high blood pressure, swelling of body parts, muscle cramps or weakness, skin thinning, feeling sad or depressed and slowed growth in children. Consult your doctor if any of these side effect worsens.

You must also inform your doctor if you experience severe depression with suicidal thoughts or severe stomach pain with blood-stained stools or vomit after receiving SOL U PRED 1GM INJECTION.

Uses Of SOL U PRED 1GM INJECTION

It is used to manage the following disease conditions:

adrenal insufficiency and its associated conditions
bone and joint problems (Ex. rheumatoid arthritis, ankylosing spondylitis)
skin and collagen disorders (Ex. severe erythema multiforme)
eye problems (Ex. optic neuritis, uveitis or iritis)
respiratory tract diseases (Ex. asthma, tuberculosis)
blood cancer (leukemia), lymph cancer (lymphoma)
problems of bowel and gut (Ex. Crohn’s disease and ulcerative colitis)
brain problems (Ex. tuberculous meningitis)
drug induced hypersensitivity reactions
allergic reactions (such as atopic dermatitis, allergic conjunctivitis and allergic rhinitis)

It can also:

prevent graft rejection following organ transplantation
reduce flare-ups of multiple sclerosis and other stressful conditions
improve urine output or reduce protein loss in urine among patients having nephrotic syndrome

How SOL U PRED 1GM INJECTION Works

SOL U PRED 1GM INJECTION is a corticosteroid medicine with anti-inflammatory and immune suppressant properties. It boosts your body with sufficient corticosteroid levels (cortisol, aldosterone) during deficient conditions and helps your body to function properly.

It also reduces the release of certain chemicals (prostaglandins) in the body that causes pain, swelling and inflammation. It manages graft rejection by suppressing the immune functions and protects your kidney from damage in patients with kidney problems.

How to use SOL U PRED 1GM INJECTION

SOL U PRED 1GM INJECTION will be given to you only by a doctor or a nurse into the muscle (intramuscularly) or into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Side Effects Of SOL U PRED 1GM INJECTION

Common

high blood pressure (causing headache, or a general feeling of being unwell)
swelling of body parts
muscle cramps, weakness or wasting
cataract, blurred vision
slowed growth in children
moon shaped face (Cushingoid facies)
feeling sad, mood changes, mania, anxiety
problems in sleeping
difficulty in thinking, confusion, loss of memory, hallucinations
fear or frightening thoughts
acne, poor wound healing
skin thinning

Rare

Contact your doctor immediately if you experience any of the following side effects while undergoing therapy with SOL U PRED 1GM INJECTION:

signs of allergic reaction (such as skin rash, itching, blistering and peeling of the skin, swelling of the face, lips, mouth, throat which may lead to breathing difficulties)
signs of bleeding in the gut (such as stomach pain which radiates until your back, bleeding from the anus, black or blood-stained stools, blood in vomit)
increased infections causing fever or a general feeling of being unwell
signs of flare up of a previous tuberculosis infection (such as coughing blood or pain in the chest)
signs of pancreatitis (inflammation of pancreas causing severe stomach pain and vomiting)
signs of blood clot in lungs (such as sharp chest pain, shortness of breath, coughing up blood)
signs of increased pressure within the skull (such as severe headaches with vomiting, lack of energy and drowsiness) usually occurs once therapy is stopped
thrombophlebitis (blood clots in vein supplying the legs causing leg pain, swelling, redness and tenderness)
feeling depressed, suicidal thoughts
blurred vision or other visual disturbances

How To Manage Side Effects

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Warning & Precautions

Pregnancy

SOL U PRED 1GM INJECTION should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor before receiving SOL U PRED 1GM INJECTION if you are pregnant, think you may be pregnant or planning to have a baby.

Breastfeeding

SOL U PRED 1GM INJECTION should be used in breastfeeding women only if it is considered necessary by the physician. Therefore, inform your doctor before receiving it.

Driving and Using Machines

Do not drive or operate any heavy tools or machines if you experience dizziness after receiving SOL U PRED 1GM INJECTION.

Alcohol

Avoid consumption of alcohol while receiving SOL U PRED 1GM INJECTION as it may make you feel drowsier.

Kidney

SOL U PRED 1GM INJECTION should be used with caution in patients with kidney diseases. Therefore, consult your doctor before receiving it.

Liver

SOL U PRED 1GM INJECTION should be used with caution in patients with liver diseases. Therefore, consult your doctor before receiving it.

Allergy

Talk to your doctor before receiving SOL U PRED 1GM INJECTION if you are allergic to Methylprednisolone.

Lungs

SOL U PRED 1GM INJECTION is not recommended for use in patients with fungal infection of the lungs. Therefore, consult your doctor before receiving it.

Heart Disease

SOL U PRED 1GM INJECTION should be used with caution in patients with heart problems (such as recent heart attack or heart failure). Therefore, consult your doctor before receiving it.

Others

SOL U PRED 1GM INJECTION is not recommended for use if you:

have a widespread fungal infection (including thrush)
got vaccinated recently or scheduled for any upcoming vaccinations
are receiving management for brain swelling caused due to malaria
are suffering from brain injury or stroke

Before receiving SOL U PRED 1GM INJECTION, inform your doctor if you:

have or had been in contact with someone who has chickenpox, measles or shingles
have worm infestation (Ex. thread worm infection)
have or ever had severe depression or bipolar disorder
have a family history of mental illness
have diabetes or a family history of diabetes
have fits
have or have a family history of glaucoma
have viral or fungal infections of the eyes
have hypertension (high blood pressure)
have underactive thyroid gland (hypothyroidism)
have joint infection
have scleroderma (an autoimmune disorder causing skin tightness, cold extremities, joint pain and heart burn)
have Kaposi’s sarcoma (a type of skin cancer)
have any muscle problems (Ex. myasthenia gravis)
have osteoporosis (brittle bones)
have pheochromocytoma (a rare tumor of the adrenal glands)
have skin abscess
have stomach ulcer or other serious stomach or intestinal problems
have thrombophlebitis (clots in veins)
have or had tuberculosis
have Cushing’s disease
have brain injury due to trauma
have any unusual stress
have inflammation of the pancreas
have septic shock
are scheduled for any upcoming surgery (including dental surgery)

Use in pediatrics:

SOL U PRED 1GM INJECTION should be used in infants, children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor for advice before receiving it.

Use in geriatrics:

SOL U PRED 1GM INJECTION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.

Interactions

A. Drug - Drug interactions:

Before receiving SOL U PRED 1GM INJECTION, inform your doctor if you are taking any of the following medicines such as:

acetazolamide (a medicine used to manage glaucoma or edema)
aminoglutethimide or cyclophosphamide (used for managing cancer)
anticoagulants (used for blood thinning) such as acenocoumarol, phenindione and warfarin
anti-cholinergic medicines used to manage myasthenia gravis (such as distigmine and neostigmine)
medicines used to manage bacterial infections (Ex. isoniazid, erythromycin, clarithromycin and troleandomycin)
medicines used to manage diabetes (Ex. metformin, glipizide)
aprepitant or fosaprepitant (used to manage nausea and vomiting)
non-steroidal anti-inflammatory medicines (used for fever and pain relief) such as aspirin, ibuprofen
medicines used to manage epilepsy (such as carbamazepine, phenytoin and primidone)
carbenoxolone and cimetidine (used to manage stomach ulcer and acid reflux)
ciclosporin, tacrolimus (medicines used to suppress immune function and to manage graft rejection)
medicines used to manage chest pain, hypertension or irregular heartbeat (such as digoxin, diltiazem or mibefradil)
oral contraceptives (birth control pills) Ex. ethinylestridiol and norethisterone
medicines used to manage HIV infection (such as ritonavir, indinavir, cobicistat)
medicines used to manage fungal infection (such as ketoconazole, amphotericin B, itraconazole)
muscle relaxants (Ex. pancuronium or vecuronium)
diuretics (used to manage edema and hypertension) Ex. furosemide, chlorothiazide, hydrochlorothiazide
medicines used to manage asthma (such as aminophylline, salmeterol, formoterol)
rifampicin and rifabutin (used to manage tuberculosis)
live vaccines

B. Drug - Food interaction:

Avoid drinking grapefruit juice or eating grapefruit while undergoing therapy with SOL U PRED 1GM INJECTION as it may lead to unwanted side effects.

Overdosage:

SOL U PRED 1GM INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

Synopsis

Drug	:	Methylprednisolone
Pharmacological Category	:	Synthetic Glucocorticoids
Therapeutic Indication	:	Adrenal insufficiency, Auto Immune Disease, Allergic reactions, Manage graft rejection, Proteinuria
Dosage Forms	:	Tablet, Injection, Cream, Lotion

More Information

Keep SOL U PRED 1GM INJECTION out of reach of children
Store SOL U PRED 1GM INJECTION at room temperature

FAQs About SOL U PRED 1GM INJECTION

What is SOL U PRED 1GM INJECTION used for?

SOL U PRED 1GM INJECTION is a corticosteroid medicine used to manage adrenal insufficiency. It can also be used to manage drug induced hypersensitivity reactions, allergic reactions and various inflammatory auto-immune disease conditions affecting the skin, collagen, bones and joints, brain, gut, eyes etc. It also helps in management of graft rejection following organ transplantation, reduces flare-ups of multiple sclerosis and increases urine output among patients with kidney problems.

How to take SOL U PRED 1GM INJECTION?

SOL U PRED 1GM INJECTION is not meant for self-administration. It will be given to you only by a doctor or a nurse into the muscle (intramuscularly) or into the vein (intravenously).

Is SOL U PRED 1GM INJECTION a steroid?

Yes. SOL U PRED 1GM INJECTION is synthetic corticosteroid used to manage problems of adrenal gland and various allergic, hypersensitivity and inflammatory autoimmune disease conditions.

What are the most common side effects of SOL U PRED 1GM INJECTION?

Can SOL U PRED 1GM INJECTION make you feel high?

Yes. SOL U PRED 1GM INJECTION may make you feel high. Such symptoms may disappear once the therapy has been stopped. However, consult your doctor if it bothers you.

How does SOL U PRED 1GM INJECTION works?

SOL U PRED 1GM INJECTION boosts your body with sufficient corticosteroid levels and helps your body to function properly. It also reduces the release of certain chemicals in the body that causes inflammation. It also manages graft rejection by suppressing the immune functions and protects your kidney from damage in patients with kidney problems.

How long will it take for SOL U PRED 1GM INJECTION to control my disease?

The time taken by SOL U PRED 1GM INJECTION to control the disease may vary from person-to-person depending upon the dose of methylprednisolone administered and disease severity.

Is SOL U PRED 1GM INJECTION safe to use in diabetic patients?

SOL U PRED 1GM INJECTION may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before receiving SOL U PRED 1GM INJECTION as a precaution.

Who should not take SOL U PRED 1GM INJECTION?

SOL U PRED 1GM INJECTION is not recommended for use in patients with serious fungal infections, brain swelling due to malaria or brain injury or stroke. It is also not suitable for use in patients who got vaccinated recently.

Can I receive SOL U PRED 1GM INJECTION daily?

Your doctor will evaluate your health condition and suggests whether can you receive SOL U PRED 1GM INJECTION every day or not.

Can SOL U PRED 1GM INJECTION be used in children?

SOL U PRED 1GM INJECTION should be used in children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor for advice before receiving it.

Will SOL U PRED 1GM INJECTION alter the effects of birth control pills?

SOL U PRED 1GM INJECTION may reduce the effects of birth control pills. Therefore, try to avoid taking birth control pills along with SOL U PRED 1GM INJECTION. Consult your doctor for advice.

Can SOL U PRED 1GM INJECTION be used in pregnant women?

References

1. KD. Tripathi. Corticosteroids. Essentials of medical pharmacology. Eighth Edition. 2019. Page – 313.

2. Antonio Ocejo, Ricardo Correa. Methylprednisolone. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. [Revised in December 2021]. [Accessed on 12th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK544340/

3. Maryam Edalatifard, Maryam Akhtari, Mohammadreza Salehi, Zohre Naderi, Ahmadreza Jamshidi, Shayan Mostafaei, Seyed Reza Najafizadeh, Elham Farhadi, Nooshin Jalili, Masoud Esfahani, Besharat Rahimi, Hossein Kazemzadeh, Maedeh Mahmoodi Aliabadi, Tooba Ghazanfari, Mohammadreza Sattarian, Hourvash Ebrahimi Louyeh, Seyed Reza Raeeskarami, Saeidreza Jamalimoghadamsiahkali, Nasim Khajavirad, Mahdi Mahmoudi and Abdolrahman Rostamian. Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial. NIH. National Library of Medicine. National Center for Biotechnology Information. December 2020. [Accessed on 12th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758541/

4. Biomendi, S.A. Electronic Medicines Compendium (EMC). [Revised in November 2016] [Accessed on 12th October 2022] https://www.medicines.org.uk/emc/files/pil.5993.pdf

5. Pharmacia NV/SA. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 12th October 2022] https://www.medicines.org.uk/emc/files/pil.1550.pdf

6. Pfizer. U.S Food and Drug Administration. [Revised in July 2014] [Accessed on 12th October 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/011757s103lbl.pdf

Useful Diagnostic Tests

Absolute Eosinophil Count
Anti-Nuclear Antibody
Anti-ds-DNA Antibody
Anti-ds-DNA Antibody-IFA
Peripheral Smear Examination
Total IgE

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. M N Himaja - MBBS

Last updated on 13 Oct 2022 | 10:22 AM(IST)

Lab updated

SOL U Pred 1gm Injection 1's