Glimestar M2 Tablet 10'S

Introduction About GLIMESTAR M2 TABLET

Glimestar M2 Tablet is used to manage type 2 diabetes mellitus when diet, exercise and the single agent does not result in adequate glycemic control. It is a combination of Glimepiride and Metformin which belongs to a group of medicines called Antidiabetic agents. Glimepiride lowers blood sugar by causing the pancreas to produce more insulin and helps the body to use insulin efficiently. Metformin reduces the total amount of sugar released into the blood by the liver.

Along management with Glimestar M2 Tablet follow regular exercise and diet plan as advised by your doctor to achieve better results. Before taking Glimestar M2 Tablet inform your doctor if you have type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney disease, acute heart problems. Inform your doctor if you are pregnant or breastfeeding. It is not suitable for use in children and adolescents under 18 years of age.

Avoid consumption of alcohol during management with Glimestar M2 Tablet as it may increase or decrease the blood sugar lowering action of Glimestar M2 Tablet and increases the risk of lactic acidosis. The most common side effects of taking Glimestar M2 Tablet are taste disturbance, diarrhea or stomach ache. Contact your doctor if any of the symptoms worsen.

Uses Of GLIMESTAR M2 TABLET

• Type 2 diabetes mellitus 

Benefits of GLIMESTAR M2 TABLET

Effective Blood Sugar Control:

Glimestar M2 Tablet stimulates insulin secretion from the pancreas, helping the body utilize sugar effectively. Metformin reduces glucose production in the liver and improves insulin sensitivity, leading to better blood sugar control?

Prevents Diabetes Complications:

Helps reduce the risk of nerve damage (neuropathy), kidney disease (nephropathy), and eye problems (retinopathy) caused by high blood sugar. Lowers the chances of heart disease by controlling blood glucose and lipid levels?

Supports Weight Management:

Unlike some other diabetes medications, Metformin in Glimestar M2 helps prevent weight gain. Patients following a healthy diet and exercise routine may experience weight loss, as Metformin helps regulate fat metabolism?

Improves Insulin Sensitivity:

Beneficial for patients with insulin resistance, as Metformin enhances the body's response to insulin and helps maintain stable glucose levels?

Reduces Sugar Cravings & Appetite:

Many users report a decrease in hunger pangs, which can be beneficial for those trying to control their food intake and weight?

Suitable for Long-Term Use:

Prescribed for long-term diabetes management, making it a reliable medication for sustained glucose control.

How GLIMESTAR M2 TABLET Works

Glimestar M2 Tablet controls blood glucose levels, where Glimepiride works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin works by lowering glucose production in the liver, delaying glucose absorption from intestine, and increasing the body's sensitivity to insulin.

How to use GLIMESTAR M2 TABLET

Recommended Dosage of Glimestar M2 Tablet Based on Age & Condition:

1. Adults with Type 2 Diabetes Mellitus:

Generally, 1 tablet per day, taken with or after food to reduce the risk of hypoglycemia.

2. Elderly Patients (65 years and above):

Elderly patients, especially those above 75 years, require careful dose adjustments due to a higher risk of kidney impairment. Frequent monitoring of kidney function is necessary

3. Children & Adolescents (Below 18 years):

The safety and efficacy of Glimestar M2 in children have not been established, so it is generally not prescribed for pediatric patients

What is the correct dosage of Glimestar M2 Tablet for diabetes?

• The usual dose of Glimestar M2 Tablet is determined by the doctor based on individual needs.
• Typically, it is taken once daily with a meal, preferably breakfast or the first major meal of the day.
• The dose should be swallowed whole with water and not crushed or chewed.
• The starting dose is usually low and may be adjusted gradually to minimize side effects and achieve better blood sugar control

Can Glimestar M2 be taken twice a day?

Glimestar M2 Tablet is usually taken once daily with food to minimize stomach upset and ensure optimal absorption. However, the dosage depends on your doctor’s prescription, as taking it twice a day might be necessary in specific cases. Do notchange your dosage without consulting your healthcare provider?

Should Glimestar M2 be taken before or after food?

It is recommended to take Glimestar M2 Tablet with food to reduce the risk of stomach discomfort and hypoglycemia (low blood sugar). Taking it before food may increase the risk of low blood sugar levels?.

Can I take Glimestar M2 with other diabetes medications?

Glimestar M2 contains Glimepiride and Metformin, which can interact with other diabetes medications such as insulin, sulfonylureas, and some other drugs used for blood sugar control. Combining multiple diabetes medications may increase the risk of severe hypoglycemia or other side effects. Always consult your doctor before taking it with other diabetes drugs?

What if I forgot to take GLIMESTAR M2 TABLET

• If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose.
• Do not double the dose to make up for the missed one, as it may lead to hypoglycemia (low blood sugar)

Overdose

• Symptoms of an overdose include dizziness, confusion, rapid heartbeat, sweating, and fainting.
• Immediate medical attention is required in case of an overdose to prevent severe hypoglycemia

Side Effects Of GLIMESTAR M2 TABLET

Like all medicine, Glimestar M2 Tablet may cause certain side effects although not everybody gets them.

Common side effects of glimestar M2 Tablet:

• taste disturbance
• diarrhea
• stomach pain
• loss of appetite

When To Seek Medical Attention?

Stop taking glimestar M2 Tablet and consult your doctor immediately if you experience any of the following side effects:

• lactic acidosis
• inflammation of the liver which may result in jaundice (yellowing of skin or eyes)
• severe allergic reactions (such as skin rash, hives, and increased sensitivity to sun, inflammation of blood vessels which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock)
• severe low blood sugar levels

How To Manage Side Effects

Diarrhea

• Take Medication with Food: Always take Glimestar M2 with meals to reduce irritation in the digestive system.
• Stay Hydrated: Drink plenty of fluids (water, electrolyte drinks, or coconut water) to prevent dehydration.
• Adjust Your Diet: Eat Low-Fiber Foods: Stick to bananas, white rice, applesauce, and toast (BRAT diet), which help firm up stools.
• Consider Probiotics: Probiotics (like yogurt, kefir, and supplements) help restore gut bacteria balance and may reduce diarrhea symptoms.

Stomach Pain

• Eat a small meal before taking it to reduce stomach irritation.
• Avoid Trigger Food: Spicy, acidic, or greasy foods can irritate the stomach and worsen pain.
• Ginger tea or peppermint tea can help soothe the stomach naturally.
• Mild antacids (like TUMS) may help neutralize stomach acid.

Warning & Precautions

Pregnancy

Consult your doctor

There are no well controlled studies regarding the use of glimestar M2 tablet in pregnant women. Available human and animal studies does not indicate major harm to the growing fetus. However, a risk to the fetus cannot be excluded. As it is crucial to maintain optimum blood glucose levels during pregnancy, your doctor may suggest you taking insulin or any other medicines as per your health condition.  

Breastfeeding

Monitoring required

Studies have shown that metformin and glimepiride can pass through breast milk. Therefore, a decision should be made to discontinue the use of glimestar M2 tablet during breastfeeding. You can consult your doctor for an alternative therapy.

Driving and Using Machines

Use with Caution

Do not drive or handle any machines if you experience low or high blood sugar levels (symptoms include dizziness, tiredness, shaking or trembling) or if you develop visual problems due to altered blood sugar levels.

Alcohol

Consult your doctor

Avoid consumption of alcohol during management with Glimestar M2 Tablet as it may increase or decrease the blood sugar lowering action of Glimestar M2 Tablet and increases the risk of lactic acidosis.

Kidney

Consult your doctor

Glimestar M2 Tablet is not recommended for use in patients with severe kidney disease and it should be used with caution in patients with kidney disease and your dose will be adjusted if needed depending upon kidney function.

Liver

Consult your doctor

Glimestar M2 Tablet is not recommended if you have severe liver disease and it should be used with caution in patients with liver disease and your dose will be adjusted if needed depending upon liver function.

Allergy

Contraindicated

Do not take Glimestar M2 Tablet if you are allergic (hypersensitive) to Glimepiride or Metformin or other sulfonylureas (such as glipizide, glibenclamide) or sulfonamides (such as sulfamethoxazole).

Heart Disease

Contraindicated

Glimestar M2 Tablet is not recommended for use in patients with acute heart problems or recently had a heart attack or have severe circulatory problems or breathing difficulties (signs of heart failure).

Use In Pediatrics

Contraindicated

Glimestar M2 Tablet is not recommended for use in children and adolescents (under 18 years of age).

Use In Geriatrics

Consult your doctor

Glimestar M2 Tablet is not recommended for use in elderly patients (aged 75 years or above) and it should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function. Your doctor may assess your kidney function more frequently during management with Glimestar M2 Tablet.

Other Warnings for GLIMESTAR M2 TABLET

Before taking Glimestar M2 Tablet inform your doctor if you:

• are recovering from injury, operation, infections with fever, or from other forms of stress
• have glucose-6-phosphate dehydrogenase (G6PD) deficiency
• have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take [GBNKEYWORD

Glimestar M2 Tablet is not recommended for use, if you have:

• type 1 diabetes mellitus
• diabetic ketoacidosis
• uncontrolled diabetes or ketoacidosis
• dehydration
• severe infection

Diet and Lifestyle Advice

1. Best Foods to Eat While Taking Glimestar M2:

High-Fiber, Low-Glycemic Index (GI) Foods: Helps control blood sugar levels.

• Whole grains: Oats, brown rice, quinoa, whole wheat bread
• Legumes: Lentils, chickpeas, kidney beans
• Non-starchy vegetables: Spinach, broccoli, kale, bell peppers

Lean Proteins: Helps prevent muscle loss and keeps you full.

• Chicken, turkey, fish, eggs, tofu, Greek yogurt, and nuts

Healthy Fats: Helps improve insulin sensitivity.

• Avocados, olive oil, nuts, seeds, and fatty fish (salmon, mackerel)

Probiotics for Gut Health: Helps reduce diarrhea caused by Metformin.

• Yogurt, kefir, sauerkraut, kimchi, and probiotic supplements

Foods to Avoid While Taking Glimestar M2 Tablet:

Refined Carbs & Sugary Foods: Can cause blood sugar spikes.

• White bread, pasta, soda, candy, packaged snacks, and sugary desserts

Fried & Processed Foods: Increases insulin resistance and weight gain.

• Fast food, chips, fried meats, margarine

Alcohol & Sugary Beverages: Increases the risk of hypoglycemia and lactic acidosis.

• Beer, wine, sugary cocktails, sodas, fruit juices

Dairy & High-Fiber Foods (If Experiencing Diarrhea): Can worsen symptoms.

• Milk, cheese, high-fiber vegetables like cabbage, cauliflower

Best Exercises for People Taking Glimestar M2:

Aerobic Exercises (Cardio) - 30 Minutes Daily

• Walking, jogging, cycling, swimming, dancing
• Lowers blood sugar by helping muscles use insulin effectively

Strength Training (2-3 Days a Week)

• Resistance band workouts, weightlifting, bodyweight exercises (push-ups, squats)
• Builds muscle, which helps improve glucose metabolism

Flexibility & Balance Exercises

• Yoga and stretching help improve circulation and reduce stress

Post-Meal Walks (10-15 Minutes)

• Helps lower post-meal blood sugar spikes

Drug - Drug interaction

Interactions with other diabetes medication

1. Increased Effects (Risk of Hypoglycemia):

H2-antagonists, anticoagulants, androgens, beta-blockers, fluconazole, salicylates, gemfibrozil, sulfonamides, tricyclic antidepressants, probenecid, MAO inhibitors, methyldopa, NSAIDs, chloramphenicol, coumarins, digitalis glycosides, and urinary acidifiers.

2. Decreased Effectiveness (Risk of Hyperglycemia):

Thiazide diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, isoniazid.

3. Liver-Damaging Drug Interactions:

Clarithromycin, Atazanavir, Cyclosporine, Erythromycin, Azithromycin.

Other Risky Medications:

Ciprofloxacin, aspirin, acetaminophen, chloroquine, labetalol, ofloxacin, methotrexate, desmopressin, hydroxychloroquine, miconazole, phenobarbital?

Drug - Food interaction

Foods & beverages to avoid while taking Glimestar M2 tablet:

• Grapefruit Juice: Avoid as it may increase the risk of side effects like muscle pain, weakness, fever, chills, joint swelling, nausea, and vomiting?
• Alcohol: Should be avoided as it can increase the risk of lactic acidosis and interfere with blood sugar control?
• High-Carb and Sugary Foods: These may counteract the effects of the medication by increasing blood sugar levels?

Synopsis

More Information

Comparisons between Glimestar M2 and similar medications

FAQs About GLIMESTAR M2 TABLET

Q: What is GLIMESTAR M2 TABLET used for?

A: GLIMESTAR M2 TABLET is used to manage type 2 diabetes mellitus in adults. This combination helps regulate blood sugar levels effectively in individuals whose blood sugar is not adequately controlled by diet, exercise, or a single diabetes medication. It helps reduce the risk of diabetes-related complications such as heart disease, nerve damage, or kidney issues.

Q: How GLIMESTAR M2 TABLET works?

A: GLIMESTAR M2 TABLET contains a combination of two medicines namely, glimepiride and metformin. Glimepiride stimulates the pancreas to release more insulin, a hormone that lowers blood sugar levels. It also improves the body’s response to insulin. Metformin decreases the amount of sugar produced by the liver and reduces sugar absorption in the intestines. It also enhances the body’s ability to use insulin more effectively, making it a comprehensive treatment for blood sugar control.

Q: What is the best time to take GLIMESTAR M2 TABLET?

A: It is usually recommended to take GLIMESTAR M2 TABLET with meals to minimize the risk of gastrointestinal side effects such as nausea or upset stomach. Following your doctor’s instructions regarding the timing is essential, as they might tailor the dose to suit your lifestyle and blood sugar patterns.

Q: How many doses of GLIMESTAR M2 TABLET can be taken in a day?

A: The dosage depends on the individual’s medical condition, blood sugar levels, and response to treatment. Typically, it is taken once or twice daily with meals, but the exact dose should be determined by a doctor. Taking more than the prescribed dose can lead to hypoglycemia (low blood sugar), so it’s crucial to stick to the recommended schedule.

Q: Can GLIMESTAR M2 TABLET be used during pregnancy?

A: The combination of Glimepiride + Metformin is generally not recommended during pregnancy due to the potential risk of harming the unborn baby. Instead, insulin is preferred for controlling blood sugar levels in pregnant women with diabetes. If you are pregnant or planning to conceive, consult your doctor for a safe treatment plan.

Q: Can GLIMESTAR M2 TABLET control blood sugar levels?

A: Yes, this medicine is highly effective in controlling blood sugar levels in people with type 2 diabetes especially when diet, lifestyle changes and treatment with single agents does not yield optimum blood sugar control. However, its effectiveness also depends on maintaining a healthy lifestyle, including regular exercise and a balanced diet. Regular monitoring of blood sugar is essential to ensure the medication works optimally.

Q: Who should not use GLIMESTAR M2 TABLET?

A: GLIMESTAR M2 TABLET is not suitable for individuals with severe kidney or liver disease, type 1 diabetes or diabetic ketoacidosis, known allergies to glimepiride, metformin, or any other ingredients in the medicine, or a history of lactic acidosis. Therefore, always inform your doctor about any pre-existing conditions or medications you are taking to avoid adverse effects.

Q: What are the common side effects of GLIMESTAR M2 TABLET?

A: The most common side effects of GLIMESTAR M2 TABLET include nausea, vomiting, diarrhea, stomach pain, dizziness, or low blood sugar (hypoglycemia. Consult your doctor if any of these side effects worsens.

Q: Is GLIMESTAR M2 TABLET safe?

A: Yes, GLIMESTAR M2 TABLET is generally safe when taken as prescribed. However, regular monitoring of kidney and liver function is necessary, as prolonged use can affect these organs. Additionally, following the recommended dose and schedule minimizes the risk of side effects.

Q: Can GLIMESTAR M2 TABLET be taken on an empty stomach or before food?

A: No, it is best taken with food to reduce the risk of stomach upset and hypoglycemia. Food helps slow down the absorption of glimepiride, preventing a sudden drop in blood sugar levels, which can cause dizziness or weakness.

Q: Is GLIMESTAR M2 TABLET safe for kidney patients?

A: GLIMESTAR M2 TABLET is not suitable for individuals with severe kidney disease, as it can increase the risk of lactic acidosis, a potentially life-threatening condition. Mild to moderate kidney impairment requires dose adjustment and close monitoring. Always consult your doctor before starting or continuing this medication.

Q: How long will it take for GLIMESTAR M2 TABLET to control blood sugar levels?

A: GLIMESTAR M2 TABLET begins to lower blood sugar within a few hours of taking a dose. However, achieving optimal blood sugar control may take a few weeks, depending on individual response and adherence to the prescribed regimen, diet, and exercise plan.

Q: Can I stop taking GLIMESTAR M2 TABLET once my blood sugar is controlled?

A: No, stopping the medication without your doctor’s advice can cause your blood sugar levels to rise again, leading to complications. Diabetes is a chronic condition requiring ongoing management. Your doctor may adjust the dose or switch medications based on your progress, but self-discontinuation is not recommended.

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.

2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on July 24th, 2021]

3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on July 24th, 2021] 

4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on July 24th, 2021] 

5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on July 24th 2021]

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 06 Mar 2025 | 12:58 PM(IST)