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INTRODUCTION ABOUT CLINZIT 1% GEL
CLINZIT 1% GEL contains Clindamycin, which belongs to the group of medicines called Antibiotics. It is used in the management of acne vulgaris. Acne vulgaris is a common skin condition that occurs when hair follicles get blocked with oil and dead skin cells. Symptoms include whiteheads, blackheads, small red, tender bumps, pimples, and pus-filled lumps on the skin.
Before applying CLINZIT 1% GEL, inform your doctor if you have or ever had diarrhea, bloody diarrhea and pseudomembranous colitis. CLINZIT 1% GEL is not recommended for use if you have a history of regional enteritis (inflammation of the small intestine), ulcerative colitis (inflammation of the large intestine) or antibiotic-associated colitis.
CLINZIT 1% GEL should be used with caution during pregnancy or by breastfeeding women only if clearly needed. The safety and effectiveness of CLINZIT 1% GEL in children under the age of 12 has not been established. The most common side effects of applying CLINZIT 1% GEL are burning, itching, and redness of the skin. Consult your doctor if symptoms worsen.
USES OF CLINZIT 1% GEL
- Manage acne vulgaris
HOW CLINZIT 1% GEL WORKS
CLINZIT 1% GEL acts against the bacteria by binding to the 50S subunit of the bacterial ribosome (site of protein synthesis), which in turn manages protein synthesis and kills the infection-causing bacteria.
DIRECTIONS FOR USE
Apply CLINZIT 1% GEL as advised by your physician. It is for external use only. Wash your hands before use. Wash and dry the whole area, apply a thin film once daily to the skin where acne lesions appear and use enough to cover the entire affected area. In case of contact with the eyes, mouth or nostrils, rinse it off immediately and thoroughly with water. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF CLINZIT 1% GEL
COMMON
- burning, itching or abnormal redness of the skin at the application site
- scaling, pain, dryness and skin irritation at the application site
UNCOMMON
- abdominal pain
- diarrhea
- oily skin
RARE
- antibiotic-associated colitis
Stop applying CLINZIT 1% GEL and contact your doctor immediately if you experience any of the following side effects:
- allergic symptoms (e.g., rashes, itchiness, difficulty in breathing or eye swelling)
- severe or bloody diarrhea. (a sign of bowel inflammation, pseudomembranous colitis)
WARNING & PRECAUTIONS
PREGNANCY
The safety and effectiveness of CLINZIT 1% GEL in pregnant women or women planning to have a baby have not been established yet. It will be given to you by the doctor only if clearly needed. Consult your doctor before applying CLINZIT 1% GEL.
BREASTFEEDING
CLINZIT 1% GEL should be used with caution in breastfeeding women as it is not known if the medicine is excreted in human milk. Your doctor will decide whether to discontinue nursing or the medicine, considering the benefits to the mother and baby. If it is applied to the chest, care should be taken to avoid accidental ingestion by the infant. Consult your doctor before applying CLINZIT 1% GEL.
ALLERGY
Do not apply CLINZIT 1% GEL if you are allergic to Clindamycin or any other ingredients of this medicine.
OTHERS
CLINZIT 1% GEL is not recommended for use if you:
- have regional enteritis (inflammation of the small intestine) or ulcerative colitis (inflammation of the large intestine)
- have a history of antibiotic-associated colitis
Before applying CLINZIT 1% GEL inform your doctor if you:
- diarrhea, bloody diarrhea
- pseudomembranous colitis (inflammation of colon)
- atopic individuals (more prone to allergies)
Use in pediatrics:
Safety and effectiveness of CLINZIT 1% GEL in children under the age of 12 have not been established. Consult your doctor before applying CLINZIT 1% GEL.
INTERACTIONS
A. Drug-Drug interactions:
Before applying CLINZIT 1% GEL, inform your doctor if you are taking any of the following medicine:
- neuromuscular blocking agents (Ex. rocuronium, vecuronium)
- other anti-acne, topical agents
Overdosage:
If you or anyone else accidentally applied too much of CLINZIT 1% GEL, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : |
Clindamycin |
| Pharmacological Category | : |
Lincosamides |
| Therapeutic Indication | : |
Acne vulgaris |
| Dosage Forms | : |
Injection, Tablet, Capsule, Gel, Cream, Lotion, Solution, Spray, Soap |
MORE INFORMATION
- Keep CLINZIT 1% GEL out of reach from children
- Store at room temperature
FAQs ABOUT CLINZIT 1% GEL
What is CLINZIT 1% GEL used for?
CLINZIT 1% GEL is used in the management of acne vulgaris. Acne vulgaris is a common skin condition that occurs when hair follicles get blocked with oil and dead skin cells. Symptoms include whiteheads, blackheads, small red, tender bumps, pimples, and pus-filled lumps on the skin.
How to use CLINZIT 1% GEL?
Apply CLINZIT 1% GEL as advised by your physician. It is for external use only. Wash your hands before use. Wash and dry the whole area, apply a thin film once daily to the skin where acne lesions appear and use enough to cover the entire affected area. In case of contact with the eyes, mouth or nostrils, rinse it off immediately with plenty of water.
How does CLINZIT 1% GEL work?
CLINZIT 1% GEL acts against the bacteria by binding to the 50S subunit of the bacterial ribosome (site of protein synthesis), which in turn manages protein synthesis and kills the infection-causing bacteria.
Can CLINZIT 1% GEL be used in pregnancy?
The safety and effectiveness of CLINZIT 1% GEL in pregnant women or women planning to have a baby have not been established yet. It will be given to you by the doctor only if clearly needed. Consult your doctor before applying CLINZIT 1% GEL.
Can CLINZIT 1% GEL be used in breastfeeding women?
CLINZIT 1% GEL should be used with caution in breastfeeding women as it is not known if the medicine is excreted in human milk. Your doctor will decide whether to discontinue nursing or the medicine, considering the benefits to the mother and baby. If it is applied to the chest, care should be taken to avoid accidental ingestion by the infant. Consult your doctor before applying CLINZIT 1% GEL.
REFERENCES
1. KD Tripathi. Macrolide, Lincosamide, Glycopeptide and Other Anti bacteria IN Antibiotics. Urinary Antiseptics. Essentials of Medical Pharmacology. Eighth Edition. 2019. Page –805-806.
2. Patrick B, Murphy, Karlyle G. Bistas, Jacqueline K.Le. Clindamycin. National Library of medicine, National center for biotechnology information. [Revised in July 2021] [Accessed on 11th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK519574/
3. Manuel Polanco Morales, Anna Paola Thome Carvallo, Karla Adriana Bautista Espinosa,and Edgar Enrique Meza Murillo. A young man with myelosuppression caused by clindamycin: a case report. National Library of medicine, National center for biotechnology information. Pubmed Central 2014. [Accessed on 11th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917410/
4. DPT Laboratories, Ltd.U.S. Food & Drug Administration. (Clindamycin topical gel). [Revised in November 2000] [Accessed on 11th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2001/50782lbl.pdf
5. Perrigo Yeruham. Daily med. (Clindamycin phosphate lotion). [Revised in December 2021] [Accessed on 11th May 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a10dda0c-28fa-4678-8cea-a6ce2fce4b52
6. Pharmaceutical Society of Singapore. Clindamycin gel/solution/lotion 1%. [Revised in March 2016] [Accessed on 11th May 2022] https://www.pss.org.sg/sites/default/files/public-resource/clindamycin_pil_31-3-2016.pdf
7. Taro Pharmaceutical Industries Ltd. Dailymed. (Clindamycin topical solution). [Revised in April 2021] [Accessed on 11th May 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=5b8a6767-2d46-401c-9f85-d427dda9eff7
8. Torque Pharma. Ticin Gel. (Clindamycin gel 1%). [Accessed on 11th May 2022] https://www.torquepharma.com/ticin-gel/
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