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INTRODUCTION
ZYVICEF 500 TABLET contains Cefuroxime which belongs to the group of medicines called Antibiotics. It is used to treat serious bacterial infections such as middle ear infections (media otitis), throat infections (pharyngitis and tonsilitis), sinus (acute sinusitis), chest and lung infections (bronchitis and pneumonia), urinary tract infections, and serious skin infections (Ex. furuncles). ZYVICEF 500 TABLET is also used to treat Lyme disease (an infection caused by the parasite called ticks).
Patients with a history of cephalosporin-associated haemolytic anaemia are not recommended to take ZYVICEF 500 TABLET. Prolonged treatment with ZYVICEF 500 TABLET can alter digestive flora, this could cause Clostridium difficile-associated diarrhoea. Inform your doctor if you are giving blood samples for screening, before taking ZYVICEF 500 TABLET, as it could cause a change in the results.
Your doctor will prescribe the right dose depends on your child’s age, body weight and disease condition. Before taking ZYVICEF 500 TABLET inform your doctor if you are pregnant or breastfeeding women. The most common side effects of taking this medicine are headache, dizziness, diarrhoea and feeling sick. Consult your doctor immediately if any of the above symptoms worsen.
USES OF ZYVICEF 500 TABLET
It is used to treat:
- lower, upper respiratory tract infection
- urinary tract infection
- gynaecological infection
- skin or soft tissue infection
HOW ZYVICEF 500 TABLET WORKS
ZYVICEF 500 TABLET contains Cefuroxime which is a second-generation cephalosporin that interferes with the synthesis of the bacterial cell wall by binding to specific binding proteins located inside the bacterial cell wall. This leads to breaking down the cell wall of the bacteria and reducing its stability, thus causing cell damage, and eventually causing bacterial elimination.
DIRECTIONS FOR USE
Take ZYVICEF 500 TABLET as advised by your physician. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the infection.
For Tablet, Capsule: Swallow ZYVICEF 500 TABLET with a glass of water. Do not crush or chew the medicine.
For Dispersible Tablet: Disperse the medicine in the specified quantity of water as mentioned in the label. Consume the medicine immediately after reconstitution.
SIDE EFFECTS OF ZYVICEF 500 TABLET
COMMON
- fungal infection
- headache
- dizziness
- diarrhoea
- nausea
- stomach pain
- increased type of white blood cells (eosinophilia)
- increase in liver enzyme
UNCOMMON
- skin rashes
- increased number of blood platelets
- decreased number of white blood cells
- positive coombs test
RARE
Stop taking ZYVICEF 500 TABLET and consult your doctor immediately if you experience any of the following side effects:
- severe allergic reaction having symptoms such as raised and itchy rash, swelling on face, mouth causing difficulty to breathe and swallow
- skin rash with blisters and peeling of skin (signs of Steven-Johnson’s syndrome/ toxic epidermal neuralgia)
- fungal infection such as thrush
- severe diarrhoea with blood and mucus, stomach pain and fever
- Jarisch-Herxheimer reaction having symptoms such as increased temperature (fever), chills, headache, muscle pain and skin rash
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Keep yourself hydrated by drinking lots of fluids, such as water or fruit juices. Avoid taking any medicine on your own for treating diarrhoea. Consult your doctor if diarrhoea is persistent.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Try avoiding driving a car or bicycle or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the dizziness is prolonged for a long time.
Stomach Pain
Try to rest and relax. Consume food which are non-greasy and oily or try to have smaller and frequent meals. Keep a heating pad on your stomach. If the symptom does not improve with time. Contact your doctor immediately.
Headache
Rest and relax. Drink plenty of fluids and apply a pain-relieving medicine/balm on the head if needed. Do not consume too much alcohol. Contact your doctor if you experience headache for long.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredThere are no adequate and well-controlled studies in pregnant women and should be used during pregnancy only if clearly needed. Hence consult your doctor before taking ZYVICEF 500 TABLET.
BREASTFEEDING
ContraindicatedZYVICEF 500 TABLET is not recommended for breastfeeding mothers, as it may pass through the breast milk to the baby. Consult your doctor before taking this medicine.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel dizzy after taking ZYVICEF 500 TABLET.
KIDNEY
Use with CautionZYVICEF 500 TABLET should be used with caution in patients with history of kidney problems and if needed dosage will be adjusted accordingly. Consult your doctor before taking the medicine.
ALLERGY
ContraindicatedDo not take ZYVICEF 500 TABLET if you are allergic to Cefuroxime, cephalosporin, penicillin, monobactams, carbapenems or to any other ingredients of this medicine.
USE IN PEDIATRICS
Consult your doctorYour doctor will prescribe the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before taking the medicine.
USE IN GERIATRICS
Use with CautionZYVICEF 500 TABLET should be used with caution in elderly especially patients with renal impairment. Consult your doctor before taking the medicine.
OTHERS
ZYVICEF 500 TABLET is not recommended for use if you:
- have cephalosporin-associated hemolytic anaemia
Before taking ZYVICEF 500 TABLET, inform your doctor if you are:
- going to undergo blood sugar test or coombs test
INTERACTIONS
A. Drug-Drug interactions:
Before taking ZYVICEF 500 TABLET, inform your doctor if you are taking any of the following medicine:
- medicines used to treat bacterial infections such as penicillin antibiotics (Ex: streptomycin, neomycin, gentamycin)
- medicines used to reduce acid in the stomach (Ex. antacids such as calcium carbonate)
- medicines used as anticoagulants (Ex. warfarin)
- medicines for contraception (Ex. ethinyl estradiol)
- medicine used to treat gout (Ex. probenecid)
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms are neurological disorders such as seizures (fits).
SYNOPSIS
| Drug | : | Cefuroxime |
| Pharmacological Category | : | Cephalosporin Antibiotics |
| Therapeutic Indication | : | Treats Bacterial infections |
| Dosage Forms | : | Tablet, Injection, Capsule, Syrup, Dry Suspension, Drops, Dispersible Tablet |
MORE INFORMATION
- Keep out of reach of children
- Store at room temperature
FAQs ABOUT ZYVICEF 500 TABLET
Q: What is ZYVICEF 500 TABLET used for?
A: ZYVICEF 500 TABLET contains cefuroxime, which is used to treat lower, upper respiratory tract infection, urinary tract infection, gynaecological infection, skin or soft tissue infection.
Q: Is ZYVICEF 500 TABLET same as penicillin?
A: No, ZYVICEF 500 TABLET belongs to the second-generation class of cephalosporins, it is active against numerous gram-positive and gram-negative bacteria, including several with resistance to other antibiotics such as penicillin. Consult your doctor before taking ZYVICEF 500 TABLET.
Q: If I start feeling well, can I skip the dose of ZYVICEF 500 TABLET?
A: No. You should complete the full course of ZYVICEF 500 TABLET as prescribed by your doctor. It is important that ZYVICEF 500 TABLET be taken at the right dose and for the right duration given. Consult your doctor before taking the medicine.
Q: What will happen if I accidentally take overdosage of ZYVICEF 500 TABLET?
A: If you have accidentally overdosed ZYVICEF 500 TABLET, you may suffer from a neurologic disorder, such as seizures (fits). Consult a doctor immediately and go to the nearby hospital.
Q: Will ZYVICEF 500 TABLET affect the contraceptive pill that is taken?
A: Yes. ZYVICEF 500 TABLET may interact with birth control pills and lowers its efficiency. So, you should tell your doctor if you are using any birth control pills. Your doctor could suggest an alternative contraceptive barrier.
Q: In what condition ZYVICEF 500 TABLET should be avoided?
A: ZYVICEF 500 TABLET should not be taken if you have a history of serious anaphylactic reaction to cefuroxime or any other cephalosporin antibiotics or if you have a history of cephalosporin-induced haemolytic anaemia. Consult your doctor before taking ZYVICEF 500 TABLET.
REFERENCES
1. KD Tripathi. Second-generation cephalosporins. Essentials of Medical Pharmacology. Eighth edition. Page - 777.
2. Cefuroxime. PubChem. National Centre for Biotechnology Information. [Accessed on 7th September 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Cephuroxime#section=2D-Structure
3. Brogden, R.N., Heel, R.C., Speight, T.M. et al. Cefuroxime: A Review of its Antibacterial Activity, Pharmacological Properties and Therapeutic Use. Drugs. [Revised in November 2012] [Accessed on 7th September 2022] https://link.springer.com/article/10.2165/00003495-197917040-00001#citeas
4. Glaxo Operations UK Ltd. Electronic Medicines Compendium (EMC). [Revised in November 2019] [Accessed on 7th September 2022] https://www.medicines.org.uk/emc/files/pil.3810.pdf
5. Sandoz Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 7th September 2022] https://www.medicines.org.uk/emc/product/426/smpc#gref
6. TEVA UK Ltd. Health Products Regulatory Authority. [Revised in June 2013] [Accessed on 7th September 2022] http://www.hpra.ie/img/uploaded/swedocuments/2126276.PA0749_082_002.8f76380d-ac29-402f-b6d0-af2d021bdf05.000001PIL.130628.pdf
7. Auro Pharma Inc. [Revised in January 2021] [Accessed on 7th September 2022] http://www.auropharma.ca/products/monograph/Auro-Cefuroxime-PM.pdf
8. Ranbaxy Pharmaceuticals Inc. [Revised in October 2008] [Accessed on 7th September 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5b6288fa-49da-4f44-b779-86e8404921db
9. Blenheim Pharmacal, Inc. [Revised in June 2010] [Accessed on 7th September 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=16a686e6-63f4-478f-a673-02dde9474eda
10. GlaxoSmithKline. [Revised in January 2007] [Accessed on 7th September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/050605s042lbl.pdf
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
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