INTRODUCTION

ZYTRAV 0.004% contains travoprost which belongs to a group of medicines called prostaglandin analogues. It works by reducing pressure in the eye which can lead to an illness called a glaucoma. It is absorbed through cornea, where it is hydrolyzed to free travoprost acid. After one to two hours of application, highest concentrations of the acid in the eye are reached. There it exerts their ocular hypotensive effect by increasing uveoscleral outflow through the prostaglandin FP receptors, located in the ciliary muscle and in the trabecular meshwork.

The recommended dose is one drop in affected eye or eyes, once a day in evening or as directed by your physician. Talk to your doctor before you use this medicine, if you have current or previous history of iritis and uveitis (eye inflammation). It may cause changes in eyelashes such as increase in its length, thickness, colour and/or number. Changes in eyelids such as unusual hair growth or in tissues around the eye have also been observed. The common side effects are dizziness, drowsiness, headache, eye redness, changes in the colour of iris, eye pain and discomfort, dry eye, itchy eye, eye irritation.

USES OF ZYTRAV 0.004%

• Treat ocular hypertension and glaucoma

HOW ZYTRAV 0.004% WORKS

ZYTRAV 0.004% is absorbed through cornea, where it is hydrolyzed to free travoprost acid. After one to two hours of application, highest concentrations of the acid in the eye are reached. There it exerts it's ocular hypotensive effect by increasing the drainage of fluid from inside your eye and which helps in lowering the pressure inside your eye.

DIRECTIONS FOR USE

The recommended dose is one drop in affected eye or eyes, once a day in evening or as directed by your physician. It is for external use only.

SIDE EFFECTS OF ZYTRAV 0.004%

HOW TO MANAGE SIDE EFFECTS

Skin redness:

Avoid bathing with hot water because hot water can irritate the skin. Moisturizers can be used on regular basis to soothe and hydrate the affected area.

Dry eyes:

Take a warm, wet cloth and hold this over your eyes for five minutes to reduce dry eye symptoms. Massage your eyelids with mild soap like baby shampoo. Close your eyes and apply the soap with your fingertips and massage your eyelids.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking or recently taken or used any other medicines.

SYNOPSIS

MORE INFORMATION

Store at room temperature 15-25°C and keep out of reach of children.

FAQs ABOUT ZYTRAV 0.004%

What is ZYTRAV 0.004% for?

It is used to treat glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision) and ocular hypertension (a condition which causes increased pressure in the eye).

What are the common side effects of ZYTRAV 0.004%?

The common side effects of this medicine are dizziness, drowsiness, headache, eye redness, changes in the colour of iris (coloured part of the eye), eye pain and discomfort, dry eye, itchy eye and eye irritation.

Is ZYTRAV 0.004% recommended for children?

It is not recommended for use in children and adolescents below 18 years of age.

REFERENCES

1. Philippe Denis, David Covert, and Anthony Realini, Travoprost in the management of open glaucoma and ocular hypertension, clinical ophthalmology, [Review on 03/2007] [Accessed 27 Oct 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699992/pdf/opth-1-11.pdf

2. Goodman and Gilman’s. The pharmacological basis of Therapeutics. Drugs used to treat glaucoma, 12th Edition, 2011. Page – 952, 1787.

3. S.A. Alcon-Couvreur N.V. (Belgium); Electronic Medicines Compendium (EMC); [Revised on 08/2018] [Accessed 26 Oct 2020] https://www.medicines.org.uk/emc/files/pil.1556.pdf