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INTRODUCTION
ZOVERAN 50 TABLET contains Diclofenac which belongs to the group of medicines called Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). It is used to treat pain and inflammation related to sprains, strains and other injuries, post-surgery, gout (excessive uric acid accumulation in joints), backache, rheumatoid arthritis (immune system attack on healthy cells by mistake, causing inflammation), osteoarthritis (flexible tissue at the ends of bones wears down), ankylosing spondylitis (spine inflammation) and pyrophosphate arthropathy (crystals of a calcium salt causing joint problems).
ZOVERAN 50 TABLET can also be used in adults to treat symptoms associated with migraine attacks (one sided headache that can cause severe throbbing pain or a pulsing sensation), frozen shoulder, fractures, dislocations, and conditions affecting tendons (Ex. tendonitis, tenosynovitis, bursitis). During ZOVERAN 50 TABLET treatment, your doctor may want to give you a check-up regularly.
ZOVERAN 50 TABLET is not recommended for use in patients with liver or kidney failure, heart problems like heart attack, stroke, or bypass, stomach ulcer, holes, or bleeding. Before taking ZOVERAN 50 TABLET, inform your doctor if you have liver, kidney, heart, or bleeding problems, diabetes, asthma, or if you are going to have any surgery.
ZOVERAN 50 TABLET is not recommended for use in pregnant (especially in last 3 months) and breastfeeding women. ZOVERAN 50 TABLET is not recommended for use in children (below 14 years of age) so, consult your child’s doctor for advice.
The most common side effects of taking ZOVERAN 50 TABLET are diarrhea, nausea, vomiting, headache, dizziness, skin rash, etc. Call your doctor if any of the symptoms worsen.
USES OF ZOVERAN 50 TABLET
ZOVERAN 50 TABLET is used to treat pain and inflammation related to
- sprains, strains and other injuries, post-surgery, gout
- backache, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, pyrophosphate arthropathy
- frozen shoulder, fractures, dislocations, conditions affecting tendons
- migraine attacks
HOW ZOVERAN 50 TABLET WORKS
ZOVERAN 50 TABLET relieves pain and inflammation by inhibiting certain enzymes (COX-1 and COX-2) involved in synthesis of prostaglandins (chemicals responsible for inducing pain and inflammation).
DIRECTIONS FOR USE
Take ZOVERAN 50 TABLET as advised by your physician. Swallow ZOVERAN 50 TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide a proper dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF ZOVERAN 50 TABLET
COMMON
- loss of appetite, diarrhea
- spinning sensation, dizziness, headache
- spots or skin rash
- raised blood levels of liver enzymes
UNCOMMON
- fast or irregular heartbeat
- heart problems like heart attack (swelling of feet or legs) or breathlessness
- trouble breathing when lying down
- chest pain
RARE
- stomach ulcers or bleeding
- gastritis (inflamed, irritated or swollen stomach lining)
- drowsiness, tiredness
- blood in vomit or stools
- black, tarry stools
- fluid retention (swollen ankles)
- asthma (wheezing, breathlessness, tight chest)
- skin rash and itching
- liver diseases including hepatitis and jaundice
Stop taking ZOVERAN 50 TABLET and contact your doctor immediately if you experience any of the following side effects:
- heart attack (sudden and crushing chest pain)
- early signs of stroke (sudden numbness or weakness in one side of face, arm or leg; sudden loss or vision disturbance, speech difficulty, migraine like headache with or without disturbance in vision)
- bleeding in stomach or intestine (bleeding while emptying your bowel, blood in vomit, black starry stools)
- allergic reactions (skin rash, itching, bruising, painful red areas, peeling or blister formation)
- stomach pain, indigestion, nausea, vomiting, gas, heartburn
- swelling in face, lips, hands, fingers
- yellowing of skin or eyeballs
- persistent sore throat or high temperature
- sudden change in amount and color of urine
- mild cramping and tenderness in stomach
- Stevens-Johnson syndrome (serious condition with blistering of skin, mouth, eyes, genitals)
- wheezing or shortness of breath
- chest pain because of serious allergic rection called Kounis syndrome
- easy bruising, frequent sore throats or infections
- weakness, slurry speech
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take ZOVERAN 50 TABLET with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. If symptom persists, contact your doctor.
Vomiting:
Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it – no need to eat or avoid any specific foods. If symptom persists, contact your doctor.
Diarrhea:
Drink lots of fluids such as water or fruit juices so that you are sufficiently hydrated. If symptom persists, contact your doctor.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to eat smaller meals in small breaks. Keep a heat pad on your stomach. If symptom persists, contact your doctor.
Indigestion:
Keep your head and shoulders raised up while sleeping so that stomach acid won’t come up. Do not eat 3 to 4 hours before going to sleep and avoid tea, coffee, cola, or alcohol. If symptom persists, contact your doctor.
Headache:
Drink plenty of water and get adequate rest. Try to be relaxed and stress free. Call your doctor before taking any medicine for headache. If headache persists, consult your doctor.
Skin rash:
Avoid hot showers as it can further irritate your skin. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. If symptom persists, contact your doctor.
WARNING & PRECAUTIONS
PREGNANCY
ZOVERAN 50 TABLET is not recommended for use in pregnancy (during last 3 months). If you are pregnant, think you may be pregnant or are planning for a baby, consult your doctor before taking it. Inform your doctor immediately if you become pregnant during treatment with ZOVERAN 50 TABLET.
BREASTFEEDING
ZOVERAN 50 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy machines if you feel dizzy, tired, sleepy or have problems with eyesight after taking ZOVERAN 50 TABLET.
ALCOHOL
Avoid consumption of alcohol while taking ZOVERAN 50 TABLET as it may increase the risk of GI bleeding. Consult your doctor for advice.
KIDNEY
ZOVERAN 50 TABLET is not recommended for use in patients with kidney failure. ZOVERAN 50 TABLET should be used with caution in patients with other kidney problems. Consult your doctor for advice.
LIVER
ZOVERAN 50 TABLET is not recommended for use in patients with liver failure. ZOVERAN 50 TABLET should be used with caution in patients with other liver problems. Consult your doctor for advice.
ALLERGY
Do not take ZOVERAN 50 TABLET if you are allergic to Diclofenac, aspirin, ibuprofen, other NSAIDs, or any of the other ingredients of this medicine.
LUNGS
ZOVERAN 50 TABLET should be used with caution in patients with a history of asthma, seasonal allergic rhinitis, nasal polyps, chronic pulmonary disease, or respiratory tract infections. Consult your doctor for advice.
HEART DISEASE
ZOVERAN 50 TABLET is not recommended for use in patients with heart failure, heart diseases such as heart attack, blood circulation problems, blockage in blood vessels to heart, and in patients who underwent operations to clear or bypass blockages. ZOVERAN 50 TABLET should be used with caution in patients with angina (chest pain), high blood pressure, raised cholesterol or triglycerides or other heart problems. Consult your doctor for advice.
OTHERS
ZOVERAN 50 TABLET is not recommended for use if you:
- have or had a stomach or intestinal ulcer, or bleeding in the gut
- had stomach or bowel issues after taking other NSAIDs
- have cerebrovascular disease like stroke or blockages in blood vessels to brain
Before taking ZOVERAN 50 TABLET, inform your doctor if you:
- have porphyria (a rare genetic condition)
- have any blood or bleeding disorder
- have blood clots
- have smoking habit
- have diabetes
- have systemic Lupus Erythematosus (autoimmune condition causing joint pain and inflammation, fever, or skin rashes)
- had undergone or are going to have any gut surgery
- have stomach or bowel problems like ulcerative colitis or Crohn’s disease
Use in Paediatrics:
ZOVERAN 50 TABLET is not recommended for use in children (below 14 years of age). Consult your child’s doctor for advice.
Use in Geriatrics:
ZOVERAN 50 TABLET should be used with caution in elderly patients. Consult your doctor for advice.
INTERACTIONS
A. Drug-Drug Interactions:
Before taking ZOVERAN 50 TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used to treat diabetes (Ex. metformin, gliclazide)
- warfarin (used to dissolve blood clots)
- medicines used to remove excess water form body (Ex. spironolactone, furosemide)
- methotrexate (used in cancer treatment)
- lithium (used for mental health problems)
- medicines used to suppress immunity (Ex. ciclosporin, tacrolimus)
- medicines used for bacterial infections (Ex. trimethoprim, ofloxacin, ciprofloxacin)
- other medicines used for pain relief (Ex. aspirin, ibuprofen)
- mifepristone (used to terminate pregnancy)
- medicines used to treat high blood pressure and other heart problems (Ex. captopril, atenolol, metoprolol, digoxin)
- medicines used to suppress inflammation (Ex. prednisolone, hydrocortisone)
- medicines used in depression (Ex. citalopram, fluoxetine)
- phenytoin (used to treat fits)
- voriconazole (used to treat fungal infections)
- medicines used to lower cholesterol (Ex. colestipol, cholestyramine)
- sulfinpyrazone (used in gout treatment)
- zidovudine (used in HIV treatment)
Overdosage:
If you or anyone else accidentally takes too much of ZOVERAN 50 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of ZOVERAN 50 TABLET overdose are headache, nausea, vomiting, stomach pain, stomach or intestinal bleeding.
SYNOPSIS
| Drug | : | Diclofenac |
| Pharmacological Category | : | Cyclooxygenase Inhibitors |
| Therapeutic Indication | : | Pain and inflammation |
| Dosage Forms | : | Tablet, Capsule, Dispersible tablet, Injection, Infusion, PFS, Eye drops, Gel, Spray, Solution, Liniment, Sachet, Patch, Suppository, Ointment, Spray |
MORE INFORMATION
- Keep ZOVERAN 50 TABLET out of reach of children
- Store ZOVERAN 50 TABLET below 25°C
FAQs ABOUT ZOVERAN 50 TABLET
Can ZOVERAN 50 TABLET be used for headache?
ZOVERAN 50 TABLET can be used in adults to treat symptoms related to migraine attacks, which are one sided headache that can cause severe throbbing pain or a pulsing sensation. Ask your doctor before taking ZOVERAN 50 TABLET for any other type of headaches.
Can ZOVERAN 50 TABLET make me feel sleepy?
ZOVERAN 50 TABLET can very occasionally make you feel sleepy or tired. In such case, do not drive or use any machineries after taking ZOVERAN 50 TABLET. Consult your doctor if sleepiness persists.
Can I take ZOVERAN 50 TABLET with paracetamol?
It is safe to take ZOVERAN 50 TABLET with paracetamol, but this does not necessarily mean no interactions exist. Consult your doctor before taking any other medicine with ZOVERAN 50 TABLET, especially other similar painkillers (NSAIDs).
What if I forget to take a dose of ZOVERAN 50 TABLET?
If you forget to take a dose of ZOVERAN 50 TABLET, take it as soon as you remember. However, omit that dose if it's almost time for the next one. Do not take ZOVERAN 50 TABLET two times to make up for the missed dose.
Is ZOVERAN 50 TABLET safe to use in patients with high blood pressure?
ZOVERAN 50 TABLET should be used with caution in patients with high blood pressure and those taking medicines for high blood pressure. Consult your doctor for advice. The doctor will determine a proper dose of ZOVERAN 50 TABLET or select a suitable alternative treatment for you according to your condition.
REFERENCES
1. KD. Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Eighth edition. 2019. Page – 221.
2. Gan, Tong J. Diclofenac: an update on its mechanism of action and safety profile. Current medical research and opinion. Taylor & Francis Online. April 2010. [Accessed on 16th August 2022] https://www.tandfonline.com/doi/abs/10.1185/03007995.2010.486301
3. Altman, Roy, Bill Bosch, Kay Brune, Paola Patrignani, and Clarence Young. Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs. Springer Link. May 2015. [Accessed on 16th August 2022] https://link.springer.com/article/10.1007/s40265-015-0392-z
4. Specifar S.A. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 16th August 2022] https://www.medicines.org.uk/emc/files/pil.5791.pdf
5. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 16th August 2022] https://www.medicines.org.uk/emc/files/pil.2662.pdf
6. Teva Pharmaceuticals. Diclofenac sodium (25 and 50mg tablets). [Revised in October 2021] [Accessed on 16th August 2022] https://products.tevauk.com/mediafile/id/51764.pdf
7. Carlsbad Tech. Diclofenac sodium DR (75mg tablets). Dailymed. [Revised in May 2016] [Accessed on 16th August 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=af8a1392-67e8-8201-e053-2a95a90a0fce&type=display
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count (CBC)
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