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INTRODUCTION
ZORYL 3MG contains Glimepiride which belongs to the group of medicines called Anti-diabetic agents. It is used to treat type 2 diabetes mellitus when diet, physical exercise and weight reduction alone have not been able to control blood sugar levels. Type 2 diabetes mellitus is a chronic health condition where the body does not produce enough insulin to control the levels of blood sugar. Symptoms include increased thirst and hunger, frequent urination, weight loss, fatigue, blurred vision, and slow-healing sores.
Glimepiride lowers blood sugar by causing the pancreas to produce increased insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This will only help lower blood sugar in people whose bodies produce insulin naturally. Along with this treatment, your doctor might ask you to make certain lifestyle changes such as following a healthy diet, physical exercise and avoiding alcohol. Your doctor may also want you to take certain blood tests, urine, and liver tests to understand your existing condition.
Avoid smoking and consumption of alcohol during treatment with ZORYL 3MG. Before taking ZORYL 3MG, inform your doctor if you are recovering from an injury, operation, infections with fever or stress. ZORYL 3MG is not recommended for use in patients having severe kidney and liver disease, insulin dependent diabetes (type 1), diabetic coma and diabetic ketoacidosis. ZORYL 3MG is generally not recommended for use in pregnancy and breastfeeding. ZORYL 3MG is also not recommended for use in children. Consult your doctor before taking. The most common side effects of taking ZORYL 3MG are low blood sugar (hypoglycemia), dizziness, weakness, headache, nausea, allergic skin reactions (reddening of the skin, rash, and itching), vomiting and diarrhea.
USES OF ZORYL 3MG
- Treats type 2 diabetes mellitus
HOW ZORYL 3MG WORKS
ZORYL 3MG lowers blood sugar by causing the pancreas to produce increased insulin (a natural substance that is needed to break down sugar in the body) and helps the body use insulin efficiently. This will only help lower blood sugar in people whose bodies produce insulin naturally.
DIRECTIONS FOR USE
Take ZORYL 3MG as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF ZORYL 3MG
RARE
- lower blood sugar than normal (hypoglycemia)
- decrease in the number of platelets (increases risk of bleeding or bruising), white blood cells (increases infections), red blood cells (makes skin pale and cause weakness, breathlessness)
Stop taking ZORYL 3MG and contact your doctor immediately if you experience any of the following side effects:
- allergic reactions (including inflammation of blood vessels, often with skin rashes, difficulty in breathing, fall in blood pressure and sometimes progressing to shock)
- abnormal liver function including yellowing of the skin and eyes (jaundice), problems with the bile flow (cholestasis), liver failure
- allergy of the skin such as itching, rashes, hives, and increased sensitivity to sun.
- serious reactions with swallowing or breathing problems, swelling of your lips, throat, or tongue
- severe hypoglycemia causing loss of consciousness or seizures
WARNING & PRECAUTIONS
PREGNANCY
ZORYL 3MG is not recommended for use in pregnancy. Consult your doctor before taking it.
BREASTFEEDING
ZORYL 3MG is not recommended for use in breastfeeding women, as it may pass through the breast milk. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Avoid driving and using machines while taking ZORYL 3MG as it may lower the ability to concentrate.
ALCOHOL
Avoid drinking alcohol as it may increase or decrease the blood sugar levels lowering the action of ZORYL 3MG.
KIDNEY
ZORYL 3MG is not recommended for patients with severe kidney disease. It should be used with caution in patients with severe kidney disorder, consult your doctor before taking it.
LIVER
ZORYL 3MG is not recommended for patients with severe liver disease. It should be used with caution in patients with severe liver disorder, consult your doctor before taking it.
ALLERGY
Do not take ZORYL 3MG if you are allergic to Glimepiride.
OTHERS
ZORYL 3MG is not recommended for use if you:
- have insulin dependent diabetes (type 1 diabetes mellitus)
- have diabetic ketoacidosis (a complication of diabetes when acid level is raised in the body and may have the following signs: fatigue, nausea, frequent urination and muscular stiffness)
- are in a diabetic coma
Before taking ZORYL 3MG, inform your doctor if you:
- are recovering from an injury, operation, infections or from stress
- cannot tolerate some sugars.
Use in pediatrics:
ZORYL 3MG is not recommended for use in children and adolescents under 18 years of age. Consult your doctor before taking it.
Use in geriatrics:
Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Consult your doctor before taking it.
INTERACTIONS
A. Drug - Drug interactions:
Before taking ZORYL 3MG, inform your doctor if you are taking any of the following medicines:
- medicines used to treat pain and inflammation (Ex. phenylbutazone,glucocorticoids, azopropazone, oxyphenbutazone, aspirin)
- for diabetes mellitus (Ex. insulin or metformin)
- to support muscle build up (anabolics)
- to prevent blood clotting (warfarin)
- to reduce weight (fenfluramine)
- to treat depression (Ex. fluoxetine, MAO inhibitors)
- to treat gout (allopurinol, probenecid, sulfinpyrazone)
- to treat cancer (Ex. cyclophosphamide, ifosfamide, trofosfamide)
- to treat bacterial, fungal infections (tetracyclines, chloramphenicol, fluconazole, miconazole, quinolones, clarithromycin)
- to treat hay fever (tritoqualine)
- to increase circulation (pentoxifylline)
- to treat urinary infections (such as sulfonamides)
- containing female sex hormones (oestrogens, progestogens)
- to treat high blood pressure (thiazidediuretics, betablockers, clonidine, guanethidine,diazoxide, glucagon, reserpine,ACE inhibitors), antiarrhythmic agents used to control abnormal heartbeat(disopyramide)
- to stimulate the thyroid gland (levothyroxine)
- to treat severe mental disorders (Ex. chlorpromazine, phenothiazine derivatives)
- adrenaline and sympathomimetics
- to treat high cholesterol level (Ex. nicotinic acid, colesevelam, fibrates)
- to treat constipation (laxatives)
- to treat fits (phenytoin)
- for nervousness, sleep problems (barbiturates)
- to treat infections, tuberculosis (rifampicine)
- for increased pressure in the eye (azetazolamide)
- for stomach ulcers (called H2 antagonists)
Overdosage:
If you or anyone else accidentally take too much of ZORYL 3MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea, vomiting, epigastric pain, restlessness, tremor, visual disturbances, co-ordination problems, sleepiness or convulsions.
SYNOPSIS
| Drug | : | Glimepiride |
| Pharmacological Category | : | Sulphonyl ureas |
| Therapeutic Indication | : | Type 2 diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep ZORYL 3MG out of reach of children.
- Do not store above 25°C.
FAQs ABOUT ZORYL 3MG
Can ZORYL 3MG make you sleepy?
No, ZORYL 3MG itself does not cause sleepiness. However, it may cause hypoglycemia (low blood sugar) when used with other anti-diabetes medicine due to which you may feel sleepy or have problems in sleeping.
Can ZORYL 3MG cause memory loss?
No, ZORYL 3MG doesn’t causes memory loss. However, it may cause low blood sugar which may cause problems with concentration and reduced alertness.
What will happen if I take more dose of ZORYL 3MG?
ZORYL 3MG should be taken strictly as advised by the doctor. Overdose may significantly decrease your blood sugar levels (hypoglycemia). In case of any symptoms, consume enough sugar (e.g., a small bar of sugar cubes, sweet juice or sweet tea) and inform a doctor immediately.
Can I stop ZORYL 3MG on my own?
Generally, the treatment is suggested for a long term. ZORYL 3MG only controls the sugar levels but does not cure it. Do not stop taking it without talking to your doctor as it may worsen your condition.
Can I consume alcohol while taking ZORYL 3MG?
Avoid alcohol while taking ZORYL 3MG as it may increase or decrease the blood sugar levels lowering action of the medicine in an unpredictable way.
REFERENCES
1. Goodman Gilmans. Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycemia. The Pharmacological Basis of Therapeutics. Twelfth Edition. 2011. Page –1255-1257.
2. Rajeev Goyal; Ishwarlal Jialal. Diabetes Mellitus Type 2. [Revised in September 2021] [Accessed on 17th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK513253/
3. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 17th May 2022] https://www.medicines.org.uk/emc/files/pil.10742.pdf
4. Sanofi India Limited.[Revised in April 2021] [Accessed on 17th May 2022] https://www.sanofi.in/dam/jcr:08a3cd36-a9e7-49eb-887b-9914600a6335/Amaryl%20and%20Semi-Amaryl%20%2005mg%20PI%20-%20rev%20April%202021.pdf
5. Glimepiride.Mayoclinic[Revised in October 2020] [Accessed on 17th May 2022] https://www.mayoclinic.org/diseases-conditions/diabetes/symptoms-causes/syc-20371444
6. Glimepiride. Rxlist. [Revised on January 2021] [Accessed on 17th May 2022] https://www.rxlist.com/consumer_glimepiride_amaryl/drugs-condition.htm
7. Glimepiride.Medlineplus. [Revised on May 2020] [Accessed on 17th May 2022] https://medlineplus.gov/druginfo/meds/a696016.html
USEFUL DIAGNOSTIC TESTS
- Blood tests (glycated hemoglobin test, random blood sugar test, fasting blood sugar test)
- Oral glucose tolerance test
- Liver function test
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