INTRODUCTION

ZORYL 3MG contains glimepiride which belongs to a blood sugar lowering group of medicines called sulfonylureas. It is used for treatment of diabetes (a disease where the body does not produce enough insulin to control the level of blood sugar). Oral hypoglycemics help control blood sugar level.

It is used in the treatment of non-insulin dependent (Type II) diabetes mellitus. Type 2 diabetes mellitus is a condition where your body does not produce enough insulin, and or the insulin that produced by your body does not work. When your body make too much sugar it gets build up in the blood may also leads to high blood sugar. This can lead to serious medical problems. If type 2 diabetes mellitus cannot be adequately controlled with diet and exercise alone, ZORYL 3MG may be used to treat this condition.

It is not recommended for use in children. Alcohol intake may increase or decrease the blood sugar lowering action of this medicine in an unpredictable way. Stay on exercise and diet as prescribed by your doctor while taking this medicine. It must be taken after food and try to take at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine. Before taking this medicine,  tell your doctor if you have ever had kidney disease, heart disease, or pancreas problems. Pregnant or breastfeeding women should consult their doctor before taking this medicine.

USES OF ZORYL 3MG

• Treat type 2 diabetes mellitus in adults

HOW ZORYL 3MG WORKS

ZORYL 3MG in lowering the blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells. It lowers blood sugar by stimulating the pancreas to produce insulin which is essential to break down sugar in the body and helping the body to use insulin effectively.

DIRECTIONS FOR USE

Always take ZORYL 3MG exactly as prescribed by your doctor. This medicine must be taken after food and try to take at the same time each day. Swallow the medicine whole with plenty of water. Do not crush or chew the medicine.

SIDE EFFECTS OF ZORYL 3MG

HOW TO MANAGE SIDE EFFECTS

Skin redness and rash:

Avoid bathing with hot water because hot water can irritate the skin. Moisturizers can be used regular basis to soothe and hydrate the affected area.

Diarrhea:

Drink lot of fluid, such as water or squash, to avoid dehydration. Do not take any other medicine without consulting your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor if you are taking:

• medicines used to treat pain and inflammation (phenylbutazone, azapropazone, oxyphenbutazone, aspirin like medicines)
• other medicines used to treat diabetes mellitus (such as insulin or metformin)
• medicines supporting muscle build up (anabolics)
• medicines used to inhibit blood clotting (coumarin derivatives such as warfarin)
• medicines used to reduce weight (fenfluramine)
• medicines called anti-arrhythmic agents used to control abnormal heartbeat (disopyramide)
• medicines lowering high cholesterol level or blood pressure
• medicines to treat depression (fluoxetine, MAO inhibitors)
• medicines to treat gout (allopurinol, probenecid, sulfinpyrazone)
• medicines to treat cancer (cyclophosphamide, ifosfamide, trofosfamide)
• medicines used to treat the bacterial and fungal infections (tetracyclines, chloramphenicol, fluconazole, miconazole, quinolones, clarithromycin)
• medicines used to treat the nasal allergies such as hay fever

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT ZORYL 3MG

How should I take ZORYL 3MG?

You should take ZORYL 3MG with breakfast or the first main meal of the day.

How does ZORYL 3MG lower blood sugar?

It lowers the blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally.

Can ZORYL 3MG cause heart problems?

Yes. You should not use this medicine if you have severe or uncontrolled heart failure, active bladder cancer, or diabetic ketoacidosis. This medicine can cause or worsen congestive heart failure.

REFERENCES

1. Anthony L McCall; Clinical review of glimepiride; Used to treat type 2 diabetes mellitus; [Published on April 2001] https://pubmed.ncbi.nlm.nih.gov/11336617/

2. Vanessa J Briscoe, Michelle L Griffith, MD & Stephen N Davis, MD; The role of glimepiride in the treatment of type 2 diabetes mellitus; [Published on 7 Jan 2010] https://www.tandfonline.com/doi/full/10.1517/17425250903512955?src=recsys

3. K.D.Tripathi, Drugs used to lower the sugar level, Essentials of medical Pharmacology, Seventh Edition, 2013. Page – 272.

4. Brown & Burk UK Limited; Electronic Medicines Compendium (EMC); [Revised on Feb 2017] [Accessed 26 Oct 2020] https://www.medicines.org.uk/emc/files/pil.10743.pdf

5. Sanofi-aventis U.S. LLC; U.S. Food & Drug Administration; [Revised on May 2009] [Accessed 26 Oct 2020]  https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf

6. Accord Healthcare Polska Sp.z o.o., ul. Lutomierska 50,95-200 Pabianice, Poland; Electronic Medicines Compendium (EMC); [Revised on 02/2019] [Accessed 26 Oct 2020] https://www.medicines.org.uk/emc/files/pil.6048.pdf