Zombistin 4.5MIU Injection 1'S

Infection Rx required
OUT OF STOCK

Best Price* ₹ 3,480.00 MRP ₹ 4,350.00
(Inclusive of all taxes) * Mkt: Abbott Health Care Solutions Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

ZOMBISTIN 4.5MIU contains Colistin which belongs to the group of medicines called Antibiotics. It is used to treat certain forms of serious bacterial infections when other antibiotics are not suitable. It is clinically effective in treating various infections caused due to the certain gram-negative bacteria such as Aerobacter aerogenes, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa.

A bacterial infection can be defined as a proliferation of various harmful strains of bacteria in the body. They can affect any part(s) of the body including the respiratory tract, urinary tract, eyes, ears, skin, soft tissue, or bones.

Colistin is a polypeptide antibiotic. It binds to the susceptible bacteria and disrupts the composition (lipids and protein) of the bacterial cell membrane. As a result, it makes the contents of the bacterial cell to leak out which subsequently leads to bacterial killing. It may also inactivate the toxins produced by the bacteria.

Before receiving ZOMBISTIN 4.5MIU, inform your doctor if you have any kidney problems. Your doctor would prescribe a low dose of colistin and constantly monitor your kidney functions while receiving ZOMBISTIN 4.5MIU to avoid the risk of side effects. You must also inform your doctor if you have any inherited blood or muscle disorders before receiving ZOMBISTIN 4.5MIU.

Do not take ZOMBISTIN 4.5MIU if you are allergic to any of the ingredients present in it. ZOMBISTIN 4.5MIU should be used in pregnant or breastfeeding women only if prescribed by the physician. The most common side effects of receiving ZOMBISTIN 4.5MIU are stomach upset, tingling sensation in the extremities, loss of sensation, fever, or dizziness. Contact your doctor if any of these side effect worsens.

USES OF ZOMBISTIN 4.5MIU

  • Treats serious bacterial infections

HOW ZOMBISTIN 4.5MIU WORKS

ZOMBISTIN 4.5MIU kills the susceptible bacteria that causes infection. It acts by disrupting the composition (lipids and protein) of the bacterial cell membrane and enters the bacterial cell. This causes the contents of the bacterial cell to leak out which subsequently leads to bacterial killing. It may also inactivate the effects of toxins produced by the harmful bacteria.

DIRECTIONS FOR USE

ZOMBISTIN 4.5MIU will be given to you only by a doctor or nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of infection.

SIDE EFFECTS OF ZOMBISTIN 4.5MIU

COMMON

  • stomach upset
  • tingling sensation in the extremities or in the tongue
  • paraesthesia (loss of sensation)
  • dizziness
  • skin rash, itching
  • fever
  • breathing difficulty
  • increased kidney enzymes

RARE

Contact your doctor immediately if you experience any of the following side effects after receiving ZOMBISTIN 4.5MIU:

  • severe allergic reaction (such as skin rash, itching, sudden swelling of the face, throat or lips leading to wheezing or breathing difficulties)
  • inability to breathe because of paralysis of the chest muscles, sense of tingling or numbness especially around the face, feeling dizzy, loss of balance, rapid changes in blood pressure or blood flow causing flushing or fainting, problems in speech, problems with vision, confusion, and mental problems (including loss of sense of reality)
  • kidney damage with symptoms such as little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath

HOW TO MANAGE SIDE EFFECTS

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely if you feel dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Skin rash:

Avoid taking hot showers, as it may further irritate your skin. Use protective clothes while going outdoors. Avoid scratching the affected area of the skin. Regularly moisturize your skin. Consult your doctor if your condition worsens.

WARNING & PRECAUTIONS

PREGNANCY

ZOMBISTIN 4.5MIU should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before receiving it.

BREASTFEEDING

ZOMBISTIN 4.5MIU should be used with caution in breast-feeding women. Therefore, consult your doctor before receiving it.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if you experience dizziness, confusion or blurred vision after receiving ZOMBISTIN 4.5MIU.

ALCOHOL

Avoid consumption of alcohol while receiving ZOMBISTIN 4.5MIU.

KIDNEY

ZOMBISTIN 4.5MIU should be used with caution in patients suffering from kidney problems. Therefore, consult your doctor before receiving it.

LIVER

ZOMBISTIN 4.5MIU should be used with caution in patients suffering from liver problems. Therefore, consult your doctor before receiving it.

ALLERGY

Inform your doctor before receiving ZOMBISTIN 4.5MIU if you are allergic to colistin.

OTHERS

Before receiving ZOMBISTIN 4.5MIU inform your doctor if you:

  • have myasthenia gravis (weak muscles)
  • have porphyria (an inherited blood disorder)

Use in pediatrics:

ZOMBISTIN 4.5MIU should be used with caution in children and adolescents (aged below 18 years). Therefore, consult your doctor before receiving it.

Use in geriatrics:

ZOMBISTIN 4.5MIU should be used with caution in elderly patients. Therefore, consult your doctor before receiving it.

INTERACTIONS

A. Drug-Drug Interaction:

Before receiving ZOMBISTIN 4.5MIU, inform your doctor if you are taking any of the following medicines such as:

  • other antibiotics such as aminoglycosides (Ex. netilmicin, gentamicin, amikacin, and tobramycin), cephalosporins (Ex. cefixime, ceftriazone), macrolides (Ex. azithromycin, clarithromycin or erythromycin) or fluoroquinolones (ofloxacin, norfloxacin and ciprofloxacin)
  • muscle relaxant medications (used for relaxing muscles before surgery) Ex. atracurium, vecuronium

Overdosage:

ZOMBISTIN 4.5MIU will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of overdosage might include muscle weakness and breathing difficulties.

SYNOPSIS

Drug :  

Colistin

Pharmacological Category :  

Polypeptide antibiotics

Therapeutic Indication :   Bacterial infection   
Dosage Forms :  

Injections, Syrup, Suspension, Dry suspension, Dry syrup, Tablet

MORE INFORMATION

  • Keep ZOMBISTIN 4.5MIU out of reach of children
  • Store ZOMBISTIN 4.5MIU room temperature

FAQs ABOUT ZOMBISTIN 4.5MIU

What is the use of ZOMBISTIN 4.5MIU?

ZOMBISTIN 4.5MIU is an antibiotic used to treat serious bacterial infections. It is used only when other antibiotics are not suitable for you. It acts by killing the susceptible bacteria that causes infection.

What ZOMBISTIN 4.5MIU does to my body?

ZOMBISTIN 4.5MIU kills the susceptible bacteria that causes infection. It acts by disrupting the composition (lipids and protein) of the bacterial cell membrane and enters the bacterial cell. This causes the contents of the bacterial cell to leak out which subsequently leads to bacterial killing. It may also inactivate the effects of toxins produced by the harmful bacteria.

What are the side effects of ZOMBISTIN 4.5MIU?

The most common side effects of receiving ZOMBISTIN 4.5MIU are stomach upset, tingling sensation in the extremities, loss of sensation, fever, or dizziness. Contact your doctor if any of these side effect worsens.

How ZOMBISTIN 4.5MIU is administered?

ZOMBISTIN 4.5MIU will be given to you only by a doctor or nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the infection.

Can ZOMBISTIN 4.5MIU be used in children?

Yes. ZOMBISTIN 4.5MIU can be used in children and adolescents (aged below 18 years) if prescribed by the physician. Your doctor will decide the suitable dose for your child based on their age, body weight and severity of infection.

What precautions do I need to follow while taking ZOMBISTIN 4.5MIU?

Before receiving ZOMBISTIN 4.5MIU, inform your doctor if you have any kidney problems. You must also inform your doctor if you have any inherited blood or muscle disorders or if you are pregnant or breastfeeding before receiving ZOMBISTIN 4.5MIU. Complete the full course of antibiotic therapy as insisted by your doctor. Regularly check your kidney functions without fail while undergoing therapy with ZOMBISTIN 4.5MIU. Consult your doctor if you experience any unusual side effects after receiving ZOMBISTIN 4.5MIU.

What medicines should I avoid while taking ZOMBISTIN 4.5MIU?

Avoid taking other antibiotics along with ZOMBISTIN 4.5MIU without consulting your doctor. Concomitant use of antibiotics along with ZOMBISTIN 4.5MIU may potentiate the effects of ZOMBISTIN 4.5MIU and may lead to unwanted side effects.

Is ZOMBISTIN 4.5MIU safe?

ZOMBISTIN 4.5MIU is generally safe when used in the doses recommended by your doctor. Therefore, carefully follow your doctor's instructions and inform your doctor immediately if you experience any unpleasant side effects after receiving ZOMBISTIN 4.5MIU.

Can I take ZOMBISTIN 4.5MIU during pregnancy?

ZOMBISTIN 4.5MIU should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before receiving it.

REFERENCES

1. K.D. Tripathi. Macrolide and Other antibacterial antibiotics. Essential of Medical Pharmacology. Seventh edition. Page – 759.

2. Ferdinando F. Andrade, Daniela Silva,  Acacio Rodrigues, and Cidalia Pina-Vaz. National Library of Medicine. Colistin Update on Its Mechanism of Action and Resistance, Present and Future Challenges. NIH. National Library of Medicine. National Centre of Biotechnology Information. PMC PubMed Central. November 2020. [Accessed on 4th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692639/

3. Beacon Pharmaceuticals Limited. Electronic Medicines Compendium (EMC). [Revised in November 2020] [Accessed on 4th April 2022] https://www.medicines.org.uk/emc/files/pil.5648.pdf

4. Teva. UK Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 30th June 2022] https://www.medicines.org.uk/emc/files/pil.9664.pdf

5. Biocon Biologics India Limited. Colistimethate Sodium for Injection IP ® Koolistin 1MIU/ 2MIU / 3MIU / 4.5MIU. Biocon. Ltd. [Revised in July 2019]. [Accessed on 30th June 2022] https://www.biocon.com/docs/domestic-market-pi/ccd/KOOLISTIN%201_2_3_4.5%20MIU%20Leaflet.pdf

6. Cipla Ltd. XYLISTIN 0.5 MIU Injection (Colistimethate Sodium for Injection IP (Lyophilized)). Ciplamed. [Revised in February 2020]. [Accessed on 30th June 2022] https://ciplamed.com/content/xylistin-05-miu-injection

7. Monarch Pharmaceuticals, Inc. [Revised in October 2006] [Accessed on 4th April 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050108s026lbl.pdf

8. Pharmaceutical Partners of Canada Inc. [Revised in February 2013] [Accessed on 4th April 2022] https://pdf.hres.ca/dpd_pm/00025454.PDF

USEFUL DIAGNOSTIC TESTS

  • Complete Blood count

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    20 g
    Ingredient
    COLISTIMETHATE SODIUM 4500000IU
    Hsn Code
    30042097
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