ZOLEPHOS contain zoledronic acid which belongs to a group of medicine called bisphosphonates. It is used to prevent bone complications such as fractures, bone metastases in adult patients and helps in reducing the amount of calcium in the blood in a condition called tumour-induced hypercalcaemia (TIH) in adult patients. Tumour can accelerate normal bone change in such a way that the release of calcium from bone is increased.
ZOLEPHOS works by suppressing the activity of osteoclasts, cells that cause destruction of bone. This strengthens the bone and minimize the risk of fracture. This medicine is strictly not recommended for use in children and adolescents under 18 years of age. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
ZOLEPHOS works by suppressing the activity of osteoclasts, cells that cause destruction of bone. This strengthens the bone and minimize the risk of fracture.
ZOLEPHOS will be administered by a doctor or nurse. It will be given as a drip (infusion) into a vein. Your doctor will decide the dose and frequency depending on your condition.
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Fever:
Drink plenty of fluids and water. Avoid taking cold bath or showers.
Nausea and vomiting:
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
ZOLEPHOS is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
ZOLEPHOS is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
Do not drive or operate any machine while taking this medicine as it may cause drowsiness, sleepiness.
Consumption of alcohol is not recommended during treatment with ZOLEPHOS.
ZOLEPHOS should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
Do not take ZOLEPHOS if you are allergic (hypersensitive) to zoledronic acid or any other ingredients in this medicine.
Tell your doctor if you have or had a condition such as,
Talk to your doctor if you are taking,
Drug | : | Zoledronic acid |
Pharmacological Category | : | Bisphosphonate Derivative |
Therapeutic Indication | : | Bone complications |
Dosage Forms | : | Injection |
Store below 20-25°C and keep out of reach of children.
Can I take ZOLEPHOS during pregnancy?
No, it is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your Doctor.
Can I take ZOLEPHOS during breastfeeding?
No, it is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your Doctor.
Can ZOLEPHOS cause headache?
Yes, this medicine may cause headache in some individuals. Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 4229-4231.
2. J R Berenson 1. Zoledronic acid in cancer patients with bone metastases: results of Phase I and II trials. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Apr 2001. [Accessed 21 Dec 2020] https://pubmed.ncbi.nlm.nih.gov/11346862/
3. Agila Specialties Polska Sp. Zo.; Electronic Medicines Compendium (EMC); [Revised on 20 Oct 2015] [Accessed 21 Dec 2020] https://www.medicines.org.uk/emc/files/pil.7205.pdf
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