INTRODUCTION

ZINIMET 850MG TABLET contains Metformin which belongs to the group of medicines called Anti-diabetic agents. It is used to treat Type II diabetes mellitus when diet and exercise alone does not result in adequate blood sugar control.

Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.

ZINIMET 850MG TABLET works by making your body utilize more amount of circulating blood glucose. It is suitable for use both in adults and in children (aged 10 years or older).

Along with the therapy, your doctor might ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise and quitting alcohol consumption.

Before taking ZINIMET 850MG TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently.

ZINIMET 850MG TABLET is not recommended for use in patients with severe uncontrollable diabetes. It is also not suitable for use in patients with shock or problems in breathing or blood circulation.

Consult your doctor before taking ZINIMET 850MG TABLET if you are pregnant or breastfeeding. The most common side effects of taking ZINIMET 850MG TABLET are nausea, stomach upset and diarrhea. These side effects can be controlled when ZINIMET 850MG TABLET is taken along with meals. However, if these side effect bothers you or worsens contact your doctor.

USES OF ZINIMET 850MG TABLET

It is used in adults and in children (aged 10 years or older) to treat:

• Type II diabetes mellitus

HOW ZINIMET 850MG TABLET WORKS

ZINIMET 850MG TABLET is an antidiabetic medicine. It makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose, thereby reducing blood sugar levels. Additionally, it also prevents glucose production by the liver and reduces its absoprtion in the body.

DIRECTIONS FOR USE

Take ZINIMET 850MG TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking ZINIMET 850MG TABLET unless your doctor advice you to stop.

SIDE EFFECTS OF ZINIMET 850MG TABLET

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

Nausea And Vomiting

Take ZINIMET 850MG TABLET with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your nausea worsens.

WARNING & PRECAUTIONS

PREGNANCY

Monitoring required

ZINIMET 850MG TABLET should be used during pregnancy only if it is considered necessary by the physician. Therefore, inform your doctor before taking ZINIMET 850MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby.

BREASTFEEDING

Contraindicated

ZINIMET 850MG TABLET is not recommended for use in breastfeeding women. However, consult your doctor before taking it.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any heavy tools or machines if your ability is affected by ZINIMET 850MG TABLET.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol while taking ZINIMET 850MG TABLET as it may increase the risk of unwanted side effects.

KIDNEY

Contraindicated

ZINIMET 850MG TABLET is not recommended for use in patients with severe kidney problems (including kidney infections). Therefore, consult your doctor before taking it.

LIVER

Consult your doctor

ZINIMET 850MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.

ALLERGY

Contraindicated

Do not take ZINIMET 850MG TABLET if you are allergic to Metformin.

LUNGS

Contraindicated

ZINIMET 850MG TABLET is not recommended for use in patients with severe infection of lungs or respiratory tract. Therefore, consult your doctor before taking it.

HEART DISEASE

Contraindicated

ZINIMET 850MG TABLET is not recommended for use in patients with heart problems (such as acute heart failure or a recent heart attack). Therefore, consult your doctor before taking it.

USE IN PEDIATRICS

Consult your doctor

ZINIMET 850MG TABLET should be used in children and adolescents (aged 10 years or older) only if prescribed by the physician. It is not recommended for use in children (aged below 10 years). However, consult your doctor before taking it.

USE IN GERIATRICS

Use with Caution

ZINIMET 850MG TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Before taking ZINIMET 850MG TABLET, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to treat diabetes (Ex. teneligliptin, rosiglitazone, pioglitazone, glimepiride)
• diuretics (used to reduce edema and to treat hypertension) Ex. furosemide, hydrochlorothiazide
• medicines used to treat pain and inflammation (such as ibuprofen and celecoxib)
• medicines used to treat high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
• medicines used to treat asthma (Ex. salbutamol or terbutaline)
• corticosteroids (used to treat pain and inflammation) Ex. hydrocortisone, prednisolone
• verapamil (a medicine used to treat heart problems)
• rifampicin (a medicine used to treat tuberculosis)
• cimetidine (a medicine used to treat stomach ulcer)
• dolutegravir (a medicine used to treat HIV infection)
• ranolazine (a medicine used to treat chest pain)
• trimethoprim (a medicine used to treat bacterial infection)
• vandetanib, crizotinib and olaparib (medicines used to treat cancer)
• isavuconazole (a medicine used to treat fungal infection)

Overdosage:

If you or anyone else accidentally take more ZINIMET 850MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.

SYNOPSIS

MORE INFORMATION

• Keep ZINIMET 850MG TABLET out of the sight and reach of children
• Store ZINIMET 850MG TABLET below 30°C

FAQs ABOUT ZINIMET 850MG TABLET

Q: What is ZINIMET 850MG TABLET used for?

A: ZINIMET 850MG TABLET is an antidiabetic medicine used to treat Type II diabetes mellitus when diet, exercise and lifestyle changes alone does not result in adequate response.

Q: How and when to take ZINIMET 850MG TABLET?

A: Take ZINIMET 850MG TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: How long should I take ZINIMET 850MG TABLET?

A: You need to take ZINIMET 850MG TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: What is the best time to take ZINIMET 850MG TABLET?

A: ZINIMET 850MG TABLET must be taken with meals to avoid gastrointestinal side effects.

Q: What to do if I forgot to take a dose of ZINIMET 850MG TABLET?

A: If you forgot to take a dose of ZINIMET 850MG TABLET, take it as soon as you remember. However, if it is time for the next dose of ZINIMET 850MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of ZINIMET 850MG TABLET to compensate the missed ones.

Q: What are the most common side effects of taking ZINIMET 850MG TABLET?

A: The most common side effects of taking ZINIMET 850MG TABLET are nausea, stomach upset and diarrhea. These side effects can be controlled when ZINIMET 850MG TABLET is taken along with meals. However, if these side effect bothers you or worsens contact your doctor.

Q: Can I stop taking ZINIMET 850MG TABLET without consulting your doctor?

A: No. You should not stop taking ZINIMET 850MG TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using ZINIMET 850MG TABLET, consult your doctor for advice.

Q: Will taking a higher dose of ZINIMET 850MG TABLET be more effective?

A: No, taking a higher dose of ZINIMET 850MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: What precautions do I need to follow while taking ZINIMET 850MG TABLET?

A: Before taking ZINIMET 850MG TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results. Consult your doctor before taking ZINIMET 850MG TABLET if you are pregnant or breastfeeding.

Q: Can I take medication for high blood pressure along with ZINIMET 850MG TABLET?

A: It is not advisable to take medicines to control blood pressure while taking ZINIMET 850MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with ZINIMET 850MG TABLET as they have known interactions with ZINIMET 850MG TABLET.

Q: What should I do if I experience low blood sugar after taking ZINIMET 850MG TABLET?

A: ZINIMET 850MG TABLET is unlikely to cause low blood sugar unless combined with other anti-diabetic medicine. However, if you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat), consume a sugary snack or sugar drink immediately. Consult your doctor if the symptom did not improve.

Q: Can ZINIMET 850MG TABLET be taken with insulin?

A: Co-administration of ZINIMET 850MG TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.

Q: Can ZINIMET 850MG TABLET be used in pregnant women?

A: ZINIMET 850MG TABLET should be used during pregnancy only if it is considered necessary by the physician. Therefore, consult your doctor for advice.

Q: How to take ZINIMET 850MG TABLET?

A: You must take ZINIMET 850MG TABLET as advised by your physician. Try to take this medicine preferably after meals and swallow it with a glass of water. Do not crush or chew the medicine.

Q: How much ZINIMET 850MG TABLET should I take?

A: ZINIMET 850MG TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

REFERENCES

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275.

2. Calette Corcoran; Tibb F. Jacobs. Metformin. StatPearls [Internet]. NIH. National Library of Medicine. National center for biotechnology information. PMC. PubMed Central. [Revised on May 2022]. [Accessed on 14th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK518983/#article-25065.s3

3. Shuyan Gu, Jihao Shi, Zhiliu Tang, Monika Sawhney, Huimei Hu, Lizheng Shi, Vivian Fonseca, Hengjin Dong. Comparison of Glucose Lowering Effect of Metformin and Acarbose in Type 2 Diabetes Mellitus: A Meta-Analysis. PLOS ONE. May 2015. [Accessed on 14th October 2022] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126704

4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 14th October 2022] https://www.medicines.org.uk/emc/files/pil.594.pdf

5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 14th October 2022] https://www.medicines.org.uk/emc/files/pil.11951.pdf

6. Merck Santé S.A.S. U.S. Food & Drug Administration. [Revised in April 2017] [Accessed on 14th October 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf

7. Franco Indian Pharmaceuticals Pvt Ltd. GLYCIPHAGE® GLYCIPHAGE 850® GLYCIPHAGE 250®TABLETS. (ORAL ANTI-HYPERGLYCEMIC AGENT). [Accessed on 14th October 2022] http://diabetix-francoindian.com/glyciphage.html

USEFUL DIAGNOSTIC TESTS

• Glucose-Fasting Blood
• Glucose-Postprandial Blood
• Glycosylated Hemoglobin

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 14 Mar 2023 | 05:28 PM(IST)