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INTRODUCTION
ZILZOX 80 TABLET contains Azilsartan which belongs to the group of medicines called Anti-hypertensives. It is used to treat high blood pressure (hypertension). This medicine used alone or in combination with other antihypertensive agents.
High blood pressure (hypertension) is the force that a person’s blood exerts against the walls of their blood vessels. This pressure depends on the resistance of the blood vessels and how hard the heart has to work.
Along with the treatment with ZILZOX 80 TABLET your doctor might ask you to make some lifestyle changes such as exercising often, limit salt intake, managing stress, weight management and quit alcohol and smoking. Prior to the treatment your doctor might want you take some blood tests to assess your condition.
Before taking ZILZOX 80 TABLET inform your doctor if you have kidney, heart or liver disease, diabetes, primary hyperaldosteronism (disease of adrenal gland), aortic or mitral valve stenosis (narrowing of valves in heart, and obstructive hypertrophic cardiomyopathy (abnormal increase in the thickness of heart muscles).
ZILZOX 80 TABLET is not recommended for use in pregnancy and breast-feeding women. Consult your doctor before taking.
ZILZOX 80 TABLET should not be given to children and adolescents (under 18 years of age) without prior consultations.
The most common side effects are dizziness, diarrhoea, nausea, feeling tired, muscle spasms and low blood pressure. Consult your doctor if any of the above side effects worsens with time.
USES OF ZILZOX 80 TABLET
- Used to treat high blood pressure (hypertension)
HOW ZILZOX 80 TABLET WORKS
ZILZOX 80 TABLET helps in the treatment of high blood pressure by relaxing the blood vessels and making it easier for the heart to pump blood. Azilsartan selectively inhibits angiotensin II from binding to the angiotensin II type-1 receptor (AT1). This receptor inhibition provides the antihypertensive activity of azilsartan because it blocks the pressor effects of angiotensin II. ZILZOX 80 TABLET blocks this effect which in turn lowers down the blood pressure.
DIRECTIONS FOR USE
Take ZILZOX 80 TABLET as advised by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF ZILZOX 80 TABLET
COMMON
- dizziness
- diarrhoea
UNCOMMON
- low blood pressure (feeling of faintness or dizziness)
- tiredness
- swelling of hands, feet, or ankles (peripheral edema)
- nausea
- muscle spasms
Stop taking ZILZOX 80 TABLET and contact your doctor immediately if you experience any of the following side effects:
- difficulties in breathing, or swallowing, swelling of the face, lips, tongue and/or throat
- itching of the skin with raised bumps or welts
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Nausea And Vomiting
Take this medicine with, or just after meals with plenty of water. Stick to simple meals. Avoid eating oily or spicy foods.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedZILZOX 80 TABLET is not recommended in early pregnancy and more than 3 months pregnant, as it may cause serious harm to the baby. Consult your doctor before taking.
BREASTFEEDING
ContraindicatedZILZOX 80 TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel dizzy and tired after taking ZILZOX 80 TABLET.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking ZILZOX 80 TABLET because it might make you feel dizzier and light-headed. Consult your doctor for advice.
KIDNEY
Consult your doctorZILZOX 80 TABLET is not recommended for patients with impaired kidney function. It should be taken with caution in patients who are on dialysis or had renal transplant. Consult your doctor before taking the medicine.
LIVER
Use with CautionZILZOX 80 TABLET should be taken with caution in patients with severe liver disease. Consult your doctor before taking.
ALLERGY
ContraindicatedDo not take ZILZOX 80 TABLET if you are allergic to Azilsartan or to any other ingredients of this medicine.
HEART DISEASE
Use with CautionZILZOX 80 TABLET should be taken with caution in patients having heart disease (heart failure, or recent heart attack), ever had a stroke, mitral valve stenosis (narrowing of valves in heart), obstructive hypertrophic cardiomyopathy (abnormal increase in the thickness of heart muscles). Consult your doctor before taking this medicine.
USE IN PEDIATRICS
Consult your doctorThere is limited data on the use of ZILZOX 80 TABLET in children and adolescents (under 18 years of age). Hence, consult your doctor before taking the medicine.
USE IN GERIATRICS
Use with CautionZILZOX 80 TABLET should be used with caution in elder patients (above 75 years of age). Consult your doctor before taking.
OTHERS
ZILZOX 80 TABLET is not recommended for use if you:
- have diabetes
Before taking ZILZOX 80 TABLET, inform your doctor if you:
- have lost a lot of body salts or fluid (vomiting, diarrhoea)
- have low blood pressure
- have hyperkalaemia (high levels of potassium in blood)
- have primary hyperaldosteronism (disease of adrenal glands)
INTERACTIONS
A. Drug-Drug Interactions:
Before taking ZILZOX 80 TABLET, inform your doctor if you are taking any of the following medicine:
- lithium (used for mental health problems)
- non-steroidal anti-inflammatory drugs (medicines to relieve pain and inflammation) Ex. ibuprofen, diclofenac, celecoxib, acetylsalicylic acid
- potassium supplements, potassium-sparing medicines or salt substitutes containing potassium (medicines that increase the amount of potassium in blood)
- heparin (used for thinning the blood)
- medicines used to reduce blood pressure (Ex. aliskiren, enalapril, lisinopril, ramipril or valsartan, telmisartan, irbesartan)
Overdosage:
If you or anyone else accidentally takes too much of ZILZOX 80 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are feeling faint and dizzy.
SYNOPSIS
| Drug | : | Azilsartan |
| Pharmacological Category | : | Angiotensin II receptor antagonists |
| Therapeutic Indication | : | Hypertension |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep ZILZOX 80 TABLET out of reach of children
- Store at room temperature
FAQs ABOUT ZILZOX 80 TABLET
Q: What if I forget to take a dose of ZILZOX 80 TABLET?
A: If you forget to take a dose of ZILZOX 80 TABLET, do not take an extra dose to compensate for the forgotten dose. Take the next dose on time. Consult your doctor once.
Q: Can ZILZOX 80 TABLET be used in children?
A: There is limited data for the use of ZILZOX 80 TABLET in children. Hence, it should not be given without consulting your doctor.
Q: What precautions should be followed while taking ZILZOX 80 TABLET?
A: Patients taking ZILZOX 80 TABLET must inform their doctor if they have pre-existing kidney, liver or, heart disease as it can lead to severe side effects. Consult your doctor immediately if you experience any such symptoms.
Q: Does ZILZOX 80 TABLET causes hyperkalemia (increased level of potassium in blood)?
A: No. ZILZOX 80 TABLET does not causes hyperkalemia. However, you must inform your doctor if you have raised levels of potassium in your blood or are on medications that causes the increase of potassium.
Q: Can ZILZOX 80 TABLET lead to kidney problems?
A: Yes. ZILZOX 80 TABLET can lead to worsening of kidney problems. It is contraindicated in patients having impaired kidney function and should be used with caution in patients having kidney problems like kidney stones. Consult your doctor before taking.
Q: Can ZILZOX 80 TABLET be stopped suddenly?
A: If you stop taking ZILZOX 80 TABLET, your blood pressure may rise again. Hence, you should not stop taking ZILZOX 80 TABLET before consulting your doctor.
REFERENCES
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Schwinghammer, Cecily V. DiPrio. Hypertension. Pharmacotherapy Handbook. Ninth Edition. 2014. Page – 89.
2. Sum Lam. Azilsartan: a newly approved angiotensin II receptor blocker. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November-December 2011. [Accessed on 21st April 2022] https://pubmed.ncbi.nlm.nih.gov/21983318/#:~:text=Azilsartan%20is%20well%20tolerated%3B%20the,those%20with%20baseline%20risk%20factors.
3. Takeda Ireland Limited. Electronic Medicines Compendium (EMC). [Revised in Jan 2021] [Accessed 21st April 2022] https://www.medicines.org.uk/emc/files/pil.4074.pdf
4. Drugs.com. [Accessed 21st April 2022] https://www.drugs.com/food-interactions/azilsartan-medoxomil.html
5. Drugs.com. [Accessed 21st April 2022] https://go.drugbank.com/drugs/DB08822
6. World Health Organization (WHO). [Accessed 21st April 2022] https://www.who.int/news-room/fact-sheets/detail/hypertension
USEFUL DIAGNOSTIC TESTS
- Serum electrolyte
- Kidney function test
- Cholesterol test
- ECG (Electrocardiogram)
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