INTRODUCTION

ZIELU CREAM contains Luliconazole, which belongs to the group of medicines called Topical Antifungal agents. It is used in the treatment of various fungal infections such as tinea pedis (fungal infection between the toes), tinea cruris (red and itchy rash in the warm and moist areas of the body) and tinea corporis (ringworm fungal infection). Fungal infections can be contagious and spread from one person to another person.

ZIELU CREAM is not recommended for use by pregnant and breastfeeding women unless considered clearly necessary. ZIELU CREAM is not recommended for use in children 12 years of age and below unless clearly necessary. ZIELU CREAM should be used with caution in elderly patients (aged 65 years or above).

Avoid applying ZIELU CREAM to the eyes, mouth or vaginal region. The most common side effects of this medicine are application site reactions such as irritation, itching and stinging. Contact your physician if any of the symptoms worsen.

USES OF ZIELU CREAM

ZIELU CREAM is used to treat various fungal infections such as:

• tinea pedis (athlete's foot)
• tinea cruris (jock itch)
• tinea corporis (ringworm)

HOW ZIELU CREAM WORKS

ZIELU CREAM works by damaging the cell membranes of the fungus (essential for the survival of the fungus as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents) and killing fungi. As a result, ZIELU CREAM relieves discomfort, itching and irritation on the skin.

DIRECTIONS FOR USE

Apply ZIELU CREAM as directed by your physician. It is for external use only. Clean and dry the skin to be treated. Wash your hands with soap and water and apply a thin layer of the medicine to the affected area of the skin and rub it gently. Avoid contact with the eyes, mouth or vaginal area. Do not cover or wrap or bandage the skin unless directed by the doctor.

SIDE EFFECTS OF ZIELU CREAM

WARNING & PRECAUTIONS

PREGNANCY

ZIELU CREAM is generally not recommended for use in pregnant women unless considered necessary. Consult your doctor before taking ZIELU CREAM.

BREASTFEEDING

ZIELU CREAM is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your doctor before taking ZIELU CREAM.

ALLERGY

Do not take ZIELU CREAM if you are allergic to luliconazole or any of the other ingredients of this medicine.

INTERACTIONS

A. Drug-Drug interactions:

Tell your doctor if you are applying or have recently taken any other medicines, including medicines obtained without a prescription, vitamin supplements or herbal products.

Overdosage:

If you or anyone else accidentally use too much of ZIELU CREAM or if you or a child accidentally swallow the medicine, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep ZIELU CREAM out of reach from children
• Store at a room temperature

FAQs ABOUT ZIELU CREAM

Q: Can I use ZIELU CREAM in children?

A: No. ZIELU CREAM is not recommended for use in children 12 years of age and below unless clearly necessary. Contact your doctor before applying it.

Q: How to apply ZIELU CREAM?

A: Apply ZIELU CREAM as directed by your physician. It is for external use only. Clean and dry the skin to be treated. Wash your hands with soap and water and apply a thin layer of the medicine to the affected area of the skin and rub it gently. Avoid contact with the eyes, mouth or vaginal area. Do not cover or wrap or bandage the skin unless directed by the doctor.

Q: When to seek medical emergency while using ZIELU CREAM?

A: Stop taking ZIELU CREAM and contact your doctor immediately if you experience an allergic reaction (symptoms like skin rash, itching or hives, swelling of the face, lips or tongue), increased inflammation, redness and pain.

Q: How does ZIELU CREAM work?

A: ZIELU CREAM works by causing holes in the cell membranes of the fungus (essential for the survival of the fungus as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents) and killing fungi. In this way, Luliconazole relieves discomfort, itching and irritation on the skin.

Q: What is the use of ZIELU CREAM?

A: ZIELU CREAM is used in the treatment of various fungal infections such as tinea pedis (athlete's foot), tinea cruris (jock itch) and tinea corporis (ringworm). Please consult your physician before using ZIELU CREAM.

Q: Is it safe to take ZIELU CREAM in pregnant and breastfeeding women?

A: ZIELU CREAM is not recommended for use among women who are pregnant and breastfeeding unless considered necessary. Please consult your physician before using ZIELU CREAM.

Q: What are the common side effects of ZIELU CREAM?

A: The most common side effects of this medicine are application site reactions such as irritation, itching and stinging. Contact your physician if any of the symptoms worsen.

REFERENCES

1. P. David Rogers and Damian J. Krysan. Antifungal Agents. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 1087-1104.

2. Deepshikha Khanna and Subhash Bharti. Luliconazole for the treatment of fungal infections: an evidence-based review. Journal of Core Evidence. September 2014 [Accessed on 11th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181444/

3. Manjot Kaur, Guru Nanak Dev, Kanwardeep Singh & Subheet Kumar Jain. Luliconazole vesicular-based gel formulations for its enhanced topical delivery. Journal of Liposome Research. October 2019. [Accessed on 11th July 2022] https://www.tandfonline.com/doi/abs/10.1080/08982104.2019.1682602?journalCode=ilpr20

4. Hiroyasu Koga, Yasuko Nanjoh, Koichi Makimura, Ryoji Tsuboi. In vitro antifungal activities of luliconazole, a new topical imidazole. Journal of Medical Mycology. September 2009. [Accessed on 11th July 2022] https://academic.oup.com/mmy/article/47/6/640/969830

5. Medicis Pharmaceuticals. US Food and Drug Administration. [Revised in November 2013] [Accessed on 11th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/204153s000lbl.pdf

6. Bausch Health Companies Inc. Luliconazole. [Revised in April 2020] [Accessed on 11th July 2022] https://pi.bauschhealth.com/globalassets/BHC/PI/Luzurx-PI.pdf

7. Taj Pharma. Luliconazole. [Revised in January 2019] [Accessed on 11th July 2022] https://issuu.com/tajpharma904/docs/luliconazole_cream_pil__taj_pharmac

8. DM Pharma. Luliconazole. [Accessed on 11th July 2022] https://www.dmpharma.co.in/Luliconazole%20Cream.html

9.  Mediboon pharma. Luliconazole. [Accessed on 11th July 2022] https://mediboonpharma.com/product/luliconazole-cream/

10. Integrated Laboratories. Luliconazole. [Accessed on 11th July 2022] https://integratedlaboratories.in/products/luliconazole-cream-1-w-w-lu-con/

11. Glamris Derma care. Luliconazole. [Accessed on 11th July 2022] https://www.glamrisdermacare.com/product/luliris

AUTHOR DETAILS

Written By Dr. Dhivakaran R, BDS
Last updated on 14 Jan 2023 | 01:08 PM(IST)