Tell your doctor if you are taking, have recently taken or might take any of the following medicines:

• other antiepileptics e.g. lamotrigine, phenytoin, fosphenytoin, primidone, sodium valproate, phenobarbitone, ethosuximide, oxcarbazepine, tiagabine, topiramate, vigabatrin, levetiracetam, progabide
• anticoagulants to thin the blood e.g. warfarin, acenocoumarol
• cimetidine or omeprazole, to treat heartburn or stomach ulcers
• medicine to treat mental illness e.g. lithium, haloperidol, thioridazine, olanzapine, risperidone, imipramine, fluoxetine, amitriptyline
• paliperidone or aripiprazole, to treat schizophrenia
• sedatives e.g. clobazam, clonazepam, alprazolam, valnoctamide
• metoclopramide or aprepitant, often used to treat motion sickness
• antibiotics e.g. doxycycline, isoniazid, erythromycin, clarithromycin, ciprofloxacin
• isoniazid, rifampicin (used to treat tuberculosis)
• antifungals e.g. itraconazole, fluconazole, ketoconazole, voriconazole, albendazole
• corticosteroids e.g. prednisolone, dexamethasone
• ciclosporin, tacrolimus or sirolimus, immunosuppressants
• painkillers containing paracetamol, dextropropoxyphene, methadone, tramadol, buprenorphine
• medicine to treat heart conditions e.g. felodipine, isradipine, digoxin, verapamil, diltiazem
• diuretics e.g. furosemide, hydrochlorothiazide
• acetazolamide, to treat glaucoma
• muscle relaxants, often used during operations e.g. pancuronium
• isotretinoin, used to treat acne
• theophylline and aminophylline, for asthma
• danazol and gestrinone (used in the treatment of endometriosis)
• hormonal contraceptives e.g. pills, patches, injections or implants
• tibolone, used as hormone Replacement Therapy (HRT)
• tadalafil, used to treat impotence
• drugs to treat cancer e.g. imatinib, lapatinib, toremifene, cisplatin, doxorubicin, temsirolimus, cyclophosphamide
• mefloquine, used to treat malaria
• drugs to treat HIV known as protease inhibitors (e.g. indinavir, ritonavir, saquinavir)
• levothyroxine to treat hypothyroidism
• antihistamines to treat allergies and hayfever, such as loratadine
• medicine or supplements containing Vitamin B (nicotinamide)

• Always take this medicine exactly as your doctor has told you
• Your doctor is likely to start treatment with a low dose and slowly increase it to suit your own needs
• Swallow the tablet whole, with a glass of water
• Do not chew, crush or suck the tablet

Recommended doses are as follows:

Adults:

• The recommended starting dose is 100 mg to 200 mg of ZEPTOL once or twice daily
• Your doctor will slowly increase this dose to control your fits until the best response is obtained, often 800 to 1200 mg daily in divided doses, although higher doses may be necessary

Use in children and adolescents:

• The recommended daily dose for children between 5 and 10 years old is 400 mg to 600 mg of ZEPTOL, divided up throughout the day
• Children over 10 years old may be given a total daily dose of between 600 mg and 1000 mg of ZEPTOL, divided up throughout the day

Trigeminal Neuralgia

• The starting dose is 200 to 400 mg daily (100 mg twice daily in elderly patients)
• Your doctor may increase the dose until you are free from pain

Treatment of Mood Swings

• The starting dose is 400 mg of ZEPTOL daily, divided up throughout the day. This dose may be increased slowly until your symptoms are controlled or until the maximum daily dose of 1600 mg of ZEPTOL is reached. The usual daily dose range is 400 – 600 mg in divided doses

If you take more ZEPTOL

• If you take more ZEPTOL than you should, contact your doctor or local hospital emergency department immediately

If you forget to take a dose

• If you forget to take a dose take it as soon as you remember unless it is nearly time for your next dose.
• Do not take double dose to make up for a forgotten dose

If you stop taking ZEPTOL

• If you stop taking ZEPTOL suddenly you may suffer unpleasant side effects. Always ask your doctor first before stopping the treatment