ZEMOSAL 500mg Tablet 10's

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Please note, before you can choose the low cost generic option, please ask your doctor to add the generic drug to your prescription.

Drug Information for ZEMOSAL 500mg Tablet 10's

What is ZEMOSAL?

  • ZEMOSAL contains sulfasalazine which is an anti-inflammatory drug and belongs to a group of medicines called amino salicylates







What ZEMOSAL is used for?

  • ZEMOSAL are used to control the flare-ups of ulcerative colitis. They may also be used at lower doses to prevent more flare-ups of ulcerative colitis
  • ZEMOSAL are used to control the flare-ups of Crohn’s Disease
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Warnings & Precautions
Tell your doctor before taking this medicine, if you:

  • are allergic (hypersensitive) to sulphasalazine any of the ingredients of ZEMOSAL
  • are allergic to salicylates or sulfonamides
  • have a disease known as porphyria
  • have any problems with your liver or kidneys
  • ever had asthma or arthritis
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  • If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine
  • You should avoid breast-feeding while taking this medicine. There have been reports of diarrhoea or blood in the stools of babies of breast-feeding mothers taking ZEMOSAL
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  • ZEMOSAL are not to be used in children under 2 years of age
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  • ZEMOSAL are unlikely to affect your ability to drive or use machinery
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Tell your doctor if you are taking the following medicines as they may interact with this medicine.

  • Medicine used to management of high blood sugar/diabetes,
  • Methenamine, an antibiotic for treating urinary tract infections
  • Digoxin, used to treat heart failure
  • Folate, sometimes taken during the first few weeks of pregnancy to reduce the risk of neural tube defects, e.g. Spina Bifida
  • Azathioprine and Mercaptopurine, drugs used to help to suppress your body’s immune response in organ transplantation and certain chronic inflammations (e.g. rheumatoid arthritis)
  • Methotrexate, used to treat rheumatoid arthritis
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  • The tablet should be taken with a glass of water and should be swallowed whole
  • Do not crush or chew the tablet

The usual doses for the following conditions are:

Ulcerative Colitis

Adults and the Elderly

Severe Flare-Ups

  • 2-4 tablets four times a day, with other medicines such as steroids
  • Do not leave more than 8 hours between the evening and following morning dose

Mild/Moderate Flare-Up

  • 2-4 tablets four times a day, but not always with other medicines

Maintenance dose to control your flare ups

  • Once the flare-up is controlled the dose is slowly reduced to 4 tablets each day. Your doctor will tell you how to reduce your dose. This lower dose may be continued for some time to help stop other flare-ups

Children 2 years of age and over

  • Your doctor will tell you what dose your child will need to use. This will be based on your child’s weight

How long you use these tablets depends on how well the tablets suit you.

For Ulcerative Colitis and Crohn’s Disease

  • The tablets should start to work in a few days
  • If they work well, you may be using them for some time because inflammatory bowel disease may be a lifelong condition
  • Don’t stop using the tablets just because you feel better without talking to your doctor

If you take more of ZEMOSAL 

  • If you take more this medicine than you should, contact your nearest hospital casualty department

If you forget to take ZEMOSAL

  • If you forget to take a dose, just take the next dose as usual
  • Do not double dose the next dose to make up for a missed one

If you stop taking ZEMOSAL 

  • Your doctor will advise you how long to take this medicine
  • Your condition may return if you stop using this medicine before you are advised
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Like all medicines, the medicine can cause side effects, although not everybody gets them.






  • an allergic reaction such as sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips, rash or itching (especially affecting the whole body)
  • bruising, fever, rash, pallor (paleness), a severe sore throat or tiredness
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  • dizziness
  • difficulty sleeping
  • headache
  • changes in taste
  • abdominal pains
  • being sick
  • ringing in the ears
  • blood shot eyes
  • inflamed mouth (stomatitis)
  • cough
  • itching of the skin
  • joint pain
  • feeling sick (nausea)
  • fever
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  • depression
  • fits, jerky, uncontrolled movements
  • loss of balance
  • shortness of breath
  • hair loss
  • hives
  • puffiness around the eyes and face
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  • inflammation of the lining of the brain
  • severe diarrhoea
  • other blood disorders including anaemia, enlarged glands (lymph nodes)
  • blood vessel inflammation
  • loss of appetite
  • hallucinations
  • changes in mental state or smell
  • inflammation of the sac surrounding the heart or heart muscle
  • bluish tint to skin due to poor circulation
  • lung complications with breathlessness
  • inflammation of the salivary glands on either side of the face
  • kidney inflammation and kidney pain
  • liver disease (hepatitis)
  • rash, reddening or blistering of the skin, eczema,
  • tingling, numbness, pain in hands and feet
  • blood in urine
  • temporary infertility in men. Fertility returns when treatment is stopped. Normal contraception should still be used
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  • permanent staining of extended wear soft contact lenses
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  • Ulcerative Colitis is an inflammatory disease which affects only the large bowel (colon and back passage). The lining of the bowel becomes inflamed (red and swollen) and symptoms include abdominal pain and diarrhoea (which may contain blood and mucus)
  • Crohn’s disease is an inflammatory disease which may affect any part of the digestive system from the mouth to the anus, but it most commonly affects the last part of the small bowel and the first part of the large bowel. Symptoms include abdominal pain and diarrhoea (which may be bloody)
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  • Keep out of the reach of children
  • Do not use this medicine after the expiry date
  • Store your tablets between (15-25°C)
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The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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