INTRODUCTION

ZELIS 5MG contains Lisinopril which belongs to a group of medicines called Angiotensin converting enzyme (ACE) inhibitors. ACE inhibitors lowers blood pressure by widening blood vessels which allows the blood to flow more easily and reduces the effort needed to pump blood around the body. It is used to treat high blood pressure (hypertension), heart failure, kidney problems in diabetic patients with high blood pressure and also used if you have recently had a heart attack (myocardial infarction).

Lisinopril is long-acting angiotensin converting enzyme inhibitor. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. The inhibition of ACE results in reducing stress on the heart and relaxes blood vessel so that blood flows more smoothly and the heart can pump blood more efficiently.

Always take this ZELIS 5MG exactly as directed by your doctor. Before taking this medicine, tell your doctor if you have liver, kidney or heart problems, pregnant women and breastfeeding mothers. It is not suitable for use in children below 6 years of age. The common side effects are dizziness, headache, cough, diarrhoea and vomiting.

USES OF ZELIS 5MG

• high blood pressure (hypertension)
• heart failure

HOW ZELIS 5MG WORKS

ZELIS 5MG is long-acting angiotensin converting enzyme inhibitor. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II which also stimulates aldosterone secretion by the adrenal cortex. It works by reducing stress on the heart and relaxing blood vessel so that blood flows more smoothly and the heart can pump blood more efficiently.

DIRECTIONS FOR USE

Always take ZELIS 5MG exactly as your doctor has told you. Swallow the medicine as a whole, with a glass of water. Do not crush or chew. It can be taken with or without food.

SIDE EFFECTS OF ZELIS 5MG

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.

Cough:

Drink more fluids and suck hard candies which helps to ease dry cough and soothe an irritated throat.

WARNING & PRECAUTIONS

INTERACTIONS

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• racecadotril (used to treat diarrhoea)
• ciclosporin, temsirolimus, sirolimus, everolimus (used to prevent organ transplant rejection)
• vildagliptin, gliclazide and metformin (used to treat diabetes)
• sacubitril/ valsartan, telmisartan, irbesartan (used to treat a type of long-term heart failure)
• heparin (used to thin blood clots)
• amiloride, triamterene, spironolactone
• trimethoprim and cotrimoxazole
• lithium, amitriptyline (used to treat mental illnesses)
• indomethacin, acetylsalicylic acid, celecoxib, rofecoxib (used to treat pain and inflammation)
• sodium aurothiomalate (used to treat arthritis)
• glyceryl trinitrate (help to lower blood pressure)
• ephedrine or pseudoephedrine (used to treat cough or cold)
• lidocaine (anaesthetic medicine)
• allopurinol (used to treat gout)
• procainamide (used to treat abnormal heart rhythms)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT ZELIS 5MG

What is ZELIS 5MG used for?

It is used to treat high blood pressure (hypertension), heart failure, kidney problems in diabetic patients with high blood pressure and also used if you have recently had a heart attack (myocardial infarction).

What are the side effects of ZELIS 5MG?

The common side effects are dizziness, headache, cough, diarrhoea and vomiting. If these reactions persist, consult your doctor for advice.

Is ZELIS 5MG safe?

It is safe if used at prescribed doses for the prescribed duration as directed by the doctor.

REFERENCES

1. KD Tripathi MD. Drugs affecting renin-angiotensin system and plasma kinins. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 503.

2. Hilal-Dandan R. Renin and Angiotensin. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 733.

3. Pfeffer MA, Opie LH. Inhibitors of the Renin-Angiotensin-Aldosterone System. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. Page -144-45.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 807-809.

5. Edgardo Olvera Lopez, Mayur Parmar; Venkata Satish Pendela and Jamie M. Terrell. Lisinopril, Dec 2, 2020 [Accessed Dec 28, 2020] https://www.ncbi.nlm.nih.gov/books/NBK482230/

6. Mylan UK Healthcare Limited, Gerard Laboratories, Electronic Medicines Compendium (EMC); [Revised July, 2019] [Accessed Dec 28, 2020] https://www.medicines.org.uk/emc/files/pil.10115.pdf

7. AstraZeneca Pharmaceuticals LP; 2008, U.S. Food & Drug Administration [Accessed Dec 28, 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019777s054lbl.pdf

8. AstraZeneca Pharmaceuticals LP; 1988, U.S. Food & Drug Administration [Revised on 2014] [Accessed Dec 28, 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019777s064lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Kidney function test