Z SAR H 50mg Tablet 10's

INTRODUCTION

Z SAR H 50MG is a combination of Hydrochlorothiazide and Losartan which belongs to the group of medicines called Thiazide like diuretics and Angiotensin II receptor antagonists respectively. Z SAR H 50MG is indicated for the treatment of essential hypertension. Essential hypertension (also known as high blood pressure) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high, and as a result it may lead to severe damage to the blood vessels of several organs, thus causing heart attack, heart or kidney failure, stroke, or even blindness.    

Losartan is an Angiotensin-receptor blocker which effectively reduces blood pressure by blocking the actions of Angiotensin – II (a substance that causes narrowing of blood vessels and increase in blood pressure) and hydrochlorothiazide is a diuretic which acts by increasing urine output, thus leading to a decrease in blood pressure. During treatment with Z SAR H 50MG your doctor might regularly monitor your blood pressure, kidney function and electrolyte levels at regular intervals to avoid any untoward side effects.

Z SAR H 50MG is not suitable for use in children (aged less than 18 years) and in adult patients with severe kidney or liver impairment. Long-term use of Z SAR H 50MG may increase the risk of some types of skin and lip cancer, and therefore always protect your skin from sun rays and UV exposure. Z SAR H 50MG is not recommended for use in breast-feeding women and pregnant women (especially after 3 months of gestation), as it may cause potential harm to the unborn baby. The most common side effects of Z SAR H 50MG are cough, diarrhea, stomach pain, dizziness, tiredness, and headache. Consult your doctor if any of the symptom bothers you. 

USES OF Z SAR H 50MG

• Treats essential hypertension

HOW Z SAR H 50MG WORKS

Z SAR H 50MG reduces elevated blood pressure, where hydrochlorothiazide works by making the kidneys pass more water and salt (i.e., urine) and losartan works by inhibiting the binding of angiotensin II (a substance produced in the kidneys which causes narrowing of blood vessels) to its receptors, thus causing the blood vessels to relax which in turn decreases elevated blood pressure.

DIRECTIONS FOR USE

Take Z SAR H 50MG as advised by your physician. Swallow Z SAR H 50MG with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. 

SIDE EFFECTS OF Z SAR H 50MG

HOW TO MANAGE SIDE EFFECTS

 Nausea:

Take Z SAR H 50MG with or just after meals. Stick to simple meals and avoid eating rich or spicy food. If the symptom did not improve, consult your doctor.

Indigestion:

Eat smaller and frequent meals. Try to eat and drink slowly and follow a regular physical activity. If the symptom did not improve, consult your doctor.

Diarrhea:

Drink lots of fluids, such as water, fruit juice or electrolytes to keep yourself hydrated. Avoid taking medicine on your own to treat diarrhea. Consult your doctor if the symptom did not improve on its own.

Stomach pain:

Try to rest and relax. Try to eat and drink slowly or have smaller and frequent meals. Keep a heat pad on your stomach and avoid eating rich or spicy food. If the symptom did not improve, consult your doctor.

Headache:  

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking Z SAR H 50MG inform to your doctor, if you are taking any of these medicines: 

• other medicine used to reduce elevated blood pressure (such as diuretics (Ex. furosemide), aliskiren, ACE inhibitors (Ex. captopril, enalapril), methyldopa)  
• lithium (used to treat mental illness)
• potassium supplements, potassium sparing diuretics such as spironolactone (used to increase potassium levels in blood)
• medicines used to treat gout (Ex. colchicine, indomethacin)
• medicines used to treat abnormal heart rhythm (Ex. digoxin, quinidine, amiodarone)
• medicines used to treat diabetes (Ex. insulin, metformin, glimepiride, teneligliptin)
• corticosteroids (used to treat pain and inflammation) Ex. dexamethasone
• medicines used to treat cancer (Ex.5-flurouracil, doxorubicin, capecitabine)
• non-steroidal anti-inflammatory medicines (Ex. aspirin, ibuprofen)
• medicines used to treat fungal infections (Ex. ketoconazole, fluconazole, itraconazole)
• medicines used to treat arthritis (Ex. methotrexate)
• medicines used to control high cholesterol levels in blood (such as cholestyramine)
• skeletal muscle relaxants (used to relieve muscle pain) Ex. tubocurarine
• medicines which induce sleep (Ex. barbiturates such as amobarbital, diazepam, clonazepam)
• opioid medicines (used to treat pain) such as morphine
• medicines that can cause an increase in blood pressure such as pressor amines (Ex. adrenaline)
• carbamazepine (a medicine used to treat epilepsy)
• calcium salts
• antipsychotics (used to treat psychosis) Ex. aripiprazole, clozapine, olanzapine, risperidone, or quetiapine 
• antidepressants (used to treat depression) Ex. amitriptyline, clomipramine, imipramine, doxepin 
• erythromycin IV (used to treat bacterial infection)
• vincamine IV (used to treat primary degenerative and vascular dementia)
• halofantrine (used to treat malaria)
• anticholinergic agents such as atropine (used to reduce bronchial secretion before surgery)
• pentamidine (used to treat serious lung infection)
• mizolastin or terfenadine (used to treat allergic symptoms such as watery eyes, running nose, sneezing)
• ciclosporin (a medicine used to prevent graft rejection and other auto-immune reactions)
• ACTH (used to control metabolic disorders)
• glycyrrhizin (used to treat bronchitis or other digestive problems)

B. Drug-Food interaction:

While taking Z SAR H 50MG avoid excessive consumption of dietary salt as it may counteract the effect of this medicine.

Overdosage:

If you or anyone else take too much of Z SAR H 50MG, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of Z SAR H 50MG include drop in blood pressure, palpitations, slow pulse, changes in blood composition and dehydration.

SYNOPSIS

MORE INFORMATION

• Keep Z SAR H 50MG out of reach of children
• Store Z SAR H 50MG at room temperature

FAQs ABOUT Z SAR H 50MG

What is Z SAR H 50MG used for?

Z SAR H 50MG is indicated for the treatment of essential hypertension. Essential hypertension (also known as high blood pressure) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high, and as a result it may lead to severe damage to the blood vessels of several organs, thus causing heart attack, heart or kidney failure, stroke, or even blindness.  

Can Z SAR H 50MG cause dizziness?

Yes. Z SAR H 50MG may cause dizziness in you. Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy as precaution. Consult with your doctor for advice before taking Z SAR H 50MG.

Can Z SAR H 50MG be taken during breastfeeding?

Z SAR H 50MG is not recommended for use in breast-feeding mothers. Your doctor may choose another treatment if you wish to breast-feed. Consult your doctor before taking Z SAR H 50MG.

Can Z SAR H 50MG be used in patients with liver disease?

Z SAR H 50MG is not recommended for use in patients with severe liver impairment. It should be used with caution in patients having history of mild to moderate liver impairment. Your doctor may adjust the dose depending upon liver function. Consult your doctor before taking Z SAR H 50MG.    

Does Z SAR H 50MG increases urination?

Yes, Z SAR H 50MG contains hydrochlorothiazide a diuretic agent which works by removing excess fluid from the body through kidneys which leads to increased passage of urination. Excess water loss in body may result in dehydration. During treatment with Z SAR H 50MG if you are always feeling tired, thirsty, or you have muscle cramps constantly, immediately consult your doctor for advice.

What to do If I forget to take Z SAR H 50MG?

You should take Z SAR H 50MG immediately when you remember. If it is time for your next dose skip the missed dose and follow your regular dose schedule. Do not double the dose of Z SAR H 50MG to match up your missed dose.

REFERENCES

1. KD. Tripathi. Drugs Affecting Renin-Angiotensin System and Plasma Kinins. Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 506 & 559.

2. Randa Hilal-Dandan. Renin and Angiotensin. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 738.

3. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2305-2308.

4. Merck Sharp & Dohme Corp. A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome (0954A-331). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in May 2017] [Accessed on 21st August 2021] https://clinicaltrials.gov/ct2/show/NCT00546052

5. J H MacKay, K E Arcuri, A I Goldberg, S M Snapinn, C S Sweet. Losartan and low-dose hydrochlorothiazide in patients with essential hypertension. A double-blind, placebo-controlled trial of concomitant administration compared with individual components. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. February 1996. [Accessed on 21st August 2021] https://pubmed.ncbi.nlm.nih.gov/8572837/

6. L M Ruilope , R L Simpson, J Toh, K E Arcuri, A I Goldberg, C S Sweet. Controlled trial of losartan given concomitantly with different doses of hydrochlorothiazide in hypertensive patients. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 1996. [Accessed on 21st August 2021] https://pubmed.ncbi.nlm.nih.gov/8777471/

7. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 21st August 2021] https://www.medicines.org.uk/emc/files/pil.3083.pdf

8. Actavis Ltd. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 21st August 2021] https://www.medicines.org.uk/emc/files/pil.2909.pdf

9. Merck Sharp & Dohme Corp. U.S. Food & Drug Administration. [Revised in March 2013] [Accessed on 21st August 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020387s057lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Kidney function test