Xtane 25mg Tablet 30'S

Cancer/Oncology Rx required

Best Price*  ₹ 953.96
MRP ₹1,059.96
(Inclusive of all taxes) *30 Tablet(s) in a Strip * Mfr: Natco Pharma Ltd * Country of Origin: India
TOTAL AMOUNT ₹ 1,059.96

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INTRODUCTION

XTANE 25MG contain exemestane which belongs to a group of medicine called aromatase inhibitors. It is used to treat hormone dependent early breast cancer in postmenopausal women after they have completed 2-3 years of treatment with the medicine tamoxifen and hormone dependent advanced breast cancer in postmenopausal women when a different hormonal drugs treatment has not worked well enough.

These medicines interfere with aromatase, which is needed to make the female sex hormones, oestrogens, especially in postmenopausal women. Reduction in oestrogen level in the body is a way of treating hormone dependent breast cancer. Cancer is a disease in which abnormal cell divide uncontrollably and destroy body tissue. Breast cancer is a disease in which cell in the breast grow out of control.

Always take XTANE 25MG exactly as your doctor has told you. This medicine must be taken after food. It is strictly not recommended for use in children and adolescents. Your doctor may perform some blood test to check for vitamin D level or bone density. Do not drive or operate machinery while taking this medicine, since it may cause dizziness, drowsiness, weakness. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, or pancreas problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.

USES OF XTANE 25MG

  • Treat hormone dependent early breast cancer in postmenopausal women after they have completed 2-3 years of treatment with the medicine tamoxifen
  • Treat hormone dependent advanced breast cancer in postmenopausal women when a different hormonal drugs treatment has not worked well enough

HOW XTANE 25MG WORKS

XTANE 25MG works by lowering the amount of estrogen (natural female hormone) produced in the body. This can lower or stop the growth of some breast cancer cell that need estrogen to grow.

DIRECTIONS FOR USE

Always take XTANE 25MG exactly as your doctor has told you. It must be taken after food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.

SIDE EFFECTS OF XTANE 25MG

SERIOUS

  • hypersensitivity reactions
  • inflammation of the liver and inflammation of the bile ducts of the liver which cause yellowing of the skin (cholestatic hepatitis)
  • chest pain, heart failure, or stroke

COMMON

  • depression
  • difficulty sleeping
  • headache, dizziness, nausea, tiredness, vomiting
  • constipation, indigestion, diarrhoea
  • hot flushes
  • increased sweating
  • muscle and joint pain (including osteoarthritis, back pain, arthritis, and joint stiffness)
  • reduction in the number of white blood cell
  • abdominal pain
  • elevated level of liver enzymes
  • elevated levels of a haemoglobin breakdown in the blood
  • elevated levels of a blood enzyme in the blood due to liver damage
  • loss of appetite
  • carpal tunnel syndrome (a combination of pins and needles, numbness and pain affecting all of the hand except the little finger) or tingling/prickling of the skin
  • hair loss
  • skin rash, hives, and itchiness
  • thinning of bone which might decrease their strength (osteoporosis), leading to bone fractures (breaks or cracks) in some cases
  • swollen hands and feet
  • reduction in the number of platelet in the blood
  • feeling of weakness, muscle weakness
  • difficulty in breathing

RARE

  • breakout of small blisters on an area of the skin in a rash
  • drowsiness

HOW TO MANAGE SIDE EFFECTS

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Nausea and vomiting:

Keep try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.

Abdominal pain:

Keep try to rest and relax. eat and drink slowly and smaller and frequent meals. Applying a heat pad or covered hot water bottle on your stomach may also help. If still pain persists, speak to your doctor.

Constipation:

Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.

Diarrhoea:

Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicine without talking to a doctor.

WARNING & PRECAUTIONS

PREGNANCY

XTANE 25MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

XTANE 25MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

Do not drive or operate machinery while taking this medicine, since it may cause dizziness, drowsiness, weakness.

ALCOHOL

Consumption of alcohol is not recommended during treatment with XTANE 25MG.

KIDNEY

XTANE 25MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.

LIVER

XTANE 25MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.

ALLERGY

Do not take XTANE 25MG if you are allergic (hypersensitive) to exemestane or any other ingredients in this medicine.

OTHERS

Tell your doctor, if you:

  • have not attained menopause (you are still having your monthly period)
  • have a history or are suffering from any condition which affects the strength of your bones

INTERACTIONS

Talk to your doctor if you are taking,

  • antibiotic such as rifampicin (used to treat infection)
  • anticonvulsants such as carbamazepine, phenytoin, phenobarbital (used to treat epilepsy)
  • herbal medicine such as St John’s Wort (Hypericum perforatum) (used to treat depression and general inflammation)
  • estrogen medicines

SYNOPSIS

Drug :   Exemestane
Pharmacological Category :  

Antineoplastic agent, Steroidal aromatase inhibitor

Therapeutic Indication :   Hormone dependent early and advanced breast cancer in postmenopausal women
Dosage Forms :   Tablet

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT XTANE 25MG

Can I stop taking XTANE 25MG?

Do not stop taking this medicine without talking to your doctor, even if you start to feel well.

What are the most common side effects of using XTANE 25MG?

The most common side effects are hot flashes, feeling tired, joint pain, headache, trouble sleeping, increased sweating, depression, feeling anxious, upset stomach and difficulty in breathing.

Can XTANE 25MG cause diarrhoea?

Yes, this medicine may cause diarrhoea in some individuals. Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicine without talking to a doctor.

REFERENCES

1. KD Tripathi. Estrogens, Progestins and Contraceptives. Essentials of Medical Pharmacology. Seventh edition,2013. Page - 315.

2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page -1513 - 1514.

3. Per E Lønning 1, Jürgen Geisler, Lars E Krag, Bjørn Erikstein, Yngve Bremnes, Anne I Hagen, Ellen Schlichting, Ernst A Lien, Erik S Ofjord, Jolanda Paolini, Anna Polli, Giorgio Massimini. Effects of exemestane administered for 2 years versus placebo on bone mineral density, bone biomarkers, and plasma lipids in patients with surgically resected early breast cancer. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. 1 Aug 2005 [Accessed 06 Nov 2020] https://pubmed.ncbi.nlm.nih.gov/15983390/

4. Pfizer Italia S.r.l; Electronic Medicines Compendium (EMC); [Revised on Nov 2018] [Accessed 06 Nov 2020] https://www.medicines.org.uk/emc/files/pil.3937.pdf

5. Pfizer Inc 1999; U.S. Food & Drug Administration; [Revised on Mar 2011] [Accessed 06 Nov 2020] http://shijiebiaopin.net/upload/product/201232718112629.PDF

6. Synthon BV; Electronic Medicines Compendium (EMC); [Revised on Mar 2015] [Accessed 06 Nov 2020] https://www.medicines.org.uk/emc/files/pil.4664.pdf

7. S.C. Sindan-Pharma SRL; Electronic Medicines Compendium (EMC); [Revised on Jul 2015] [Accessed 06 Nov 2020] https://www.medicines.org.uk/emc/files/pil.4663.pdf

8. Accord Healthcare Limited; Electronic Medicines Compendium (EMC); [Revised on Mar 2019] [Accessed 06 Nov 2020] https://www.accord-healthcare.com/ie/sites/default/files/pil/pil_exemestane-25-mg_website.pdf

USEFUL DIAGNOSTIC TESTS

  • breast Cancer (CA 15.3/ ER/ PR)

Manufacturer/Marketer Details

    Net Qty
    1
    Shelf Life
    NA
    Item Weight
    40
    No. of Units in a Kit
    NA
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Xtane 25mg Tablet 30'S

Xtane 25mg Tablet 30'S Mfr: Natco Pharma Ltd

M.R.P.: Rs.1,059.96
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