INTRODUCTION

XRATE DX SYRUP is a combination of Chlorpheniramine, Dextromethorphan and Phenylephrine which belongs to the group of medicines called Antihistamines, Antitussives and Decongestants respectively. It is used to relieve dry cough and other symptoms associated with upper respiratory tract infections like the common cold or allergies.

The common cold is a viral infection of the nose or throat that can cause symptoms like a blocked or runny nose, sore throat, headaches, muscle aches, coughs, sneezing, fever, pressure in your ears and face and loss of taste and smell.

The safety and efficacy of GBNKEYWORD] in children (aged less than 2 years) have not been studied. Before taking XRATE DX SYRUP, inform your doctor if you have any kidney, lung, liver, heart, thyroid or prostrate problems, diabetes, fits or glaucoma.

XRATE DX SYRUP should be used with caution during pregnancy and breastfeeding. Consult your doctor before taking it. The most common side effect of taking XRATE DX SYRUP is drowsiness. Contact your doctor if any of your symptoms get worse or persist.

USES OF XRATE DX SYRUP

• Relieves cough and other symptoms associated with upper respiratory tract infections like common cold or allergies

HOW XRATE DX SYRUP WORKS

XRATE DX SYRUP relieves symptoms of allergy and the common cold, where chlorpheniramine binds to the histamine H1 receptor and blocks its action, resulting in temporary relief of the negative symptoms (runny nose, sneezing, watery and itchy eyes) brought on by histamine, dextromethorphan suppresses non-productive cough associated with cold by suppressing the cough reflex by directly acting on the cough center in the brain and phenylephrine decreases nasal congestion by acting on α1-adrenergic receptors in the small vessels of the nasal mucosa to produce constriction, resulting in decreased swelling and increased drainage of the nasal cavities.

DIRECTIONS FOR USE

Take XRATE DX SYRUP as advised by your physician. Shake well before use. Your doctor will decide the correct dose and duration for you according to your age, body weight and disease condition.

SIDE EFFECTS OF XRATE DX SYRUP

HOW TO MANAGE SIDE EFFECTS

Dizziness or drowsiness:

Try to rest and relax. Get enough sleep. Avoid driving or operating machinery if you feel drowsiness or dizziness. Avoid alcohol consumption as it can aggravate dizziness or drowsiness. Contact your doctor if your dizziness or drowsiness worsens.

WARNING & PRECAUTIONS

PREGNANCY

XRATE DX SYRUP should be used with caution in pregnant women. Consult your doctor before taking it.

BREASTFEEDING

XRATE DX SYRUP should be used with caution in breastfeeding women. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or use any machines if you feel drowsy after taking XRATE DX SYRUP.

ALCOHOL

Avoid consuming alcohol while taking XRATE DX SYRUP.

KIDNEY

XRATE DX SYRUP should be used with caution in patients with kidney dysfunction. Consult your doctor before taking XRATE DX SYRUP.

LIVER

XRATE DX SYRUP should be used with caution in patients with liver problems. Consult your doctor before taking XRATE DX SYRUP.

ALLERGY

Do not take XRATE DX SYRUP if you are allergic to Chlorpheniramine, Dextromethorphan, Phenylephrine or any of the other ingredients of this medicine.

LUNGS

XRATE DX SYRUP is not recommended for use in patients having an asthma attack. XRATE DX SYRUP should be used with caution in patients with bronchitis, bronchiectasis emphysema or a history of cough lasting for a few weeks or a cough with a lot of phlegm. Consult your doctor before taking XRATE DX SYRUP.

HEART DISEASE

XRATE DX SYRUP is not recommended for use in patients with heart or circulatory problems or high blood pressure (including because of a tumour near your eyes). XRATE DX SYRUP should be used with caution in patients with circulation problems like Raynaud’s phenomenon (a problem causing cold hands and feet) or other heart or circulatory problems. Consult your doctor before taking XRATE DX SYRUP.

INTERACTIONS

A. Drug-Drug interactions:

Before taking XRATE DX SYRUP, inform your doctor if you are taking any of the following medicines:

• medicines used to treat depression (Ex. fluoxetine, paroxetine, sertraline, bupropion, phenelzine, procarbazine, amitriptyline)
• medicines used to treat mood disorders or to induce sleep (Ex. haloperidol, thioridazine, perphenazine)
• medicines used to treat irregular heartbeats, high blood pressure and other heart problems (Ex. amiodarone, propafenone, quinidine, flecainide, amlodipine, digoxin)
• cinacalcet (used to treat secondary hyperparathyroidism)
• terbinafine (used to treat fungal infections)
• medicines used to relieve pain (Ex. codeine, tramadol, morphine, methadone)
• medicines used to treat the symptoms of allergic reactions (Ex. clemastine, cyproheptadine)
• other medicines containing phenylephrine
• phenytoin (used to treat fits)
• atropine (used to treat low heart rate)

Overdosage:

If you or anyone else accidentally took too much of XRATE DX SYRUP, contact your doctor immediately. Symptoms of overdose include nausea, vomiting, dizziness, slurred speech, drowsiness, excitation, mental confusion, psychosis, respiratory depression, shaking, hallucinations, fits, high blood pressure or irregular heartbeat.

SYNOPSIS

MORE INFORMATION

• Keep XRATE DX SYRUP out of reach from children
• Store below 30°C

FAQs ABOUT XRATE DX SYRUP

Q: Can we use XRATE DX SYRUP for babies?

A: The safety and efficacy of GBNKEYWORD in children (aged less than 2 years) have not been studied. Your doctor will determine the correct dose and duration for your child according to age, body weight and disease condition.

Q: What if I forget to take a dose of XRATE DX SYRUP?

A: If you forget to take a dose of XRATE DX SYRUP, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not take the medicine twice to make up for the forgotten dose.

Q: Can I stop taking XRATE DX SYRUP?

A: Continue taking XRATE DX SYRUP until your doctor tells you to stop, unless you experience any unwanted effects, a worsening of your condition or any new symptoms. Consult your doctor immediately for advice.

Q: Does XRATE DX SYRUP have an aspirin?

A: No. XRATE DX SYRUP is a combination of chlorpheniramine, dextromethorphan and phenylephrine. Consult your doctor for further queries.

Q: What precautions do I need to follow while taking XRATE DX SYRUP?

A: Patients taking XRATE DX SYRUP must inform their doctor about their pre-existing conditions, like any heart, kidney, lung, liver, heart or thyroid problems, diabetes, fits, glaucoma or prostrate problem. Patients should also inform their providers if they are pregnant, breastfeeding or allergic to anything else. Consult your doctor if you experience anything different.

Q: Can I take XRATE DX SYRUP if I am pregnant?

A: XRATE DX SYRUP should be used with caution by pregnant women. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking it. Inform your doctor immediately if you become pregnant during treatment with XRATE DX SYRUP.

Q: Can I take other medicines with XRATE DX SYRUP?

A: Before taking XRATE DX SYRUP, inform your doctor if you are taking, have taken or might take any other medicine, including prescription, non-prescription or any herbal medicine, as these might interact with each other and cause serious side effects.

REFERENCES

1. KD Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of Medical Pharmacology. Eighth edition. 2013. Page – 239.

2. Mayuresh Kiran, Sharvari Lotankar, Lalit Pawaskar. Efficacy and Safety of a Combination of Phenylephrine, Chlorpheniramine and Dextromethorphan in Cold and Dry Cough in Children. ResearchGate. December 2017. [Accessed on 25th July 2022] https://www.researchgate.net/publication/331223037_EFFICACY_AND_SAFETY_OF_A_COMBINATION_OF_PHENYLEPHRINE_CHLORPHENIRAMINE_AND_DEXTROMETHORPHAN_IN_COLD_AND_DRY_COUGH_IN_CHILDREN

3. PubChem Compound Summary for CID 2725, Chlorpheniramine. National Center for Biotechnology Information. June 2022. [Accessed on 25th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Chlorpheniramine#section=Mechanism-of-Action

4. Blue Cross Laboratories Pvt. Ltd. Chlorpheniramine + Dextromethorphan + Phenylephrine. [Revised in January 2021] [Accessed on 25th July 2022] https://bluecrosslabs.com/wp-content/uploads/2021/01/TUSQ-DX-LIQUID.pdf

5. Cipla Ltd. Chlorpheniramine + Dextromethorphan + Phenylephrine. [Revised in December 2020] [Accessed on 25th July 2022] https://www.ciplamed.com/content/asthalin-dx-syrup

6. ICPA Health Products Ltd. Chlorpheniramine + Dextromethorphan + Phenylephrine. [Accessed on 25th July 2022] https://www.icpahealth.com/product/koftame/

USEFUL DIAGNOSTIC TESTS

• Nasal cytology

AUTHOR DETAILS

Written By Dr. Dhivakaran R, BDS
Last updated on 12 Jan 2023 | 11:53 AM(IST)