INTRODUCTION

XOXE contain Cefuroxime which belongs to a group of medicine called cephalosporin antibiotics. It is an antibiotic used in adults and children to treat infections of throat, sinus, middle ear, lungs or chest, urinary tract, skin, and soft tissues. It works by preventing bacteria from forming the bacterial protective covering (cell wall). This causes the cell walls to rupture resulting in the death of the bacteria.

The common side effects are fungal infections (such as Candida), headache, dizziness, diarrhoea, nausea, stomach pain, increase in a type of white blood cell, increase in liver enzymes. This medicine must be taken after food. Do not mix XOXE with hot liquids. It can be diluted in cold fruit juices, or milk drinks but should be taken immediately. Shake well before use. It is strictly not recommended for children aged under 3 months. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.  

USES OF XOXE

• Treat infections of throat, sinus, middle ear, lungs or chest, urinary tract, skin, and soft tissues

HOW XOXE WORKS

XOXE works by preventing bacteria from forming the bacterial protective covering (cell wall). This causes the cell walls to rupture resulting in the death of the bacteria.

DIRECTIONS FOR USE

Always take XOXE exactly as your doctor has told you to. This medicine must be taken after food. Do not mix the medicine with hot liquids. It can be diluted in cold fruit juices, or milk drinks but should be taken immediately. Shake the bottle before use.

SIDE EFFECTS OF XOXE

HOW TO MANAGE SIDE EFFECTS

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.  

Diarrhoea:

Drink lot of fluids, such as water or squash, to avoid dehydration. Do not take any other medicines without consulting to a doctor.

Nausea:

Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.

Stomach pain:

Keep try to rest and relax. Eat and drink slowly and smaller and frequent meals. Applying a heat pad or covered hot water bottle on your stomach may also help. If still pain persists, speak to your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor if you are taking,

• medicine used to reduce the amount of acid in your stomach (e.g. antacids used to treat heartburn)
• probenecid (used to treat gout)
• oral anticoagulants
• contraceptive pills

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT XOXE

Can XOXE be taken on an empty stomach?

No, it should not be taken on an empty stomach like other antibiotics of its class. It should be taken after food.

How XOXE Works?

It works by kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

Can XOXE cause dizziness?

Yes, this medicine may cause dizziness in some individuals. Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

REFERENCES

1. KD Tripathi. Beta-Lactam Antibiotics. Essentials of Medical Pharmacology. Seventh Edition,2013. Page - 727.

2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 686-688.

3. L J Scott 1, D Ormrod, K L Goa. Cefuroxime axetil: an updated review of its use in the management of bacterial infections. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. 2001 [Accessed 02 Dec 2020] https://pubmed.ncbi.nlm.nih.gov/11558834/

4. C M Ginsburg, G H McCracken, Jr, M Petruska, and K Olson. Pharmacokinetics and bactericidal activity of cefuroxime axetil. US National Library of Medicines, National Institutes of Health. Oct 1985. [Accessed 02 Dec 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC180292/

5. Glaxo Operations UK Ltd; Electronic Medicines Compendium (EMC); [Revised on Nov 2019] [Accessed 02 Dec 2020] https://www.medicines.org.uk/emc/files/pil.3814.pdf

USEFUL DIAGNOSTIC TESTS

• Complete blood count
• Peripheral smear examination