Xovoltib 40mg Tablet 7'S

Cancer/Oncology Rx required
OUT OF STOCK

Best Price*  ₹ 11,797.80
MRP ₹14,747.25
(Inclusive of all taxes) *7 Tablet(s) in a Strip * Mkt: Boehringer Ingelheim India Pvt Ltd * Country of Origin: GERMANY * Delivery charges if applicable will be applied at checkout



INTRODUCTION

XOVOLTIB 40MG contains Afatinib which belongs to the group of medicines called antineoplastic agents. It is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in adult patients with non-resistant epidermal growth factor receptor (EGFR) mutations either as a first line therapy or if prior chemotherapy treatment has been insufficient. It can also be used to treat metastatic squamous NSCLC if prior chemotherapy treatment has been insufficient.

Afatinib works by inhibiting the activity of various proteins (including EGFR, HER2 and HER4) involved in the growth and spread of cancer cells. XOVOLTIB 40MG must be taken without meals. It should be taken preferably 1 hour before or 3 hours after meals. Your doctor will decide the correct dose and duration of therapy for you depending upon the severity of the disease. The most common side effects of taking this medicine are nausea, vomiting, indigestion, mouth sores, dry skin, itching and weight loss. Contact your doctor if any of the symptoms bothers you.

Before taking this medicine, inform your doctor if you have or had any lung, liver, kidney or heart problems. Proper dose titrations and careful monitoring are required in such patients. Avoid getting pregnant while taking this medicine, because it may harm your unborn fetus. Also, consult your doctor for advice after taking the last dose of this medicine, if you are planning to become pregnant, because your body may not have fully eliminated this medicine. This medicine is strictly not recommended for use in lactating mothers and in children (under 18 years). Consult your doctor before taking.

USES OF XOVOLTIB 40MG

  • Treats metastatic non-small cell lung cancer (NSCLC) in adult patients

HOW XOVOLTIB 40MG WORKS

Afatinib is a tyrosine kinase inhibitor. It acts by inhibiting the activity of various proteins (including EGFR, HER2 and HER4) involved in the growth and spread of cancer cells. As a result, it causes downregulation of these protein signaling and inhibits autophosphorylation and proliferation of epidermal growth factor receptor (EGFR) overexpressing cancer cells.

DIRECTIONS FOR USE

Take XOVOLTIB 40MG as directed by your physician. It must be taken without meals either 1 hour before or 3 hours after a meal. Swallow the medicine as whole with a sip of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon the severity of your disease. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF XOVOLTIB 40MG

SERIOUS

  • diarrhea
  • skin rash
  • symptoms of interstitial lung disease (such as a sudden worsening of shortness of breath, possibly with a cough or fever)
  • symptoms of gastrointestinal perforation (such as vomiting, abdominal rigidity, bloating, pain in your stomach or intestines, fever, chills or sickness)
  • worsening of eye pain and redness, blurred vision, increased eye watering and sensitivity to light

COMMON

  • nausea or vomiting
  • stomach pain, heartburn, indigestion
  • dry skin, itching
  • mouth sores and inflammation
  • nail infection
  • decreased appetite
  • nose bleeds
  • pain, swelling, redness or peeling of the skin of the hands and feet
  • liver problems (increased levels of liver enzymes)
  • cystitis (inflammation of the bladder, painful urination and need to urinate)
  • dysgeusia (change in taste)
  • weight loss
  • runny nose
  • muscle spasms
  • fever

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

This side effect is more common while taking chemotherapy and it is nothing to worry about. Stick to simple meals. Do not eat rich or spicy food. Contact your doctor if it really bothers you.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

Skin drying or itching:

Avoid hot showers because hot water can irritate the skin. Do not rub or scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use moisturizers to soothe and hydrate the affected area. If the symptom still persists, contact your doctor.

Decreased appetite:

Eat when you are hungry. Try to eat smaller meals more often than usual. Snack only when you're hungry. Always try to have a nutritious snack that is high in calories and protein, such as dried fruit and nuts.

WARNING & PRECAUTIONS

PREGNANCY

XOVOLTIB 40MG is not recommended for use during pregnancy. If you become pregnant while taking this medicine, inform your doctor immediately. Your doctor will decide whether you should continue the treatment or not.

BREASTFEEDING

Do not take XOVOLTIB 40MG if you are breast-feeding. Consult your doctor for advice.

DRIVING AND USING MACHINES

Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL

Avoid consumption of alcohol while taking this medicine.

KIDNEY

XOVOLTIB 40MG should be taken with caution in patients with kidney problems. Consult your doctor for advice before taking.

LIVER

XOVOLTIB 40MG is not recommended for use in patients having liver disease. Consult your doctor for advice before taking.

ALLERGY

Do not take this medicine if you are allergic to Afatinib.

LUNGS

XOVOLTIB 40MG should be taken with caution in patients having a history of lung inflammation (interstitial lung disease). Consult your doctor for advice before taking.

HEART DISEASE

XOVOLTIB 40MG should be taken with caution in patients with a history of heart problems. Consult your doctor for advice before taking.

OTHERS

Before taking XOVOLTIB 40MG, inform your doctor if you:

  • are a female
  • have a low body weight (less than 50 kg)
  • have a history of eye problems (such as severe dry eyes, eye ulcers or inflammation of cornea)
  • had any GI ulcers or diverticular disease in the past

INTERACTIONS

Talk to your doctor, if you are taking,

  • medicines used to treat various infections (e.g. ritonavir, nelfinavir, saquinavir, itraconazole, ketoconazole or erythromycin)
  • medicines used to treat heart problems (e.g. verapamil, quinidine, amiodarone)
  • medicines used to suppress your immune system (e.g. cyclosporine A and tacrolimus)
  • medicines used to treat epilepsy (e.g. phenytoin, carbamazepine and phenobarbital)
  • St. John’s wort (a herbal medicine used for depression and other mental illness)
  • rifampicin (used to treat tuberculosis)
  • sulfasalazine (used to treat inflammation or infection)
  • rosuvastatin (used to treat high blood cholesterol levels)
  • non-steroidal anti-inflammatory drugs (e.g. ibuprofen, aspirin)
  • corticosteroids (used to treat allergies and inflammation) e.g. dexamethasone, prednisolone

SYNOPSIS

Drug :   Afatinib
Pharmacological Category :   Antineoplastic agent, Tyrosine kinase inhibitor, Epidermal Growth Factor Receptor (EGFR) inhibitor
Therapeutic Indication :   Non-Small Cell Lung Cancer
Dosage Forms :   Tablet

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT XOVOLTIB 40MG

Is XOVOLTIB 40MG a chemotherapy?

However, this medicine does not belong to conventional chemotherapy, it is also an anticancer agent used to treat NSCLC in adults.

What happens if I forget to take XOVOLTIB 40MG?

Take the missed dose as soon as you remember until it is time for your next dose. At any cause, do not take a double dose to make up a forgotten dose.

How long should I take XOVOLTIB 40MG?

You should continue to take this medicine as long as your doctor tells you to do so. Do not stop taking this medicine abruptly as it may reduce its effectiveness. Your doctor will decide the duration of the therapy depending upon the severity of the disease.

REFERENCES

1. KD. Tripathi. Anticancer agents. Essentials of medical pharmacology. Seventh edition. 2013. Page – 870.

2. Boehringer Ingelheim. Afatinib in Patients with Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Mutations. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on March 2017] [Accessed 27th January 2021] https://clinicaltrials.gov/ct2/show/NCT02044380

3. Scott M. Wirth. Afatinib in Non–Small Cell Lung Cancer. NCBI; PMC US National Library of Medicine, National Institute of Health. September 2015. [Accessed 27th January 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803462/#:~:text=Afatinib%20is%20a%20second%2Dgeneration,and%20HER4%20(ErbB4)%20receptors.

4. Boehringer Ingelheim Pharma GmbH & Co. KG. Electronic Medicines Compendium (EMC); [Revised on September 2020] [Accessed 27th January 2021] https://www.medicines.org.uk/emc/files/pil.7699.pdf

5. Boehringer Ingelheim Pharma GmbH & Co. KG. Electronic Medicines Compendium (EMC); [Revised on September 2020] [Accessed 27th January 2021] https://www.medicines.org.uk/emc/files/pil.7701.pdf

6. Boehringer Ingelheim Pharma GmbH & Co. KG. Electronic Medicines Compendium (EMC); [Revised on September 2020] [Accessed 27th January 2021] https://www.medicines.org.uk/emc/files/pil.7698.pdf

7. Boehringer Ingelheim Pharma GmbH & Co. KG. Electronic Medicines Compendium (EMC); [Revised on September 2020] [Accessed 27th January 2021] https://www.medicines.org.uk/emc/files/pil.5147.pdf

8. Boehringer Ingelheim Pharmaceuticals, Inc. U.S. Food & Drug Administration. [Revised on January 2018] [Accessed 27th January 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/201292s014lbl.pdf

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    15 g
    Ingredient
    AFATINIB DIMALEATE 40MG
    Hsn Code
    30021500
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