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INTRODUCTION

XOCLAVE 375MG TABLET is a combination of Amoxicillin and Clavulanic Acid which belongs to the group of medicines called Antibiotics. It is used to treat bacterial infections including middle ear & sinus infections, respiratory tract infections, genital tract infections, urinary tract infections, skin & soft tissue infections such as dental infections, bone & joint infections, septic abortion and abdominal infections. The symptoms of bacterial infection include fever, difficulty in breathing, pus formation, and pain.

XOCLAVE 375MG TABLET is not recommended for use if you have liver problems or jaundice upon taking an antibiotic or amoxicillin-clavulanate. Before taking this medicine, inform your doctor if you are suffering from a hepatic impairment, liver disease, renal impairment, kidney disease, glandular fever, or are unable to pass water properly.

XOCLAVE 375MG TABLET should be used with caution in pregnant and breastfeeding women only if it is considered necessary. It should be used with caution in children (aged below 12 years) and elderly patients (above 50 years). Consult your doctor before taking XOCLAVE 375MG TABLET.

The common side effects associated with the use of XOCLAVE 375MG TABLET are diarrhoea, thrush (fungal infection in the vagina, skin folds, or mouth), nausea, and vomiting. Contact your doctor immediately if any of the symptoms worsen.

USES OF XOCLAVE 375MG TABLET

  • Treats bacterial infection

HOW XOCLAVE 375MG TABLET WORKS

XOCLAVE 375MG TABLET helps in treating bacterial infection where amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of the integral structural component of the bacterial cell wall whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby preventing the inactivation of amoxicillin.

DIRECTIONS FOR USE

Film-coated tablets:

Take XOCLAVE 375MG TABLET as advised by your physician. Swallow the tablet with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Dispersible tablets:

Take XOCLAVE 375MG TABLET as advised by your physician. Place the tablet in the mouth, let it dissolve, and then swallow. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Powder for oral suspension (in sachets):

Take XOCLAVE 375MG TABLET as advised by your physician. Open the sachet, mix the contents thoroughly in a glass of water, and swallow the mixture immediately. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF XOCLAVE 375MG TABLET

COMMON

  • diarrhoea
  • thrush (fungal infection in the vagina, skin folds, or mouth)
  • nausea
  • vomiting

UNCOMMON

  • skin rash
  • itching
  • raised itchy rash (hives)
  • indigestion
  • dizziness
  • headache

RARE

  • erythema multiforme (a skin rash that looks like small targets)
  • reversible leucopoenia including neutropenia (deficiency of white blood cells)
  • reversible thrombocytopenia (deficiency of blood platelets)

Stop taking XOCLAVE 375MG TABLET and contact your doctor if you experience any of the following side effects:   

  • signs of allergic reactions on the skin such as skin rash
  • signs of vasculitis (inflammation of blood vessels) such as raised red or purple spots on the skin
  • signs of allergic reactions such as fever, joint pain, swollen glands in the neck, armpit or groin
  • signs of angioedema such as swelling on the face or mouth resulting in difficulty in breathing, or collapse
  • inflammation of the liver (hepatitis)
  • jaundice
  • inflammation of kidney tubes
  • prolongation of blood clotting time
  • convulsions
  • black tongue with hairy look
  • staining of teeth

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.

Nausea and vomiting:

Try to take XOCLAVE 375MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.

WARNING & PRECAUTIONS

PREGNANCY

XOCLAVE 375MG TABLET should be used with caution in pregnant women only if it is considered clearly necessary. Consult your doctor before taking XOCLAVE 375MG TABLET.

BREASTFEEDING

XOCLAVE 375MG TABLET should be used with caution in breastfeeding women. Consult your doctor before taking XOCLAVE 375MG TABLET.

DRIVING AND USING MACHINES

Do not drive or operate machines while taking if you feel unwell.

KIDNEY

XOCLAVE 375MG TABLET should be used with caution in patients with renal impairment or kidney problems. Consult your doctor before taking XOCLAVE 375MG TABLET.

LIVER

XOCLAVE 375MG TABLET is not recommended for use if you have if you ever had liver problems or jaundice upon taking an antibiotic or amoxicillin-clavulanate. It should be used with caution in patients with hepatic impairment or liver problems. Consult your doctor before taking XOCLAVE 375MG TABLET.

ALLERGY

Do not take XOCLAVE 375MG TABLET if you are allergic to amoxicillin, clavulanic acid, penicillin, any antibiotic, or any other ingredients of this medicine. Consult your doctor before taking XOCLAVE 375MG TABLET.

OTHERS

Before taking XOCLAVE 375MG TABLET, inform your doctor if you:    

  • have glandular fever
  • are unable to pass water properly

Use in Paediatrics:

XOCLAVE 375MG TABLET should be used with caution in children (below 12 years). Consult your doctor before taking XOCLAVE 375MG TABLET.

Use in Geriatrics:

XOCLAVE 375MG TABLET should be used with caution in elderly patients (above 50 years). Consult your doctor before taking XOCLAVE 375MG TABLET.

INTERACTIONS

A. Drug-Drug Interactions

Before taking XOCLAVE 375MG TABLET, inform your doctor, if you are taking any of the following medicine:

  • allopurinol, probenecid (medicine used to treat gout)
  • warfarin (medicine used to delay blood clotting)
  • methotrexate (medicine used to treat rheumatic diseases or certain cancers)
  • mycophenolate mofetil (a medicine used to prevent the organ rejection after organ transplant)
  • contraceptives (medicines used to prevent conception)

Overdosage:

If you or anyone else accidentally takes too much of XOCLAVE 375MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastrointestinal symptoms (including heartburn, indigestion, bloating, and constipation).

SYNOPSIS

Drug :   Amoxicillin, Clavulanic Acid
Pharmacological Category :   Antibiotics
Therapeutic Indication :   Bacterial infections
Dosage Forms :   Tablet, Dispersible Tablet, Capsule, Sachet

MORE INFORMATION

  • Keep the medicine out of reach of children
  • Store XOCLAVE 375MG TABLET at a temperature not exceeding 30°C

REFERENCES

1. KD Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 723.

2. Justin Evans, Maryam Hannoodee, Micah Wittler. Amoxicillin Clavulanate. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. December 2021. [Assessed on 26th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK538164/

3. Lek Pharmaceuticals d.d. Health Products Regulatory Authority (HPRA). [Revised in December 2014] [Assessed on 26th October 2022] https://www.hpra.ie/img/uploaded/swedocuments/pl-clean-2157753-09062015140435-635694554758986250.pdf

4. GSK group of companies. Augmentin. [Revised in December 2017] [Assessed on 26th October 2022] https://gskpro.com/content/dam/global/hcpportal/en_MU/PI/Clavulin-228.5mg5ml-Susp-GDS-24.pdf

5. Macleods Pharmaceuticals Ltd. Polyclav DS Tab. [Assessed on 26th October 2022] https://www.macleodspharma.com/products/

6. Micro Labs Ltd. Erox CV Dispersible Tablets. [Assessed on 26th October 2022] http://www.microlabsltd.com/elibrary/node/2192

USEFUL DIAGNOSTIC TESTS

  • blood tests
  • urine tests
  • liver function test

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    AMOXYCILLIN 250 mg+CLAVULANIC ACID 125 mg
    Hsn Code
    30041090
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Xoclave 375Mg Tablet 10's

Xoclave 375Mg Tablet 10's Mkt: Corona Remedies Pvt Ltd

M.R.P.: Rs.193.20
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