INTRODUCTION

WINCOLD Z TABLET is a combination of Cetirizine, Paracetamol and Phenylephrine which belongs to the group of medicines called Antihistamines, Analgesic & Antipyretic, and Nasal Decongestant respectively. WINCOLD Z TABLET is used to relieve symptoms of the common cold such as a blocked nose, runny nose, watery eyes, sneezing, congestion or stuffiness, fever, and headache. It reduces congestion and helps in easy breathing. Common cold is a viral infection that affects the nose and throat. Fever is generally increased body temperature in response to an infection.

Avoid alcohol consumption while taking WINCOLD Z TABLET as it leads to excessive drowsiness. WINCOLD Z TABLET is not recommended to use in patients with severe hypertension, coronary artery disease, or liver dysfunction. WINCOLD Z TABLET should be used with caution in patients with occlusive vascular disease including Raynaud’s phenomenon, liver problems, and kidney problems.

WINCOLD Z TABLET should be used with caution in pregnant women and it is not recommended to use in breastfeeding women. WINCOLD Z TABLET is not recommended to use in children and adolescents below 12 years of age. Consult your doctor before taking it. The most common side effects of WINCOLD Z TABLET are nausea, vomiting, fatigue, dry mouth, headache, abdominal pain, drowsiness, dizziness. Consult your doctor for advice if any of the above side effects worsen or persists for a longer duration.

USES OF WINCOLD Z TABLET

It is used to relieve common cold symptoms such as:

• blocked, runny nose
• watery eyes
• sneezing
• congestion, stuffiness
• fever
• headache

HOW WINCOLD Z TABLET WORKS

WINCOLD Z TABLET is a combination of Cetirizine, Paracetamol and Phenylephrine where Cetirizine is an H1 receptor antagonist that works by blocking the action of a chemical messenger (histamine) responsible for runny nose, watery eyes, and sneezing. Paracetamol is an analgesic and antipyretic that acts by inhibiting the synthesis of prostaglandins (chemicals that cause inflammation, pain, and fever) which helps in reducing pain and fever. Phenylephrine is a nasal decongestant that acts by narrowing the small blood vessels providing temporary relief from congestion or stuffiness in the nose.

DIRECTIONS FOR USE

Take WINCOLD Z TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew this medicine. The dose and duration for you will be decided by your physician depending on your age, body weight, and disease condition.

SIDE EFFECTS OF WINCOLD Z TABLET

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling drowsy. Do not drink alcohol, as it can worsen your drowsiness. Consult your doctor if the symptom did not improve.

Nausea And Vomiting

Drink clear or ice-cold drinks. Eat light, bland foods. Avoid fried, greasy, or sweet foods.  Eat slowly and smaller and more frequent meals, drink gradually larger amounts of clear liquids, avoid solid food until the vomiting episode has passed, and take rest. If the symptom does not improve, contact your doctor.

Stomach Pain

Try to rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.

WARNING & PRECAUTIONS

PREGNANCY

Monitoring required

WINCOLD Z TABLET should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor before taking it.

BREASTFEEDING

Contraindicated

WINCOLD Z TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any machines if you feel sleepy or drowsy after taking WINCOLD Z TABLET.

ALCOHOL

Consult your doctor

Avoid alcohol consumption while using WINCOLD Z TABLET as it leads to excessive drowsiness.

KIDNEY

Use with Caution

WINCOLD Z TABLET should be used with caution in patients with kidney problems. Consult your doctor before taking it.

LIVER

Consult your doctor

WINCOLD Z TABLET is not recommended in patients with severe hepatic dysfunction. It should be used with caution in patients with mild to moderate liver problems. Consult your doctor before taking it.

ALLERGY

Contraindicated

Do not take WINCOLD Z TABLET if you are allergic to Cetirizine, Paracetamol, and Phenylephrine, or to any other ingredients of this medicine.

HEART DISEASE

Contraindicated

WINCOLD Z TABLET is not recommended to use in patients with coronary artery disease and severe hypertension. Consult your doctor before taking it.

USE IN PEDIATRICS

Contraindicated

WINCOLD Z TABLET is not recommended for use in children and adolescents below 12 years of age. Consult your healthcare professionals before giving it to your child.

USE IN GERIATRICS

Use with Caution

WINCOLD Z TABLET should be used with caution in elderly patients.  Consult your doctor before taking.

INTERACTIONS

A. Drug-Drug interactions:

Before taking WINCOLD Z TABLET, inform your doctor if you are taking any of the following medicine:

• medicines used to treat depression (Ex. isocarboxazid, phenelzine)
• medicines used for colds, cough, sleeping, or pain (Ex. chlorpheniramine, diazepam, opioids)
• medicines used to treat epilepsy (Ex. phenobarbital, phenytoin, sodium valproate, primidone, carbamazepine)
• medicines used to treat HIV infections (Ex. zidovudine)
• warfarin (medicine used to treat blood clotting)
• medicines used to treat nausea and vomiting (Ex. domperidone, metoclopramide)

Overdosage:

If you or anyone else accidentally takes too much of WINCOLD Z TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are restlessness, irritability, palpitations, hypertension, difficulty in micturition, nausea, vomiting, thirst, convulsions, and liver damage.

SYNOPSIS

MORE INFORMATION

• Keep WINCOLD Z TABLET out of sight and reach of children
• Store WINCOLD Z TABLET at room temperature

FAQs ABOUT WINCOLD Z TABLET

Q: Is WINCOLD Z TABLET cause drowsiness?

A: Yes, the most common side effect of WINCOLD Z TABLET is drowsiness. Caution should be exercised while driving or operating heavy machines. Do not drive or handle heavy machines if you experience side effects like dizziness or drowsiness while taking WINCOLD Z TABLET. Consult your healthcare professional if the symptom did not improve.

Q: Can I consume alcohol along with WINCOLD Z TABLET?

A: No, it is not advisable to drink alcohol while taking WINCOLD Z TABLET. Consuming alcohol along with WINCOLD Z TABLET may aggravate the symptoms of WINCOLD Z TABLET and cause severe liver damage, dizziness, and drowsiness. Consult your doctor before using it.

Q: Can I give WINCOLD Z TABLET to my child?

A: WINCOLD Z TABLET is not recommended for use in children and adolescents below 12 years of age. Consult your doctor before giving it to your child.

Q: Can we use WINCOLD Z TABLET during pregnancy and breastfeeding?

A: WINCOLD Z TABLET should be used with caution in pregnant women and it is not recommended for use in breastfeeding women. Consult your doctor before using it.

Q: Is WINCOLD Z TABLET an antibiotic?

A: No, WINCOLD Z TABLET is not an antibiotic. WINCOLD Z TABLET is a combination of Cetirizine, Paracetamol and Phenylephrine which belong to the group of medicines called Anti-allergic, Analgesic, Antipyretic, and Decongestant respectively. It is used to relieve symptoms of the common cold such as a blocked nose, runny nose, fever, watery eyes and sneezing, allergic rhinitis, and nasal congestion. It does not treat bacterial infections.

Q: What precautions are to be taken if I forget to take WINCOLD Z TABLET?

A: If you forget to take a dose of WINCOLD Z TABLET, take it as soon as you remember. However, if it is time for the next scheduled dose skip the missed dose and take the usual prescribed dose. Do not take a double dose for the forgotten missed dose.

Q: Can I stop taking WINCOLD Z TABLET if I feel better?

A: Do not stop taking WINCOLD Z TABLET, even though you feel better. Your symptoms may reoccur if you stop taking WINCOLD Z TABLET. Inform your doctor before stopping it.

REFERENCES

1. KD. Tripathi Autacoids and Related Drugs, Adrenergic System and Drugs, Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics Essentials of medical pharmacology. Seventh edition. 2013. page no -166, 135, 192.

2. Aasim Naqvi; Valerie Gerriets. Cetirizine. NIH. National Library of Medicine. National Center for Biotechnology Information. StatPearls. November 2022. [Accessed on 3rd March 2023] https://www.ncbi.nlm.nih.gov/books/NBK549776/

3. Samir S Ayoub. Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action. The Journal of Temperature. February 2021. [Accessed on 3rd March 2023] https://www.tandfonline.com/doi/full/10.1080/23328940.2021.1886392

4. Evan Richards; Michael J. Lopez; Christopher V. Maani. Phenylephrine. NIH. National Library of Medicine. National Center for Biotechnology Information. StatPearls. July 2022. [Accessed on 3rd March 2023] https://www.ncbi.nlm.nih.gov/books/NBK534801/

5. Phenylephrine. NIH. National Library of Medicine. [Accessed on 3rd March 2023] https://medlineplus.gov/druginfo/meds/a606008.html

6. Cetirizine, Paracetamol, and Phenylephrine. Tajlifeceiences. [Accessed on 3rd March 2023] https://tajlifesciences.com/

7. Cetirizine, Paracetamol, and Phenylephrine. Ikon remedies. [Accessed on 3rd March 2023] https://www.ikonremedies.com/product/rhinorest-cold-tablets/

8. Cetirizine, Paracetamol, and Phenylephrine. www.leeford.in. [Accessed on 3rd March 2023] https://www.leeford.in/product/617/coldfiz