Votrient 400mg Tablet 30'S

Cancer/Oncology Rx required
OUT OF STOCK

Best Price*  ₹ 13,896.00
MRP ₹17,370.00
(Inclusive of all taxes) *30 Tablet(s) in a Bottle * Mfr: Novartis India Ltd * Country of Origin: India



INTRODUCTION

VOTRIENT 400MG contains pazopanib which belongs to the group of medicines called tyrosine kinase inhibitors. It is used to treat advanced kidney cancer or certain forms of soft-tissue sarcoma (a type of cancer that affects the supportive tissues of the body) in adults. It prevents the activity of proteins which are involved in the growth and spread of cancer cells. It can raise your blood pressure. So, inform your doctor if you are previously suffering from high blood pressure. Try taking this medicine at the same time each day. Take it at least 1 hour before or 2 hours after a meal. Avoid drinking grapefruit juice while taking this medicine.

Take VOTRIENT 400MG as directed by your physician. Do not take this medicine with food. Take it at least 1 hour before or 2 hours after a meal. Before taking this medicine, inform your doctor if you are undergoing any operation. This medicine may affect fertility in both men and women and should not be used in pregnant or breastfeeding women and in children below 18 years of age. Do not drive or operate any machines if you feel dizzy, tired or weak, or if your energy levels are low. The common side effects such as diarrhea, nausea, vomiting, bloating, stomach pain, loss of appetite, weight loss, taste disturbance, sore mouth and headache.

USES OF VOTRIENT 400MG

  • Treats advanced kidney cancer or advanced soft-tissue sarcoma in adults

HOW VOTRIENT 400MG WORKS

VOTRIENT 400MG is a tyrosine kinase inhibitor which inhibits the activity of various growth factor receptors associated with angiogenesis and tumor cell proliferation. Following oral administration, it inhibits the activity of vascular endothelial growth factor receptor-1, -2 and -3, platelet-derived growth factor receptor-alpha and -beta and c-kit and prevents the growth and spread of cancer cells.

DIRECTIONS FOR USE

Take VOTRIENT 400MG as directed by your physician. Do not take this medicine with food. Take it at least 1 hour before or 2 hours after a meal. Try taking this medicine at the same time each day. Avoid drinking grapefruit juice while taking this medicine, which may increase the chance of side effects. Your doctor will decide the correct dose for you depending upon your condition. Do not stop taking this medicine, unless your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF VOTRIENT 400MG

SERIOUS

  • reversible posterior leukoencephalopathy syndrome (such as swelling of the brain with loss of speech, change of vision, seizure, confusion and high blood pressure)
  • cardiovascular dysfunction (such as irregular heartbeat, fainting, chest pain, pain in arms, back, neck or jaw, shortness of breath, leg swelling and stroke)
  • passing blood in stools or urine
  • yellowing of skin or whites of eyes
  • dark urine
  • Tumor lysis syndrome
  • infections (such as fever, flu-like symptoms)

COMMON

  • high blood pressure
  • diarrhea, nausea, vomiting, bloating, stomach pain, loss of appetite
  • weight loss
  • taste disturbance
  • sore mouth
  • headache
  • tumor pain
  • feeling weak or tired
  • unusual hair loss or thinning
  • loss of skin pigment, skin rash, redness and swelling of palms or soles
  • slow heartbeat
  • swelling of face, hands, ankles, feet or eyelids
  • tingling, weakness or numbness of hands, arms, legs or feet
  • unusual bleeding
  • sensation of coldness and shivering
  • excessive sweating
  • dehydration
  • muscle, joint or tendon pain
  • coughing up blood

RARE

  • pneumonitis (inflammation of lung)

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with or just after meal. Stick to simple meals. Do not eat rich or spicy food.

Bloating:

Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptoms get worse, contact your doctor immediately.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

WARNING & PRECAUTIONS

PREGNANCY

VOTRIENT 400MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

VOTRIENT 400MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizzy, tired or weak, or if your energy levels are low.

ALCOHOL

Avoid consumption of alcohol while taking this medicine.

KIDNEY

VOTRIENT 400MG should be taken with caution in patients with kidney disease. Consult your doctor for advice.

LIVER

VOTRIENT 400MG should be taken with caution in patients with liver disease. Consult your doctor for advice.

ALLERGY

Do not take this medicine if you are allergic (hypersensitive) to pazopanib or any other ingredients in this medicine.

LUNGS

VOTRIENT 400MG should be taken with caution in patients who had prior collapse of a lung. Consult your doctor for advice.

HEART DISEASE

VOTRIENT 400MG should be taken with caution in patients with heart disease or have had heart failure or a heart attack previously. Consult your doctor for advice.

OTHERS

Before taking this medicine, inform your doctor if you haveor had:

  • problems with bleeding, blood clots or narrowing of the arteries
  • perforation or fistula in the bowel
  • thyroid problems

INTERACTIONS

Talk to your doctor, if you are taking,

  • medicines used to treat bacterial infection (e.g. clarithromycin, ketoconazole, itraconazole, rifampicin, telithromycin, voriconazole)
  • medicines used to treat HIV infections (e.g. atazanavir, indinavir, nelfinavir, ritonavir, saquinavir)
  • medicines used to reduce stomach acid (e.g. omeprazole, cimetidine, ranitidine, aluminium hydroxide)
  • nefazodone (used to treat depression)
  • statins (used to treat high cholesterol levels) e.g. simvastatin, atorvastatin, rosuvastatin

SYNOPSIS

Drug :   Pazopanib
Pharmacological Category :  

Anti-neoplastic agent, Tyrosine kinase inhibitor vascular endothelial growth factor receptor inhibitor

Therapeutic Indication :   Advanced kidney cancer, Advanced soft-tissue sarcoma
Dosage Forms :   Tablet

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

REFERENCES

1. Bruce A. Chabner, Jeffery Barnes, Joel Neal, Erin Olson, Hamza Mujagic, Lecia Sequist, Wynham Wilson, Dan L. Longo, Constantine Mitsiades and Paul Richardson. Targeted therapies: Tyrosine kinase inhibitors, Monoclonal antibodies and Cytokines. Goodman & Gilman’s: The Pharmacological basics of therapeutics. 12th Edition. New York Mc Graw Hill Medical 2011. Page – 1739.

2. Gerald G. Briggs, Roger K. Freeman. P. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation, Tenth Edition. Page – 3005-3006.

3. Novartis. Phase 3, randomized, double-blind, placebo-controlled, multicenter trial to evaluate the efficacy and safety of VOTRIENT® (pazopanib) tablets in first-line or cytokine-pretreated patients (N=435) with advanced RCC of clear cell or predominantly clear cell histology. Clinical Trials Votrient. [Revised on August 2020] [Accessed 27th October 2020] https://www.novartis.us/sites/www.novartis.us/files/votrient.pdf

4. Novartis Pharmaceuticals. A Study to Evaluate Pazopanib as an Adjuvant Treatment for Localized Renal Cell Carcinoma (RCC) (PROTECT). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on April 2020] [Accessed 27th October 2020] https://clinicaltrials.gov/ct2/show/NCT01235962

5. David Cella and Jennifer L. Beaumont. Pazopanib in the treatment of advanced renal cell carcinoma. NCBI; PMC U.S. National Library of Medicine, National Institute of Health. February 2016 [Accessed 27th October 2019] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707425/#:~:text=In%20clinical%20trials%2C%20pazopanib%20has,sunitinib%20in%20this%20patient%20cohort.

6. Novartis Pharmaceuticals UK Ltd. [Revised on October 2020] 2016 [Accessed 27th October 2019] https://www.medicines.org.uk/emc/files/pil.572.pdf

7. GlaxoSmithKline. [Revised on October 2009] 2016 [Accessed 27th October 2019] https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022465lbl.pdf

USEFUL DIAGNOSTIC TESTS

  • Biopsy
  • Computerized tomography (CT) scan
  • Magnetic resonance imaging (MRI)
  • Positron emission tomography (PET) scan

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Manufacturer/Marketer Details

    Net Qty
    1
    Shelf Life
    NA
    Item Weight
    40
    No. of Units in a Kit
    NA
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