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INTRODUCTION
VORMIND 20 TABLET contains Vortioxetine which belongs to the group of medicines called Antidepressants. It is used to treat depression (major depressive episodes) in adults. Depression is a mood disorder characterized by persistent feeling of sadness, loss of interest, feeling guilty or worthless, attention impairment, lack of energy, suicidal thoughts and slow or abnormal physical movements.
Before taking VORMIND 20 TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you currently have or have a previous history of fits (epilepsy), glaucoma, suicidal thoughts, mania or bleeding problems as a precaution.
VORMIND 20 TABLET is not recommended for use in pregnant or breastfeeding women unless considered necessary by the physician. It is also not suitable for use in children aged below 18 years.
The most common side effects of taking VORMIND 20 TABLET are nausea, vomiting, diarrhoea, constipation, dizziness, itching of the whole body, abnormal dreams (nightmares) and increased sweating. These side effects are usually temporary and will resolve on its own within 2 weeks of therapy. However, consult your doctor if they worsen.
You must also inform your doctor if you experience worsening of depression or suicidal thoughts or behaviour after taking VORMIND 20 TABLET.
USES OF VORMIND 20 TABLET
- Treats depression in adults
HOW VORMIND 20 TABLET WORKS
VORMIND 20 TABLET is an antidepressant medication. It acts by increasing the levels of certain chemical messengers (such as serotonin) in the brain that can stabilize mood and mental health. As a result, it improves your mood and energy and reduce the signs of depression.
DIRECTIONS FOR USE
Take VORMIND 20 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. It can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Do not stop taking VORMIND 20 TABLET without consulting your doctor as it may make your symptoms re-appear once again.
SIDE EFFECTS OF VORMIND 20 TABLET
COMMON
- nausea, vomiting
- diarrhoea, constipation
- dizziness
- itching of the whole body
- abnormal dreams (nightmares)
- increased sweating
UNCOMMON
- flushing
- night sweats
RARE
- enlarged pupils
Stop taking VORMIND 20 TABLET and consult your doctor immediately if you experience any of the following side effects:
- signs of serotonin syndrome (such as feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles or muscle twitching, loss of coordination, nausea, vomiting, diarrhea or seizures)
- signs of allergic reactions (such as skin rash, swelling of the hands, face, tongue, neck or throat, increased fluid in tissues, fast heart rate, difficulty in breathing)
- unexplained bleeding
- feeling anxious, aggressive, irritated or angry
- worsening of depression, suicidal thoughts or behavior
- fits (seizures)
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating rich or spicy food. Contact your doctor if nausea worsens.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise regularly. Contact your doctor if constipation persists.
Diarrhoea:
Drink fluids, such as water or fruit juice in enough quantity to keep yourself hydrated. Don’t take any medicine on your own for treating diarrhoea without talking to your doctor. Contact your doctor if diarrhoea worsen.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate machinery if you feel dizzy. Avoid consumption of alcohol as it could aggravate your dizziness. Contact your doctor if dizziness worsens.
WARNING & PRECAUTIONS
PREGNANCY
VORMIND 20 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
BREASTFEEDING
VORMIND 20 TABLET may pass through breast milk and so it is generally not recommended for use in breast feeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
VORMIND 20 TABLET does not impair your ability to drive or handle heavy tools. However, it may cause dizziness in some individuals. Therefore, do not drive or operate any heavy tools or machines if you experience dizziness after taking VORMIND 20 TABLET as a precaution.
ALCOHOL
Avoid consumption of alcohol while taking VORMIND 20 TABLET as it may increase the risk of side effects.
KIDNEY
VORMIND 20 TABLET should be used with caution in patients with severe kidney diseases. Therefore, consult your doctor before taking it.
LIVER
VORMIND 20 TABLET should be used with caution in patients with severe liver diseases (such as liver cirrhosis). Therefore, consult your doctor before taking it.
ALLERGY
Do not take VORMIND 20 TABLET if you are allergic to Vortioxetine.
OTHERS
Before taking VORMIND 20 TABLET, inform your doctor if you:
- currently have or have a previous history of fits (or seizures)
- have ever had mania (mood disorder that causes high levels of excitement)
- have increased tendency to bleed or bruise easily
- have low sodium levels in the blood
- currently have or have a previous history of glaucoma
- are going to have a urine test
- have a history of bleeding problems
- have a previous history of suicidal thoughts
Use in pediatrics:
VORMIND 20 TABLET is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor before taking it.
Use in Geriatrics:
VORMIND 20 TABLET should be used with caution in elderly people (aged 65 years or above). Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug-drug interactions:
Before taking VORMIND 20 TABLET, inform your doctor if you are taking any of the following medicines such as:
- medicines used to treat pain (such as tramadol, fentanyl, nefopam, morphine or morphine related substances like codeine, dihydrocodeine, buprenorphine)
- medicines used to treat migraine headache (Ex. sumatriptan)
- other medicines used to treat depression (Ex. phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, moclobemide, fluoxetine, paroxetine, amitriptyline, imipramine etc.)
- medicines used to treat parkinsonism (Ex. selegiline, rasagiline)
- linezolid (an antibiotic used to treat bacterial infections)
- lithium (a medicine used to treat depression and mental disorders)
- tryptophan (an amino acid used to induce sleep)
- rifampicin (a medicine used to treat tuberculosis)
- medicines used to treat epilepsy (Ex. carbamazepine, phenytoin)
- medicines used to prevent blood clots (Ex. warfarin, dipyridamole, phenprocoumon, aspirin)
- mefloquine (a medicine used to treat and prevent malaria)
- bupropion (a medicine used to quit smoking)
- St. John’s wort (an herbal medicine used to treat depression)
- quinidine (a medicine used to treat irregular heartbeat)
- medicines used to treat psychiatric disorders (Ex. haloperidol, chlorpromazine, chlorprothixene)
Over dosage:
If you accidentally took more VORMIND 20 TABLET than the prescribed dose, contact your doctor or go to the nearest hospital immediately. Symptoms of overdosage might include nausea, dizziness, diarrhoea, stomach discomfort, flushing, feeling sleepy or drowsy and itching of the whole body.
SYNOPSIS
| Drug | : | Vortioxetine |
| Pharmacological Category | : | Selective Serotonin Reuptake Inhibitors |
| Therapeutic Indication | : | Depression |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep VORMIND 20 TABLET out of sight and reach of children
- Store VORMIND 20 TABLET below 25°C
FAQs ABOUT VORMIND 20 TABLET
What is the use of VORMIND 20 TABLET?
VORMIND 20 TABLET is used to depression (major depressive episodes) in adults.
Is VORMIND 20 TABLET a strong antidepressant?
Yes. VORMIND 20 TABLET is a strong antidepressant that effectively controls signs of depression. It works by increasing the levels of certain chemicals (serotonin) within the brain that stabilizes mental health.
What is the best time to take VORMIND 20 TABLET?
Take VORMIND 20 TABLET approximately at the same time each day. You can take VORMIND 20 TABLET either in the morning or in the evening as per doctor’s instructions. Taking it at the same time each day will have the best effect and it would also help you remember your daily dose.
Can VORMIND 20 TABLET be used to reduce anxiety?
VORMIND 20 TABLET is a prescription medicine used to treat depression. It has been shown to reduce anxiety. However, there are no proper evidence to prove that. If you wish to control anxiety using VORMIND 20 TABLET, speak with your doctor for advice.
How does VORMIND 20 TABLET works?
VORMIND 20 TABLET works by increasing the levels of certain chemicals within the brain (such as serotonin) that controls mood and mental health. As a result, it elevates mood and makes you feel active and energetic.
Will the use of VORMIND 20 TABLET make you feel dizzy?
Yes, VORMIND 20 TABLET may make your feel dizzy. Do not drive or handle heavy machines or tool if you feel dizzy. Avoid consumption of alcohol as it can aggravate your dizziness.
Can VORMIND 20 TABLET be used in children?
VORMIND 20 TABLET is generally not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.
What to do if I forget to take a dose of VORMIND 20 TABLET?
If you forget to take a dose of VORMIND 20 TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of VORMIND 20 TABLET to compensate a missed dose, as it could lead to toxicity.
Will taking a higher dose of VORMIND 20 TABLET than the prescribed one be beneficial?
No, taking a higher dose of VORMIND 20 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Can I stop taking VORMIND 20 TABLET once my symptoms subside?
No. Do not stop taking VORMIND 20 TABLET without consulting your doctor even if you feel better during the mid-way of the therapy. You may feel better only after 2 weeks of therapy with VORMIND 20 TABLET, but it might take several weeks for you to experience complete benefits.
Can VORMIND 20 TABLET be taken daily?
Yes. VORMIND 20 TABLET can be taken daily as per your doctor’s instruction. However, if you are doubtful, consult your doctor.
Can VORMIND 20 TABLET be used in pregnant women?
VORMIND 20 TABLET is not recommended for use in pregnant women as it may harm the growing fetus. Therefore, consult your doctor before taking it.
How to take VORMIND 20 TABLET?
Take VORMIND 20 TABLET as advised by your physician. It can be taken with or without food. Swallow the medicine with a glass of water. Do not chew or crush the medicine.
Can I stop taking VORMIND 20 TABLET once I started feeling better?
Do not stop taking VORMIND 20 TABLET without consulting your doctor as it may make your symptoms reappear.
How long will it take for VORMIND 20 TABLET to reduce my symptoms?
VORMIND 20 TABLET starts working after 1-2 weeks of the therapy. However, you may notice a difference in your condition only after 2-4 weeks of the therapy. It may take around 4-6 months for VORMIND 20 TABLET to completely reduce the symptoms of depression. Therefore, take VORMIND 20 TABLET consistently as advised by your physician to achieve better results.
What are the side effects of VORMIND 20 TABLET?
The most common side effects of taking VORMIND 20 TABLET are nausea, vomiting, diarrhoea, constipation, dizziness, itching of the whole body, abnormal dreams (nightmares) and increased sweating. These side effects are usually temporary and will resolve on its own within 2 weeks of therapy. However, consult your doctor if they worsen.
Can VORMIND 20 TABLET cause constipation?
Yes. Constipation is a common side effect of taking VORMIND 20 TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.
Is VORMIND 20 TABLET safe?
VORMIND 20 TABLET is safe at doses prescribed by the doctor. Do not alter the dosage of VORMIND 20 TABLET without consulting your doctor.
REFERENCES
1. KD. Tripathi. Antidepressant and Antianxiety Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 460.
2. Mahableshwarkar AR, Jacobsen PL, Serenko M, Chen Y, Trivedi MH. A randomized, double-blind, placebo-controlled study of the efficacy and safety of 2 doses of vortioxetine in adults with major depressive disorder. NIH National Library of Medicine; National centre for biotechnology information. May 2015. [Accessed on 25th November 2022] https://pubmed.ncbi.nlm.nih.gov/26035186/
3. Pae, C. U., Wang, S. M., Han, C., Lee, S. J., Patkar, A. A., Masand, P. S., & Serretti, A. Vortioxetine: a meta-analysis of 12 short-term, randomized, placebo-controlled clinical trials for the treatment of major depressive disorder. NIH National Library of Medicine; National centre for biotechnology information. May 2015. [Accessed on 25th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409435/
4. H. Lundbeck A/S. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 25th November 2022] https://www.medicines.org.uk/emc/files/pil.10443.pdf
USEFUL DIAGNOSTIC TESTS
- Complete blood count
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