INTRODUCTION

VOGLITAB M 0.3MG TABLET is a combination of Metformin and Voglibose which belongs to the group of medicines called Antidiabetic agents. VOGLITAB M 0.3MG TABLET is indicated as a second-line therapy for the treatment of type II diabetes mellitus when diet, exercise and therapy with single agents does not result in adequate glycemic control.

Type II diabetes is a chronic medical condition in which the body does not make enough insulin, or the produced insulin does not work well. Symptoms include excessive urination, excessive thirst, hunger, fatigue and blurred vision.

Along treatment with VOGLITAB M 0.3MG TABLET, follow regular exercise and diet plan as advised by your doctor to achieve better results. 

Prior and during therapy with VOGLITAB M 0.3MG TABLET, your doctor might access your kidney functions frequently to avoid the risk of side effects, especially if you are elderly with poor kidney functions. Avoid consumption of alcohol while taking VOGLITAB M 0.3MG TABLET as it could aggravate your existing disease condition and increase the risk of lactic acidosis.

VOGLITAB M 0.3MG TABLET is generally not recommended for use in pregnant or breastfeeding women and in children (aged less than 18 years) due to lack of safety and effectiveness. It should be used with caution in elderly patients (aged 65 years or above).

The most common side effects of taking VOGLITAB M 0.3MG TABLET are nausea, vomiting, diarrhea, stomach pain, headache and dizziness. Consult your doctor if any of the side effects worsen.

USES OF VOGLITAB M 0.3MG TABLET

• To treat type II diabetes mellitus (as second-line of therapy) when diet, exercise and therapy with single agents does not result in adequate glycemic control

HOW VOGLITAB M 0.3MG TABLET WORKS

[GBNKYWORD] helps to control blood sugar levels, where metformin works by reducing the amount of glucose released into the blood by the liver and voglibose acts by reversibly inhibiting the activity of various carbohydrate digestive enzymes (Ex. sucrose, maltose, zomaltase, etc.) in the gut, thus leading to delayed digestion and absorption of glucose into the blood stream.

DIRECTIONS FOR USE

Take VOGLITAB M 0.3MG TABLET as advised by your physician. Swallow VOGLITAB M 0.3MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF VOGLITAB M 0.3MG TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Try to take VOGLITAB M 0.3MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did not improve.

Diarrhoea:

Drink lot of fluids such as water to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.

Headache:  

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.

Loss of appetite:

Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Always try to have a nutritious snack that is rich in calories and protein such as dried fruit and nuts. Consult your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking VOGLITAB M 0.3MG TABLET inform to your doctor, if you are taking any of these medicines:

• diuretics (medicines used to increase urine output) Ex. furosemide, chlorothiazide, hydrochlorothiazide
• other medicines used to treat diabetes (Ex. insulin, glipizide, glyburide, glimepiride)
• medicines used to control blood cholesterol levels such as fibric acid derivatives (Ex. fenofibrate, gemfibrozil)
• antipsychotics (used to treat mental illness) Ex. chlorpromazine, fluphenazine, mesoridazine, perphenazine, or prochlorperazine 
• monoamine oxidase inhibitors (used to treat depression) Ex. fluoxetine, sertraline
• sympathomimetic agents (used to treat circulatory disorders) Ex. ephedrine, adrenaline, noradrenaline, isoprenaline, phenylephrine and phenylpropanolamine
• medicines used to treat certain cancer (Ex. vandetanib, crizotinib, olaparib)
• cimetidine (used to treat ulcers)
• ranolazine (used to treat chest pain)
• medicines used to treat infections (isavuconazole, dolutegravir, trimethoprim)
• medicines used to treat heart problems such as alpha-blockers (alfuzosin, prazosin), beta-blockers (Ex. propranolol, atenolol), calcium channel blockers (Ex. nifedipine, verapamil)
• medicines used to treat epilepsy (Ex. phenytoin, valproic acid)
• medicines used to treat pain and inflammation (such as ibuprofen and celecoxib)
• medicines used to treat high blood pressure (Ex. captopril, enalapril, losartan, valsartan)
• bronchodilators (used to treat asthma) Ex. salbutamol, terbutaline, salmeterol, formoterol, ipratropium
• carbonic anhydrase inhibitors (used to treat glaucoma) Ex. topiramate, zonisamide, acetazolamide or dichlorphenamide
• thyroid hormones (used to treat abnormal thyroid function) Ex. thyroxine, triiodothyronine
• hormonal replacement therapy (used to correct menstrual disorders) Ex. estradiol, ethinyl estradiol
• oral contraceptives (abortion pill) Ex. mifepristone
• nicotinic acid (used to treat or prevent niacin deficiency)
• corticosteroids (used to treat inflammation) Ex. dexamethasone, prednisolone
• isoniazid (used to treat tuberculosis)
• medicines containing alcohol (such as cough syrup)
• iodinated contrast agents (used during an X-ray or scan)

Overdosage:

If you or anyone else accidentally take too much of VOGLITAB M 0.3MG TABLET, consult your doctor immediately or go to a nearest hospital straight away as it could lead to a life-threatening condition called lactic acidosis and stomach discomfort or diarrhea may occur. Symptoms of lactic acidosis might include nausea, vomiting, stomach pain with muscle cramps, decreased heartbeat, general weakness with severe tiredness, difficulty in breathing or reduced body temperature.

SYNOPSIS

MORE INFORMATION

• Keep VOGLITAB M 0.3MG TABLET out of reach of children
• Store at room temperature     

FAQs ABOUT VOGLITAB M 0.3MG TABLET

Can I consume alcohol while taking VOGLITAB M 0.3MG TABLET?

No, avoid consumption of alcohol while taking VOGLITAB M 0.3MG TABLET since it may increase the risk of lactic acidosis, dizziness or sleepiness. Consult your doctor before taking VOGLITAB M 0.3MG TABLET if you are alcoholic or having history of alcohol consumption.

Can VOGLITAB M 0.3MG TABLET be used in pregnant women?

No, VOGLITAB M 0.3MG TABLET is not recommended for use in pregnant women. Consult your doctor for advice before taking VOGLITAB M 0.3MG TABLET if you are pregnant or planning to get pregnant.  

Is VOGLITAB M 0.3MG TABLET safe to use in elderly patients?

Yes, VOGLITAB M 0.3MG TABLET should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before taking this medicine. Your doctor might check your kidney function frequently to avoid kidney damage and for dose adjustment.

What is VOGLITAB M 0.3MG TABLET used for?

VOGLITAB M 0.3MG TABLET is indicated as a second-line therapy for the treatment of type II diabetes mellitus when diet, exercise and therapy with single agents does not result in adequate glycemic control.

What to do if I forget to take a dose of VOGLITAB M 0.3MG TABLET?

You should take VOGLITAB M 0.3MG TABLET immediately when you remember. If it is time for your next dose of VOGLITAB M 0.3MG TABLET skip the dose and follow your regular dose schedule. Do not double the dose of this medicine to match up your missed dose.

REFERENCES

1. KD. Tripathi. Insulin, Oral Hypoglycemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275-276 & 277.

2. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2451-2456.

3. Takeda. Voglibose Tablets 0.2 / OD Tablets 0.2 Special Drug Use Surveillance "Long-term Use in Patients with Impaired Glucose Tolerance". NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in December 2018]. [Accessed on 9th October 2021] https://clinicaltrials.gov/ct2/show/NCT01993927

4. Tae Jung Oh, Jae Myung Yu, Kyung Wan Min, Hyun Shik Son, Moon Kyu Lee, Kun Ho Yoon, Young Duk Song, Joong Yeol Park, In Kyung Jeong, Bong Soo Cha, Yong Seong Kim, Sei Hyun Baik, In Joo Kim, Doo Man Kim, Sung Rae Kim, Kwan Woo Lee, Jeong Hyung Park, In Kyu Lee, Tae Sun Park, Sung Hee Choi and Sung Woo Park. Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial. NCBI; PMC US National Library of Medicine, National Institute of Health. June 2019. [Accessed on 9th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581551

5. Torrent Pharmaceuticals Ltd. Voglitor MF. Torrentian.com. [Revised in July 2020]. [Accessed on 9th October 2021] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1720.pdf

6. Torrent Pharmaceuticals Ltd. Voglitor MF Forte. Torrentian.com. [Revised in July 2020]. [Accessed on 9th October 2021] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2851.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose - Fasting Blood
• Glucose - Postprandial Blood
• Glycosylated Hemoglobin