INTRODUCTION

VITENCIAL TABLET contains Mecobalamin which belongs to the group of medicines called Vitamins. VITENCIAL TABLET is used to treat peripheral neuropathies (peripheral nerve damage that affects hands, feet and arms), and megaloblastic anaemia (blood disorder that occurs due to abnormal production of red blood cells) caused by vitamin B12 deficiency in affected individuals.

VITENCIAL TABLET is not recommended for use in patients allergic to Mecobalamin, and/or other B12 containing medicines. It also not recommended for use in patients with Leber’s disease (inherited form of vision loss).

Before taking VITENCIAL TABLET, inform your doctor if you are in an occupation of handling mercury, and/or have kidney problems (such as renal failure)/liver problems (such as hepatic impairment).

VITENCIAL TABLET is not recommended for use in pregnant and breastfeeding women. It should be used with caution in children and adolescents (aged 6 months to 18 years) and is advised to be used with caution in elderly patients (aged 65 years and above) after consulting the doctor.

The most common side effects of taking VITENCIAL TABLET are weakness, headache, back pain, muscle pain, indigestion, nausea, and/or vomiting. Consult your doctor if any of these side effects worsens.

USES OF VITENCIAL TABLET

• Treats peripheral neuropathies
• Treats megaloblastic anaemia (caused by vitamin B12 deficiency) in affected individuals

HOW VITENCIAL TABLET WORKS

VITENCIAL TABLET works by aiding in the synthesis of myelin (lipid rich material that covers nerve fibres) which helps in protecting the nerve fibres and thereby providing relief from painful diabetic neuropathy in affected individuals.   It also promotes nucleic acid synthesis in the bone marrow which helps in the maturation and division of erythroblasts thus preventing poor production of red blood cells and thereby improving megaloblastic anaemia in affected individuals.

DIRECTIONS FOR USE

Tablet:

Take VITENCIAL TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Oral Disintegrating Tablet:

Take VITENCIAL TABLET as advised by your physician. Place VITENCIAL TABLET inside your mouth and allow it to dissolve completely. Do not swallow or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Sublingual Tablet:

Take VITENCIAL TABLET as advised by your physician. Place VITENCIAL TABLET under the tongue till it dissolves. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF VITENCIAL TABLET

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult your doctor and inform them if the symptom gets worse.

Nausea And Vomiting

Take VITENCIAL TABLET with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Talk with your doctor if the condition worsens.

Headache

If VITENCIAL TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking VITENCIAL TABLET. If it lasts more than a week or severe, inform your doctor.

Indigestion

Try to have smaller and more frequent meals and drink slowly. Reduce consumption of coffee, cola, tea, or alcohol and lose weight if you are obese.  Try to avoid smoking and don’t have rich, fatty or spicy foods. Consult your doctor and inform if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

VITENCIAL TABLET is not recommended for use in pregnant women. Consult your doctor before taking VITENCIAL TABLET.

BREASTFEEDING

Contraindicated

VITENCIAL TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking VITENCIAL TABLET.

KIDNEY

Use with Caution

VITENCIAL TABLET should be used with caution in patients with kidney problems such as renal failure. Consult your doctor before taking the medicine.

LIVER

Use with Caution

VITENCIAL TABLET should be used with caution in patients with liver problems such as hepatic impairment. Consult your doctor before taking the medicine.

ALLERGY

Contraindicated

Do not take VITENCIAL TABLET if you are allergic to mecobalamin, other B12 containing medicines, and/or any other ingredients of this medicine.

INTERACTIONS

A. Drug-Drug interactions:

Before taking VITENCIAL TABLET, inform your doctor if you are taking any of the following medicine:

• neomycin (used to prevent/treat bacterial skin infections)
• amino salicylic acid (used to treat tuberculosis)
• histamine H2-antagonists (used to treat and prevent recurrence of duodenal ulcers) Ex. ranitidine, famotidine 
• colchicine (used in the treatment of gout)
• oral contraceptives (used to prevent pregnancy) Ex. ethinyl estradiol and norethindrone
• chloramphenicol (used to treat bacterial infections)
• omeprazole (used to treat gastric & duodenal ulcers, erosive esophagitis, and gastroesophageal reflux disease)

Overdosage:

If you or anyone else accidentally take too much of VITENCIAL TABLET, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.

SYNOPSIS

MORE INFORMATION

• Keep VITENCIAL TABLET out of reach of children
• Store VITENCIAL TABLET below 30°C

FAQs ABOUT VITENCIAL TABLET

Q. What is VITENCIAL TABLET used for?

A. VITENCIAL TABLET is used to treat peripheral neuropathies (peripheral nerve damage that affects hands, feet and arms), and megaloblastic anaemia (blood disorder that occurs due to abnormal production of red blood cells) which occurs due to deficiency of vitamin B12 in affected individuals.

Q. How VITENCIAL TABLET be taken?

A. Tablet:

Take VITENCIAL TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Oral Disintegrating Tablet:

Take VITENCIAL TABLET as advised by your physician. Place VITENCIAL TABLET inside your mouth and allow it to dissolve completely. Do not swallow or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Sublingual Tablet:

Take VITENCIAL TABLET as advised by your physician. Place VITENCIAL TABLET under the tongue till it dissolves. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Q. What are the side effects of VITENCIAL TABLET?

A. The most common side effects of taking VITENCIAL TABLET are weakness, headache, back pain, muscle pain, indigestion, nausea, and/or vomiting. Consult your doctor if any of these side effects worsens.

Q. How VITENCIAL TABLET works?

A. VITENCIAL TABLET works by aiding in the synthesis of myelin (lipid rich material that covers nerve fibres) which helps in protecting the nerve fibres and thereby providing relief from painful diabetic neuropathy in affected individuals.   It also promotes nucleic acid synthesis in the bone marrow which helps in the maturation and division of erythroblasts thus preventing poor production of red blood cells and thereby improving megaloblastic anaemia in affected individuals.

Q. Can VITENCIAL TABLET be used in pregnant and breastfeeding women?

A. No, VITENCIAL TABLET is not recommended for use in pregnant and breastfeeding women since it may cause some undesirable effects to the foetus and breastfed baby. Consul your doctor before taking VITENCIAL TABLET.

REFERENCES

1. KD. Tripathi. Drugs affecting blood and blood formation, Vitamins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 606.

2. Advait Vasavada; Devang Sanghavi. Cyanocobalamin.  NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. September 2022. [Accessed on 4th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK555964/

3. A S M Al Amin; Vikas Gupta. Vitamin B12 (Cobalamin).  NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. June 2022. [Accessed on 4th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK559132/

4. Rabia G Sezer, Abdulkadir Bozaykut, Handan A Akoglu, Gül N Özdemir. The Efficacy of Oral Vitamin B12 Replacement for Nutritional Vitamin B12 Deficiency.  NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov.  March 2018. [Accessed on 4th November 2022] https://pubmed.ncbi.nlm.nih.gov/29189512/

5. Emmanuel Andrès, Thomas Vogel, Laure Federici, Jacques Zimmer,  Ecaterina Ciobanu, and Georges Kaltenbach. Cobalamin Deficiency in Elderly Patients: A Personal View. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. May 2008.  [Accessed on 4th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672039/

6. Getz Pharma (Pvt) Ltd. Nervon. [Accessed on 4th November 2022] https://getzpharma.com/wp-content/uploads/2016/08/Nervon-Range-Leaflet-Export-GA.pdf

7. Mova Pharmaceutical Pvt Ltd. MOVACOBAL MD 3. [Accessed on 4th November 2022] http://movapharma.com/cod-division.php

8. Micro Labs Ltd. Meconerv Tablet. [Accessed on 4th November 2022] https://www.microlabsltd.com/elibrary/node/1908

9. Kivonyx Healthcare. Vibicol SL. [Accessed on 4th November 2022] https://www.kivonyx.com/product/Vibicol-SL

USEFUL DIAGNOSTIC TESTS

• Nerve conduction test
• Complete blood count