INTRODUCTION

VIREAD 300MG contains tenofovir disoproxil fumarate which is an antiretroviral or antiviral medicine. It is a nucleotide reverse transcriptase inhibitor, generally known as an NRTI and works by interfering with the normal working of enzymes (in HIV reverse transcriptase; in hepatitis B DNA polymerase) that are essential for the viruses to reproduce themselves. It is used with other antiviral medicines to treat Human Immunodeficiency Virus (HIV) in adults and children 2 years of age and older. HIV is the virus that causes the AIDS (Acquired Immune Deficiency Syndrome).

It is also used to treat chronic hepatitis B virus infection [HBV]. Take this medicine at the same time every day. For adults, the usual dose of this medicine is one 300 mg tablet each day or as directed by physician. If you have kidney problems, your healthcare provider may tell you to take VIREAD 300MG. It is not recommended for pregnant or breastfeeding. Before taking, tell your doctor if you have liver, kidney or heart problems. Do not drive or operate any machinery while taking this medicine, it may make you feel dizzy. The common side effects are diarrhea, vomiting, nausea, dizziness, rash, feeling weak.

USES OF VIREAD 300MG

• treat in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older
• treat chronic hepatitis B, an infection with HBV (hepatitis B virus)

HOW VIREAD 300MG WORKS

VIREAD 300MG may help to increase the number of CD4 (T) cells in your blood which help fight off other infections. Reducing the amount of HIV and increasing CD4 (T) cell count may improve your immune system. This may reduce the risk of death or infections that can happen when your immune system is weak (opportunistic infections).

DIRECTIONS FOR USE

The recommended dose of this medicine is one 300 mg tablet each day or as directed by physician. Swallow the medicine whole with plenty of water.

SIDE EFFECTS OF VIREAD 300MG

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Keep try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.

Headache:

Rest and drink plenty of fluids. Apply a cold, wet cloth or ice pack to your forehead. Rest in a quiet, comfortable, dark room.

Rash:

Avoid bathing with hot water because hot water can irritate the skin. Moisturizers can be used regular basis to soothe and hydrate the affected area.

Diarrhea:

Drink lot of fluid, such as water or squash, to avoid dehydration. Do not take any other medicine without consulting your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor if you are taking:

• medicines used to treat bacterial infections including tuberculosis, containing rifabutin, rifampicin or rifapentine
• medicines used to treat the HIV, such as ritonavir or cobicistat boosted darunavir, lopinavir or atazanavir
• anticonvulsants used to treat epilepsy, such as carbamazepine, oxcarbazepine, phenobarbital or phenytoin
• herbal remedies used to treat the depression and anxiety, containing St. John’s wort (Hypericum perforatum)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT VIREAD 300MG

Can VIREAD 300MG be used in pregnant women?

No. It is not recommended for use in the pregnant women. Consult your doctor before taking.

Does VIREAD 300MG cure hepatitis B?

It can treat hepatitis B very effectively in some people. In some situation, it is more effective than adefovir and lamivudine.

REFERENCES

1. Goodman and Gilman’s: The Pharmacological Basis of Therapeutics. Chapter – 58; Antiviral agents; 12th ed. New York, New York: McGraw-Hill Medical, 2011. Page – 1618, 1619.

2. E. Jenny Heathcote; Efficacy and safety of tenofovir disoproxil fumarate in patients with chronic hepatitis B; [Published on 2010] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002569/

3. Alice M Jenh  Paul A Pham; Tenofovir disoproxil fumarate in the treatment of chronic hepatitis B; [Published on 2010] https://pubmed.ncbi.nlm.nih.gov/20954872/

4. CIPLA (EU) Limited; Electronic Medicines Compendium (EMC); [Revised on Nov 2020] [Accessed 13 Oct 2020 https://www.medicines.org.uk/emc/files/pil.9932.pdf

5. Gilead Sciences, Inc; U.S. Food and Drug Administration; [Revised on Jan 2012] [Accessed 13 Oct 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022577lbl.pdf