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INTRODUCTION
VILDANIL M TABLET is a combination of Metformin and Vildagliptin which belongs to a group of medicines called Antidiabetic agents. VILDANIL M TABLET is used to treat type 2 diabetes (also known as non-insulin dependent diabetes mellitus) in adult patients, whose diabetes cannot be controlled by diet and exercise alone and/or with other medicines used to treat diabetes (insulin or sulphonylureas such as glimepiride, glipizide).
Type 2 diabetes is a chronic medical condition in which the body does not make enough insulin or the insulin that is produced does not work well. Symptoms include excessive urination, excessive thirst, hunger, fatigue and blurred vision.
Before taking VILDANIL M TABLET, inform your doctor if you have liver, kidney or heart problems. It should be used during pregnancy only if advised by your doctor and is not recommended for pregnant women. VILDANIL M TABLET is not suitable for use in children and adolescents under 18 years of age and it should be used with caution in elderly patients (65 years of age and above).
Avoid consumption of alcohol during treatment with VILDANIL M TABLET as it may increase the risk of lactic acidosis. The most common side effects of taking VILDANIL M TABLET are nausea, vomiting, stomach pain, headache, low blood sugar and diarrhoea. Contact your doctor if any of the symptoms worsen.
USES OF VILDANIL M TABLET
- Treats type II diabetes mellitus (whose diabetes cannot be controlled by diet and exercise alone and/or with other medicines used to treat diabetes)
HOW VILDANIL M TABLET WORKS
VILDANIL M TABLET helps to control the blood sugar level, where metformin works by helping the body to make better use of insulin and vildagliptin works by making the pancreas produce more insulin and less glucagon.
DIRECTIONS FOR USE
Always take VILDANIL M TABLET as directed by your physician. Take this medicine with or just after the food, swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age and health condition. Do not stop taking VILDANIL M TABLET without informing your doctor.
SIDE EFFECTS OF VILDANIL M TABLET
COMMON
- nausea
- vomiting
- diarrhoea
- stomach pain
- loss of appetite
- dizziness
- headache
- metallic taste
- low blood glucose
- uncontrolled trembling
UNCOMMON
- joint pain, tiredness
- constipation
- swollen hands, ankles or feet (oedema)
RARE
Stop taking VILDANIL M TABLET and contact your doctor immediately if you experience any of the following side effects:
- symptoms of lactic acidosis (such as vomiting, stomach pain, decreased heartbeat, difficulty in breathing, muscle cramps, general weakness with severe tiredness or reduced body temperature)
- signs of an inflamed pancreas (severe and persistent pain in the abdomen with or without nausea or vomiting)
- signs of liver disease like hepatitis (such as yellowing of skin and eyes, nausea, loss of appetite or dark-coloured urine)
- severe allergic reactions called angioedema (such as swelling of the face, lips, mouth, tongue or throat that may lead to difficulty in breathing or swallowing)
- condition that may be associated with dehydration such as severe vomiting, diarrhoea, fever, exposure to heat or if you drink less fluid than normal
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Avoid taking any medicine on your own to treat diarrhoea. Consult your doctor if the symptom does not improve.
Constipation:
Consume fiber-rich foods such as fresh fruits and vegetables, whole grain cereals and plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom does not improve.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. Do not self-treat on your own; consult your doctor if the symptom does not improve on its own.
Nausea and vomiting:
Stick to simple meals. Avoid eating oily, fried or spicy food. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom does not improve.
Headache:
Rest and relax. Drink a sufficient amount of fluids, such as water. Apply a pain-relieving balm to the head if required. Consult your doctor if the symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
VILDANIL M TABLET is generally not recommended for pregnant women unless it is considered necessary. Consult your doctor before taking VILDANIL M TABLET.
BREASTFEEDING
VILDANIL M TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking VILDANIL M TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience dizziness after taking VILDANIL M TABLET.
ALCOHOL
Consumption of alcohol is not recommended during treatment with VILDANIL M TABLET since it may increase the risk of lactic acidosis.
KIDNEY
VILDANIL M TABLET is not recommended in patients with severely reduced kidney function. Consult your doctor before taking VILDANIL M TABLET.
LIVER
VILDANIL M TABLET is not recommended in patients with liver disease. Consult your doctor before taking VILDANIL M TABLET.
ALLERGY
Do not take VILDANIL M TABLET if you are allergic (hypersensitive) to Metformin or Vildagliptin.
HEART DISEASE
VILDANIL M TABLET is not recommended in patients who recently had a heart attack or heart failure or any signs of heart problems such as serious blood circulation problems or difficulty breathing. Consult your doctor before taking VILDANIL M TABLET.
OTHERS
VILDANIL M TABLET is not recommended for you, if you have:
- Type 1 diabetes mellitus
- uncontrolled diabetes (with severe low blood sugar levels, nausea, vomiting, diarrhoea, rapid weight loss, ketoacidosis or lactic acidosis)
- severe infection or seriously dehydrated
- are going to have a contrast x-ray (a specific type of x-ray involving an injectable dye)
Before taking VILDANIL M TABLET, inform your doctor if you have or had:
- disease of the pancreas
- going to undergo any surgery
- vitamin B12 deficiency
- malnutrition with adrenal or pituitary insufficiency
Use in Pediatrics:
VILDANIL M TABLET is not recommended for use in children and adolescents less than 18 years of age due to a lack of safety and effectiveness. Consult with your doctor for advice.
Use in Geriatrics:
VILDANIL M TABLET should be used with caution in elderly patients above 65 years of age, especially in patients with impaired kidney function. Your doctor will adjust the dose depending on kidney function and your kidney function will be monitored regularly. Consult with your doctor before taking VILDANIL M TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking VILDANIL M TABLET inform your doctor, if you are taking any of these medicines:
- glucocorticoids such as dexamethasone and prednisolone (treats inflammation)
- beta-2 agonists such as albuterol and terbutaline (treats respiratory disorders)
- diuretics such as chlorthalidone and hydrochlorothiazide (used to increase urine production)
- ibuprofen and celecoxib (treats pain and inflammation)
- angiotensin-converting enzyme (ACE) inhibitors (Ex. enalapril, lisinopril) and angiotensin II receptor antagonists (Ex. losartan, telmisartan) (treats high blood pressure)
- medicines affecting the nervous system and thyroid
- other medicines used to treat diabetes (Ex. glimepiride, glipizide)
- ranolazine (treats chest pain)
- dolutegravir (treats HIV infection)
- vandetanib (treats medullary thyroid cancer)
- cimetidine (treats heartburn and peptic ulcers)
Overdosage:
If you or anyone else accidentally take too much of VILDANIL M TABLET, consult your doctor immediately. Overdosage symptoms of VILDANIL M TABLET might include low blood sugar levels, lactic acidosis, muscle pain, mild and transient burning or tickling sensation in the body, fever and oedema
SYNOPSIS
| Drug | : | Metformin and Vildagliptin |
| Pharmacological Category | : | Antidiabetic agent (Biguanides & Dipeptidyl Peptidase 4 Inhibitor) |
| Therapeutic Indication | : | Type 2 Diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep VILDANIL M TABLET out of reach from children
- Do not store above 30°C
FAQs ABOUT VILDANIL M TABLET
Q: What is VILDANIL M TABLET used for?
A: VILDANIL M TABLET is used to treat type 2 diabetes (also known as non-insulin dependent diabetes mellitus) in adults whose diabetes cannot be controlled by diet and exercise alone and/or in combination with other diabetes medications (insulin or sulphonylureas such as glimepiride or glipizide).
Q: Is it safe to use VILDANIL M TABLET on elderly patients?
A: VILDANIL M TABLET should be used with caution in elderly patients over 65 years of age, especially in patients with impaired kidney function. Your doctor will adjust the dose depending on kidney function and your kidney function will be monitored regularly. Consult with your doctor before taking VILDANIL M TABLET.
Q: Is it safe to use VILDANIL M TABLET in patients with heart problems?
A: VILDANIL M TABLET is not recommended in patients who have recently had a heart attack, heart failure or any signs of heart problems such as serious problems with blood circulation or difficulty breathing. Consult your doctor before taking VILDANIL M TABLET.
Q: What are the most common side effects of taking VILDANIL M TABLET?
A: The most common side effects of taking VILDANIL M TABLET are nausea, vomiting, stomach pain, headache, dizziness, loss of appetite, metallic taste, uncontrolled trembling, low blood sugar and diarrhoea. Contact your doctor if any of the symptoms worsen.
Q: Can I consume alcohol while taking VILDANIL M TABLET?
A: Consumption of alcohol is not recommended during treatment with VILDANIL M TABLET since it may increase the risk of lactic acidosis. Consult your doctor before taking VILDANIL M TABLET if you are an alcoholic or have a history of alcoholism.
REFERENCES
1. KD Tripathi MD. Hormones and related drugs. Essentials of Medical Pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.
2. Paresh Ved and Samrat Shah. Evaluation of vildagliptin and fixed dose combination of vildagliptin and metformin on glycemic control and insulin dose over 3 months in patients with type 2 diabetes mellitus. March 2012. [Accessed on 30th June 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354946/
3. Serge Halimi, Anja Schweizer, Biljana Minic, James Foley and Sylvie Dejage. Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet. March 2008. [Accessed on 30th June 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515409/
4. Novartis Pharma GmbH. Electronic Medicines Compendium (EMC) [Revised in August 2021] [Accessed on 30th June 2021] https://www.medicines.org.uk/emc/files/pil.6226.pdf
5. Cipla Ltd. VYSOV-M Tablets (Vildagliptin + Metformin hydrochloride). [Revised in July 2020] [Accessed on June 30, 2021] https://ciplamed.com/print-product-pdf/37162
USEFUL DIAGNOSTIC TESTS
- Glucose - Fasting Blood
- Glucose - Postprandial Blood
- Glycosylated Hemoglobin
AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS
Last updated on 13 Jan 2023 | 12:04 PM(IST)
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