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INTRODUCTION
VILAZINE 40MG TABLET contains Vilazodone which belongs to the group of medicines called Antidepressants. It is indicated for the treatment of major depressive disorder.
Depression is a mood disorder that causes a constant feeling of sadness and loss of interest. It affects the way you feel, think and behave and can lead to a variety of emotional and physical problems.
Before taking VILAZINE 40MG TABLET inform your doctor if you have family history of mental diseases (suicide, depression, bipolar disorder, mania or hypomania), bleeding disorder, seizures, glaucoma (increased pressure in your eyes), low levels of sodium in your blood or if you drink alcohol.
Some serious side effects of VILAZINE 40MG TABLET includes suicidal thoughts. Contact your doctor immediately if you experience any such thoughts.
VILAZINE 40MG TABLET should be used with caution in pregnant, breast-feeding women and elders above 65 years of age. VILAZINE 40MG TABLET is not recommended in children and adolescents below 18 years of age. Consult with your doctor before taking VILAZINE 40MG TABLET.
The most common symptoms of VILAZINE 40MG TABLET are trouble sleeping, nausea, vomiting and diarrhoea. Check with your doctor if the symptoms get worse.
USES OF VILAZINE 40MG TABLET
- treats major depressive disorder
HOW VILAZINE 40MG TABLET WORKS
VILAZINE 40MG TABLET works by inhibiting the reuptake of a brain chemical called serotonin, thus, increasing the level of serotonin which helps in regulating the mood. Thus, helps in the symptomatic relief of depressive disorder.
DIRECTIONS FOR USE
Take VILAZINE 40MG TABLET as advised by your doctor. VILAZINE 40MG TABLET should be swallowed along with a glass of water. Do not crush or chew the medicine. Your doctor will decide the proper dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF VILAZINE 40MG TABLET
COMMON
- diarrhoea
- nausea or vomiting
- trouble sleeping
UNCOMMON
- mania/hypomania: elevated or irritated mood, decreased need for sleep, racing thoughts
- signs of seizures such as loss of consciousness along with uncontrollable shaking
RARE
- glaucoma (increased pressure in the eyes, eye pain and blurred vision)
- signs of low sodium level in blood such as tiredness, weakness, confusion, combined with achy, stiff or uncoordinated muscles
Stop taking VILAZINE 40MG TABLET and consult with your doctor, if you experience any of the following:
- serotonin syndrome: a reaction which may cause feelings of agitation, confusion, fast heartbeat, dizziness, flushing, tremors, stiff muscles or muscle twitching, seizures, seeing or hearing things that are not real (hallucinations), coma. blood pressure changes, sweating, high body temperature, loss of coordination, nausea, vomiting, diarrhoea
- signs of low platelets such as bruising or unusual bleeding from the skin or other areas
- signs of mania/hypomania such as greatly increased energy, racing thoughts, unusually grand ideas, severe trouble sleeping, talking more or faster than usual, reckless behaviour, excessive happiness or irritability
- discontinuation syndrome due to sudden stopping taking the medicine (nausea, changes in your mood, irritability and agitation, dizziness, electric shock sensation (paresthesia), anxiety, confusion, sweating, headache, tiredness, problems sleeping, hypomania, ringing in your ears, seizures)
- seizures
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Ask for your doctor’s advice if diarrhoea doesn’t improve.
Nausea:
Take this medicine with or after meals. Stick to simple meals while taking this medicine. Avoid eating rich or spicy food. Do not take any medication on your own. Ask for your doctor’s advice if nausea doesn’t improve.
Vomiting:
Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, oily or sweet foods. Avoid carbonated drinks. Ask for your doctor’s advice if vomiting doesn’t improve.
WARNING & PRECAUTIONS
PREGNANCY
VILAZINE 40MG TABLET should be used with caution in pregnant women. Consult with your doctor if you are pregnant or planning to have a baby before taking VILAZINE 40MG TABLET.
BREASTFEEDING
VILAZINE 40MG TABLET should be used with caution in breast feeding women as it is not known if it passes through breast milk. Consult with your doctor before taking VILAZINE 40MG TABLET.
DRIVING AND USING MACHINES
Do not take VILAZINE 40MG TABLET if you feel sleepy or reduced ability to think clearly, make decisions or react quickly after taking VILAZINE 40MG TABLET.
ALCOHOL
Avoid the consumption of alcohol while taking VILAZINE 40MG TABLET.
ALLERGY
Do not take VILAZINE 40MG TABLET if you are allergic to Vilazodone or any other ingredients of this medicine.
OTHERS
Before taking VILAZINE 40MG TABLET, inform your doctor if you have:
- family history of mental diseases (suicide, depression, bipolar disorder, mania or hypomania)
- bleeding disorders
- seizures
- glaucoma (increased pressure in your eyes)
- low levels of sodium in your blood
- habit of drinking alcohol
Use in Pediatrics:
VILAZINE 40MG TABLET is not recommended for use in children and adolescents under 18 years of age. Check with your child’s doctor before giving VILAZINE 40MG TABLET to your child.
Use in Geriatrics:
VILAZINE 40MG TABLET should be used with caution in elderly patients above 65 years of age. Inform and check with your doctor before taking VILAZINE 40MG TABLET.
INTERACTIONS
A. Drug - Drug interactions:
Before taking VILAZINE 40MG TABLET, inform your doctor if you are taking the following medicines:
- monoamine oxidase inhibitors such as isocarboxazid, tricyclic antidepressants such as amitriptyline, doxepin, St. John Wart (used to treat depression)
- antibiotics such as linezolid (used to treat bacterial infection)
- intravenous methylene blue (used to treat methemoglobinemia)
- triptans such as sumatriptan (used to treat migraine)
- fentanyl, tramadol (used to treat severe pain)
- lithium (used to treat mental illness)
- tryptophan (used for biosynthesis of proteins to ensure proper body growth)
- buspirone (used to treat anxiety)
- amphetamine (used to treat ADHD, narcolepsy)
- aspirin, warfarin, dabigatran (used in the treatment of blood clotting)
- acetylsalicylic acid and other non-steroidal anti-inflammatory drugs such as ibuprofen (used to relive pain and inflammation)
- diuretics such as furosemide, spironolactone (used in the treatment of high blood pressure, oedema, heart failure)
Overdosage:
If you or anyone else accidentally take too much of VILAZINE 40MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage include serotonin syndrome (agitation, confusion, fast heartbeat, dizziness, flushing, tremors, stiff muscles or muscle twitching, seizures, seeing or hearing things that are not real (hallucinations), coma. blood pressure changes, sweating, high body temperature, loss of coordination, nausea, vomiting, diarrhoea), lethargy, restlessness, hallucinations and disorientation.
SYNOPSIS
| Drug | : | Vilazodone |
| Pharmacological Category | : | Serotonin modulators |
| Therapeutic Indication | : | Major Depressive disorder |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep VILAZINE 40MG TABLET out of the reach in children
- Store VILAZINE 40MG TABLET at a temperature between 15°C-30°C
FAQs ABOUT VILAZINE 40MG TABLET
What is VILAZINE 40MG TABLET and why is it prescribed?
VILAZINE 40MG TABLET contains Vilazodone which belongs to the group of medicines called Antidepressants. It is indicated for the treatment of major depressive disorder.
Can I stop taking VILAZINE 40MG TABLET on my own if I start to feel better?
Do not stop taking VILAZINE 40MG TABLET until and unless advised by your doctor. Stopping suddenly may cause discontinuation syndrome characterized by nausea, changes in your mood, irritability and agitation, dizziness, electric shock sensation (paraesthesia), anxiety, confusion, sweating, headache, tiredness, problems sleeping, hypomania, ringing in your ears, seizures. Ask for your doctor’s advice if you wish to discontinue taking VILAZINE 40MG TABLET.
What are the common side effects of VILAZINE 40MG TABLET?
The common side effects of VILAZINE 40MG TABLET are the following: diarrhoea, nausea or vomiting and trouble sleeping. Consult with your doctor if the symptoms get worse or does not improve.
What shall I avoid while taking VILAZINE 40MG TABLET?
VILAZINE 40MG TABLET can make you feel sleepy or may affect your ability to think clearly, make decisions or react quickly. Wait until you know how you feel after you have taken VILAZINE 40MG TABLET before you drive or use heavy machines. Avoid the consumption of alcohol while taking VILAZINE 40MG TABLET.
What is the best time to take VILAZINE 40MG TABLET?
VILAZINE 40MG TABLET should be taken with food to help with its absorption. It also helps to prevent upset stomach. Additionally, VILAZINE 40MG TABLET can be taken as close to bedtime as possible.
REFERENCES
1. Björn C. Knollmann, Laurence Brunton and Randa Hilal-Dandan. Neuropharmacology. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. Thirteenth Edition. 2017. Page - 241
2. Wang, S. M., Han, C., Lee, S. J., Patkar, A. A., Masand, P. S., & Pae, C. U. Vilazodone for the Treatment of Depression. NIH National Library of Medicine; National centre for biotechnology information. Pubmed Central. May 2016. [Accessed on 3rd December 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880584/
3. Thomas L. Schwartz, Umar A. Siddiqui, Stephen M. Stahl. Vilazodone: a brief pharmacological and clinical review of the novel serotonin partial agonist and reuptake inhibitor. NIH National Library of Medicine; National centre for biotechnology information. Pubmed Central. June 2011. [Accessed on 3rd December 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736894/
4. Martin Paspe Cruz. Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor for the Treatment of Major Depressive Disorder. NIH National Library of Medicine; National centre for biotechnology information. Pubmed Central. January 2012. [Accessed on 3rd December 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278186/
5. Allergan USA, Inc. VIIBRYD tablets (Vilazodone). Dailymed. [Revised in November 2022]. [Accessed on 3rd December 2022]. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bfef9e19-d0f5-40fa-954c-b73c812eb242
6. Allergan USA, Inc. VIIBRYD tablets (Vilazodone). [Revised in September 2021] [Accessed on 3rd December 2022]. https://www.rxabbvie.com/pdf/viibryd_pi.pdf
7. Allergan Sales, LLC. VIIBRYD tablets (Vilazodone). [Revised in March 2021] [Accessed on 3rd December 2022]. https://allergan-web-cdn-prod.azureedge.net/allergancanadaspecialty/allergancanadaspecialty/media/actavis-canada-specialty/en/products/pms/viibryd-pm-eng_03march2021.pdf
USEFUL DIAGNOSTIC TESTS
- Complete blood cell count
AUTHOR DETAILS
Written By Dr. Priyanka Goel, BDS
Last updated on 03 Dec 2022 | 11:45 AM(IST)
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