INTRODUCTION

VIBOLIV 500MG TABLET contains Metadoxine which belongs to a group of medicines called Alcohol Deterrents. VIBOLIV 500MG TABLET is used in the treatment of alcohol intoxication which occurs as a disturbance in behaviour/mental function during or after alcohol consumption in affected individuals.

VIBOLIV 500MG TABLET is also used to treat chronic alcoholism which occurs due to habitual and prolonged use of alcoholic beverages in affected individuals.

VIBOLIV 500MG TABLET is not recommended for use in patients allergic to Methadoxine.

Before taking VIBOLIV 500MG TABLET, inform your doctor if suffer from Parkinson's disease (brain disorder that causes unintended/uncontrollable movements), and/or have kidney problems, or liver problems (such as alcoholic liver damage).

VIBOLIV 500MG TABLET is not recommended for use during pregnancy unless it is clearly necessary. It is also not recommended for use in breastfeeding women as it reduces the synthesis of prolactin (hormone responsible for producing milk during pregnancy and after birth).

The medicine is also not recommended for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.

The most common side effects of taking VIBOLIV 500MG TABLET are diarrhea, skin rash, numbness, and/or drowsiness. Consult your doctor if any of these symptoms worsen.

USES OF VIBOLIV 500MG TABLET

• Aids in alcohol intoxication
• Treats chronic alcoholism

HOW VIBOLIV 500MG TABLET WORKS

VIBOLIV 500MG TABLET works by increasing alcohol elimination from blood and tissues which results in reduced absorption of alcohol by liver thus aiding in alcohol intoxication and preventing liver damage in affected individuals.

DIRECTIONS FOR USE

Take VIBOLIV 500MG TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF VIBOLIV 500MG TABLET

HOW TO MANAGE SIDE EFFECTS

Diarrhea:

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult and inform your doctor if the symptom worsens.

WARNING & PRECAUTIONS

INTERACTIONS

A.Drug-Drug Interactions:

• levodopa (used to treat Parkinson’s disease)

Overdosage:

If you or anyone else accidentally takes too much of VIBOLIV 500MG TABLET, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.

SYNOPSIS

MORE INFORMATION

• Keep VIBOLIV 500MG TABLET out of reach in children
• Store VIBOLIV 500MG TABLET below 30°C

FAQs ABOUT VIBOLIV 500MG TABLET

What is VIBOLIV 500MG TABLET used for?

VIBOLIV 500MG TABLET is used to treat alcohol intoxication which occurs as a disturbance in behaviour/mental function during or after alcohol consumption. It is also used to treat chronic alcoholism which occurs due to habitual and prolonged use of alcoholic beverages in affected individuals.

What are the common side effects of taking VIBOLIV 500MG TABLET?

The most common side effects of taking VIBOLIV 500MG TABLET are diarrhea, skin rash, numbness, and/or drowsiness. Consult your doctor if any of these symptoms worsen.

How VIBOLIV 500MG TABLET works?

VIBOLIV 500MG TABLET works by increasing alcohol elimination from blood and tissues which results in reduced absorption of alcohol by liver thus aiding in alcohol intoxication and preventing liver damage in affected individuals.

How VIBOLIV 500MG TABLET should be taken?

Take VIBOLIV 500MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Can VIBOLIV 500MG TABLET be used in pregnant and breastfeeding women?

No, VIBOLIV 500MG TABLET is generally not recommended for use during pregnancy unless it is clearly necessary.  It is also not recommended for use in breastfeeding women as it reduces the synthesis of prolactin (hormone responsible for producing milk during pregnancy and after birth). Consult your doctor before taking the medicine.

REFERENCES

1. Randi Fredricks. Diet and Substance related disorders. Healing and Wholeness: Complementary and Alternative Therapies for Mental Health. Edition :2008. Page – 288.

2. G Addolorato, C Ancona, E Capristo, G Gasbarrini. Metadoxine in the treatment of acute and chronic alcoholism: a review. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. December 2003. [Accessed on 8th July 2022] https://pubmed.ncbi.nlm.nih.gov/14611722/

3. Yi-Min Mao, Min-de Zeng, You-Ming Li, Bing-Yuan Wang, Jia Shang, Rui-Hua Shi, Ji-Yong Liu, Lun-Gen Lu, Ai-Ping Cao. Capsule metadoxine in the treatment of alcoholic liver disease: a randomized, double-blind, placebo-controlled, multicenter study. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. March 2009.  [Accessed on 8th July 2022] https://pubmed.ncbi.nlm.nih.gov/19335986/

4. Fátima Higuera-de la Tijera, Alfredo I Servín-Caamaño, Aurora E Serralde-Zúñiga, Javier Cruz-Herrera, Eduardo Pérez-Torres, Juan M Abdo-Francis, Francisco Salas-Gordillo, José L Pérez-Hernández. Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.  NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. April 2015. [Accessed on 8th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408471/

5. Icon Life Sciences. LIVODOX. [Accessed on 8th July 2022] https://iconlifesciences.in/products.php

6. Robert joseph miela, Wieslaw jerzy cubala, Katarzyna jakuszkowiak-wojten, Dariusz wojciech mazurkiewicz.  Pharmacotherapy of Alcohol Use disorder: A Review of Current Literature.  ResearchGate. November 2018. [Accessed on 8th July 2022] https://www.researchgate.net/publication/330281803_Pharmacotherapy_of_Alcohol_Use_disorder_A_Review_of_Current_Literature

7. Icon Life Sciences. LIVODOX. [Accessed on 8th July 2022] https://iconlifesciences.in/products.php

8. Laboratori Baldacci Spa. Italian Medicines Agency (AIFA). [Revised in June 2016] [Accessed on 8th July 2022] https://farmaci.agenziafarmaco.gov.it/bancadatifarmaci/farmaco?farmaco=025316

USEFUL DIAGNOSTIC TESTS

• Blood test
• Urine Analysis test