VELTIP 2MG contain Bortezomib which belongs to a group of medicine called proteasome inhibitor. Proteasomes plays an important role in controlling cell function and growth. By interfering with their function, it can kill cancer cells. It is used to treat multiple myeloma (a cancer of the bone marrow) and mantle cell lymphoma (a type of cancer affecting the lymph nodes) in patients 18 years or older.
Multiple myeloma is a cancer of plasma cells (a type of white blood cell in the bone marrow). In this condition, a group of plasma cell becomes cancerous and multiplies causing damage to the bone, immune system, kidney, and red blood cell count. It is also called as kahler's disease. Mantle cell lymphoma develops when B-cell (also called B-lymphocyte) become abnormal. B-cell are white blood cell that fight infection. The abnormal B-cell (lymphoma cell) usually build up in lymph nodes, but they can affect other parts of the body.
VELTIP 2MG will be given to you by a doctor or nurse. It is intended to be administered by intravenous or subcutaneous. It is strictly not recommended for use in children and adolescents under 18 years. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine. The most common side effects are nausea, vomiting, loss of appetite, constipation, with or without bloating, diarrhoea, tiredness (fatigue), feeling weak or loss of consciousness, muscle pain, bone pain, low or high blood pressure, reduced kidney function, headache and shivering.
VELTIP 2MG works by blocking or slowing the breakdown of proteins in cells. As a result, there is an increase in a number of proteins in the cancer cells leading to their death.
VELTIP 2MG will be given to you by a doctor or nurse. It is intended to be administered by intravenous or subcutaneous. Your doctor will decide the dose and frequency depending on your condition.
Fever:
Drink plenty of fluids and water. Avoid taking cold bath or showers.
Nausea and vomiting:
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Constipation:
Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.
Diarrhoea:
Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without talking to a doctor.
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
VELTIP 2MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
VELTIP 2MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
Do not drive or operate any machine while taking this medicine as it may cause tiredness, dizziness, fainting, or blurred vision.
Consumption of alcohol is not recommended during treatment with VELTIP 2MG.
VELTIP 2MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
VELTIP 2MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
Do not take VELTIP 2MG if you are allergic (hypersensitive) to bortezomib or any other ingredients in this medicine.
VELTIP 2MG is not recommended in patients with active lung diseases (severe lung). Before taking this medicine consult your doctor.
VELTIP 2MG is not recommended in patients with active heart diseases. Before taking this medicine consult your doctor.
Tell your doctor if you have or had a condition such as,
Talk to your doctor if you are taking,
Drug | : | Bortezomib |
Pharmacological Category | : | Antineoplastic Agent, Proteasome Inhibitor |
Therapeutic Indication | : | Multiple myeloma and mantle cell lymphoma |
Dosage Forms | : | Injection |
Store below 20-25°C and keep out of reach of children.
Is VELTIP 2MG toxic?
It can cause toxic effects if not given in appropriate dose, although not everybody gets them.
Can VELTIP 2MG cause fever?
Yes, this medicine may cause fever in some individuals. Drink plenty of fluids and water. Avoid taking cold bath or showers.
1. KD Tripathi. Anticancer Drugs. Essentials of Medical Pharmacology. Seventh Edition, 2013. Page - 871.
2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 461-462.
3. Antonia Field-Smith, Gareth J Morgan, and Faith E Davies. Bortezomib (Velcade™) in the Treatment of Multiple Myeloma. US National Library of Medicines, National Institutes of Health. Sep 2006. [Accessed 16 Dec 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936263/
4. Bryan Hambley 1, Paolo F Caimi 1, Basem M William 2. Bortezomib for the treatment of mantle cell lymphoma: an update. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Aug 2019. [Accessed 16 Dec 2020] https://pubmed.ncbi.nlm.nih.gov/27493710/
5. STADA Arzneimittel AG; Electronic Medicines Compendium (EMC); [Revised on Feb 2020] [Accessed 16 Dec 2020] https://www.medicines.org.uk/emc/files/pil.10201.pdf
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