INTRODUCTION
VANCOGRAM 1GM contains Vancomycin which belongs to a group of medicines called glycopeptide antibiotics. It is used to treat severe infections caused by susceptible strains of methicillin-resistant (betalactam-resistant) staphylococci and staphylococcal endocarditis.
Vancomycin is a tricyclic glycopeptide antibiotic which inhibits the synthesis of the cell wall in sensitive bacteria by binding with high affinity to the D-alanyl-D-alanine terminus of cell wall precursor units. The bactericidal action of vancomycin against Staphylococcus aureus and the vegetative cells of Clostridium difficile results primarily from the inhibition of cell wall biosynthesis and alters the bacterial cell membrane permeability and RNA synthesis.
Before receiving VANCOGRAM 1GM inform your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. Your physician will administer the right dose depends on your child’s age and body weight. The common side effects are inflammation at the injection site, decrease in blood pressure, breathlessness and laboured breathing.
USES OF VANCOGRAM 1GM
- Treats severe infections caused by susceptible strains of methicillin-resistant (betalactam-resistant) staphylococci and staphylococcal endocarditis
HOW VANCOGRAM 1GM WORKS
Vancomycin which belongs to a class of medications called glycopeptide antibiotics which work by killing the bacteria in the intestines.
DIRECTIONS FOR USE
VANCOGRAM 1GM will be administered by your doctor or nurse by intravenously.
SIDE EFFECTS OF VANCOGRAM 1GM
SERIOUS
- swelling of the face or throat, breathing difficulties, feeling of weakness, itching skin or nettle rash
COMMON
- inflammation at the injection site
- decrease in blood pressure
- breathlessness, laboured breathing
RARE
- decrease in number of blood platelets and white blood cells
- severe allergic reactions
- dizziness
- temporary or lasting worsening of hearing function
- ringing in the ear
- nausea
- redness of the skin of the upper body
- inflammation of kidney tissue
- pain and cramps in chest and back muscles
- drug fever
- trembling
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take normal regular meals and do not eat spicy foods.
Dizziness:
Get up and move around to feel awake and eat a healthy food to boost your energy.
WARNING & PRECAUTIONS
PREGNANCY
VANCOGRAM 1GM should be used with caution in pregnant women only if clearly needed. Consult your doctor for advice.
BREASTFEEDING
VANCOGRAM 1GM should be used with caution during breastfeeding. Consult your doctor for advice.
KIDNEY
VANCOGRAM 1GM should be used with caution in patients with active kidney diseases. Consult your doctor for advice.
LIVER
VANCOGRAM 1GM should be used with caution in patients with active liver diseases. Consult your doctor for advice.
ALLERGY
Tell your doctor if you are allergic (hypersensitive) to Vancomycin.
OTHERS
Inform your doctor if you have or had,
- hard of hearing
- are older than 60 years
INTERACTIONS
Tell your doctor if you are taking,
- anti-motility agents
- ototoxic and/or nephrotoxic drug
- teicoplanin, aminoglycosides, streptomycin, neomycin, gentamicin, kanamycin, amikacin, bacitracin, tobramycin, polymyxin B, colistin (treats infection)
- amphotericin B (treats fungal infections)
- ciclosporin (suppress the activity of the immune system)
- diuretic medicines (loop diuretics)
- anaesthetics
- muscle relaxants
- oral contraceptives
SYNOPSIS
| Drug | : | Vancomycin |
| Pharmacological Category | : | Glycopeptide antibiotics |
| Therapeutic Indication | : | Staphylococcal infections, Endocarditis |
| Dosage Forms | : | Capsule, Injection |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT VANCOGRAM 1GM
Can I stop taking VANCOGRAM 1GM when my symptoms are relieved?
No, do not stop taking and complete the full course of treatment even if you feel better.
How long does VANCOGRAM 1GM take to work?
It starts working soon after taking it. But it may take some days to kill all the harmful bacteria.
How is VANCOGRAM 1GM given?
It will be administered intravenously by your doctor or nurse.
REFERENCES
1. KD Tripathi MD. Beta-lactam antibiotics. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 721.
2. MacDougall C, Chambers HF. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 539-542.
3. Chambers HF, Deck DH. Beta-Lactam and Other Cell Wall- & Membrane-Active Antibiotics. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 786-787.
4. Will A. McGuinness, Natalia Malachowa, and Frank R. DeLeo. Vancomycin Resistance in Staphylococcus aureus. June 23, 2017. [Accessed on June 23, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482303/
5. Biocon Limited. Neon Laboratories Limited. [Accessed on June 23, 2021] https://www.biocon.com/docs/prescribing_information/ccd/vancowarcp_pi.pdf
6. Vancomycin Hospira. [Accessed on June 23, 2021] https://mri.cts-mrp.eu/Human/Downloads/AT_H_0551_001_FinalPL.pdf
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
PRODUCT DETAILS
ALTERNATE BRANDS
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