Recently Searched
Valparin Chrono 500mg Tablet 10'S
Choose Generic substitutes to Save up to 50% off 
Availability & Expiry
INTRODUCTION
VALPARIN CHRONO 500MG TABLET contains Sodium Valproate which belongs to the group of medicines called Mood stabilizers. It is used to manage or control mania (feeling very excited, enthusiastic, over-active and easily irritated or distracted) caused by bipolar disorder. Bipolar disorder is when the mood fluctuates between feeling very high (mania) and very low (depression).
VALPARIN CHRONO 500MG TABLET can be used when lithium cannot be used. VALPARIN CHRONO 500MG TABLET is also used to treat complex partial seizures (in adults and children 10 years of age and older) and simple and complex absence seizures, with or without other types of seizures.
A seizure results from an excessive discharge of specific nerve cells and is characterized by changes in electrical activity. VALPARIN CHRONO 500MG TABLET can also be used to prevent migraine headaches (episodes of moderate to severe headache, mostly unilateral, generally associated with nausea and hypersensitivity to light and sound).
Before taking VALPARIN CHRONO 500MG TABLET, inform your doctor if you have fits, porphyria, liver, kidney, or pancreatic problems, diabetes, systemic lupus erythematosus, or any genetic diseases. Patients should be monitored for signs of suicidal ideation and behaviour and advised to seek medical advice if any such signs occur.
Avoid consumption of alcohol while taking VALPARIN CHRONO 500MG TABLET. VALPARIN CHRONO 500MG TABLET is not recommended for use in pregnant or breastfeeding women or children (younger than 2 years) who are at a considerably increased risk of developing liver toxicity.
The most common side effects of taking VALPARIN CHRONO 500MG TABLET are nausea, vomiting, headache, sleepiness, blurry or double vision, weight gain, hair loss, problems with walking, etc. Consult your doctor if any of the symptoms get worse.
USES OF VALPARIN CHRONO 500MG TABLET
VALPARIN CHRONO 500MG TABLET is used:
- Manage or control mania caused by bipolar disorder
- Treat complex partial seizures (adults and children 10 years of age and older) and simple and complex absence seizures, with or without other types of seizure
- Prevent migraine headaches
HOW VALPARIN CHRONO 500MG TABLET WORKS
VALPARIN CHRONO 500MG TABLET works by acting on GABA (γ aminobutyric acid) levels in the CNS, whose inhibitory activity is impaired in seizures and also in migraine headaches. It may also exert antiepileptic effects by reducing the high-frequency firing (excessive discharge) of nerve cells. VALPARIN CHRONO 500MG TABLET stabilizes mood by stabilizing the levels of chemicals in your brain that are responsible to affect your mood.
DIRECTIONS FOR USE
Take VALPARIN CHRONO 500MG TABLET as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of VALPARIN CHRONO 500MG TABLET for you based upon your age, body weight and disease condition. Do not stop taking VALPARIN CHRONO 500MG TABLET unless your doctor advises you to stop.
SIDE EFFECTS OF VALPARIN CHRONO 500MG TABLET
COMMON
- nausea, vomiting, diarrhea, increased or decreased appetite, stomach pain
- headache, dizziness
- sleepiness
- weakness, shakiness
- blurry or double vision
- weight gain
- hair loss
- problems with walking or coordination
RARE
- skin problems like rashes
Stop taking VALPARIN CHRONO 500MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- toxic epidermal necrolysis or Stevens-Johnson Syndrome (blistering, peeling or bleeding of your lips, eyes, mouth, nose, genitals, hands or feet with or without rash, fever, chills or aching muscles)
- erythema multiforme (skin rash especially on palms or feet, or lesions with a pink or red ring and a pale centre which may be itchy, scaly or filled with fluid)
- angioedema or an anaphylactic reaction (allergy-triggered swelling with painful itchy welts around the eyes, lips, throat and sometimes hands and feet, trouble swallowing or breathing)
- Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) causing skin rash, fever, lymph node enlargement and possible impairment of other organs
- liver problems (a sudden illness causing nausea, vomiting, extreme tiredness, drowsiness, weakness, stomach pain, yellow skin or whites of the eyes, loss of appetite, swelling of the legs and feet, recurrence of fits, dark urine, swollen face)
- pancreatic problems (severe stomach pain that might spread in your back, nausea or vomiting that does not go away)
- decreased platelet count (spontaneous bruising or bleeding due to blood clotting problems, or getting more infections than usual)
- severe decrease of white blood cells or bone marrow failure (fever and breathing difficulty)
- low red blood cell count or abnormally increased red blood cell size
- pancytopenia (bone marrow disorders that affect red blood cells, white blood cells and platelets)
- jerky muscle movements
- increased blood ammonia levels (problems with balance and co-ordination, feeling lethargic or less alert, associated with vomiting, changes in mental status)
- underactive thyroid gland (tiredness or weight gain)
- inflammation of the envelope of the lungs (breathing difficulty and pain)
- rapid, uncontrollable eye movements
- worsening of fits
- muscle pain and weakness
- systemic lupus erythematosus (SLE) causing joint pain, fever, fatigue or rash
- kidney problems (renal failure, tubulointerstitial nephritis and Fanconi syndrome) which may cause reduced urinary output or blood in the urine
- Syndrome of Inappropriate Antidiuretic Hormone (SIADH) secretion causing confusion
- suicidal thoughts or actions (thoughts about dying, attempts to commit suicide, new or worse depression, anxiety or irritability, agitation, restlessness, panic attacks, trouble sleeping (insomnia), aggression, anger, violence, acting on dangerous impulses, extreme excitability, other unusual changes in behavior or mood)
- very low body temperature
- drowsiness or sleepiness (elderly)
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drink lots of fluids, like water or fruit juice, to keep yourself hydrated. Check with your doctor before taking any medicine for diarrhoea. If the diarrhoea does not get better, contact your doctor.
Dizziness Or Drowsiness
Lie down until the dizziness is resolved, then get up slowly. Do not hurry and move slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. If dizziness does not get better, consult your doctor.
Headache
Drink plenty of water and get adequate rest. Try to be relaxed and stress-free. Check with your doctor before taking any medicine for a headache. If your headache does not get better, consult your doctor.
Loss Of Appetite
Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack rich in calories and protein, such as dried fruit and nuts. If your appetite does not improve, contact your doctor.
Nausea And Vomiting
Take VALPARIN CHRONO 500MG TABLET with, or just after, meals. Stick to simple meals. Avoid eating oily or spicy foods. If you still feel nauseous, contact your doctor. Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like eating; you don't have to eat or avoid any specific foods. Do not take any medicine for vomiting without your doctor's consultation. If vomiting does not get better, contact your doctor.
Stomach Pain
Try to rest and relax. Eat and drink slowly, or try to eat smaller meals more frequently. Keep a heating pad on your stomach. If your stomach still aches, contact your doctor.
Visual Disturbances
Avoid driving or going outside on your own if you have blurred eyesight. Close your eyes for some time until your eyesight gets clear. Contact your doctor if your vision remains blurred for a long period.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedVALPARIN CHRONO 500MG TABLET is not recommended for use in pregnant women, especially if you are taking it to prevent migraine headaches. Females of child-bearing capability must use effective contraception. Consult your doctor before taking it.
BREASTFEEDING
Use with CautionVALPARIN CHRONO 500MG TABLET should be used with caution in breastfeeding women as a little amount may pass through the breast milk. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel sleepy, confused or dizzy after taking VALPARIN CHRONO 500MG TABLET.
ALCOHOL
ContraindicatedAlcohol consumption is not recommended while taking VALPARIN CHRONO 500MG TABLET as it may cause sleepiness or dizziness or make these worse.
KIDNEY
Use with CautionVALPARIN CHRONO 500MG TABLET should be taken with caution in patients with kidney problems. Consult your doctor before taking it.
LIVER
ContraindicatedVALPARIN CHRONO 500MG TABLET is not recommended in patients with liver problems or a family history of liver problems caused by taking medicine. Consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take VALPARIN CHRONO 500MG TABLET if you are allergic to Valproic acid, divalproex sodium, sodium valproate, aspirin or any of the other ingredients of this medicine.
USE IN PEDIATRICS
ContraindicatedVALPARIN CHRONO 500MG TABLET is not recommended for use in children (younger than two years) who are at a considerably increased risk of developing liver toxicity. Consult your doctor before taking it.
USE IN GERIATRICS
Use with CautionVALPARIN CHRONO 500MG TABLET should be used with caution in elderly patients as they may experience drowsiness or sleepiness. Consult your doctor before taking it.
OTHERS
VALPARIN CHRONO 500MG TABLET is not recommended for use if you:
- have porphyria (a rare illness affecting metabolism)
- have urea cycle disorder (too much ammonia builds up in the body)
- have a genetic problem caused by a mitochondrial disorder (Ex. Alpers-Huttenlocher syndrome)
Before taking VALPARIN CHRONO 500MG TABLET, inform your doctor if you:
- are switching from another medicine that contains valproate
- have fits, a brain disease or condition affecting your brain
- have problems with your pancreas
- have high blood sugar or are being tested for diabetes
- are carnitine palmitoyl transferase type II deficient
- have systemic lupus erythematosus (a rare immune system disease which affects the skin, bones, joints and internal organs)
- have or had depression, mood disorders, or suicidal thoughts or behavior
- have any other medical conditions
INTERACTIONS
A. Drug-Drug interactions:
Before taking VALPARIN CHRONO 500MG TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used for pain, inflammation and fever (Ex. aspirin, metamizole)
- medicines used to treat fits (Ex. phenobarbital, primidone, acetazolamide, lamotrigine, phenytoin, carbamazepine, rufinamide, topiramate, felbamate)
- medicines used to calm emotional and mental health disorders (Ex. quetiapine, diazepam, olanzapine)
- moclobemide (used in depression and anxiety)
- selegiline (used to treat Parkinson’s disease)
- warfarin (used for blood thinning)
- medicines used to treat HIV (Ex. zidovudine, lopinavir, ritonavir)
- medicines used to treat bacterial infections (Ex. panipenem, imipenem, meropenem, rifampicin, erythromycin, linezolid)
- medicines used to treat or prevent malaria (Ex. mefloquine, chloroquine)
- temozolomide (used to treat cancer)
- cimetidine (used to treat stomach ulcers)
- cholestyramine (used to control blood fat levels)
- nimodipine (used for bleeding in the brain)
- propofol (used for anaesthesia)
- medicines containing oestrogen
Overdosage:
If you or anyone else accidentally take too much of VALPARIN CHRONO 500MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of GBNKEYWORD] overdose are nausea, vomiting, headache, blurred eyesight, dizziness, poor reflexes, confusion, memory loss, tiredness, weak or ‘floppy’ muscles, fits, loss of consciousness, behavioural changes, fast breathing, shortness of breath or chest pain.
SYNOPSIS
| Drug | : | Valproic acid |
| Pharmacological Category | : | Aliphatic carboxylic acid |
| Therapeutic Indication | : | Mania, Seizures, Migraine headaches |
| Dosage Forms | : | Tablet, Oral solution |
MORE INFORMATION
- Keep VALPARIN CHRONO 500MG TABLET out of reach of children
- Store VALPARIN CHRONO 500MG TABLET between 15-30°C
FAQs ABOUT VALPARIN CHRONO 500MG TABLET
Q: Can VALPARIN CHRONO 500MG TABLET be taken during pregnancy?
A: VALPARIN CHRONO 500MG TABLET is not recommended for use by pregnant women, especially if you are taking it to prevent migraine headaches. Females of childbearing capability must use effective contraception. Do not stop taking your contraception until your doctor advises you further.
If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking VALPARIN CHRONO 500MG TABLET. Inform your doctor immediately if you become pregnant during treatment with VALPARIN CHRONO 500MG TABLET.
Q: Can VALPARIN CHRONO 500MG TABLET make me feel suicidal?
A: Thoughts of harming or killing oneself are seen in a small number of patients being treated with VALPARIN CHRONO 500MG TABLET. Patients taking VALPARIN CHRONO 500MG TABLET should be monitored for signs of suicidal ideation and behaviours, especially sudden changes in mood, behaviours, thoughts, or feelings, and advised to seek medical advice if any such signs occur.
Q: Can VALPARIN CHRONO 500MG TABLET cause weight gain?
A: Yes. Taking VALPARIN CHRONO 500MG TABLET may make you put on weight. Discuss with your doctor for advice before taking VALPARIN CHRONO 500MG TABLET.
Q: Can I take other medicines with VALPARIN CHRONO 500MG TABLET?
A: Before taking VALPARIN CHRONO 500MG TABLET, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, over-the-counter or herbal medicine, as these might cause serious side effects by interacting with each other.
Q: Can VALPARIN CHRONO 500MG TABLET cause erectile dysfunction?
A: According to some studies, men on VALPARIN CHRONO 500MG TABLET therapy show irregularities in androgens blood levels, sperm motility, and erectile dysfunction. Consult your physician if you have trouble getting an erection or related symptoms during VALPARIN CHRONO 500MG TABLET treatment.
Q: Can VALPARIN CHRONO 500MG TABLET cause autism?
A: Autism and related disorders are more often diagnosed in children exposed to VALPARIN CHRONO 500MG TABLET during pregnancy. Consult your doctor for further doubts.
Q: Can VALPARIN CHRONO 500MG TABLET be given to children?
A: VALPARIN CHRONO 500MG TABLET is not recommended for use in children (younger than two years) who are at a considerably increased risk of developing liver toxicity. Your doctor will decide on the correct dose of VALPARIN CHRONO 500MG TABLET or select a suitable alternative treatment for your child.
Q: What if I forget to take a dose of VALPARIN CHRONO 500MG TABLET?
A: If you forget to take a dose of VALPARIN CHRONO 500MG TABLET, take it as soon as you remember. However, omit the missed dose if it's almost time for the next one. Do not take VALPARIN CHRONO 500MG TABLET twice to make up for the missed dose.
Q: Can VALPARIN CHRONO 500MG TABLET be stopped?
A: Continue taking VALPARIN CHRONO 500MG TABLET until your doctor tells you to stop unless you experience any unwanted effects, a worsening of your condition, or any new symptoms. Contact your doctor in such cases.
If you stop taking VALPARIN CHRONO 500MG TABLET without your doctor’s advice, your condition may get worse. When your doctor finds it okay to discontinue VALPARIN CHRONO 500MG TABLET treatment, your dose will be lowered gradually.
REFERENCES
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Epilepsy. Pharmacotherapy Handbook. Ninth edition. Page-518, 530.
2. Rahman M, Nguyen H. Valproic Acid. NIH National Library of Medicine, National center for biotechnology information. StatPearls [Internet]. July 2022. [Accessed on 9th August 2022] https://www.ncbi.nlm.nih.gov/books/NBK559112/
3. Cutrer FM, Limmroth V, Moskowitz MA. Possible mechanisms of valproate in migraine prophylaxis. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. April 1997. [Accessed on 9th August 2022] https://pubmed.ncbi.nlm.nih.gov/9137844/#:~:text=Valproate%20increases%20brain%20GABA%20levels,and%20directly%20attenuates%20nociceptive%20neurotransmission.
4. Sanofi-aventis SA. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 9th August 2022] https://www.medicines.org.uk/emc/files/pil.6102.pdf
5. AbbVie Ltd. Valproic Avid. [Revised in October 2021] [Accessed on 9th August 2022] https://www.rxabbvie.com/pdf/depakote.pdf
USEFUL DIAGNOSTIC TESTS
- Electroencephalogram (EEG)
- MRI
AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS
Last updated on 05 Apr 2023 | 05:47 PM(IST)
VIDEOS
Sodium Valproate TABLET - Drug Information
Sodium Valproate TABLET : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
PRODUCT DETAILS
ALTERNATE BRANDS View All
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
