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Best Price*  ₹ 116.00
MRP ₹145.00
(Inclusive of all taxes) * Mkt: Colinz Laboratories Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

USIT is a combination of Clindamycin and Nicotinamide which belongs to a group of medicines called Lincomycin antibiotics and Vitamin B3 complex, respectively.  USIT is used to treat mild to moderate acne which is a skin condition that occurs when hair follicles become plugged with oil and dead skin cells which may occur due to variety of causes such as genetics, fluctuating hormone levels, stress, high humidity or using oily or greasy personal care products which may affect people of all ages. It is characterized by symptoms such as open or closed plugged pores, small red & tender bumps, pimples, large, solid, or painful lumps under the skin, and painful & pus-filled lumps under the skin.

Clindamycin is a lincomycin antibiotic that reduces free fatty acid concentrations on the skin and suppresses the growth of Propionibacterium acnes (Corynebacterium acnes), a bacteria found in sebaceous glands and follicles. Nicotinamide is a vitamin of B3 complex that exerts anti-inflammatory effect in acne and interrupts sebum production.

Avoid applying USIT, if you are allergic to Clindamycin or Nicotinamide, and or have a history of regional enteritis (inflamed gastrointestinal tract), ulcerative colitis (inflammatory bowel disease), antibiotic associated colitis (inflammation of large intestine), liver or renal impairment. Before applying USIT, inform your doctor if you have eczema (skin inflammation), or asthma.

USIT is not recommended for use during pregnancy and in breastfeeding women, which is also not recommended for use in children and adolescents (below 12 years). Consult your doctor before applying USIT. The most common symptoms of using USIT are skin inflammation, contact dermatitis (red, itchy rash), inflammation of hair follicles, itchy skin, dry skin, peeling of skin and skin redness. Consult your doctor if any of these symptoms worsen.

USES OF USIT

  • Treats mild to moderate acne

HOW USIT WORKS

USIT helps to treat acne, where clindamycin reduces free fatty acid concentrations on the skin and suppresses the growth of Propionibacterium acnes (Corynebacterium acnes), a bacteria found in sebaceous glands and follicles, and nicotinamide exerts anti-inflammatory effect in acne and interrupts sebum production.

DIRECTIONS FOR USE

Apply USIT as advised by your physician. It is for external use only. Before applying the medicine normally wash and dry the affected area and apply a thin layer of this medicine on the affected area. Treated areas on the face need not be covered with a plaster or bandage. Do not apply USIT on your face beyond the recommended duration. Avoid applying USIT around your eyes, including eyelids. Rinse it off with water if you accidentally get it in these areas. 

SIDE EFFECTS OF USIT

COMMON

  • skin inflammation
  • contact dermatitis (red, itchy rash)
  • dermatitis fungal (scaly and itchy rash or discoloration of skin caused by fungal infection)
  • inflammation of hair follicles
  • signs of photosensitivity reactions such as rash, blisters and red bumps
  • itching skin
  • skin redness
  • dry skin
  • peeling of skin

UNCOMMON

  • skin irritation

RARE

  • signs of allergic reactions such as itching, redness, swelling or burning sensations can occur

Stop applying USIT and contact your doctor if you experience any of the following side effects:

  • diarrhoea

HOW TO MANAGE SIDE EFFECTS

Dry Skin:

Try moisturizing your skin with an ointment, cream, or lotion 2 or 3 times a day, or as more often as needed.  Moisturizers help to keep the area moisture, so they work best on damp skin. After you bathe, pat your skin dry then apply your moisturizer. Consult your before using any moisturizer. Try to avoid using skin care products and soaps that contain alcohol, fragrances, dyes, or other chemicals.

Diarrhoea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhea and consult your doctor if the symptom gets worse.

WARNING & PRECAUTIONS

PREGNANCY

USIT is not recommended for use during pregnancy. Consult your doctor before applying USIT.

BREASTFEEDING

USIT is not recommended for use in breastfeeding women. Consult your doctor before applying USIT.

DRIVING AND USING MACHINES

USIT should not affect your ability to drive or operate machines. Consult your doctor before applying USIT.

KIDNEY

USIT is not recommended for use in patients having kidney disease such as kidney impairment. It should be used with caution in patients having other kidney diseases. Consult your doctor before applying USIT.

LIVER

USIT is not recommended for use in patients having liver disease such as liver impairment. It should be used with caution in patients having other liver diseases. Consult your doctor before applying USIT.

ALLERGY

Do not use USIT if you are allergic to Clindamycin or Nicotinamide or any other ingredients of this medicine.

LUNGS

USIT should be used with caution in patients having asthma. Consult your doctor before applying USIT.

OTHERS

USIT is not recommended for use if you have:

  • history of regional enteritis (inflamed gastrointestinal tract)
  • history of ulcerative colitis (inflammatory bowel disease)
  • history of antibiotic associated colitis (inflammation of large intestine)

Before applying USIT, inform your doctor if you have:

  • eczema (skin inflammation)

Use in Pediatrics:

USIT is not recommended for use in children and adolescents (below 12 years). Consult your doctor before applying USIT.

Use in Geriatrics:

USIT should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before applying USIT.

INTERACTIONS

A. Drug - Drug interactions:

Before using USIT, inform your doctor if you are taking any of the following medicines:

  • neuromuscular blocking agents (used adjunctively with anesthesia to produce paralysis) Ex. cisatracurium, vecuronium
  • birth control pills (used to prevent pregnancy) Ex. conjugated estrogen

Overdosage:

If you or anyone else accidentally applies too much of USIT, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are diarrhea, bloody diarrhea, and colitis including pseudomembranous colitis (swelling or inflammation of the large intestine that occurs after antibiotic use).

SYNOPSIS

Drug :  

Clindamycin, Nicotinamide

Pharmacological Category :  

Lincomycin antibiotics, Vitamin B3 complex

Therapeutic Indication :  

Mild to moderate acne

Dosage Forms :  

Gel

MORE INFORMATION

  • Keep USIT out of reach of children
  • Store below 25 °C

FAQs ABOUT USIT

What special precautions should I follow while using USIT?

Patients before using USIT must inform their doctor about their pre-existing conditions such as kidney, liver, or digestive tract diseases. Patients should also inform if they are pregnant, breast-feeding, having any allergies, or ulcerative colitis. Contact your doctor immediately if you have any unusual symptoms.

Is USIT safe to use in patients with liver problems?

USIT is not recommended for use in patients having liver disease such as liver impairment. It should be used with caution in patients having other liver diseases. Consult your doctor before applying USIT.

What is USIT used for?

USIT is indicated for the treatment of mild to moderate acne in patients above 12 years of age. Do not use it for any other condition other than that prescribed by your doctor.

How should I use USIT?

Always apply USIT, as directed by your physician. It is for external use only. On the affected area, apply a thin layer of this medicine. Treated areas on the face need not be covered with a plaster or bandage. Do not apply USIT on your face beyond 5 days. Avoid applying USIT around your eyes, including eyelids.

Is USIT safe to use in pregnant and breastfeeding women?

USIT is not recommended for use during pregnancy and in women planning for pregnancy, also it is not recommended for use in breastfeeding women. Consult your doctor before applying USIT.

REFERENCES

1. KD. Tripathi. Macrolide, Lincosamide, Glycopeptide & Other Antibacterial Antibiotics; Urinary Antiseptics and Vitamins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 756 & 914.

2. Pooja Bains, Manpreet Kaur, Jasleen Kaur, Saurabh Sharma. Nicotinamide: Mechanism of action and indications in dermatology. Indian Journal of Dermatology, Venereology, and Leprology. 2018. [Accessed on 7th June 2022] https://ijdvl.com/nicotinamide-mechanism-of-action-and-indications-in-dermatology/

3. A R Shalita, J G Smith, L C Parish, M S Sofman, D K Chalker. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. June 1995. [Accessed on 7th June 2022] https://pubmed.ncbi.nlm.nih.gov/7657446/

4. Aeropak Ltd. Electronic medicines compendium (EMC). [Revised in January 2019] [Accessed on 7th June 2022] https://www.medicines.org.uk/emc/files/pil.6765.pdf

5. Amgen Inc. U.S. Food & Drug Administration. [Revised in August 2011] [Accessed on 7th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2001/50782lbl.pdf

6. Wellona Pharma. Acnewell-N. Clindamycin Phosphate & Nicotinamide Gel. [Accessed on 7th June 2022] https://wellonapharma.com/product/finished/clindamycin-phosphate-and-nicotinamide-gel

7. Curatio. Clinmiskin Gel. [Accessed on 7th June 2022] https://curatiohealthcare.com/product/clinmiskin-gel/

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    40 g
    Ingredient
    CLINDAMYCIN 1%+NICOTINAMIDE 4%
    Hsn Code
    30042095
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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