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INTRODUCTION
UNIFEN MR TABLET is a combination of Diclofenac, Methocarbamol, and Paracetamol which belongs to the group of medicines called Nonsteroidal Anti-inflammatory agents, Skeletal Muscle Relaxants and Analgesics & Antipyretics respectively. It is used to relieve pain, reduce swelling, and muscle spasm associated with conditions affecting the joints, muscles and tendons like sprains, strains and backache, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dental or minor surgery and other injuries.
Arthritis is the tenderness or swelling of one or more joints characterized by pain, stiffness, and reduced movements.
UNIFEN MR TABLET is not recommended for use in patients with asthma, liver, kidney, and heart. Consult your doctor for advice.
UNIFEN MR TABLET is not recommended for use in woman who are pregnant, and it should be used with caution in breastfeeding woman. Consult your doctor for advice.
UNIFEN MR TABLET is not recommended for use in children and adolescents below 12 years of age and it should be used with caution in elderly patients. Consult your doctor for advice.
The most common side effects of taking UNIFEN MR TABLET are stomach pain, indigestion, heart burn and vomiting. Consult your doctor if the symptoms does not improve.
USES OF UNIFEN MR TABLET
Used to relieve pain, reduce swelling, and muscle spasm associated with conditions such as:
- joints, muscles
- tendons like sprains, strains
- backache
- rheumatoid arthritis
- osteoarthritis
- ankylosing spondylitis
- dental or minor surgery and
- other injuries
HOW UNIFEN MR TABLET WORKS
[GBKEYWORD] act as a painkiller and muscle relaxant where Diclofenac and Paracetamol works by reducing the effects of prostaglandin (substance produced during injury and inflammation causing pain) thereby blocking the pain signals between the brain and nerve endings. Methocarbamol blocks the effects of acetylcholine (neurotransmitter responsible for muscle contraction.
DIRECTIONS FOR USE
Take UNIFEN MR TABLET as advised by your physician. Swallow this medicine with a glass of water and do not crush or chew the medicine. Your doctor will decide the right dose and duration depending upon your age, body weight and disease condition.
SIDE EFFECTS OF UNIFEN MR TABLET
COMMON
- stomach pain
- loss of appetite
- indigestion
- vomiting, nausea
- heartburn, pain
- dizziness
- headache
- spots or skin rash
UNCOMMON
- fast or irregular heartbeat
- chest pain
RARE
- stomach ulcers or bleeding
- gastritis
- vomiting blood
- diarrhoea with blood
- tiredness, drowsiness
- symptoms of fluid retention like swollen ankles
- signs of asthma include coughing, chest tightness, wheezing
Stop taking UNIFEN MR TABLET and contact your doctor immediately if you experience any of the following side effects:
- sudden and crushing chest pain
- signs of heart failure like breathlessness, difficulty in breathing when lying down, swelling of hands and feet
- signs of stroke include sudden numbness or weakness in the face, arm, or leg especially on one side of the body, sudden loss or disturbance of vision, difficulty in speaking or ability to understand speech, sudden migraine-like headaches
- signs of bleeding in the stomach or intestine when emptying your bowels, blood in vomit or black, tarry faeces
- skin rash, itching, bruising painful red areas, peeling or blistering
- wheezing or shortness of breath (bronchospasm)
- yellowing of skin or the whites of your eyes
- persistent sore throat or high temperature (fever)
- change in the amount of urine produced and/or its appearance
- mild cramping and tenderness of the abdomen
- Stevens Johnson Syndrome (serious illness with blistering of the skin, mouth, eyes, and genitals)
HOW TO MANAGE SIDE EFFECTS
Nausea or Vomiting:
Take this medicine with, or just after meals. Stick to simple meals and try to avoid oil rich or spicy foods, sugary snacks, and drinks. Take liquid drink slowly in between meals. Consult your doctor.
Diarrhoea:
Drinking lots of fluids, such as water or fruit juice helps to keep yourself hydrated. Do not consume any medication on your own without physician consultation.
Stomach pain:
Try to rest and relax. Try to have smaller and frequent meals. Keep a heat pad on your stomach. Discuss with your doctor if the symptoms is not improving.
Flatulence:
Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptom does not improve. Contact your doctor for advice.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly.
WARNING & PRECAUTIONS
PREGNANCY
UNIFEN MR TABLET is not recommended for use in woman who are pregnant. Consult your doctor before taking UNIFEN MR TABLET.
BREASTFEEDING
UNIFEN MR TABLET should be used with caution in breastfeeding woman. Consult your doctor for advice before taking UNIFEN MR TABLET.
DRIVING AND USING MACHINES
Do not drive or handle any machines while taking UNIFEN MR TABLET, since it may cause dizziness, tiredness, and sleepiness.
ALCOHOL
Avoid consumption of alcohol while taking UNIFEN MR TABLET because it can aggravate the side effects.
KIDNEY
UNIFEN MR TABLET is not recommended for use in patients having kidney failure. Consult your doctor before taking UNIFEN MR TABLET.
LIVER
UNIFEN MR TABLET is not recommended for use in patients having liver failure. Consult your doctor before taking UNIFEN MR TABLET.
ALLERGY
Do not take UNIFEN MR TABLET if you are allergic to Diclofenac, Methocarbamol, and Paracetamol or any other ingredients of this medicine.
LUNGS
UNIFEN MR TABLET is not recommended for use in patients with asthma, seasonal allergic rhinitis, swelling of the nasal mucosa (nasal polyps), chronic pulmonary diseases or infections of the respiratory tract. Consult your doctor before taking UNIFEN MR TABLET.
HEART DISEASE
UNIFEN MR TABLET is not recommended for use in patients having stablished heart disease and/or cerebrovascular disease, heart attack, stroke, mini stroke (TIA) or blockages to blood vessels to the heart or operation to clear or bypass blockages. It should be used with caution in patients having angina, blood clots, and high blood pressure. Consult your doctor before taking UNIFEN MR TABLET.
OTHERS
UNIFEN MR TABLET is not recommended for use if you have:
- stomach or duodenal (peptic) ulcer
- bleeding in the digestive tract which may cause blood in vomit, bleeding when emptying bowels, fresh blood in faeces or black, tarry faeces
- problems with your blood circulation (peripheral arterial disease)
Before taking UNIFEN MR TABLET, inform your doctor if you have:
- stomach or bowel disorders including ulcerative colitis or Crohn’s disease
- porphyria or bleeding disorders
- high cholesterol or raised triglycerides
- diabetes
- Systemic Lupus Erythematosus
Use in pediatrics:
UNIFEN MR TABLET is not recommended for use in children and adolescents below 12 years of age. Consult your doctor for advice before taking [GBNKRYWORD].
Use in geriatrics:
UNIFEN MR TABLET should be used with caution in elderly patients. Consult your doctor for advice.
INTERACTIONS
A. Drug-Drug interactions:
Before taking UNIFEN MR TABLET inform your doctor if you are taking any of the following medicine:
- medicines used to treat diabetes (Ex. metformin, glibenclamide)
- blood thinning agents (Ex. warfarin)
- furosemide, bumetanide (medicine used to treat edema)
- lithium (medicine used to treat mental problems)
- methotrexate (medicine used for treatment of some inflammatory diseases and some cancers)
- ciclosporin and tacrolimus (medicine used to treat some inflammatory diseases and after transplants)
- trimethoprim (medicine used to prevent or treat urinary tract infections)
- levofloxacin, ciprofloxacin (medicines used for infections)
- NSAID or COX-2 like aspirin or ibuprofen (medicines used to as painkillers)
- mifepristone (medicine used to terminate pregnancy)
- digoxin (used to treat heart problems)
- citalopram, fluoxetine (medicines used to treat depression)
- steroids like prednisolone (medicine used as an anti-inflammatory agent)
- medicines used to treat heart conditions or high blood pressure (Ex. telmisartan, enalapril)
- voriconazole (medicine used to treat fungal infections)
- phenytoin (medicine used to treat seizures or fits)
- colestipol/cholestyramine (medicine used to lower cholesterol)
SYNOPSIS
| Drug | : | Diclofenac, Methocarbamol, Paracetamol |
| Pharmacological Category | : | Nonsteroidal Anti-inflammatory agents, Skeletal Muscle Relaxants, Analgesics & Antipyretics |
| Therapeutic Indication | : | Pain associated with muscle spasms |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep UNIFEN MR TABLET out of reach of children
- Store at room temperature
FAQs ABOUT UNIFEN MR TABLET
Q: What is UNIFEN MR TABLET used for?
A: UNIFEN MR TABLET contains Diclofenac, Methocarbamol, Paracetamol which is used to relieve pain, reduce swelling, and muscle spasm associated with conditions affecting the joints, muscles and tendons like sprains, strains and backache, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dental or minor surgery and other injuries.
Q: How does [GBNKWYWORD] work?
A: [GBKEYWORD] act as a painkiller and muscle relaxant where Diclofenac and Paracetamol works by reducing the effects of prostaglandin (substance produced during injury and inflammation causing pain) thereby blocking the pain signals between the brain and nerve endings and Methocarbamol blocks the effects of acetylcholine neurotransmitter responsible for muscle contraction.
Q: Can UNIFEN MR TABLET be given to children?
A: UNIFEN MR TABLET is not recommended for use in children and adolescents below 12 years of age. Your doctor will recommend you the correct dose and duration. Consult your doctor for advice before taking [GBNKRYWORD].
Q: Can UNIFEN MR TABLET be used in heart patients?
A: UNIFEN MR TABLET is not recommended for use in patients having stablished heart disease and/or cerebrovascular disease, heart attack, stroke, mini stroke (TIA) or blockages to blood vessels to the heart or operation to clear or bypass blockages and should be used with caution in patients having angina, blood clots, and high blood pressure. Consult your doctor before taking UNIFEN MR TABLET.
REFERENCES
1. KD. Tripathi. Nonsteroidal Anti-inflammatory Drugs, Skeletal Muscle Relaxants. Essentials of medical pharmacology. Eighth edition. 2019. Page –221, 383.
2. Justyna Kolodziejska and Michal Kolodziejczyk. Diclofenac in the treatment of pain in patients with rheumatic diseases. National Library of Medicine, National center for biotechnology information. PubMed Central. Revised in June 2018. [Accessed 23rd June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052370/
3. Jeffrey Sibrack; Rachel Hammer. Methocarbamol. National Library of Medicine, National center for biotechnology information. StatPearls. Revised in November 2019. [Accessed 23rd July 2022] https://www.ncbi.nlm.nih.gov/books/NBK565868/
4. J. C. McCrae, E. E. Morrison, I. M. MacIntyre, J. W. Dear, and D. J. Webb . Long-term adverse effects of paracetamol – a review. National Library of Medicine, National center for biotechnology information. PubMed Central. Revised in July2018. [Accessed 23rd July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138494/
5. Schwarz Pharma, Inc. U.S. Food & Drug Administration. [Revised in February 2003]. [Accessed 23rd July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/011011Orig1s070s071lbl.pdf
6. Reliable 1 Laboratories. [Revised in October 2021] [Accessed 23rd July 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=25626b46-78f8-7226e0540144ff8d46c#:~:text=temporarily%20relieves%20minor%20aches%20and,cramps%20%2D%20temporarily%20reduces%20...&text=Liver%20warning%3A%20This%20product%20contains%20acetaminophen.
7. Dexcel -Pharma. Electronic Medicines Compendium (EMC). [Revised in April 2021] [Accessed 23rd July 2022] https://www.medicines.org.uk/emc/files/pil.2660.pdf
AUTHOR DETAILS
Written By Dr. Janet.C, Pharm.D
Last updated on 03 Jan 2023 | 01:03 PM(IST)
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