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TRUMAB 440mg Infusion 1's
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INTRODUCTION
TRUMAB INFUSION contains Trastuzumab which belongs to the group of medicines called Anticancer drugs. It is used to treat breast cancer and stomach cancer. It can be used either alone or in combination with other anticancer drugs (such as paclitaxel, cisplatin, docetaxel, 5-fluorouracil, capecitabine) or hormonal drugs (such as tamoxifen, anastrozole) to achieve better results.
TRUMAB INFUSION will be administered to you only by an oncologist or by a trained professional into your vein or beneath the skin. It is suitable for use in patients with high levels of human epidermal growth factor 2 (HER2) or hormone receptor positive metastatic breast cancer (cancer this is more sensitive for hormonal changes).
Before receiving TRUMAB INFUSION inform your doctor if you have any heart problems (such as heart attack, heart valve disease, or abnormal heartbeat). You must also inform your doctor if you have hypertension as a precaution.
TRUMAB INFUSION is not recommended for use in patients with breathing difficulties. It is also not suitable for use in pregnant or breastfeeding women. Both men and women receiving TRUMAB INFUSION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with TRUMAB INFUSION.
The most common side effects of receiving this medicine are increased infections, sore throat, mouth ulcers, skin rashes, nausea, stomach upset, lack of sleep, weight loss, tingling and numbness of hands and feet, muscle pain, joint pain, hair loss, shakiness and increased sweating. Consult your doctor if any of these side effect worsens.
USES OF TRUMAB INFUSION
It is used to treat:
- Breast cancer (early and advanced)
- Stomach cancer (advanced)
HOW TRUMAB INFUSION WORKS
TRUMAB INFUSION is a monoclonal antibody. It works by blocking the actions of certain cellular proteins (HER2) that triggers cancer cell formation. It also blocks various downstream cell signalling pathways that triggers cancer growth within the body. As a result, it reduces cancer formation and prevents its further growth within the body.
DIRECTIONS FOR USE
TRUMAB INFUSION will be given to you only by a doctor or a nurse into the vein (intravenously) or beneath the skin (subcutaneously).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF TRUMAB INFUSION
COMMON
- increased infections
- low RBC, WBC and platelet counts in blood
- nausea, vomiting, diarrhea, stomach pain, constipation, indigestion
- mouth ulcers, sore throat
- hair loss
- bladder infection
- headache, dizziness, tiredness, weakness
- liver inflammation, weight loss, lack of appetite
- pain, numbness, tingling sensation of hands and feet
- restlessness, problems in falling asleep, anxiety, depression
- flushing (skin redness), skin rash or itching, acne
- eye inflammation, dry eyes or watery eyes
- shortness of breath, runny nose, nasal itching and repeated sneezing
- increased sweating, night sweats
- muscle pain, joint pain, back pain, neck pain
- tremors (shakiness)
- swelling of the hands or ankles
- breast inflammation
- haemorrhoids, leg pain
- muscle problems
UNCOMMON
- hearing problems
- bumpy skin rash
- inflammation or scarring of lungs
RARE
Contact your doctor immediately if you experience any of the following side effects:
- fever, chills, flu-like symptoms, nausea, vomiting, increased muscle tension and shaking, headache, dizziness, breathing difficulties, high or low blood pressure, heart rhythm disturbances swelling of the face and lips, rash and tiredness
- signs of heart failure (such as breathlessness, cough, fluid retention (swelling) in the legs or arms, palpitations)
- kidney problems (weakness, shortness of breath, fatigue and confusion), heart problems (fluttering of the heart), fits, vomiting or diarrhoea and tingling in the mouth, hands or feet
HOW TO MANAGE SIDE EFFECTS
Constipation
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.
Diarrhea
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.
Mouth Ulcers
Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.
Nausea And Vomiting
Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea worsens, consult your doctor for advice
Skin Rash Or Itching
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedTRUMAB INFUSION is not recommended for use in pregnant women. Therefore, consult your doctor before receiving it. Women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with TRUMAB INFUSION and until 7 months after stopping the therapy. If you accidentally became pregnant while receiving TRUMAB INFUSION, inform your doctor immediately.
BREASTFEEDING
ContraindicatedTRUMAB INFUSION may pass through breast milk. Therefore, it is not recommended for use in breastfeeding women. However, consult your doctor before receiving it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if your ability is affected by TRUMAB INFUSION.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while receiving TRUMAB INFUSION as it may make you feel drowsier.
ALLERGY
ContraindicatedTalk to your doctor before receiving TRUMAB INFUSION if you are allergic to Trastuzumab.
LUNGS
ContraindicatedTRUMAB INFUSION is not recommended for use in patients with breathing difficulties and in patients with a need of oxygen therapy. Therefore, consult your doctor before receiving it.
HEART DISEASE
Use with CautionTRUMAB INFUSION should be used with caution in patients with heart problems (such as recent heart attack, stroke, hypertension, heart valve diseases). Therefore, consult your doctor before receiving it.
USE IN PEDIATRICS
ContraindicatedUse in pediatrics:
TRUMAB INFUSION is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before receiving it.
USE IN GERIATRICS
Use with CautionUse in geriatrics:
TRUMAB INFUSION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.
INTERACTIONS
A. Drug - Drug interactions:
Before receiving TRUMAB INFUSION, inform your doctor if you are taking any of the following medicines such as:
- doxorubicin or epirubicin (medicines used for cancer)
Overdosage:
TRUMAB INFUSION will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms.
SYNOPSIS
| Drug | : | Trastuzumab |
| Pharmacological Category | : | Unarmed Monoclonal Antibody |
| Therapeutic Indication | : | Breast cancer, Stomach cancer |
| Dosage Forms | : | Injection, Infusion |
MORE INFORMATION
- Keep TRUMAB INFUSION out of reach of children
- Store TRUMAB INFUSION in a refrigerator between (2-8°C)
FAQs ABOUT TRUMAB INFUSION
Q: What TRUMAB INFUSION is used for?
A: TRUMAB INFUSION is used to treat breast cancer and stomach cancer.
Q: How does TRUMAB INFUSION works on my body?
A: TRUMAB INFUSION is a monoclonal antibody. It works by blocking the actions of certain cellular proteins (HER2) that triggers cancer cell formation. It also blocks various downstream cell signalling pathways that trigger cancer growth within the body. As a result, it reduces cancer formation and prevents it further growth within the body.
Q: Can TRUMAB INFUSION cure cancer?
A: The cure rate of cancer depends upon the severity of the disease. However, TRUMAB INFUSION acts by preventing the abnormal growth and multiplication of cancer cells in the body, which may help in curing cancer completely.
Q: Can the use of TRUMAB INFUSION cause hair loss?
A: Hair loss is one of the common side effects of receiving TRUMAB INFUSION. If it bothers you, consult your doctor for advice.
Q: Can the use of TRUMAB INFUSION cause mouth ulcers?
A: Mouth ulcers are one of the common side effects of receiving TRUMAB INFUSION. Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.
Q: Can TRUMAB INFUSION be used in children?
A: TRUMAB INFUSION is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before receiving it.
Q: What precautions must be followed while receiving TRUMAB INFUSION?
A: Before receiving TRUMAB INFUSION inform your doctor if you have any heart problems (such as heart attack, heart valve disease, or abnormal heartbeat). You must also inform your doctor if you have hypertension as a precaution. TRUMAB INFUSION is not recommended for use in patients with breathing difficulties. It is also not suitable for use in pregnant or breastfeeding women. Both men and women receiving TRUMAB INFUSION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with TRUMAB INFUSION.
Q: What happens if I stop receiving TRUMAB INFUSION?
A: No. Do not stop receiving TRUMAB INFUSION without consulting your doctor as it may make your symptoms reappear. Therefore, take TRUMAB INFUSION as advised by your doctor for the stipulated duration.
Q: Can TRUMAB INFUSION be used during pregnancy?
A: TRUMAB INFUSION is not recommended for use in pregnant women. If you accidentally became pregnant while receiving TRUMAB INFUSION, inform your doctor immediately.
Q: Can the use of TRUMAB INFUSION make me feel tired?
A: Yes. TRUMAB INFUSION may make you feel tired easily. This is because it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after receiving TRUMAB INFUSION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while taking this medicine.
Q: Can I drive a car after receiving TRUMAB INFUSION?
A: TRUMAB INFUSION may make you feel tired or dizzy. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by TRUMAB INFUSION.
Q: How TRUMAB INFUSION is administered?
A: TRUMAB INFUSION will be given to you only by a doctor or a nurse into a vein (intravenously) or beneath the skin (subcutaneously).
Q: How to control nausea caused due to TRUMAB INFUSION?
A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with TRUMAB INFUSION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.
Q: What are the side effects of receiving TRUMAB INFUSION?
A: The most common side effects of receiving this medicine are increased infections, sore throat, mouth ulcers, skin rashes, nausea, stomach upset, lack of sleep, weight loss, tingling and numbness of hands and feet, muscle pain, joint pain, hair loss, shakiness and increased sweating. Consult your doctor if any of these side effects worsens.
REFERENCES
1. KD. Tripathi. Chemotherapy of Neoplastic Diseases. Essentials of Medical Pharmacology. 7th Edition. Page – 872.
2. Karl Greenblatt. Karam Khaddour. Trastuzumab. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed central. November 2022. [Accessed on 2nd February 2023]. https://www.ncbi.nlm.nih.gov/books/NBK532246/
3. Biocon Biologics India Limited. CanMab. Trastuzumab for Injection (r-DNA Origin). [Revised in December 2019]. [Accessed on 2nd February 2023]. https://www.biocon.com/docs/domestic-market-pi/onco/CANMAB%20PI.pdf
4. Roche Products Limited. Herceptin 150 mg powder for concentrate for solution for infusion trastuzumab. Electronics Medicines Compendium. [Revised in January 2022]. [Accessed on 7th February 2023]. https://www.medicines.org.uk/emc/files/pil.3856.pdf
5. Roche Products Limited. Herceptin 600 mg solution for injection in vial trastuzumab. Electronics Medicines Compendium. [Revised in January 2022]. [Accessed on 7th February 2023]. https://www.medicines.org.uk/emc/files/pil.1227.pdf
6. Central Drugs Standard Control Organization. Trastuzumab powder concentrate infusion. July 2002. [Accessed on 7th February 2023]. https://cdscoonline.gov.in/CDSCO/Drugs
7. Eleftha. Trastuzumab Lyophilized Powder for Concentrate for Solution for Infusion. Intas Pharmaceuticals. [Revised in August 2008]. [Accessed on 7th February 2023]. https://www.intaspharma.com/wp-content/uploads/2019/09/Eleftha_Vial_Insert_AW-QA-1863-00.pdf
8. Central Drugs Standard Control Organization. 4-54/Cadila/PAC-RTrastuzumab (375 mg)/2020-BD Trastuzumab 375 mg. November 2021. [Accessed on 7th February 2023]. https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadCommitteeFiles/Recommendations%20Oncology&%20Haematology%2011.11.21&12.11.21.pdf
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
- Peripheral Smear Examination
- Rheumatoid Factor - Agglutination
- Rheumatoid Factor - Turbidometry
- Rheumatoid Factor IgG Antibody
AUTHOR DETAILS
Written By Srilekha. R, B.Pharm
Last updated on 08 Feb 2023 | 02:11 PM(IST)
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