INTRODUCTION
TRIMOX CV 228.5MG DRY SYRUP contains a combination of Amoxicillin and Clavulanic Acid which belongs to the group of medicines called Antibiotics. It is used to treat bacterial infections such as middle ear and sinus infections, respiratory tract infections, genital tract infections, urinary tract infections, skin and soft tissue infections such as dental infections, bone and joint infections, septic abortion (any abortion complicated by uterine infection) and abdominal infections. The symptoms of a bacterial infection may include fever, difficulty breathing, pus formation and pain.
Do not take TRIMOX CV 228.5MG DRY SYRUP if you have a history of hypersensitivity to beta-lactams, including penicillin and cephalosporins or any other ingredients of this medicine. TRIMOX CV 228.5MG DRY SYRUP is not recommended for use if you have a history of amoxicillin-clavulanate-associated jaundice or hepatic dysfunction.
Before taking TRIMOX CV 228.5MG DRY SYRUP, inform your doctor if you are suffering from hepatic or renal impairment. TRIMOX CV 228.5MG DRY SYRUP should be used with caution in pregnant women and only when necessary. In breastfeeding women, TRIMOX CV 228.5MG DRY SYRUP should be used with caution.TRIMOX CV 228.5MG DRY SYRUP should be used with caution in children (aged below 12 years) and elderly patients (above 50 years). Consult your doctor before taking TRIMOX CV 228.5MG DRY SYRUP.
The common side effects associated with the use of TRIMOX CV 228.5MG DRY SYRUP are diarrhoea, thrush (a fungal infection in the vagina, skin folds or mouth), nausea and vomiting. Contact your doctor immediately if any of the symptoms worsen.
USES OF TRIMOX CV 228.5MG DRY SYRUP
It is used for treating bacterial infections such as:
- middle ear & sinus infections
- respiratory tract infections
- genital tract infections
- urinary tract infections
- skin & soft tissue infections such as dental infections
- bone & joint infections
- septic abortion (any abortion complicated by uterine infection)
- abdominal infections
HOW TRIMOX CV 228.5MG DRY SYRUP WORKS
TRIMOX CV 228.5MG DRY SYRUP helps in treating bacterial infection where amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of an integral structural component of the bacterial cell wall whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby preventing the inactivation of amoxicillin.
DIRECTIONS FOR USE
Syrup/Oral Suspension:
Take TRIMOX CV 228.5MG DRY SYRUP as advised by your physician. Shake well before use. Use the dosing syringe, cup or spoon supplied with the pack to measure the dose accurately. A dosing syringe is recommended to dose a child below the age of 3 months accurately. Your doctor will determine the correct dose and duration for you depending on your age, body weight and disease condition.
Dry Syrup/Dry Suspension:
Take TRIMOX CV 228.5MG DRY SYRUP as advised by your physician. Open the sachet, reconstitute the dry powder thoroughly in a glass of water and swallow the mixture immediately. Your doctor will determine the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF TRIMOX CV 228.5MG DRY SYRUP
COMMON
- diarrhoea
- thrush (fungal infection in the vagina, skin folds or mouth)
- nausea
- vomiting
UNCOMMON
- dizziness
- headache
- indigestion
- skin rash
- itching
- bumpy itchy rash (hives)
RARE
- erythema multiforme (a skin rash that looks like small targets)
- reversible leucopenia including neutropenia (deficiency of white blood cells)
- reversible thrombocytopenia (deficiency of blood platelets)
Stop taking TRIMOX CV 228.5MG DRY SYRUP and contact your doctor if you experience any of the following side effects:
- signs of allergic reactions on the skin such as skin rash
- signs of vasculitis (inflammation of blood vessels) such as raised red or purple spots on the skin
- signs of allergic reactions such as fever, joint pain, swollen glands in the neck, armpit or groin
- signs of angioedema such as swelling on the face or mouth resulting in difficulty in breathing or collapse
- erythema multiforme (a skin rash that looks like small targets)
- Stevens-Johnson syndrome (widespread rash with blistering and skin peeling)
- exanthemous pustulosis (widespread red rash with blisters containing pus)
- bullous exfoliative dermatitis (itchy, red, scaly rash with bumps & blisters)
- signs of drug reaction with eosinophilia and systemic symptoms such as flu-like symptoms, rashes, fever and swelling in glands
- inflammation of the liver (hepatitis)
- jaundice
- severe diarrhoea
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.
Nausea and vomiting:
Try to take TRIMOX CV 228.5MG DRY SYRUP with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
WARNING & PRECAUTIONS
PREGNANCY
TRIMOX CV 228.5MG DRY SYRUP should be used with caution in pregnant women only if it is considered necessary. Consult your doctor before taking it.
BREASTFEEDING
TRIMOX CV 228.5MG DRY SYRUP should be used with caution in breastfeeding women. Consult your doctor before taking it.
KIDNEY
TRIMOX CV 228.5MG DRY SYRUP should be used with caution in patients with renal impairment. Consult your doctor before taking it.
LIVER
TRIMOX CV 228.5MG DRY SYRUP is not recommended for use if you have a history of amoxicillin-clavulanate-associated jaundice/hepatic dysfunction. It should be used with caution in patients with hepatic impairment. Consult your doctor before taking it.
ALLERGY
Do not take TRIMOX CV 228.5MG DRY SYRUP if you have a history of hypersensitivity to beta-lactams, including penicillin and cephalosporins or any other ingredients of this medicine. Consult your doctor before taking it.
OTHERS
Use in Paediatrics:
TRIMOX CV 228.5MG DRY SYRUP should be used with caution in children (below 12 years). Consult your doctor before taking it.
Use in Geriatrics:
TRIMOX CV 228.5MG DRY SYRUP should be used with caution in elderly patients (above 50 years). Consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug Interactions
Before taking TRIMOX CV 228.5MG DRY SYRUP, inform your doctor, if you are taking any of the following medicine:
- medicine used to treat gout Ex. allopurinol, probenecid
- medicine used to delay blood clotting Ex. warfarin, acenocoumarol
- mycophenolate mofetil (a medicine used to prevent organ rejection after an organ transplant)
- contraceptives (medicines used to prevent conception) Ex. oestrogen
Overdosage:
If you or anyone else accidentally takes too much of TRIMOX CV 228.5MG DRY SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastrointestinal symptoms (including heartburn, indigestion, bloating and constipation), fluid & electrolyte disturbance and amoxicillin crystalluria which may lead to renal failure in some cases.
SYNOPSIS
| Drug | : | Amoxicillin, Clavulanic Acid |
| Pharmacological Category | : | Antibiotics |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Tablet, Capsule, Sachet, Dry Syrup, Suspension, Syrup, Tablet, Capsule, Sachet, Dry Syrup, Suspension, Syrup, Drops, Injections |
MORE INFORMATION
- Keep the medicine out of sight and reach from children
- Store TRIMOX CV 228.5MG DRY SYRUP at a temperature not exceeding 25°C (77°F)
FAQs ABOUT TRIMOX CV 228.5MG DRY SYRUP
Q: What is the function of TRIMOX CV 228.5MG DRY SYRUP?
A: TRIMOX CV 228.5MG DRY SYRUP is used for treating bacterial infections including middle ear and sinus infections, respiratory tract infections, genital tract infections, urinary tract infections, skin and soft tissue infections such as dental infections, bone and joint infections, septic abortion (any abortion complicated by uterine infection) and abdominal infections.
Q: What happens if you take more TRIMOX CV 228.5MG DRY SYRUP than your required dose?
A: If you or anyone else accidentally takes too much TRIMOX CV 228.5MG DRY SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastrointestinal symptoms (including heartburn, indigestion, bloating and constipation), fluid and electrolyte disturbances and amoxicillin crystalluria, which may lead to renal failure in some cases.
Q: What side effects are seen with TRIMOX CV 228.5MG DRY SYRUP?
A: The common side effects associated with the use of TRIMOX CV 228.5MG DRY SYRUP are diarrhoea, thrush (a fungal infection in the vagina, skin folds or mouth), nausea and vomiting. Contact your doctor immediately if any of the symptoms worsen.
Q: Who should avoid taking TRIMOX CV 228.5MG DRY SYRUP?
A: Do not take TRIMOX CV 228.5MG DRY SYRUP if you have a history of hypersensitivity to beta-lactams, including penicillin and cephalosporins or any other ingredients of this medicine. It is not recommended for use if you have a history of amoxicillin-clavulanate-associated jaundice or hepatic dysfunction.
Q: Is TRIMOX CV 228.5MG DRY SYRUP safe to use in children's books?
A: TRIMOX CV 228.5MG DRY SYRUP should be used with caution in children (those under the age of 12). A graduated syringe is used to dispense the correct volume of suspension to children (under 3 months). For administering this medicine to children (aged 2 years or below), suspensions should be diluted to half-strength with water. Consult your doctor before taking it.
Q: How does TRIMOX CV 228.5MG DRY SYRUP work?
A: TRIMOX CV 228.5MG DRY SYRUP helps in treating bacterial infection, where amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of an integral structural component of the bacterial cell wall, whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby preventing the inactivation of amoxicillin.
Q: What is the method for taking TRIMOX CV 228.5MG DRY SYRUP?
A: Syrup/Oral Suspension
Take TRIMOX CV 228.5MG DRY SYRUP as advised by your physician. Shake well before use. Use the dosing syringe, cup or spoon supplied with the pack to measure the dose accurately. A dosing syringe is recommended to dose children below 3 months accurately. Your doctor will determine the correct dose and duration for you depending on your age, body weight and disease condition.
Dry Syrup/Dry Suspension
Take TRIMOX CV 228.5MG DRY SYRUP as advised by your physician. Open the sachet, reconstitute the dry powder thoroughly in a glass of water and swallow the mixture immediately. Your doctor will determine the correct dose and duration for you depending on your age, body weight and disease condition.
Q: What if I forget to take my TRIMOX CV 228.5MG DRY SYRUP dose?
A: If you forgot to take TRIMOX CV 228.5MG DRY SYRUP dose, take it as early as possible. Do not take a double dose to compensate for the missed dose. Consult your doctor before taking it if you are not sure what to do.
Q: When should I discontinue using TRIMOX CV 228.5MG DRY SYRUP?
A: Do not stop taking TRIMOX CV 228.5MG DRY SYRUP without thoroughly discussing it with your doctor until the treatment course is completed, even if you start feeling better. This is because if some bacteria survive due to incomplete medication, they may relapse into the infection.
Q: Is TRIMOX CV 228.5MG DRY SYRUP safe to use in patients with liver disease?
A: TRIMOX CV 228.5MG DRY SYRUP is not recommended for use if you have a history of amoxicillin-clavulanate-associated jaundice or hepatic dysfunction. It should be used with caution in patients with hepatic impairment. Consult your doctor before taking TRIMOX CV 228.5MG DRY SYRUP.
REFERENCES
1. KD Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 723.
2. Justin Evans, Maryam Hannoodee, Micah Wittler. Amoxicillin Clavulanate. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. December 2021. [Assessed on 26th October 2022]. https://www.ncbi.nlm.nih.gov/books/NBK538164/
3. GSK group of companies. Augmentin. [Revised in December 2017] [Assessed on 27th October 2022]. https://gskpro.com/content/dam/global/hcpportal/en_MU/PI/Clavulin-228.5mg5ml-Susp-GDS-24.pdf
4. Micro Labs Ltd. Erox CV 228.5 Dry Syrup. [Assessed on 27th October 2022]. http://www.microlabsltd.com/elibrary/node/2170
5. Micro Labs Ltd. Erox CV 457 Dry Syrup. [Assessed on 27th October 2022]. http://www.microlabsltd.com/elibrary/node/2181
6. Geno Pharmaceuticals Pvt. Ltd. Genomox-CV. [Assessed on 27th October 2022]. https://genopharma.com/pharma/
USEFUL DIAGNOSTIC TESTS
- Blood tests
- Urine tests
- Liver function test
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