INTRODUCTION

TRIMEDOR 500MG contains Metformin hydrochloride which belongs to a group of medicines known as biguanides. Diabetes is a condition where the pancreas does not make enough insulin, a hormone which makes your body take in glucose (sugar) from the blood. This leads to a high level of glucose in your blood.

TRIMEDOR 500MG helps to lower your blood glucose to normal level. It is an antihyperglycemic agent used in patients with type 2 diabetes which improves glucose tolerance. In liver it suppresses hepatic gluconeogenesis (glycogen breaks down into glucose-1-phosphate and glycogen and glycogenolysis (breakdown of glycogen to glucose) which is responsible for lowering of blood glucose in diabetic patients.

Your doctor decides upon the dose depending on your age, other medications you take and based on your problems related to kidney or liver. This medicine is not recommended for breastfeeding mothers. The common side effects of TRIMEDOR 500MG are nausea, vomiting, headache, diarrhoea and abdominal pain. This medicine is suitable for children and adolescents over 10 years of age as recommended by your physician.

USES OF TRIMEDOR 500MG

• Treats type 2 diabetes (non-insulin dependent diabetes)

HOW TRIMEDOR 500MG WORKS

TRIMEDOR 500MG works by reducing the amount of sugar releases by liver into your blood. Metformin acts by decreasing glucose production from the liver and decreases absorption of glucose from the intestine after taking food while improving the sensitivity of the body organs and muscles towards insulin, thus helping in controlling the blood sugar level.

DIRECTIONS FOR USE

Always take TRIMEDOR 500MG exactly as instructed by your doctor. Take the medicine with or after a meal. It will avoid you from having side effects like affecting your digestion. Do not crush or chew the medicine. Swallow with a glass of water.

SIDE EFFECTS OF TRIMEDOR 500MG

HOW TO MANAGE SIDE EFFECTS

Feeling sick (nausea) or vomiting:

Try simple meals and do not eat oil rich or spicy foods.

Diarrhoea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Abdominal pain:

Keep a hot water bottle or heated bag on your abdomen. Drink plenty of clear fluids and water.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:

• diuretics (increase urine production)
• ibuprofen and celecoxib (used to treat pain and inflammation)
• ACE inhibitors and angiotensin ii receptor antagonists (treatment of high blood pressure)
• salbutamol or terbutaline (used to treat asthma)
• corticosteroids (used to treat severe inflammation of the skin or in asthma)
• verapamil, rifampicin, cimetidine, dolutegravir, ranolazine, trimethoprim, vandetanib,
• isavuconazole, crizotinib, olaparib
• Other medicines used to treat diabetes (sulphonylureas, insulin, meglitinides)

Overdosage:

If you or anyone else accidentally took too much of TRIMEDOR 500MG, consult your doctor immediately. Overdose may cause symptoms such as very low blood sugar and increase the chance of developing lactic acidosis (buildup of lactic in blood).

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT TRIMEDOR 500MG

What does TRIMEDOR 500MG do exactly?

In type 2 diabetes, your body will not be able to make sufficient insulin or respond normally to the insulin made by your body. TRIMEDOR 500MG acts by decreasing glucose production from the liver and decreases absorption of glucose from the intestine after taking food while improving the sensitivity of the body organs and muscles towards insulin.

Can TRIMEDOR 500MG make you sleepy?

TRIMEDOR 500MG is usually well tolerated and does not cause sleepiness. But rarely, it causes sleep disorders and insomnia.

How to take TRIMEDOR 500MG?

Take TRIMEDOR 500MG with meal or after a meal. Do not crush or chew the medicine and swallow it with a glass of water. Always take as prescribed by your doctor.

Can TRIMEDOR 500MG cause low blood sugar levels? How to know its symptoms?

No, TRIMEDOR 500MG when used alone does not cause low blood sugar levels, when used in combination with other diabetic drugs or insulin may cause low blood sugar levels. Symptoms include increased sweating, visual disturbances, fast heartbeat, dizziness.

Can I take TRIMEDOR 500MG with alcohol?

No, taking TRIMEDOR 500MG with alcohol may alter your blood sugar levels and can cause serious side effects like lactic acidosis (excess build up of lactic acid in the blood). This medical condition should be treated only at the hospital. Usually, your doctor may warn about the symptoms of lactic acidosis.

REFERENCES

1. KD Tripathi MD. Insulin, oral hypoglycaemic drugs and glucagon. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 275.

2. Powers AC, D Alessio D. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. Page - 1258-1260.

3. Nolte MS. Pancreatic hormones and antidiabetic drugs.  Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 741-742.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 873-875.

5. Graham Rena, Grahame Hardie and Ewan R. The mechanisms of action of metformin: Diabetologia. Aug 3, 2017; [Accessed Oct 1, 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552828/

6. Milpharm Limited, Electronic Medicines Compendium (EMC); [Revised July 2020] [Accessed Oct 1, 2020] https://www.medicines.org.uk/emc/files/pil.7347.pdf

7. Bristol-Myers Squibb Company. U.S. Food & Drug Administration; [Revised March 2014] [Accessed Oct 1, 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose - Fasting Blood
• Glucose - Postprandial Blood
• Glycosylated Hemoglobin