Availability & Expiry
INTRODUCTION
TRIMEDOR 500MG TABLET contains Metformin which belongs to the group of medicines called Anti-diabetic agents. It is used to treat Type II diabetes mellitus when diet and exercise alone does not result in adequate blood sugar control.
Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.
TRIMEDOR 500MG TABLET works by making your body utilize more amount of circulating blood glucose. It is suitable for use both in adults and in children (aged 10 years or older).
Along with the therapy, your doctor might ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise and quitting alcohol consumption.
Before taking TRIMEDOR 500MG TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently.
TRIMEDOR 500MG TABLET is not recommended for use in patients with severe uncontrollable diabetes. It is also not suitable for use in patients with shock or problems in breathing or blood circulation.
Consult your doctor before taking TRIMEDOR 500MG TABLET if you are pregnant or breastfeeding. The most common side effects of taking TRIMEDOR 500MG TABLET are nausea, stomach upset and diarrhea. These side effects can be controlled when TRIMEDOR 500MG TABLET is taken along with meals. However, if these side effect bothers you or worsens contact your doctor.
USES OF TRIMEDOR 500MG TABLET
It is used in adults and in children (aged 10 years or older) to treat:
- Type II diabetes mellitus
HOW TRIMEDOR 500MG TABLET WORKS
TRIMEDOR 500MG TABLET is an antidiabetic medicine. It makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose, thereby reducing blood sugar levels. Additionally, it also prevents glucose production by the liver and reduces its absoprtion in the body.
DIRECTIONS FOR USE
Take TRIMEDOR 500MG TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking TRIMEDOR 500MG TABLET unless your doctor advice you to stop.
SIDE EFFECTS OF TRIMEDOR 500MG TABLET
COMMON
- nausea, vomiting
- diarrhea, stomach pain, loss of appetite
- changes in taste, metallic taste
Stop taking TRIMEDOR 500MG TABLET and consult your doctor immediately if you experience any of the following side effects:
- serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
- signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)
- signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
Nausea And Vomiting
Take TRIMEDOR 500MG TABLET with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your nausea worsens.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredTRIMEDOR 500MG TABLET should be used during pregnancy only if it is considered necessary by the physician. Therefore, inform your doctor before taking TRIMEDOR 500MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby.
BREASTFEEDING
ContraindicatedTRIMEDOR 500MG TABLET is not recommended for use in breastfeeding women. However, consult your doctor before taking it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected by TRIMEDOR 500MG TABLET.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking TRIMEDOR 500MG TABLET as it may increase the risk of unwanted side effects.
KIDNEY
ContraindicatedTRIMEDOR 500MG TABLET is not recommended for use in patients with severe kidney problems (including kidney infections). Therefore, consult your doctor before taking it.
LIVER
Consult your doctorTRIMEDOR 500MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take TRIMEDOR 500MG TABLET if you are allergic to Metformin.
LUNGS
ContraindicatedTRIMEDOR 500MG TABLET is not recommended for use in patients with severe infection of lungs or respiratory tract. Therefore, consult your doctor before taking it.
HEART DISEASE
ContraindicatedTRIMEDOR 500MG TABLET is not recommended for use in patients with heart problems (such as acute heart failure or a recent heart attack). Therefore, consult your doctor before taking it.
USE IN PEDIATRICS
Consult your doctorTRIMEDOR 500MG TABLET should be used in children and adolescents (aged 10 years or older) only if prescribed by the physician. It is not recommended for use in children (aged below 10 years). However, consult your doctor before taking it.
USE IN GERIATRICS
Use with CautionTRIMEDOR 500MG TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.
OTHERS
TRIMEDOR 500MG TABLET is not recommended for use if you:
- have severe, uncontrollable diabetes
- have lactic acidosis or ketoacidosis (buildup of lactic acid or ketones in the body)
- are dehydrated (due to severe vomiting or diarrhea during recent days)
- have any systemic infection which is severe
- have shock or problems in blood circulation
- have problems in breathing
- are an alcoholic
Before taking TRIMEDOR 500MG TABLET, inform your doctor if you:
- are about to have any X-ray or scan
- are about a have a major surgery
- are in fasting
INTERACTIONS
A. Drug-Drug interactions:
Before taking TRIMEDOR 500MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to treat diabetes (Ex. teneligliptin, rosiglitazone, pioglitazone, glimepiride)
- diuretics (used to reduce edema and to treat hypertension) Ex. furosemide, hydrochlorothiazide
- medicines used to treat pain and inflammation (such as ibuprofen and celecoxib)
- medicines used to treat high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
- medicines used to treat asthma (Ex. salbutamol or terbutaline)
- corticosteroids (used to treat pain and inflammation) Ex. hydrocortisone, prednisolone
- verapamil (a medicine used to treat heart problems)
- rifampicin (a medicine used to treat tuberculosis)
- cimetidine (a medicine used to treat stomach ulcer)
- dolutegravir (a medicine used to treat HIV infection)
- ranolazine (a medicine used to treat chest pain)
- trimethoprim (a medicine used to treat bacterial infection)
- vandetanib, crizotinib and olaparib (medicines used to treat cancer)
- isavuconazole (a medicine used to treat fungal infection)
Overdosage:
If you or anyone else accidentally take more TRIMEDOR 500MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.
SYNOPSIS
| Drug | : | Metformin |
| Pharmacological Category | : | Biguanides |
| Therapeutic Indication | : | Type II Diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep TRIMEDOR 500MG TABLET out of the sight and reach of children
- Store TRIMEDOR 500MG TABLET below 30°C
FAQs ABOUT TRIMEDOR 500MG TABLET
Q: What is TRIMEDOR 500MG TABLET used for?
A: TRIMEDOR 500MG TABLET is an antidiabetic medicine used to treat Type II diabetes mellitus when diet, exercise and lifestyle changes alone does not result in adequate response.
Q: How and when to take TRIMEDOR 500MG TABLET?
A: Take TRIMEDOR 500MG TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: How long should I take TRIMEDOR 500MG TABLET?
A: You need to take TRIMEDOR 500MG TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: What is the best time to take TRIMEDOR 500MG TABLET?
A: TRIMEDOR 500MG TABLET must be taken with meals to avoid gastrointestinal side effects.
Q: What to do if I forgot to take a dose of TRIMEDOR 500MG TABLET?
A: If you forgot to take a dose of TRIMEDOR 500MG TABLET, take it as soon as you remember. However, if it is time for the next dose of TRIMEDOR 500MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of TRIMEDOR 500MG TABLET to compensate the missed ones.
Q: What are the most common side effects of taking TRIMEDOR 500MG TABLET?
A: The most common side effects of taking TRIMEDOR 500MG TABLET are nausea, stomach upset and diarrhea. These side effects can be controlled when TRIMEDOR 500MG TABLET is taken along with meals. However, if these side effect bothers you or worsens contact your doctor.
Q: Can I stop taking TRIMEDOR 500MG TABLET without consulting your doctor?
A: No. You should not stop taking TRIMEDOR 500MG TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using TRIMEDOR 500MG TABLET, consult your doctor for advice.
Q: Will taking a higher dose of TRIMEDOR 500MG TABLET be more effective?
A: No, taking a higher dose of TRIMEDOR 500MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: What precautions do I need to follow while taking TRIMEDOR 500MG TABLET?
A: Before taking TRIMEDOR 500MG TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results. Consult your doctor before taking TRIMEDOR 500MG TABLET if you are pregnant or breastfeeding.
Q: Can I take medication for high blood pressure along with TRIMEDOR 500MG TABLET?
A: It is not advisable to take medicines to control blood pressure while taking TRIMEDOR 500MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with TRIMEDOR 500MG TABLET as they have known interactions with TRIMEDOR 500MG TABLET.
Q: What should I do if I experience low blood sugar after taking TRIMEDOR 500MG TABLET?
A: TRIMEDOR 500MG TABLET is unlikely to cause low blood sugar unless combined with other anti-diabetic medicine. However, if you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat), consume a sugary snack or sugar drink immediately. Consult your doctor if the symptom did not improve.
Q: Can TRIMEDOR 500MG TABLET be taken with insulin?
A: Co-administration of TRIMEDOR 500MG TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.
Q: Can TRIMEDOR 500MG TABLET be used in pregnant women?
A: TRIMEDOR 500MG TABLET should be used during pregnancy only if it is considered necessary by the physician. Therefore, consult your doctor for advice.
Q: How to take TRIMEDOR 500MG TABLET?
A: You must take TRIMEDOR 500MG TABLET as advised by your physician. Try to take this medicine preferably after meals and swallow it with a glass of water. Do not crush or chew the medicine.
Q: How much TRIMEDOR 500MG TABLET should I take?
A: TRIMEDOR 500MG TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
REFERENCES
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275.
2. Calette Corcoran; Tibb F. Jacobs. Metformin. StatPearls [Internet]. NIH. National Library of Medicine. National center for biotechnology information. PMC. PubMed Central. [Revised on May 2022]. [Accessed on 14th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK518983/#article-25065.s3
3. Shuyan Gu, Jihao Shi, Zhiliu Tang, Monika Sawhney, Huimei Hu, Lizheng Shi, Vivian Fonseca, Hengjin Dong. Comparison of Glucose Lowering Effect of Metformin and Acarbose in Type 2 Diabetes Mellitus: A Meta-Analysis. PLOS ONE. May 2015. [Accessed on 14th October 2022] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126704
4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 14th October 2022] https://www.medicines.org.uk/emc/files/pil.594.pdf
5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 14th October 2022] https://www.medicines.org.uk/emc/files/pil.11951.pdf
6. Merck Santé S.A.S. U.S. Food & Drug Administration. [Revised in April 2017] [Accessed on 14th October 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
7. Franco Indian Pharmaceuticals Pvt Ltd. GLYCIPHAGE® GLYCIPHAGE 850® GLYCIPHAGE 250®TABLETS. (ORAL ANTI-HYPERGLYCEMIC AGENT). [Accessed on 14th October 2022] http://diabetix-francoindian.com/glyciphage.html
USEFUL DIAGNOSTIC TESTS
- Glucose-Fasting Blood
- Glucose-Postprandial Blood
- Glycosylated Hemoglobin
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