INTRODUCTION

TRIBEN contains Clotrimazole which belongs to the group of medicines called azole antifungal agents. It is used to treat cutaneous fungal infections such as athlete’s foot, ringworm, fungal nappy rash (in babies) and fungal sweat rash. Topically applied clotrimazole acts by blocking the biosynthesis of fungal ergosterol which leads to the disruption of fungal cell membrane and inhibition of fungal growth.

This medicine is for external use only. Do not swallow it. Your doctor will decide the duration of the therapy depending upon the type of infection. Along with the treatment, try to keep the infected area clean by washing it daily. Always wear loose-fitting clothes and try not to share your towels and bathmats with other people to avoid the spread of infection.

In case of having athlete’s foot, always try to keep your feet and toes dry. Always wash your socks and tights thoroughly in hot water. If possible, change your footwear daily. Although you may feel itching in the infected area, avoid scratching vigorously as it may damage your skin and cause the infection to spread further.

The most common side effects of applying TRIBEN are application site redness, swelling, itching, burning or peeling. Contact your doctor if any of the symptom bothers you. If you are pregnant or think you may be pregnant or breastfeeding, consult your doctor for advice before using. Your doctor will decide whether you should use this medicine or not.

USES OF TRIBEN

• Treats fungal skin infections such as athlete’s foot, ringworm, fungal nappy rash and fungal sweat rash

HOW TRIBEN WORKS

Clotrimazole exerts its antifungal activity by inhibiting the biosynthesis of ergosterol, an essential constituent of fungal cell membrane which helps to keep the fungal cell intact and directly promotes its growth. Inhibition of ergosterol biosynthesis damages the fungal cell integrity and leads to the inhibition of fungal growth.

DIRECTIONS FOR USE

Shake well before use. Wash the infected area thoroughly and pat it dry. Apply a thin layer of this medicine evenly to the affected areas and gently rub it. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and type or severity of the infection.

It is for external use only. Do not swallow the medicine. Avoid contact with eyes or mouth, if happens rinse it thoroughly with water. Continue to apply this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF TRIBEN

HOW TO MANAGE SIDE EFFECTS

Application site reactions:

Avoid hot showers because hot water can irritate the skin. Do not use perfumed soaps or vaginal deodorants. Do not rub or scratch the affected area. Use sunscreen and protective clothing when outdoors. Wear cotton underwear and loose-fitting clothes and change your sanitary protection regularly. Regularly use moisturizers to soothe and hydrate the affected area. If the symptoms persist, contact your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor about all the medicines you use, including non-prescription and prescription medicines and herbal supplements.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Do not store above 25°C

FAQs ABOUT TRIBEN

Can TRIBEN cure yeast infection?

Yes. This medicine can be used to treat yeast (fungus) infections such as athlete’s foot, ringworm, and fungal sweat rash.

Can I use TRIBEN when I’m pregnant?

This medicine must be used with great caution in pregnant women. Consult your doctor before taking. Your doctor will decide whether you should use this medicine are not.

Can TRIBEN be used to treat pimples?

No. This medicine is only used to treat fungal skin infections such as athlete’s foot, ringworm and fungal sweat rash.

REFERENCES

1. KD. Tripathi. Antifungal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 792.

2. John E. Bennett. Antifungal agents. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1587.

3. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 895-897.

4. Fahima M. Hashem, Dalia S. Shaker, Mohamed Khalid Ghorab, Mohamed Nasr and Aliaa Ismail. Formulation, Characterization, and Clinical Evaluation of Microemulsion Containing Clotrimazole for Topical Delivery. NCBI; PMC US National Library of Medicine, National Institute of Health. July 2011. [Accessed 19th January 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167257/

5. E S Mahgoub. Clinical trial with clotrimazole cream (Bay b 5097) in dermatophytosis and onychomycosis. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 1975. [Accessed 19th January 2021] https://pubmed.ncbi.nlm.nih.gov/128698/

6. Palsons Derma Pvt Ltd. KANSEL-DS Gel, lotion. Palsonsderma.com. [Accessed 19th January 2021] https://www.palsonsderma.com/kansel-ds-gel-ds-lotion

7. Mylan UK Healthcare Limited. Electronic Medicines Compendium (EMC); [Revised on July 2020] [Accessed 19th January 2021] https://www.medicines.org.uk/emc/files/pil.2598.pdf

8. GP Grenzach Produktions GmbH. Electronic Medicines Compendium (EMC); [Revised on January 2019] [Accessed 19th January 2021] https://www.medicines.org.uk/emc/files/pil.1282.pdf