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INTRODUCTION

TRADEP 5/2MG TABLET is a combination of Trifluoperazine and Benzhexol which belongs to the group of medicines called Phenothiazine antipsychotics and Antimuscarinics respectively. TRADEP 5/2MG TABLET is used to treat symptoms and prevent relapse in schizophrenia (disorder that affects a person's ability to think, feel and behave clearly) and in other psychoses, especially paranoid type which is also used as an adjunct in the short-term management of severe psychomotor agitation and of dangerously impulsive behavior such as mental sub-normality.

It is also used for the symptomatic control of all forms of Parkinsonism (disorder of the central nervous system that affects movement) including the postencephalitic arteriosclerotic and idiopathic types which favorably influences rigidity and akinesia in the majority of patients with reduction of salivation.

Avoid taking TRADEP 5/2MG TABLET, if you suffer from any blood disorders, planned for a special x-ray examination of the brain or spinal cord involving a chemical called metrizamide, have closed angle or a narrow angle glaucoma or paralytic ileus, severe liver disease or heart failure.

Before taking TRADEP 5/2MG TABLET, inform your doctor if you have diabetes, blood vessel disease such as varicose veins, fits, abnormal muscle weakness, stomach ulcer, severe heartburn or kidney disease.

TRADEP 5/2MG TABLET is not recommended for use during pregnancy and breast-feeding unless it is clearly advised by the doctor. TRADEP 5/2MG TABLET is not recommended for use in children and it should be used with extreme caution in elderly patients.

The most common side effects of taking TRADEP 5/2MG TABLET are dizziness, headache, blurred vision, dry mouth and constipation. Consult your doctor if any of the side effects get worse during or after treatment with TRADEP 5/2MG TABLET.

USES OF TRADEP 5/2MG TABLET

  • Treats symptom and prevent relapse in schizophrenia
  • Used as an adjunct in the short-term management of severe psychomotor agitation
  • Treats symptomatic control of all forms of Parkinson's disease

HOW TRADEP 5/2MG TABLET WORKS

TRADEP 5/2MG TABLET helps to treat and prevents the symptoms of schizophrenia with symptomatic control of Parkinson’s disease, where trifluoperazine blocks the action of a chemical messenger (dopamine) in the brain that affects thoughts and mood. Benzhexol acts by blocking a certain natural substance (acetylcholine) which helps to reduce muscle stiffness, sweating and the production of saliva thereby improving walking ability in people with Parkinson's disease.

DIRECTIONS FOR USE

Take TRADEP 5/2MG TABLET as advised by your physician. Swallow TRADEP 5/2MG TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF TRADEP 5/2MG TABLET

COMMON

  • drowsiness, dizziness
  • headache, blurred vision
  • dry mouth, nausea
  • constipation
  • tremor
  • restlessness, confusion, nervousness
  • muscle spasm
  • weight gain
  • increased heart rate
  • urinary retention

UNCOMMON

  • dementia-associated psychosis (decline in thinking and problem solving skills)
  • neuroleptic malignant syndrome (life-threatening neurological disorder)
  • tardive dyskinesia (involuntary neurological movement disorder)
  • low blood pressure

RARE

  • serious arrhythmias
  • suppurative parotitis (bacterial infection of parotid gland)
  • skin rashes
  • paralytic ileus (intestinal obstruction)
  • delusion, hallucination

Stop taking TRADEP 5/2MG TABLET and contact your doctor immediately if you experience any of the following side effects:     

  • signs of an allergic reaction such as rash, swallowing or breathing problems, swelling of your lips, face, eyelids, throat or tongue
  • signs of neuroleptic malignant syndrome (life threatening neurological disorder) such as high temperature, rigid muscles, drowsiness, occasional loss of consciousness
  • chest pain (angina) which is getting worse
  • breast enlargement in men
  • inappropriate milk production
  • altered menstrual cycle
  • signs of blood problems such as sore throat, high fever, feeling very tired, becoming pale, developing bruises and nose bleeds
  • slurred speech, odd movements of the face, particularly of the tongue, eyes, head or neck (such as twisting of the neck which causes an unnatural positioning of the head, rigid muscles, restlessness or tremors and difficulty while sitting still)
  • constant chewing or tongue movements or other gentle movements of the neck, head or trunk
  • uncontrollable movements of the arms and legs
  • difficulty in sleeping
  • immediate or short-term memory loss
  • large pupils and lack of near vision
  • eye discomfort and increased sensitivity to light
  • painful increased pressure in the eye
  • reddening and dryness of the skin or skin rashes
  • difficulty in passing urine or inability to pass urine

HOW TO MANAGE SIDE EFFECTS

Dizziness:

Try to rest and relax and get enough sleep. Try to avoid driving or operating any tools or machines while you are feeling dizzy. Limit your consumption of alcohol, as it can aggravate your dizziness. Consult and inform your doctor if the symptom does not improve.

Nausea:

Try to take TRADEP 5/2MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating oil rich or spicy food. Consult your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.

Dry mouth:

Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

TRADEP 5/2MG TABLET is not recommended for use during pregnancy unless it is considered clearly necessary. Consult your doctor before taking TRADEP 5/2MG TABLET.

BREASTFEEDING

TRADEP 5/2MG TABLET is not recommended for use in breastfeeding women unless it is considered clearly necessary. Consult your doctor before taking TRADEP 5/2MG TABLET.

DRIVING AND USING MACHINES

TRADEP 5/2MG TABLET might cause dizziness, drowsiness or blurred vision. If you experience these side effects, try to avoid driving or operating heavy machines. Consult your doctor before taking TRADEP 5/2MG TABLET.

ALCOHOL

Avoid consumption of alcohol while taking TRADEP 5/2MG TABLET since it tends to weaken blood vessels and can raise blood pressure.

KIDNEY

TRADEP 5/2MG TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking TRADEP 5/2MG TABLET.

LIVER

TRADEP 5/2MG TABLET is not recommended for use in patients with liver problems. Consult your doctor before taking TRADEP 5/2MG TABLET.

ALLERGY

TRADEP 5/2MG TABLET is not recommended for use if you are allergic to Trifluoperazine, Benzhexol or any other ingredients of this medicine.

HEART DISEASE

TRADEP 5/2MG TABLET is not recommended for use if you have inability of the heart to maintain adequate circulation causing breathlessness and swelling of the ankles. It should be used with caution in patients with heart problems such as heart attack, chest pain, artificial heart valve and irregular heartbeat. Consult your doctor before taking TRADEP 5/2MG TABLET.

OTHERS

TRADEP 5/2MG TABLET is not recommended for use if you:

  • have any blood disorders
  • having a special x-ray examination of the brain or spinal cord involving a chemical called metrizamide
  • have closed-angle glaucoma or a narrow angle glaucoma (eye disorder that cause blindness)
  • have paralytic ileus (disorder that occurs due to temporary paralyzation of muscle contractions to move food through intestine)

Before taking TRADEP 5/2MG TABLET, inform your doctor if you:                                                 

  • have any blood vessel disease such as varicose veins
  • have fits, abnormal muscle weakness
  • have enlargement of prostate gland
  • are exposed to extremes in temperature
  • suffer from loss of cognitive (memory, language, intelligence) ability - dementia
  • have history of blood clot disorders
  • have transient ischaemic attack (mini stroke)
  • have uncontrolled high blood pressure
  • have diabetes, high cholesterol
  • are smoking
  • have stomach ulcer, severe heartburn and acid indigestion
  • tardive dyskinesia (unusual movements of face and tongue)

Use in Pediatrics:

TRADEP 5/2MG TABLET is not recommended for use in children. Consult your child’s doctor for advice.

Use in Geriatrics:

TRADEP 5/2MG TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking TRADEP 5/2MG TABLET.

INTERACTIONS

A. Drug-Drug Interactions:

Before taking TRADEP 5/2MG TABLET, inform your doctor, if you are taking any of the following medicines:

  • sleeping tablets (medicines used to treat sleeping disorders such as insomnia) Ex. temazepam, triazolam
  • anesthetics used prior to surgery Ex.propofol, etomidate, isoflurane
  • strong painkillers (used to relieve pain) Ex. codeine
  • medicines (used to treat low blood pressure) Ex. guanethidine
  • anticholinergic medicines used to reduce saliva and lung secretions (Ex. atropine, procyclidine)
  • antidepressants (medicines used to treat depression) Ex. phenothiazines, lithium
  • anticonvulsants (medicines used for fits) Ex. acetazolamide, carbamazepine, tegretol
  • other medicines used to treat Parkinson’s disease (Ex. levodopa)
  • anticoagulants (blood thinning medicines Ex. warfarin)
  • medicines used to treat iron poisoning (Ex. desferrioxamine)
  • antacids (medicines used to treat indigestion) Ex calcium carbonate, magnesium hydroxide
  • medicines used for psychiatric conditions such as neuroleptics Ex. phenothiazine, dibenzoxazepine

Overdosage:

If you or anyone else accidentally takes too much of TRADEP 5/2MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of TRADEP 5/2MG TABLET includes low blood pressure, fast heart rate, high fever, restlessness, confusion, excitement and hallucinations passing into delirium.

SYNOPSIS

Drug :   Trifluoperazine, Benzhexol
Pharmacological Category :   Phenothiazine antipsychotics, Antimuscarinics
Therapeutic Indication :   Treat symptoms and prevent relapse in Schizophrenia, Parkinson’s disease
Dosage Forms :   Tablet

MORE INFORMATION

  • Keep TRADEP 5/2MG TABLET out of reach in children
  • Store TRADEP 5/2MG TABLET at room temperature

FAQs ABOUT TRADEP 5/2MG TABLET

What is TRADEP 5/2MG TABLET used for?

TRADEP 5/2MG TABLET is used to treat symptoms and prevent relapse in schizophrenia (serious mental disorder) which is also used as an adjunct in the short-term management of severe psychomotor agitation and used in the treatment of symptomatic control of all forms of Parkinson's disease (neurological disorder that affects movement).

Who should avoid taking TRADEP 5/2MG TABLET?

TRADEP 5/2MG TABLET is not recommended for use in patients who have blood disorders, planned for a special x-ray examination of the brain or spinal cord involving a chemical called metrizamide, have closed angle or a narrow angle glaucoma (eye disorder that cause blindness) or paralytic ileus (disorder that occurs due to temporary paralyzation of muscle contractions to move food through intestine), severe liver disease or heart failure.

What side effects are seen with TRADEP 5/2MG TABLET?

The most common side effects of taking TRADEP 5/2MG TABLET are drowsiness, dizziness, headache, blurred vision, dry mouth and constipation. Consult your doctor if any of the side effects get worse during or after treatment with TRADEP 5/2MG TABLET.

Is it safe to drive after taking TRADEP 5/2MG TABLET?

TRADEP 5/2MG TABLET might cause dizziness, drowsiness or blurred vision. If you experience these side effects, try to avoid driving or operating heavy machines. Consult your doctor before taking TRADEP 5/2MG TABLET.

What happens if you take more TRADEP 5/2MG TABLET than your required dose?

If you or anyone else accidentally takes too much of TRADEP 5/2MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of TRADEP 5/2MG TABLET low blood pressure, fast heart rate, high fever, restlessness, confusion, excitement and hallucinations passing into delirium.

REFERENCES

1. KD. Tripathi. Antiparkinsonian Drugs & Drugs Used in Mental Illness: Antipsychotic and Antimanic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 433 & 439

2. Adrianna Vlachos. The Use of Trifluoperazine in Transfusion Dependent DBA (DBA). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in October 2021] [Accessed on 1st June 2022] https://clinicaltrials.gov/ct2/show/NCT03966053

3. Bethesda. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. NIH National Library of Medicine, National center for biotechnology information. July 2020 [Accessed on 1st June 2022] https://www.ncbi.nlm.nih.gov/books/NBK548927/

4. Bethesda. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. NIH National Library of Medicine, National center for biotechnology information. July 2017 [Accessed on 1st June 2022] https://www.ncbi.nlm.nih.gov/books/NBK547977/

5. Mercury Pharmaceuticals Ltd. Electronic medicines compendium (EMC). [Revised in October 2018] [Accessed on 1st June 2022] https://www.medicines.org.uk/emc/files/pil.5667.pdf

6. Thomton & Ross Ltd. Electronic medicines compendium (EMC). [Revised in July 2016] [Accessed on 1st June 2022] https://www.medicines.org.uk/emc/files/pil.5271.pdf

7. Actavis pharma, Inc. Trihexyphenidyl hydrochloride tablet. DailyMed. NIH U.S. National Library of Medicine. [Revised in July 2015] [Accessed on 1st June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a44d7803-164d-4a67-9356-581c45de8596

8. Torrent Pharmaceuticals Ltd. Electronic medicines compendium (EMC). [Revised in May 2013] [Accessed on 1st June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/484.pdf

USEFUL DIAGNOSTIC TESTS

  • Magnetic resonance imaging (MRI)
  • Computed tomography (CT scan)

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    TRIHEXIPHENIDYL 2MG+TRIFLUOPERAZINE 5MG
    Hsn Code
    30049099
ALTERNATE BRANDS
Shicalm Plus 5/2mg Tablet 10'S
Prescription Schizophrenia Rx required
Out of stock
Rs.18.00
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Tradep 5/2mg Tablet 10'S

Tradep 5/2mg Tablet 10'S Mkt: East West Pharmaceuticals Pvt Ltd

M.R.P.: Rs.35.00
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