INTRODUCTION

TOPORAB 170MG CAPSULE is a combination of Itopride and Rabeprazole which belongs to the group of medicines called Gastroprokinetic agent and Proton-pump inhibitors respectively. It is used to treat Gastroesophageal reflux disease (acid reflux) and Peptic ulcer disease.

Gastroesophageal reflux disease (GERD) is a digestive disorder that occurs when acidic stomach juices or food and fluids back up from the stomach into the oesophagus.

Peptic ulcers are open sores that develop on the inside lining of stomach and the upper portion of small intestine. Rarely, peptic ulcer may develop just above your stomach in your oesophagus. The most common symptom of a peptic ulcer is stomach pain.

Before taking this medicine inform your doctor if you have heart disease, liver disease or kidney disease. Pregnant and breastfeeding women should consult their doctors before taking this medicine.

There is no proper information regarding the use of this medicine in children and adultescents. Consult your doctor before taking this medicine.

TOPORAB 170MG CAPSULE should be used with caution in elderly patients. Consult your doctor before taking this medicine.

The most common side effects are stomach pain, headache, constipation, diarrhoea, dizziness, and rash. Consult your doctor if any of the above side effects worsen or persist for a longer duration.

USES OF TOPORAB 170MG CAPSULE

It is used to treat:

• gastroesophageal reflux disease (acid reflux)
• peptic ulcer disease

HOW TOPORAB 170MG CAPSULE WORKS

TOPORAB 170MG CAPSULE is a combination of Itopride and Rabeprazole. Itopride works by on the region in the brain that controls vomiting and also acts on the upper digestive tract and helps food move more easily through the stomach. Rabeprazole works by reducing the amount of acid in the stomach which helps to relieve acid-related indigestion and heartburn.

DIRECTIONS FOR USE

Take TOPORAB 170MG CAPSULE as directed by your physician. Swallow the medicine as a whole and do not crush or chew the medicine. Take it preferably 30 minutes before food. Your doctor will decide the correct dose for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF TOPORAB 170MG CAPSULE

HOW TO MANAGE SIDE EFFECTS

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrheoa. Consult your doctor if the symptom did not improve.

Constipation: 

Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

Headache:  

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Flatulence:

Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. Consult your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Tell your doctor about all the medicines you take, including prescription, non-prescription medicines and herbal supplements.

Overdosage:

If you or anyone else accidentally takes too much of this medicine, contact your doctor immediately or go to a nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store at room temperature

FAQs ABOUT TOPORAB 170MG CAPSULE

Q: Can TOPORAB 170MG CAPSULE cause constipation?

A: Yes, this medicine may cause constipation in some individuals. Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

Q: Can I take TOPORAB 170MG CAPSULE during pregnancy?

A: No, it is not recommended for use in pregnant women. Consult your doctor before taking this medicine.

Q: Can TOPORAB 170MG CAPSULE cause flatulence?

A: Yes, this medicine may cause flatulence in some individuals. Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. Consult your doctor if the symptom did not improve.

Q: Can I take TOPORAB 170MG CAPSULE if I have liver disease?

A: TOPORAB 170MG CAPSULE should be used with caution in patients suffering from liver impairment, severe liver disease. Consult your doctor before taking this medicine.

REFERENCES

1. KD. Tripathi. Antiemetic, Prokinetic and Digestant Drugs & Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page – 667-653.

2. Takeshi Kamiya, Michiko Shikano, Eiji Kubota, Tsutomu Mizoshita, Tsuneya Wada, Satoshi Tanida, Hiromi Kataoka, Hiroshi Adachi, Makoto Hirako, Noriaki Okuda, and Takashi Joh. A multicenter randomized trial comparing rabeprazole and itopride in patients with functional dyspepsia in Japan: the NAGOYA study. March 2017. [Accessed on March 17th 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370523/

3. American academy of Allergy asthma and Immunology. Gastroesophageal Reflux Disease. [Accessed on March 17th 2022] https://www.aaaai.org/Conditions-Treatments/related-conditions/gastroesophageal-reflux-disease

4. NIH. [Accessed on March 17th 2022] https://www.niddk.nih.gov/health-information/digestive-diseases/peptic-ulcers-stomach-ulcers/definition-facts

5. Krosyl Pharmaceutials. [Accessed on March 17th 2022] https://krosylpharma.com/product/rabeprazole-sodium-itopride-hydrochloride-capsules-rabetopride/

6. Medindia. [Accessed on March 17th 2022] https://www.medindia.net/doctors/drug_information/rabeprazole_itopride.htm

7. MIMS.com. [Accessed on March 17th 2022] https://www.mims.com/india/drug/info/itopie-rd/itopie-rd%20cap

8. Genericure. [Accessed on March 17th 2022] https://www.genericure.in/rabalkem-it-20mg-150mg-capsule